Article
Clinical Neurology
Behnam Iravani, Elaheh Abdollahi, Fatemeh Eslamdoust-Siahestalkhi, Robabeh Soleimani
Summary: This study assessed the relationship between neuropsychiatric symptoms in patients with Alzheimer's disease and caregiver burden. The results showed a significant correlation between NPS and CB, with apathy being the most common symptom in AD patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Taylor Rigby, David K. Johnson, Angela Taylor, James E. Galvin
Summary: This cross-sectional study found no differences in caregiver characteristics or disease severity distribution between DLB, PDD, and AD. Instead, the caregiver's experience was dependent on caregiver and care recipient characteristics, as well as the most disturbing symptoms, with behavior, personality changes, and sleep having the greatest impact on psychosocial constructs.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Geriatrics & Gerontology
Emmanuel Cognat, Severine Sabia, Alexandra Fayel, Matthieu Lilamand, Ron Handels, Sara Fascendini, Sverre Bergh, Giovanni B. Frisoni, Andrea Fabbo, Magdalina Tsolaki, Lutz Frolich, Oliver Peters, Paola Merlo, Alfonso Ciccone, Patrizia Mecocci, Julien Dumurgier, Carlo A. Defanti, Jacques Hugon, Claire Paquet
Summary: A study found that the profiles of behavioral and psychological symptoms of dementia (BPSD) vary depending on etiology in patients with mild-to-moderate BPSD. However, it is not known if similar differences exist in patients with severe BPSD.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Victoria Garcia-Martin, M. Canto de Hoyos-Alonso, Rosalia Delgado-Puebla, Gloria Ariza-Cardiel, Isabel del Cura-Gonzalez
Summary: This cross-sectional observational study estimated the prevalence of burden among caregivers of dementia patients and its association with neuropsychiatric symptoms (NPSs) and identified NPSs causing greater caregiver distress at different dementia stages. The results showed that caregiver burden is high and associated with the presence and intensity of NPSs, with disinhibition and irritability causing the highest burden. In mild, mild-moderate, and severe dementia, depression, hyperactivity, and psychosis symptoms respectively produce more distress.
Article
Clinical Neurology
Alberto Jaramillo-Jimenez, Lasse M. Giil, Diego A. Tovar-Rios, Miguel German Borda, Daniel Ferreira, Kolbjorn Bronnick, Ketil Oppedal, Dag Aarsland
Summary: The study found that larger amygdala volume in patients with mild dementia is associated with an increased likelihood of developing depression symptoms, a decreased likelihood of agitation/aggression, and a slower rate of cognitive decline over a 5-year period.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
M. van de Beek, I van Steenoven, J. J. van der Zande, I Porcelijn, F. Barkhof, C. J. Stam, P. G. H. M. Raijmakers, P. Scheltens, C. E. Teunissen, W. M. van der Flier, A. W. Lemstra
Summary: The DEvELOP project aims to phenotype patients with dementia with Lewy bodies and study the associations between symptoms and disease burden. The study found that cognitive and motor symptoms are related to daily functioning, while negative neuropsychiatric symptoms and functional dependency are important determinants of quality of life and caregiver burden. Follow-up research is ongoing to address specific gaps in DLB research.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Psychiatry
Xinran Bao, Junying Xu, Qingbo Meng, Jinghuan Gan, Xiao-Dan Wang, Hao Wu, Shuai Liu, Yong Ji
Summary: During the pandemic, social isolation, physical inactivity, and sleep disturbances led to increased caregiver burden and worsened psychological states among caregivers of Alzheimer's disease (AD), Dementia with Lewy Bodies (DLB), and Mild Cognitive Impairment (MCI) patients, particularly among DLB caregivers.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Juyoung Park, James E. Galvin
Summary: Being the caregiver of a spouse, lower caregiver well-being, lower psychological well-being of the caregiver, and higher level of burden are associated with increased pre-loss grief in caregivers of older adults with DLB. There is no significant difference in caregiver burden, well-being, or depression according to the various stages of DLB in the care recipients. There is no significant difference in pre-loss grief in caregivers of DLB care recipients compared to caregivers of patients with other dementias.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Fabricio Ferreira de Oliveira, Marjorie Camara Miraldo, Eduardo Ferreira de Castro-Neto, Sandro Soares de Almeida, Sandro Luiz de Andrade Matas, Paulo Henrique Ferreira Bertolucci, Maria da Graca Naffah-Mazzacoratti
Summary: Behavioral features may predict proteinopathies in neurodegenerative diseases, study examined associations of CSF biomarkers with neuropsychiatric features in DLB compared with AD and controls. DLB patients showed more intense behavioral burden, biomarker ratios were similar to AD, and APOE epsilon 4 status influenced amyloidogenesis and tau pathology differently in DLB and AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Karri Kaivola, Zalak Shah, Ruth Chia, Sonja W. Scholz
Summary: The GBA gene is associated with risk for dementia with Lewy bodies (DLB) in patients without the APOE ε4 allele, while the APOE ε4 allele is associated with DLB co-pathology with Alzheimer's disease. APOE ε4 is not an independent driver of alpha-synuclein pathology in pure DLB, but GBA plays a significant role in the pure DLB subgroup.
