The Shiga Toxin Receptor Globotriaosylceramide as Therapeutic Target in Shiga Toxin E. coli Mediated HUS

Eliglustat prevents Shiga toxin 2 cytotoxic effects in human renal tubular epithelial cells

(2021) Daiana S. Sánchez et al.   PEDIATRIC RESEARCH

Developments in the treatment of Fabry disease

(2020) Sanne J. Veen et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Verotoxin Receptor-Based Pathology and Therapies

(2020) Clifford Lingwood   Frontiers in Cellular and Infection Microbiology

Shiga Toxin-Bearing Microvesicles Exert a Cytotoxic Effect on Recipient Cells Only When the Cells Express the Toxin Receptor

(2020) Karl Johansson et al.   Frontiers in Cellular and Infection Microbiology

Primary Human Derived Blood Outgrowth Endothelial Cells: An Appropriate In Vitro Model to Study Shiga Toxin Mediated Damage of Endothelial Cells

(2020) Wouter J. C. Feitz et al.   Toxins

Pharmacokinetics, pharmacodynamics, and safety of moss-aGalactosidase A in patients with Fabry disease

(2019) Julia B. Hennermann et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Endocytosis, Cytotoxicity, and Translocation of Shiga Toxin-2 Are Stimulated by Infection of Human Intestinal (HCT-8) Monolayers With an Hypervirulent E. coli O157:H7 Lacking stx2 Gene

(2019) Nicolás Garimano et al.   Frontiers in Cellular and Infection Microbiology

Particulate Shiga Toxin 2 in Blood is Associated to the Development of Hemolytic Uremic Syndrome in Children

(2019) Maurizio Brigotti et al.   THROMBOSIS AND HAEMOSTASIS

Effectiveness of plasma lyso-Gb3 as a biomarker for selecting high-risk patients with Fabry disease from multispecialty clinics for genetic analysis

(2018) Hiroki Maruyama et al.   GENETICS IN MEDICINE

Shiga toxin-glycosphingolipid interaction: Status quo of research with focus on primary human brain and kidney endothelial cells

(2018) Nadine Legros et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Sphingolipids and Lipoproteins in Health and Metabolic Disorders

(2017) Jahangir Iqbal et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Microvesicle Involvement in Shiga Toxin-Associated Infection

(2017) et al.   Toxins

Shiga toxin of enterohaemorrhagicEscherichia colidirectly injures developing human erythrocytes

(2016) Josefine Betz et al.   CELLULAR MICROBIOLOGY

Recommendations for the use of eliglustat in the treatment of adults with Gaucher disease type 1 in the United States

(2016) Manisha Balwani et al.   MOLECULAR GENETICS AND METABOLISM

Mannose receptor-mediated delivery of moss-made α-galactosidase A efficiently corrects enzyme deficiency in Fabry mice

(2015) Jin-Song Shen et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Prevention of renal damage caused by Shiga toxin type 2: Action of Miglustat on human endothelial and epithelial cells

(2015) Magalí C. Girard et al.   TOXICON

Eliglustat tartrate for the treatment of adults with type 1 Gaucher disease

(2015) Lunawati Bennett et al.   Drug Design Development and Therapy

A Novel Mechanism of Bacterial Toxin Transfer within Host Blood Cell-Derived Microvesicles

(2015) Anne-lie Ståhl et al.   PLoS Pathogens

Protection of Human Podocytes from Shiga Toxin 2-Induced Phosphorylation of Mitogen-Activated Protein Kinases and Apoptosis by Human Serum Amyloid P Component

(2014) Anne K. Dettmar et al.   INFECTION AND IMMUNITY

Shiga Toxin Promotes Podocyte Injury in Experimental Hemolytic Uremic Syndrome via Activation of the Alternative Pathway of Complement

(2014) M. Locatelli et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Long-term outcomes of Shiga toxin hemolytic uremic syndrome

(2013) Joann M. Spinale et al.   PEDIATRIC NEPHROLOGY

Quantification of Globotriaosylsphingosine in Plasma and Urine of Fabry Patients by Stable Isotope Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry

(2012) H. Gold et al.   CLINICAL CHEMISTRY

Need for Long-term Follow-up in Enterohemorrhagic Escherichia coli–Associated Hemolytic Uremic Syndrome Due to Late-Emerging Sequelae

(2012) Alejandra Rosales et al.   CLINICAL INFECTIOUS DISEASES

Establishment of outgrowth endothelial cells from peripheral blood

(2012) Javier Martin-Ramirez et al.   Nature Protocols

STEC-HUS, atypical HUS and TTP are all diseases of complement activation

(2012) Marina Noris et al.   Nature Reviews Nephrology

Shiga toxin in enterohemorrhagic E.coli: regulation and novel anti-virulence strategies

(2012) Alline R. Pacheco et al.   Frontiers in Cellular and Infection Microbiology

A Glucosylceramide Synthase Inhibitor Protects Rats Against the Cytotoxic Effects of Shiga Toxin 2

(2011) CLAUDIA SILBERSTEIN et al.   PEDIATRIC RESEARCH