Article
Clinical Neurology
Grace J. Goodwin, Stacey Moeller, Amy Nguyen, Jeffrey L. Cummings, Samantha E. John
Summary: This study examined the network structure of neuropsychiatric symptoms in older adults with cognitive impairment. The results showed significant connectivity among these symptoms, and disinhibition and agitation/aggression were found to be the most central symptoms in the network. Targeting these symptoms may lead to overall improvement in neuropsychiatric symptoms.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Review
Nursing
Jana Koch, Jessica G. Amos, Elizabeth Beattie, Nicola T. Lautenschlager, Coleen Doyle, Kaarin J. Anstey, Moyra E. Mortby
Summary: This umbrella review examines the efficacy of non-pharmacological interventions in managing neuropsychiatric symptoms of dementia in residential aged care settings. The findings suggest that tailored interventions, sensory stimulation interventions, environmental interventions, exercise interventions, and multiple intervention types can effectively improve symptoms in patients. However, there is considerable heterogeneity in outcome measures and intervention protocols across different interventions.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2022)
Review
Neurosciences
Milap A. Nowrangi, John D. Outen, John Kim, Dimitrios Avramopoulos, Constantine G. Lyketsos, Paul B. Rosenberg
Summary: This article reviews the neurobiological mechanisms of neuropsychiatric symptoms of Alzheimer's disease (NPS-AD), including depression, psychosis, and agitation. The authors found that mechanisms involving monoaminergic biosynthesis and function are likely key elements of NPS-AD, but the lack of effectiveness of current treatments may be due to contributions from additional mechanisms.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Ioannis Liampas, Vasileios Siokas, Constantine G. Lyketsos, Efthimios Dardiotis
Summary: This study aimed to investigate whether associations between individual neuropsychiatric symptoms (NPS) and incident Alzheimer's dementia (AD) differed between men and women. Data from cognitively unimpaired individuals and participants with mild cognitive impairment (MCI) were analyzed. The results showed that in cognitively unimpaired individuals, female sex moderated the risk conferred by moderate/severe apathy and depression, while augmenting the risks conferred by mild depression and agitation. However, no significant differences in the risks of future AD between men and women with MCI were found.
JOURNAL OF NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Aaron Choi, Anthony Martyr, Linda Clare, Jane Fossey, Zunera Khan, Joanne McDermid, Clive Ballard
Summary: Delusions and hallucinations in people with dementia living in nursing homes are associated with poorer quality of life. The effects remain significant even after controlling for other factors. Agitation, anxiety, and depression partially mediate the relationship between each psychotic symptom and quality of life.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Review
Behavioral Sciences
Simona Karamazovova, Veronika Matuskova, Zahinoor Ismail, Martin Vyhnalek
Summary: In addition to motor coordination, the cerebellum also plays an important role in cognitive and affective processes. Spinocerebellar ataxias (SCA) and Friedreich ataxia (FRDA) are rare neurodegenerative diseases of the cerebellum that not only affect motor functions but also have cognitive and neuropsychiatric symptoms. This review discusses the prevalence, clinical features, and treatment approaches of neuropsychiatric impairments such as depression, anxiety, apathy, agitation, impulse dyscontrol, and psychosis in SCA and FRDA patients. Further research is needed to improve the detection and treatment options for these co-morbidities in ataxia patients due to their significant impact on quality of life.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Editorial Material
Clinical Neurology
Richard M. Camicioli, Carlo Colosimo
Summary: This study examined the association between different NPS profiles and the risk of cognitive decline in PD-MCI patients, which is of great importance for the diagnosis and management of PD-MCI patients.