Article
Psychology, Clinical
Paul C. Donaghy, Joanna Ciafone, Rory Durcan, Calum A. Hamilton, Sally Barker, Jim Lloyd, Michael Firbank, Louise M. Allan, John T. O'Brien, John-Paul Taylor, Alan J. Thomas
Summary: MCI-LB is characterized by more neuropsychiatric symptoms compared to MCI-AD. The presence of two or more neuropsychiatric supportive symptoms as defined by MCI-LB diagnostic criteria is highly specific and moderately sensitive for a diagnosis of MCI-LB. The cognitive profile of MCI-LB differs from MCI-AD.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Chunyan Liu, Shuai Liu, Xiaodan Wang, Yong Ji
Summary: The study compared neuropsychiatric symptoms in patients with MCI-LB and MCI-AD, finding that MCI-LB patients had more severe symptoms and higher prevalence rates compared to MCI-AD patients. MCI-LB patients also exhibited more supportive symptoms, such as visual hallucinations and RBD, making them easier to differentiate from MCI-AD.
AGING & MENTAL HEALTH
(2021)
Article
Geriatrics & Gerontology
Manee Pinyopornpanish, Kanokporn Pinyopornpanish, Atiwat Soontornpun, Surat Tanprawate, Angkana Nadsasarn, Nahathai Wongpakaran, Tinakon Wongpakaran
Summary: This study found that caregiver burden is indirectly associated with patients' neuropsychiatric symptoms through the caregiver's depressive symptoms and perception of stress. Early detection and appropriate interventions can help in reducing and preventing caregiver burden.
Article
Psychology, Clinical
Hamish Naismith, Robert Howard, Robert Stewart, Alexandra Pitman, Christoph Mueller
Summary: This study examines factors associated with suicidal ideation around the time of dementia diagnosis. The findings suggest that depression, dementia with Lewy bodies, impaired activities of daily living, and vascular dementia are associated with a higher risk of suicidal ideation. The study highlights the importance of identifying and treating depressive symptoms in individuals with dementia and encourages further research on under-researched dementia subtypes.
INTERNATIONAL PSYCHOGERIATRICS
(2022)
Article
Geriatrics & Gerontology
Pai-Yi Chiu, Cheng-Yu Wei, Guang-Uei Hung, Shey-Lin Wu
Summary: By utilizing a composite scale consisting of MDQ and DAT imaging, it can aid in detecting DLB easily in healthcare settings without movement disorder specialists. The study findings also indicate that the composite scale significantly improves the diagnostic accuracy compared to using MDQ or SBR alone.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Ingrid Myrvoll Lorentzen, Jacob Espenes, Erik Hessen, Knut Waterloo, Geir Brathen, Santiago Timon, Dag Aarsland, Tormod Fladby, Bjorn-Eivind Kirsebom
Summary: The study developed regression-based norms for the FAS phonemic fluency test and found that years of education was the only significant predictor of test performance. The proposed norms provided a more accurate adjustment for demographics in the Norwegian population compared to American norms.
APPLIED NEUROPSYCHOLOGY-ADULT
(2023)
Article
Public, Environmental & Occupational Health
Serena Sabatini, Obioha C. Ukoumunne, Clive Ballard, Rachel Collins, Sarang Kim, Anne Corbett, Dag Aarsland, Adam Hampshire, Helen Brooker, Linda Clare
Summary: This study explored the factors associated with subjective age, finding that it may result from the interaction between factors that increase or decrease age-related thoughts and mental processes. The results show that individuals reporting an older subjective age are more likely to experience significant negative changes and engage in negative age-related thoughts. Women experience a more negative subjective age and more age-related events than men.
PSYCHOLOGY & HEALTH
(2023)
Article
Geriatrics & Gerontology
Dag Aarsland, Khadija Khalifa, Anne K. Bergland, Hogne Soennesyn, Ketil Oppedal, Lise B. A. Holteng, Ragnhild Oesterhus, Arne Nakling, Jonas A. Jarholm, Chiara de Lucia, Tormod Fladby, Helen Brooker, Ingvild Dalen, Clive Ballard
Summary: This study aimed to investigate the safety and effectiveness of anthocyanins, a nutritional compound, in maintaining cognitive functioning in older people. The 24-week trial on 206 participants with mild cognitive impairment or cardiometabolic disorders showed that anthocyanin supplementation was safe and well-tolerated. Although there was no significant group difference in episodic memory at the end of the study, there were significant differences in slopes during weeks 8-24, with improvement in the anthocyanin group and deterioration in the placebo group.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Clinical Neurology
Oleg O. Glebov, David Williamson, Dylan M. Owen, Tibor Hortobagyi, Claire Troakes, Dag Aarsland
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2023)
Article
Psychology, Clinical
Ingvild Vollo Eliassen, Bjorn-Eivind Kirsebom, Tormod Fladby, Knut Waterloo, Sigrid Botne Sando, Mathilde Suhr Hemminghyth, Dag Aarsland, Santiago Timon-Reina, Anders Wallin, Fredrik Ohman, Marie Eckerstrom, Erik Hessen
Summary: This study aimed to develop 2-year cognitive change norms for adults aged 41-84 and evaluated these norms in groups with AD biomarkers. The results showed that the group with cognitive complaints exhibited a trend of cognitive decline, with the A+T/N+ subgroup showing the most significant decline.
