Inwardly Rectifying Potassium Channel Kir2.1 and its “Kir-ious” Regulation by Protein Trafficking and Roles in Development and Disease

Mechanisms for Regulating and Organizing Receptor Signaling by Endocytosis

(2021) Mark von Zastrow et al.   Annual Review of Biochemistry

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Structural insights into GIRK2 channel modulation by cholesterol and PIP2

(2021) Yamuna Kalyani Mathiharan et al.   Cell Reports

Kir2.1 interactome mapping uncovers PKP4 as a modulator of the Kir2.1-regulated inward rectifier potassium currents.

(2020) Sung-Soo Park et al.   MOLECULAR & CELLULAR PROTEOMICS

Endocytosis: A Turnover Mechanism Controlling Ion Channel Function

(2020) Irene Estadella et al.   Cells

Andersen-Tawil Syndrome

(2020) Andrés Ricardo Pérez-Riera et al.   Cardiology in Review

AMPK-Mediated Regulation of Alpha-Arrestins and Protein Trafficking

(2019) Allyson F. O’Donnell et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Altering integrin engagement regulates membrane localization of Kir2.1 channels

(2019) Swarnali Sengupta et al.   JOURNAL OF CELL SCIENCE

Inward Rectifier Potassium Channels (Kir2.x) and Caveolin-3 Domain–Specific Interaction

(2018) Ravi Vaidyanathan et al.   Circulation-Arrhythmia and Electrophysiology

Kir2.1 is important for efficient BMP signaling in mammalian face development

(2018) Matthew T. Belus et al.   DEVELOPMENTAL BIOLOGY

Clathrin-independent endocytosis: an increasing degree of complexity

(2018) Kirsten Sandvig et al.   HISTOCHEMISTRY AND CELL BIOLOGY

The endosomal trafficking factors CORVET and ESCRT suppress plasma membrane residence of the renal outer medullary potassium channel (ROMK)

(2018) Timothy D. Mackie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Select α-arrestins control cell-surface abundance of the mammalian Kir2.1 potassium channel in a yeast model

(2018) Natalie A. Hager et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteogenic and Chondrogenic Master Genes Expression Is Dependent on the Kir2.1 Potassium Channel Through the Bone Morphogenetic Protein Pathway

(2018) Jonathan Pini et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Familial Esophageal Squamous Cell Carcinoma with damaging rare/germline mutations in KCNJ12/KCNJ18 and GPRIN2 genes

(2018) Narjes Khalilipour et al.   Cancer Genetics

Golgin-97 Targets Ectopically Expressed Inward Rectifying Potassium Channel, Kir2.1, to the trans-Golgi Network in COS-7 Cells

(2018) Tarvinder K. Taneja et al.   Frontiers in Physiology

Cholesterol up-regulates neuronal G protein-gated inwardly rectifying potassium (GIRK) channel activity in the hippocampus

(2017) Anna N. Bukiya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of a Human Induced Pluripotent Stem Cell–Derived Cardiomyocyte Model for the Study of Variant PathogenicityCLINICAL PERSPECTIVE

(2017) Roselle Gélinas et al.   Circulation-Cardiovascular Genetics

A Common Signal Patch Drives AP-1 Protein-dependent Golgi Export of Inwardly Rectifying Potassium Channels

(2016) Xiangming Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bioelectric signalling via potassium channels: a mechanism for craniofacial dysmorphogenesis in KCNJ2-associated Andersen-Tawil Syndrome

(2016) Dany Spencer Adams et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulating Rho GTPases and their regulators

(2016) Richard G. Hodge et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protein assemblies of sodium and inward rectifier potassium channels control cardiac excitability and arrhythmogenesis

(2015) B. Cicero Willis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Genetically induced dysfunctions of Kir2.1 channels: implications for short QT3 syndrome and autism–epilepsy phenotype

(2014) Elena Ambrosini et al.   HUMAN MOLECULAR GENETICS

Silencing of Kir2 channels by caveolin-1: cross-talk with cholesterol

(2014) Huazhi Han et al.   JOURNAL OF PHYSIOLOGY-LONDON

Clathrin-Independent Pathways of Endocytosis

(2014) S. Mayor et al.   Cold Spring Harbor Perspectives in Biology

Interplay Between Lipid Modulators of Kir2 Channels: Cholesterol and PIP2

(2014) Avia Rosenhouse-Dantsker et al.   Computational and Structural Biotechnology Journal

Identification of Novel Cholesterol-binding Regions in Kir2 Channels

(2013) Avia Rosenhouse-Dantsker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ESCRT regulates surface expression of the Kir2.1 potassium channel