Article
Psychology, Clinical
Paul C. Donaghy, Joanna Ciafone, Rory Durcan, Calum A. Hamilton, Sally Barker, Jim Lloyd, Michael Firbank, Louise M. Allan, John T. O'Brien, John-Paul Taylor, Alan J. Thomas
Summary: MCI-LB is characterized by more neuropsychiatric symptoms compared to MCI-AD. The presence of two or more neuropsychiatric supportive symptoms as defined by MCI-LB diagnostic criteria is highly specific and moderately sensitive for a diagnosis of MCI-LB. The cognitive profile of MCI-LB differs from MCI-AD.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Yu-Yuan Huang, Teng Teng, Cinzia D. Giovane, Rong-Ze Wang, John Suckling, Xue-Ning Shen, Shi-Dong Chen, Shu-Yi Huang, Kevin Kuo, Wen-Jie Cai, Ke-Liang Chen, Lei Feng, Can Zhang, Cai-Yan Liu, Chun-Bo Li, Qian-Hua Zhao, Qiang Dong, Xin-Yu Zhou, Jin-Tai Yu
Summary: This article summarizes the comparative efficacy and acceptability of currently available monotherapy drug regimens for reducing NPS in dementia. The results suggest that risperidone is probably the best pharmacological option to consider for alleviating NPS in people with dementia in short-term treatment.
Review
Geriatrics & Gerontology
Sakti Oktaria Batubara, Santo Imanuel Tonapa, Ita Daryanti Saragih, Mulyadi Mulyadi, Bih-O Lee
Summary: Animal-assisted interventions (AAIs) have been developed as non-pharmacological and cost-effective methods to improve outcomes in dementia patients, but the effects are inconclusive. This study analyzed the efficacy of AAIs for people with dementia by conducting a systematic review and meta-analysis of relevant literature. The results showed significant differences in depression levels between the intervention and control groups, but no significant differences in cognitive function, neuropsychiatric symptoms, or independence in activities of daily living were observed. Future research is needed to examine the effects of AAIs on depression in different stages of dementia. Therapists providing AAIs may collaborate with healthcare workers to enhance the benefits of AAIs.
Review
Cell Biology
Tien-Wei Hsu, Brendon Stubbs, Chih-Sung Liang, Tien-Yu Chen, Ta-Chuan Yeh, Chih-Chuan Pan, Che-Sheng Chu
Summary: This meta-analysis demonstrates that serotonergic antidepressants effectively alleviate overall neuropsychiatric symptoms, agitation, depressive symptoms, and care burden in patients with dementia, as well as improving cognitive function.
AGEING RESEARCH REVIEWS
(2021)
Review
Health Care Sciences & Services
Tomoyuki Nagata, Shunichiro Shinagawa, Keisuke Inamura, Masahiro Shigeta
Summary: Alzheimer's disease is the most common form of dementia, with cognitive impairment being the main symptom. Non-cognitive symptoms, known as neuropsychiatric symptoms (NPSs), also occur and worsen the prognosis. Current treatment guidelines recommend non-pharmacological treatments as the first line, followed by pharmacological treatments. However, pharmacological treatment for urgent NPSs can be challenging due to lack of efficacy or intolerance. Structural deterioration in elderly people with dementia and difficult psychosocial relations may contribute to this difficulty.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Damiana Scuteri, Maria Tiziana Corasaniti, Paolo Tonin, Pierluigi Nicotera, Giacinto Bagetta
Summary: Abnormal neuronal and synaptic plasticity are present in Alzheimer's disease and depression. Current drug therapies for treating neuropsychiatric symptoms have not been able to provide a complete cure, despite numerous clinical trials investigating drugs with different structures and mechanisms of action.
CURRENT OPINION IN PHARMACOLOGY
(2021)
Review
Cell Biology
Clare Yu, Andrew Sommerlad, Lena Sakure, Gill Livingston
Summary: Although socially assistive robots are generally feasible and acceptable, there is currently no clear evidence that people with dementia benefit from robots in terms of cognition, neuropsychiatric symptoms, or quality of life.