Article
Behavioral Sciences
Gavin R. Stewart, Anne Corbett, Clive Ballard, Byron Creese, Dag Aarsland, Adam Hampshire, Helen Brooker, Rebecca A. Charlton, Francesca Happe
Summary: Cognitive differences in memory, information processing speed, and executive functions are common in autistic and high autistic trait populations. Older adults with high autistic traits experience more difficulties in memory, IPS, and EF tasks compared to those with low autistic traits. Further research is needed to examine age-related changes in cognitive profiles of older adults with autism traits.
Article
Geriatrics & Gerontology
S. Sabatini, B. Dritschel, F. S. Rupprecht, O. C. Ukoumunne, C. Ballard, H. Brooker, A. Corbett, L. Clare
Summary: Lower awareness of age-related gains and higher awareness of age-related losses are risk factors for depressive and anxiety symptoms. The study found that higher AARC-losses predicted more depressive and anxiety symptoms, and these associations were stronger in individuals who frequently ruminate. Age did not moderate the associations between AARC-gains/losses and depressive/anxiety symptoms.
AGING & MENTAL HEALTH
(2023)
Article
Medicine, General & Internal
Oleg O. Glebov, Christoph Mueller, Robert Stewart, Dag Aarsland, Gayan Perera
Summary: A retrospective study found that antidepressant drugs, especially selective serotonin reuptake inhibitors, may reduce the risk of COVID-19 infection. However, the study was limited to a cohort of mental health outpatients and further prospective studies are needed to validate their potential preventative effect.
Article
Clinical Neurology
Zsofia Csajbok, Dag Aarsland, Pavla Cermakova
Summary: This epidemiological study aimed to explore the temporal relationship between depressive symptoms and cognitive function. The results demonstrated a bidirectional association between the two, with cognitive function initially having a slightly stronger impact on depressive symptoms, and depressive symptoms having a stronger impact on cognitive function during follow-up. However, within-person effects showed a dominant influence of depressive symptoms on cognitive function.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Behavioral Sciences
Sara Pisani, Brandon Gunasekera, Yining Lu, Miriam Vignando, Dominic Ffytche, Dag Aarsland, K. Ray Chaudhuri, Clive Ballard, Jee-Young Lee, Yu Kyeong Kim, Latha Velayudhan, Sagnik Bhattacharyya
Summary: This study conducted a meta-analysis of MRI studies to explore the neuroanatomical alterations underlying psychosis in Parkinson's Disease (PDP). The results revealed widespread grey matter volume loss in the parieto-temporo-occipital regions of PDP patients, which was associated with the expression of serotonergic receptor genes (5-HT1a and 5-HT2a), but not dopaminergic receptors.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Health Care Sciences & Services
Elizabeth ONions, Irene Petersen, Joshua E. J. Buckman, Rebecca Charlton, Claudia Cooper, Anne Corbett, Francesca Happe, Jill Manthorpe, Marcus Richards, Rob Saunders, Cathy Zanker, Will Mandy, Joshua Stott
Summary: This study estimated the numbers of diagnosed and undiagnosed autistic individuals in England and examined the differences in diagnostic rates based on socio-demographic factors. The results showed a higher prevalence of diagnosed autism in children/young people compared to adults/older adults. Age-related inequalities were also evident in new diagnoses, indicating the urgent need to improve access to adult autism diagnostic services.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Geriatrics & Gerontology
Jon Arild Aakre, Joern Schulz, Clive Ballard, Anne Corbett, Bjorn Bjorvatn, Dag Aarsland, Byron Creese, Adam Hampshire, Helen Brooker, Ingelin Testad
Summary: Short sleep duration, long sleep duration, and sleep fragmentation are associated with cognitive decline.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Melanie Le Sayec, Diogo Carregosa, Khadija Khalifa, Chiara de Lucia, Dag Aarsland, Claudia N. Santos, Ana Rodriguez-Mateos
Summary: This study investigated the presence of (poly)phenol and methylxanthine metabolites in plasma and cerebrospinal fluid from individuals at risk of dementia and predicted their transport mechanism across the blood-brain barrier using in silico modeling. The results suggest that (poly)phenols and methylxanthines can cross the blood-brain barrier via passive diffusion or transport carriers to exert neuroprotective effects.
