Article
Biochemistry & Molecular Biology
Jian-xiong Wang, Feng-yang Jing, Yue-chen Xu, He-xiang Zong, Yi-ran Chu, Cong Wang, Ke-ming Chen, Wan-qiu Tong, Xi-le Wang, Sheng-qian Xu
Summary: This study analyzed the expression profiles of lncRNAs, miRNAs, and mRNAs in whole blood cells of AS patients and healthy individuals, identifying lncRNA 122K13.12 and lncRNA 326C3.7 as potential biomarkers in AS. A ceRNA network involving these lncRNAs, 30 miRNAs, and five mRNAs was constructed, potentially regulating the TNF signaling pathway in AS development. Furthermore, a lncRNA-based nomogram was developed for predicting bone bridge formation with promising clinical applications.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Immunology
Jian-Xiong Wang, Xu Zhao, Sheng-Qian Xu
Summary: This study identified three novel upregulated lncRNAs in AS and proposed a new lncRNA-RBPmRNA interaction that may regulate adaptive immune response.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Medicine, General & Internal
Chuangxin Li, Wa Qu, Xuefeng Yang
Summary: The present study investigated the expression profiles of lncRNA in AS and identified enriched immune and inflammation-related signaling pathways. The findings provide reference for further research on candidate lncRNAs with potential value in early AS diagnosis.
Article
Genetics & Heredity
Shuizhong Cen, Mingxi Cai, Yihan Wang, Xiuyi Lu, Zhipeng Chen, Haobo Chen, Yingdong Fang, Changping Wu, Sujun Qiu, Zhenhua Liu
Summary: In this study, the expression profiles of differentially expressed (DE) long noncoding RNAs (lncRNAs) and mRNAs during adipogenesis in mesenchymal stem cells from patients with ankylosing spondylitis (ASMSCs) and healthy donors (HDMSCs) were analyzed. Several specific lncRNAs and mRNAs, as well as DE lncRNA-DE mRNA pairs related to the PPAR signaling pathway, were identified to potentially contribute to the enhanced adipogenic differentiation in ASMSCs.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Lin Li, Jianping Ge
Summary: In this study, it was demonstrated that exosomes-derived lncRNA-Ankrd26 from DPSCs promoted dental pulp restoration via regulating miR-150-TLR4 signaling in MSCs.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Liping Zhang, Junyi Hu, Bahar I. Meshkat, Kenneth W. Liechty, Junwang Xu
Summary: In diabetic wounds, MALAT1 and TGF-β1 expression are significantly up-regulated, and knockdown of MALAT1 attenuates TGF-β1-induced EMT in HaCaT cells by inducing the expression of the critical transcription factor ZEB1, providing new insights into the pathogenesis of diabetic wounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Yi-Ping Tang, Quan-Bo Zhang, Fei Dai, Xia Liao, Zeng-Rong Dong, Ting Yi, Yu-Feng Qing
Summary: Differentially expressed circRNAs were found in PBMCs of AS patients, which may be involved in the occurrence and development of AS. Among them, hsa_circRNA_012732 has the potential to be an indicator of disease activity, and hsa_circRNA_001544 has the potential to be a molecular marker for AS diagnosis.
CHINESE MEDICAL JOURNAL
(2021)
Article
Health Care Sciences & Services
Marwa M. Esawy, Amany M. Ebaid, Amir Abd-elhameed, Felwa A. Thagfan, Murad A. Mubaraki, Ahmed S. Alazzouni, Mohamed A. Dkhil, Marwa A. Shabana
Summary: Ankylosing spondylitis (AS) is a chronic inflammatory disease that causes severe pain and stiffness in the joints. The role of lncRNA H19 in AS was investigated and it was found to play a key role in the pathogenesis of the disease. The expression of lncRNA H19 was significantly upregulated in AS patients compared to healthy controls and was positively correlated with disease activity and inflammatory markers.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Orthopedics
Li Wei, Xin Zhang, Yu Yao, Weizhuo Zheng, Jun Tian
Summary: This study reveals that the lncRNA HOTTIP/miR-30b-3p/PGK1 axis plays a regulatory role in the progression of ankylosing spondylitis (AS). By inhibiting the proliferation and differentiation of synoviocytes, this pathway can improve the disease.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Chuming Tao, Haitao Luo, Luyue Chen, Jingying Li, Xingen Zhu, Kai Huang
Summary: This study identified a nine-EMT-related lncRNA signature with prognostic value in gliomas, showing that patients in the low-risk group had longer survival and were associated with specific genetic characteristics. The findings were validated in different genomic datasets. The lncRNA-mediated ceRNA network may play a potential role in EMT progression in gliomas.
