Melanoma‐derived extracellular vesicles mediate lymphatic remodelling and impair tumour immunity in draining lymph nodes

Upregulation of VCAM-1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation

(2021) Jorge Arasa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD169+ lymph node macrophages have protective functions in mouse breast cancer metastasis

(2021) Carlotta Tacconi et al.   Cell Reports

Lymphatic PD-L1 Expression Restricts Tumor-Specific CD8+ T-cell Responses

(2021) Nikola Cousin et al.   CANCER RESEARCH

Melanoma cell-derived exosomes in plasma of melanoma patients suppress functions of immune effector cells

(2020) Priyanka Sharma et al.   Scientific Reports

Single-cell mapping reveals new markers and functions of lymphatic endothelial cells in lymph nodes

(2020) Noriki Fujimoto et al.   PLOS BIOLOGY

Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

(2020) Ayuko Hoshino et al.   CELL

The PD-1/PD-L1-Checkpoint Restrains T cell Immunity in Tumor-Draining Lymph Nodes

(2020) Floris Dammeijer et al.   CANCER CELL

Blockade of immune checkpoints in lymph nodes through locoregional delivery augments cancer immunotherapy

(2020) David M. Francis et al.   Science Translational Medicine

The R package Rsubread is easier, faster, cheaper and better for alignment and quantification of RNA sequencing reads

(2019) Yang Liao et al.   NUCLEIC ACIDS RESEARCH

Colorectal cancer exosomes induce lymphatic network remodeling in lymph nodes

(2019) Bo Sun et al.   INTERNATIONAL JOURNAL OF CANCER

Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients

(2019) Maria A.S. Broggi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Use of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and BRAFV600E mutation

(2019) Susana García-Silva et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Transcriptional profiling of breast cancer‐associated lymphatic vessels reveals VCAM‐1 as regulator of lymphatic invasion and permeability

(2019) Lothar C. Dieterich et al.   INTERNATIONAL JOURNAL OF CANCER

Single-Cell Survey of Human Lymphatics Unveils Marked Endothelial Cell Heterogeneity and Mechanisms of Homing for Neutrophils

(2019) Akira Takeda et al.   IMMUNITY

Extracellular vesicles or exosomes? On primacy, precision, and popularity influencing a choice of nomenclature

(2019) Kenneth W. Witwer et al.   Journal of Extracellular Vesicles

Tumor-derived extracellular vesicles: molecular parcels that enable regulation of the immune response in cancer

(2019) Colin Sheehan et al.   JOURNAL OF CELL SCIENCE

Mechanisms of Tumor-Induced Lymphovascular Niche Formation in Draining Lymph Nodes

(2018) Catharina D. Commerford et al.   Cell Reports

SCnorm: robust normalization of single-cell RNA-seq data

(2017) Rhonda Bacher et al.   NATURE METHODS

Tumor lymphangiogenesis and new drug development

(2016) Lothar C. Dieterich et al.   ADVANCED DRUG DELIVERY REVIEWS

Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils

(2016) Yanfang Liu et al.   CANCER CELL

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

(2016) Annette Becker et al.   CANCER CELL

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

The CD169 sialoadhesin molecule mediates cytotoxic T-cell responses to tumour apoptotic vesicles

(2016) Lane VC Black et al.   IMMUNOLOGY AND CELL BIOLOGY

SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions

(2016) F. Pucci et al.   SCIENCE

Lymphatic transport of exosomes as a rapid route of information dissemination to the lymph node

(2016) Swetha Srinivasan et al.   Scientific Reports

The lymph node pre-metastatic niche

(2015) Jonathan P. Sleeman   JOURNAL OF MOLECULAR MEDICINE-JMM

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Sentinel lymph node metastases in cancer: Causes, detection and their role in disease progression

(2015) S.D. Nathanson et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters

(2015) Charles P. Lai et al.   Nature Communications

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Mechanisms of lymphatic metastasis

(2014) Sinem Karaman et al.   JOURNAL OF CLINICAL INVESTIGATION

Steady-State Antigen Scavenging, Cross-Presentation, and CD8+ T Cell Priming: A New Role for Lymphatic Endothelial Cells

(2014) S. Hirosue et al.   JOURNAL OF IMMUNOLOGY

Full-length RNA-seq from single cells using Smart-seq2

(2014) Simone Picelli et al.   Nature Protocols

Antigen capture and archiving by lymphatic endothelial cells following vaccination or viral infection

(2014) Beth A. Tamburini et al.   Nature Communications

Immune Cell-Poor Melanomas Benefit from PD-1 Blockade after Targeted Type I IFN Activation

(2014) T. Bald et al.   Cancer Discovery

Role of the Lymphotoxin/LIGHT System in the Development and Maintenance of Reticular Networks and Vasculature in Lymphoid Tissues

(2014) Theresa T. Lu et al.   Frontiers in Immunology

Use of a PEG-conjugated bright near-infrared dye for functional imaging of rerouting of tumor lymphatic drainage after sentinel lymph node metastasis

(2013) Steven T. Proulx et al.   BIOMATERIALS

Endothelial cell–specific lymphotoxin-β receptor signaling is critical for lymph node and high endothelial venule formation

(2013) Lucas Onder et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells

(2012) E. F. Tewalt et al.   BLOOD

Lymph Node Macrophages

(2012) Elizabeth E. Gray et al.   Journal of Innate Immunity

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Subcapsular Sinus Macrophage Fragmentation and CD169+ Bleb Acquisition by Closely Associated IL-17-Committed Innate-Like Lymphocytes

(2012) Elizabeth E. Gray et al.   PLoS One

Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis

(2011) J. L. Hood et al.   CANCER RESEARCH

The role of core TNF/LIGHT family members in lymph node homeostasis and remodeling

(2011) Mingzhao Zhu et al.   IMMUNOLOGICAL REVIEWS

Lymph node–resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation

(2010) Jarish N. Cohen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation

(2009) Tri Giang Phan et al.   NATURE IMMUNOLOGY

High Levels of Exosomes Expressing CD63 and Caveolin-1 in Plasma of Melanoma Patients

(2009) Mariantonia Logozzi et al.   PLoS One