Current Advances of Artificial Pancreas Systems: A Comprehensive Review of the Clinical Evidence

Fully Closed Loop Glucose Control With a Bihormonal Artificial Pancreas in Adults With Type 1 Diabetes: An Outpatient, Randomized, Crossover Trial

(2021) Helga Blauw et al.   DIABETES CARE

Diabeloop DBLG1 Closed-Loop System Enables Patients With Type 1 Diabetes to Significantly Improve Their Glycemic Control in Real-Life Situations Without Serious Adverse Events: 6-Month Follow-up

(2021) Coralie Amadou et al.   DIABETES CARE

A comparison of two hybrid closed-loop systems in adolescents and young adults with type 1 diabetes (FLAIR): a multicentre, randomised, crossover trial

(2021) Richard M Bergenstal et al.   LANCET

Hybrid closed‐loop glucose control with faster insulin aspart compared with standard insulin aspart in adults with type 1 diabetes: A double‐blind, multicentre, multinational, randomized, crossover study

(2021) Charlotte K. Boughton et al.   DIABETES OBESITY & METABOLISM

Performance of the Insulin-Only iLet Bionic Pancreas and the Bihormonal iLet Using Dasiglucagon in Adults With Type 1 Diabetes in a Home-Use Setting

(2021) Luz E. Castellanos et al.   DIABETES CARE

One Year Real-World Use of the Control-IQ Advanced Hybrid Closed-Loop Technology

(2021) Marc D. Breton et al.   Diabetes Technology & Therapeutics

Fast-acting insulin aspart (Fiasp®) improves glycemic outcomes when used with MiniMedTM 670G hybrid closed-loop system in simulated trials compared to NovoLog®

(2021) Benyamin Grosman et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

An analysis of Medtronic MiniMed 670G insulin pump use in clinical practice and the impact on glycemic control, quality of life, and compliance

(2021) Maxwell E. Horowitz et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Real-world use of a new hybrid closed-loop improves glycemic control in youth with type 1 diabetes

(2021) Laurel H Messer et al.   Diabetes Technology & Therapeutics

Non-Insulin Antidiabetes Treatment in Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis

(2021) Xiaoling Cai et al.   Diabetes & Metabolism Journal

A Novel Dual-Hormone Insulin-and-Pramlintide Artificial Pancreas for Type 1 Diabetes: A Randomized Controlled Crossover Trial

(2020) Ahmad Haidar et al.   DIABETES CARE

DIY artificial pancreas systems: the clinician perspective

(2020) Emma G Wilmot et al.   Lancet Diabetes & Endocrinology

Glycemic Outcomes of Use of CLC Versus PLGS in Type 1 Diabetes: A Randomized Controlled Trial

(2020) Sue A. Brown et al.   DIABETES CARE

Diabetes UK Position Statements Do‐it‐yourself closed‐loop systems for people living with type 1 diabetes

(2020) L. Dowling et al.   DIABETIC MEDICINE

Do-It-Yourself (DIY) Artificial Pancreas Systems for Type 1 Diabetes: Perspectives of Two Adult Users, Parent of a User and Healthcare Professionals

(2020) Syed Haris Ahmed et al.   ADVANCES IN THERAPY

One-year experience of hybrid closed-loop system in children and adolescents with type 1 diabetes previously treated with multiple daily injections: drivers to successful outcomes

(2020) Goran Petrovski et al.   ACTA DIABETOLOGICA

Six Months of Hybrid Closed-Loop Versus Manual Insulin Delivery With Fingerprick Blood Glucose Monitoring in Adults With Type 1 Diabetes: A Randomized, Controlled Trial

(2020) Sybil A. McAuley et al.   DIABETES CARE

Dual-Hormone Closed-Loop System Using a Liquid Stable Glucagon Formulation Versus Insulin-Only Closed-Loop System Compared With a Predictive Low Glucose Suspend System: An Open-Label, Outpatient, Single-Center, Crossover, Randomized Controlled Trial

(2020) Leah M. Wilson et al.   DIABETES CARE

Patients with highly unstable type 1 diabetes eligible for islet transplantation can be managed with a closed‐loop insulin delivery system: A series of N‐of‐1 randomized controlled trials

(2020) Pierre‐Yves Benhamou et al.   DIABETES OBESITY & METABOLISM

A Randomized Trial of Closed-Loop Control in Children with Type 1 Diabetes

(2020) Marc D. Breton et al.   NEW ENGLAND JOURNAL OF MEDICINE

First Outpatient Evaluation of a Tubeless Automated Insulin Delivery System with Customizable Glucose Targets in Children and Adults with Type 1 Diabetes