Article
Endocrinology & Metabolism
Chengxin Li, Lewei Zheng, Gaoran Xu, Qianqian Yuan, Ziyang Di, Yalong Yang, Xingxing Dong, Jinxuan Hou, Gaosong Wu
Summary: In this study, an EMT-related lncRNA signature was constructed to predict the prognosis of breast cancer patients. A risk score signature consisting of 10 lncRNAs associated with the EMT process was developed and validated. The signature was also evaluated for its impact on drug sensitivity and tumor immune cell infiltration in breast cancer.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Ophthalmology
Shiheng Lu, Peirong Lu
Summary: This study comprehensively analyzed the expression of lncRNAs in peripheral blood of patients with three major autoimmune diseases (ankylosing spondylitis, Behçet's disease, and sarcoidosis) to search for potential hub genes and molecular mechanisms for noninfectious uveitis. The results identified several lncRNAs and mRNAs that may be key genes for these diseases and are involved in signaling pathways and inflammatory cytokine regulation. This study provides new insights into the molecular pathogenesis of noninfectious uveitis and potential biomarkers and therapeutic targets.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Lili Dong, Linhao Li, Yang Song, Yunnan Fang, Jinlin Liu, Peixing Chen, Sixiang Wang, Chunli Wang, Tingting Xia, Wanqian Liu, Li Yang
Summary: The study focuses on reducing macrophage-driven inflammation in injured tendons to inhibit adhesion formation, by regulating M1 to M2 macrophage polarization. By developing an acellular immunomodulatory biomaterial functionalized with MSC-derived ECM, the research successfully demonstrated the immunoregulatory potential of iECM-functionalized fibrous scaffolds in attenuating foreign-body reactions and preventing tendon adhesion.
ACTA BIOMATERIALIA
(2021)
Article
Orthopedics
Dan Huang, Jian Liu, Lei Wan, Yanyan Fang, Yan Long, Ying Zhang, Bingxi Bao
Summary: This study identified several lncRNAs specifically expressed in peripheral blood mononuclear cells of AS patients, indicating their potential key roles in the pathogenesis of this autoimmune disease. Specifically, NONHSAT118801.2 and NONHSAT183847.1 were found to be correlated with disease severity, suggesting their involvement in the occurrence and development of AS.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Pharmacology & Pharmacy
Binliang Gan, Youwu He, Yonggang Ma, Linfeng Mao, Chuanjie Liao, Ganlu Deng
Summary: This study identified 32 differentially expressed long non-coding RNAs (lncRNAs), of which 12 were associated with the prognosis of hepatocellular carcinoma (HCC) patients. A prognostic signature comprising 6 prognostic lncRNAs was developed and showed excellent predictive ability. Additionally, a differential m6A regulator, RBMX, was found to be negatively correlated with the hub lncRNA AC115619.1. AC115619.1 was downregulated in HCC tissues compared to normal tissues, and its expression was significantly related to clinicopathological features, survival rate, and drug sensitivity. Overexpression of AC115619.1 inhibited proliferation, migration, and invasion of HCC cells.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell & Tissue Engineering
Yu-Xi Li, Fu-Chao Chen, Ting Liu, Zhao-Peng Cai, Keng Chen, Guo-Xue Tang, Jun-Shen Huang, Xiang-Ge Liu, Jia-Jun Huang, Peng Wang, Yu-Wei Liang, Lin Huang
STEM CELLS INTERNATIONAL
(2020)
Article
Orthopedics
Xiang-Ge Liu, Pei-Jie Liang, Han-Hui Liu, Guang-Fu Chen, Xiao-Dong Zhao
Summary: This study investigated the impact of the morphology of the superior articular processes of L5 vertebra on the accuracy of pedicle screw placement. The results showed that an MCD < 6 mm was associated with an increased screw placement failure rate and a decreased Zygapophysial Joints Angle (ZJA). The MCD was positively correlated with the Inter-Facet Distance (IFD), while no significant change in Inter-Pedicle Distance (IPD) was observed. Simulation analysis showed that the Maximum Safe Transverse Angle (STA(max)) decreased with a decrease in MCD. Assessing the relationship between the trans-mammillary vertical line and the pedicle can help predict abnormal morphology of the superior articular process before surgery.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Letter
Orthopedics
Xiang-Ge Liu, Xin Chen, Biao Chen, Pei-Jie Liang, Han-Hui Liu, Meiqi Fu
Summary: This study aimed to measure the vertebral bone quality (VBQ) in people of all ages and compare changes in VBQ across ages. Differences in VBQ under various MRI parameters were compared.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xin Chen, Xiangge Liu, Zhiru Yuan, Zhanqi Zhang
Summary: In this study, the expression and prognostic relevance of CRP, PCT, and IL-15 in patients with postoperative infection due to spinal injury were analyzed. The results showed that the infected group had higher levels of CRP, PCT, and IL-15 compared to the uninfected group. Furthermore, CRP, PCT, and IL-15 were significantly associated with prognosis in spinal injury patients with postoperative infection.
CELLULAR AND MOLECULAR BIOLOGY
(2022)