AGEING RESEARCH REVIEWS
(2022)
Review
Geriatrics & Gerontology
Jeffrey Cummings
Summary: Neuropsychiatric syndromes and symptoms are playing increasingly important roles in research diagnostic criteria for neurodegenerative disorders. They are often core diagnostic criteria, and the relationships between neuropsychiatric symptoms and cognitive, motor, and autonomic symptoms are being studied and better understood.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Public, Environmental & Occupational Health
M. L. Omholt, T. H. Tveito, C. Ihlebaek
OCCUPATIONAL MEDICINE-OXFORD
(2017)
Article
Public, Environmental & Occupational Health
Camilla Ihlebaek, Geir Aamodt, Renata Aradi, Bjorgulf Claussen, Kine Halvorsen Thoren
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2018)
Article
Oncology
Birgit Brusletto, Steffen Torp, Camilla Martha Ihlebaek, Hege Forbech Vinje
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2018)
Article
Rehabilitation
Birgit Brusletto, Camilla Martha Ihlebaek, Nina Helen Mjosund, Steffen Torp
SCANDINAVIAN JOURNAL OF OCCUPATIONAL THERAPY
(2020)
Article
Psychology, Clinical
Nina Joranson, Christine Olsen, Giovanna Calogiuri, Camilla Ihlebaek, Ingeborg Pedersen
Summary: This study investigated the effects of robot-assisted group activity on sleep patterns in nursing home residents with dementia. Results showed positive effects on sleep in the intervention group, including increased sleep efficiency, total sleep time, and reduced nighttime awakenings. Social stimulation through engaging group activity could contribute to improved sleep quality in older people with dementia, affecting central indicators of good sleep quality.
INTERNATIONAL PSYCHOGERIATRICS
(2021)
Article
Public, Environmental & Occupational Health
Birgit Brusletto, Roy A. Nielsen, Harald Engan, Line Oldervoll, Camilla M. Ihlebaek, Nina Helen Mjosund, Steffen Torp
Summary: The aim of the study was to investigate the labor-force participation, working hours, job changes, and education over 9 years among those who survived cancer for more than 10 years, compared to controls. The results showed a significant reduction in labor force participation and working hours among cancer survivors, especially more pronounced in women than men. Gender differences and differences in working patterns were also observed between cancer survivors and controls.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2021)
Article
Environmental Studies
Camilla Ihlebaek, Petter Naess, Harpa Stefansdottir
Summary: The study suggests that the built environment is associated with health outcomes, but does not necessarily result in overall negative health impacts. Living close to the main city centre may contribute to better self-reported general health, while high local-area density shows a slight opposite association.
EUROPEAN PLANNING STUDIES
(2021)
Article
Psychology, Social
Victoria T. Hjellset, Camilla Ihlebaek
INTERNATIONAL JOURNAL OF INTERCULTURAL RELATIONS
(2020)
Article
Transportation
Harpa Stefansdottir, Petter Naess, Camilla Martha Ihlebaek
TRAVEL BEHAVIOUR AND SOCIETY
(2019)
Article
Public, Environmental & Occupational Health
Victoria Telle Hjellset, Camilla Ihlebaek
JOURNAL OF IMMIGRANT AND MINORITY HEALTH
(2019)
Article
Gerontology
Christine Olsen, Ingeborg Pedersen, Astrid Bergland, Marie-Jose Enders-Slegers, Camilla Ihlebaek
DEMENTIA-INTERNATIONAL JOURNAL OF SOCIAL RESEARCH AND PRACTICE
(2019)
Article
Psychology, Clinical
Emma Charlott Andersson Nordbo, Geir Aamodt, Camilla Martha Ihlebaek
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2017)
Article
Rehabilitation
Tone Langjordet Johnsen, Aage Indahl, Hege Randi Eriksen, Camilla Ihlebaek, Torill Helene Tveito
JOURNAL OF OCCUPATIONAL REHABILITATION
(2017)
Article
Public, Environmental & Occupational Health
Ingeborg Pedersen, Lina Harvold Dalskau, Camilla Ihlebaek, Grete Patil
WORK-A JOURNAL OF PREVENTION ASSESSMENT & REHABILITATION
(2016)
Article
Public, Environmental & Occupational Health
Ingeborg Pedersen, Grete Patil, Bente Berget, Camilla Ihlebaek, Marianne Thorsen Gonzalez
WORK-A JOURNAL OF PREVENTION ASSESSMENT & REHABILITATION
(2016)