(2020) Gregory P. Forlenza et al.   Diabetes Technology & Therapeutics

Incidence and Prevalence of Type 1 Diabetes Mellitus among Korean Children and Adolescents between 2007 and 2017: An Epidemiologic Study Based on a National Database

(2020) Hyun Wook Chae et al.   Diabetes & Metabolism Journal

State of Type 1 Diabetes Management and Outcomes from the T1D Exchange in 2016–2018

(2019) Nicole C. Foster et al.   Diabetes Technology & Therapeutics

Home Use of Day-and-Night Hybrid Closed-Loop Insulin Delivery in Very Young Children: A Multicenter, 3-Week, Randomized Trial

(2019) Martin Tauschmann et al.   DIABETES CARE

Normoglycaemic control with a selfmade fully closed-loop insulin delivery system during emergency surgery: an extemporaneous stress test

(2019) Andreas Holstein et al.   ACTA DIABETOLOGICA

Performance of Omnipod Personalized Model Predictive Control Algorithm with Moderate Intensity Exercise in Adults with Type 1 Diabetes

(2019) Gregory P. Forlenza et al.   Diabetes Technology & Therapeutics

Efficacy of Artificial Pancreas Use in Patients With Type 2 Diabetes Using Intensive Insulin Therapy: A Randomized Crossover Pilot Trial

(2019) Nadine Taleb et al.   DIABETES CARE

Glycaemic control in individuals with type 1 diabetes using an open source artificial pancreas system (OpenAPS)

(2019) Andreas Melmer et al.   DIABETES OBESITY & METABOLISM

Realizing a Closed-Loop (Artificial Pancreas) System for the Treatment of Type 1 Diabetes

(2019) Rayhan A Lal et al.   ENDOCRINE REVIEWS

Efficacy and safety of suspend-before-low insulin pump technology in hypoglycaemia-prone adults with type 1 diabetes (SMILE): an open-label randomised controlled trial

(2019) Emanuele Bosi et al.   Lancet Diabetes & Endocrinology

One Year Clinical Experience of the First Commercial Hybrid Closed-Loop

(2019) Rayhan A. Lal et al.   DIABETES CARE

Incidences of Severe Hypoglycemia and Diabetic Ketoacidosis and Prevalence of Microvascular Complications Stratified by Age and Glycemic Control in U.S. Adult Patients With Type 1 Diabetes: A Real-World Study

(2019) Jeremy H. Pettus et al.   DIABETES CARE

Do-It-Yourself Artificial Pancreas Systems in Type 1 Diabetes: Perspectives of Two Adult Users, a Caregiver and Three Physicians

(2019) Dominic C. Marshall et al.   Diabetes Therapy

Efficacy of the Diabeloop closed‐loop system to improve glycaemic control in patients with type 1 diabetes exposed to gastronomic dinners or to sustained physical exercise

(2019) Hélène Hanaire et al.   DIABETES OBESITY & METABOLISM

Safety and Performance of the Omnipod Hybrid Closed-Loop System in Adults, Adolescents, and Children with Type 1 Diabetes Over 5 Days Under Free-Living Conditions

(2019) Jennifer L. Sherr et al.   Diabetes Technology & Therapeutics

Changing the landscape for type 1 diabetes: the first step to prevention

(2019) Colin M Dayan et al.   LANCET

Six-Month Randomized, Multicenter Trial of Closed-Loop Control in Type 1 Diabetes

(2019) Sue A. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long‐term real‐life glycaemic outcomes with a hybrid closed‐loop system compared with sensor‐augmented pump therapy in patients with type 1 diabetes

(2019) Halis Kaan Akturk et al.   DIABETES OBESITY & METABOLISM

Six months of hybrid closed loop in the real‐world: An evaluation of children and young adults using the 670G system

(2019) Cari Berget et al.   PEDIATRIC DIABETES

Customization of home closed-loop insulin delivery in adult patients with type 1 diabetes, assisted with structured remote monitoring: the pilot WP7 Diabeloop study

(2018) Pierre Yves Benhamou et al.   ACTA DIABETOLOGICA

Open Artificial Pancreas System Reduced Hypoglycemia and Improved Glycemic Control in Patients with Type 1 Diabetes

(2018) SOO BONG CHOI et al.   DIABETES

Closing the Loop with OpenAPS in People with Type 1 Diabetes—Experience from Italy