(2013) Alexander R. Kolb et al.   MOLECULAR BIOLOGY OF THE CELL

Extracellular Potassium Homeostasis: Insights from Hypokalemic Periodic Paralysis

(2013) Chih-Jen Cheng et al.   SEMINARS IN NEPHROLOGY

Cargo Recognition in Clathrin-Mediated Endocytosis

(2013) L. M. Traub et al.   Cold Spring Harbor Perspectives in Biology

Molecular bioelectricity in developmental biology: New tools and recent discoveries

(2012) Michael Levin   BIOESSAYS

An inwardly rectifying K+ channel is required for patterning

(2012) G. R. Dahal et al.   DEVELOPMENT

A Tandem Di-hydrophobic Motif Mediates Clathrin-dependent Endocytosis via Direct Binding to the AP-2 ασ2 Subunits

(2012) Bernardo Ortega et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A molecular switch on an arrestin-like protein relays glucose signaling to transporter endocytosis

(2012) Michel Becuwe et al.   JOURNAL OF CELL BIOLOGY

Dynamic reciprocity of sodium and potassium channel expression in a macromolecular complex controls cardiac excitability and arrhythmia

(2012) M. L. Milstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholesterol Sensitivity of KIR2.1 Is Controlled by a Belt of Residues around the Cytosolic Pore

(2011) Avia Rosenhouse-Dantsker et al.   BIOPHYSICAL JOURNAL

Golgi Export of the Kir2.1 Channel Is Driven by a Trafficking Signal Located within Its Tertiary Structure

(2011) Donghui Ma et al.   CELL

A Novel KCNJ2 Nonsense Mutation, S369X, Impedes Trafficking and Causes a Limited Form of Andersen-Tawil Syndrome

(2011) Takahiro Doi et al.   Circulation-Cardiovascular Genetics

V-ATPase-dependent ectodermal voltage and ph regionalization are required for craniofacial morphogenesis

(2011) Laura N. Vandenberg et al.   DEVELOPMENTAL DYNAMICS

Identification and Functional Characterization of Kir2.6 Mutations Associated with Non-familial Hypokalemic Periodic Paralysis

(2011) Chih-Jen Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2

(2011) Scott B. Hansen et al.   NATURE

The mammalian KIR2.x inward rectifier ion channel family: expression pattern and pathophysiology

(2010) T. P. De Boer et al.   Acta Physiologica

Mutations in Potassium Channel Kir2.6 Cause Susceptibility to Thyrotoxic Hypokalemic Periodic Paralysis

(2010) Devon P. Ryan et al.   CELL

α-Arrestins Aly1 and Aly2 Regulate Intracellular Trafficking in Response to Nutrient Signaling

(2010) Allyson F. O'Donnell et al.   MOLECULAR BIOLOGY OF THE CELL

Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles

(2010) Hiroshi Hibino et al.   PHYSIOLOGICAL REVIEWS

Arrestin-Mediated Endocytosis of Yeast Plasma Membrane Transporters

(2009) Elina Nikko et al.   TRAFFIC

Recent Advances in Understanding Integrative Control of Potassium Homeostasis

(2008) Jang H. Youn et al.   Annual Review of Physiology

Lysosome mediated Kir2.1 breakdown directly influences inward rectifier current density

(2008) John A. Jansen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Arrestin-Related Ubiquitin-Ligase Adaptors Regulate Endocytosis and Protein Turnover at the Cell Surface

(2008) Charles H. Lin et al.   CELL

Initiation of human myoblast differentiation via dephosphorylation of Kir2.1 K+ channels at tyrosine 242

(2008) V. Hinard et al.   DEVELOPMENT

Topological and Developmental Expression Gradients of Kir2.1, an Inward Rectifier K+ Channel, in Spiral Ganglion and Cochlear Hair Cells of Mouse Inner Ear

(2008) Qingwei Ruan et al.   DEVELOPMENTAL NEUROSCIENCE

Clathrin-independent endocytosis used by the IL-2 receptor is regulated by Rac1, Pak1 and Pak2

(2008) Alexandre Grassart et al.   EMBO REPORTS

Arrestin-like proteins mediate ubiquitination and endocytosis of the yeast metal transporter Smf1

(2008) Elina Nikko et al.   EMBO REPORTS

AP-2-dependent Internalization of Potassium Channel Kir2.3 Is Driven by a Novel Di-hydrophobic Signal

(2008) Amanda K. Mason et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Kir2.1 channels by the Rho-GTPase, Rac1

(2008) Stephanie B. Boyer et al.   JOURNAL OF CELLULAR PHYSIOLOGY