Journal
NATURE BIOMEDICAL ENGINEERING
Volume 6, Issue 6, Pages 741-753Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41551-021-00817-7
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Funding
- European Research Council (ERC) under the European Union [949191]
- Knut and Alice Wallenberg Foundation
- Swedish Research Council (Vetenskapsradet) [2018-04505]
- Swedish Foundation for Strategic Research
- Columbia University, School of Engineering and Applied Science
- Columbia University Medical Center, Department of Neurology and Institute for Genomic Medicine
- MEYS CR [LM2018110]
- Croatian Science Foundation [UIP-2019-04-1753]
- Croatian Government
- European Union through the European Regional Development Fund - Competitiveness and Cohesion Operational Programme [KK.01.1.1.02.0013]
- QuantiXLie Center of Excellence
- European Union through the European Regional Development Fund - the Competitiveness and Cohesion Operational Programme [KK.01.1.1.01.0004]
- Center of Excellence for Advanced Materials and Sensors, Croatia
- project CeNIKS
- Vinnova [2018-04505] Funding Source: Vinnova
- Swedish Research Council [2018-04505] Funding Source: Swedish Research Council
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The study demonstrates the use of an organic electrolytic photocapacitor for wireless chronic electrical stimulation of the sciatic nerve in rats, transducing deep-red light into electrical signals and implanted within a thin cuff around the nerve for over 100 days. This device shows potential for reliable and safe modulation of neural tissue with reduced invasiveness.
Implantable devices for the wireless modulation of neural tissue need to be designed for reliability, safety and reduced invasiveness. Here we report chronic electrical stimulation of the sciatic nerve in rats by an implanted organic electrolytic photocapacitor that transduces deep-red light into electrical signals. The photocapacitor relies on commercially available semiconducting non-toxic pigments and is integrated in a conformable 0.1-mm(3) thin-film cuff. In freely moving rats, fixation of the cuff around the sciatic nerve, 10 mm below the surface of the skin, allowed stimulation (via 50-1,000-mu s pulses of deep-red light at wavelengths of 638 nm or 660 nm) of the nerve for over 100 days. The robustness, biocompatibility, low volume and high-performance characteristics of organic electrolytic photocapacitors may facilitate the wireless chronic stimulation of peripheral nerves. An organic electrolytic photocapacitor transducing deep-red light into electrical signals and implanted within a thin cuff around the sciatic nerve of rats allows for wireless electrical stimulation of the nerve for over 100 days.
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