(2018) VINCENZO PROVENZANO et al.   DIABETES

Randomized Outpatient Trial of Single- and Dual-Hormone Closed-Loop Systems That Adapt to Exercise Using Wearable Sensors

(2018) Jessica R. Castle et al.   DIABETES CARE

Day-and-Night Closed-Loop Insulin Delivery in a Broad Population of Pregnant Women With Type 1 Diabetes: A Randomized Controlled Crossover Trial

(2018) Zoe A. Stewart et al.   DIABETES CARE

Type 1 diabetes

(2018) Linda A DiMeglio et al.   LANCET

Closed-Loop Insulin Delivery for Glycemic Control in Noncritical Care

(2018) Lia Bally et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cardiovascular benefits of GLP-1 agonists in type 2 diabetes: a comparative review

(2018) James G. Boyle et al.   CLINICAL SCIENCE

Predictive Low-Glucose Suspend Reduces Hypoglycemia in Adults, Adolescents, and Children With Type 1 Diabetes in an At-Home Randomized Crossover Study: Results of the PROLOG Trial

(2018) Gregory P. Forlenza et al.   DIABETES CARE

Control of Postprandial Hyperglycemia in Type 1 Diabetes by 24-Hour Fixed-Dose Coadministration of Pramlintide and Regular Human Insulin: A Randomized, Two-Way Crossover Study

(2018) Matthew C. Riddle et al.   DIABETES CARE

Retrospective Analysis of 3-Month Real-World Glucose Data After the MiniMed 670G System Commercial Launch

(2018) Michael P. Stone et al.   Diabetes Technology & Therapeutics

Performance of the Omnipod Personalized Model Predictive Control Algorithm with Meal Bolus Challenges in Adults with Type 1 Diabetes

(2018) Bruce A. Buckingham et al.   Diabetes Technology & Therapeutics

First Look at Control-IQ: A New-Generation Automated Insulin Delivery System

(2018) Sue Brown et al.   DIABETES CARE

DREAM5: An open-label, randomized, cross-over study to evaluate the safety and efficacy of day and night closed-loop control by comparing the MD-Logic automated insulin delivery system to sensor augmented pump therapy in patients with type 1 diabetes at h

(2018) Torben Biester et al.   DIABETES OBESITY & METABOLISM

Safety Evaluation of the MiniMed 670G System in Children 7–13 Years of Age with Type 1 Diabetes

(2018) Gregory P. Forlenza et al.   Diabetes Technology & Therapeutics

Appearance of Do-It-Yourself closed-loop systems to manage type 1 diabetes

(2018) Tien-Ming Hng et al.   INTERNAL MEDICINE JOURNAL

Association of Insulin Pump Therapy vs Insulin Injection Therapy With Severe Hypoglycemia, Ketoacidosis, and Glycemic Control Among Children, Adolescents, and Young Adults With Type 1 Diabetes

(2017) Beate Karges et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Day-and-night glycaemic control with closed-loop insulin delivery versus conventional insulin pump therapy in free-living adults with well controlled type 1 diabetes: an open-label, randomised, crossover study

(2017) Lia Bally et al.   Lancet Diabetes & Endocrinology

Multinational Home Use of Closed-Loop Control Is Safe and Effective

(2016) Stacey M. Anderson et al.   DIABETES CARE

Home Use of Day-and-Night Hybrid Closed-Loop Insulin Delivery in Suboptimally Controlled Adolescents With Type 1 Diabetes: A 3-Week, Free-Living, Randomized Crossover Trial

(2016) Martin Tauschmann et al.   DIABETES CARE

Randomized Summer Camp Crossover Trial in 5- to 9-Year-Old Children: Outpatient Wearable Artificial Pancreas Is Feasible and Safe

(2016) Simone Del Favero et al.   DIABETES CARE

Mitigating Meal-Related Glycemic Excursions in an Insulin-Sparing Manner During Closed-Loop Insulin Delivery: The Beneficial Effects of Adjunctive Pramlintide and Liraglutide

(2016) Jennifer L. Sherr et al.   DIABETES CARE

Performance and safety of an integrated bihormonal artificial pancreas for fully automated glucose control at home

(2016) H. Blauw et al.   DIABETES OBESITY & METABOLISM

Glucagon in artificial pancreas systems: Potential benefits and safety profile of future chronic use

(2016) Nadine Taleb et al.   DIABETES OBESITY & METABOLISM

Safety of a Hybrid Closed-Loop Insulin Delivery System in Patients With Type 1 Diabetes

(2016) Richard M. Bergenstal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Single- and Dual-Hormone Artificial Pancreas for Overnight Glucose Control in Type 1 Diabetes

(2016) Ahmad Haidar et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Exercise-stimulated glucose uptake — regulation and implications for glycaemic control

(2016) Lykke Sylow et al.   Nature Reviews Endocrinology

Closed-Loop Insulin Delivery during Pregnancy in Women with Type 1 Diabetes

(2016) Zoe A. Stewart et al.   NEW ENGLAND JOURNAL OF MEDICINE

Day and night glycaemic control with a bionic pancreas versus conventional insulin pump therapy in preadolescent children with type 1 diabetes: a randomised crossover trial

(2016) Steven J Russell et al.   Lancet Diabetes & Endocrinology

Effect of Repeated Glucagon Doses on Hepatic Glycogen in Type 1 Diabetes: Implications for a Bihormonal Closed-Loop System

(2015) Jessica R. Castle et al.   DIABETES CARE

Predictive Low-Glucose Insulin Suspension Reduces Duration of Nocturnal Hypoglycemia in Children Without Increasing Ketosis

(2015) Bruce A. Buckingham et al.   DIABETES CARE

Day and Night Closed-Loop Control Using the Integrated Medtronic Hybrid Closed-Loop System in Type 1 Diabetes at Diabetes Camp

(2015) Trang T. Ly et al.   DIABETES CARE

Role of Amylin in Type 1 and Type 2 Diabetes

(2015) Laura Hieronymus et al.   DIABETES EDUCATOR

Continuous Intraperitoneal Insulin Infusion Versus Subcutaneous Insulin Therapy in the Treatment of Type 1 Diabetes: Effects on Glycemic Variability

(2015) Peter R. van Dijk et al.   Diabetes Technology & Therapeutics

Home Use of an Artificial Beta Cell in Type 1 Diabetes

(2015) Hood Thabit et al.   NEW ENGLAND JOURNAL OF MEDICINE

Outpatient overnight glucose control with dual-hormone artificial pancreas, single-hormone artificial pancreas, or conventional insulin pump therapy in children and adolescents with type 1 diabetes: an open-label, randomised controlled trial

(2015) Ahmad Haidar et al.   Lancet Diabetes & Endocrinology

2 month evening and night closed-loop glucose control in patients with type 1 diabetes under free-living conditions: a randomised crossover trial

(2015) Jort Kropff et al.   Lancet Diabetes & Endocrinology

Comparison of dual-hormone artificial pancreas, single-hormone artificial pancreas, and conventional insulin pump therapy for glycaemic control in patients with type 1 diabetes: an open-label randomised controlled crossover trial

(2015) Ahmad Haidar et al.   Lancet Diabetes & Endocrinology

MD-Logic Overnight Control for 6 Weeks of Home Use in Patients With Type 1 Diabetes: Randomized Crossover Trial

(2014) Revital Nimri et al.   DIABETES CARE

Safety of Outpatient Closed-Loop Control: First Randomized Crossover Trials of a Wearable Artificial Pancreas

(2014) Boris P. Kovatchev et al.   DIABETES CARE

Overnight Glucose Control With an Automated, Unified Safety System in Children and Adolescents With Type 1 Diabetes at Diabetes Camp

(2014) Trang T. Ly et al.   DIABETES CARE

First Use of Model Predictive Control in Outpatient Wearable Artificial Pancreas

(2014) Simone Del Favero et al.   DIABETES CARE

A Randomized Trial of a Home System to Reduce Nocturnal Hypoglycemia in Type 1 Diabetes

(2014) David M. Maahs et al.   DIABETES CARE

Overnight Closed-Loop Insulin Delivery in Young People With Type 1 Diabetes: A Free-Living, Randomized Clinical Trial

(2014) Roman Hovorka et al.   DIABETES CARE

Day and Night Home Closed-Loop Insulin Delivery in Adults With Type 1 Diabetes: Three-Center Randomized Crossover Study

(2014) Lalantha Leelarathna et al.   DIABETES CARE

Outpatient Glycemic Control with a Bionic Pancreas in Type 1 Diabetes

(2014) Steven J. Russell et al.   NEW ENGLAND JOURNAL OF MEDICINE

Home use of closed-loop insulin delivery for overnight glucose control in adults with type 1 diabetes: a 4-week, multicentre, randomised crossover study

(2014) Hood Thabit et al.   Lancet Diabetes & Endocrinology

Comparative Effectiveness and Safety of Methods of Insulin Delivery and Glucose Monitoring for Diabetes Mellitus

(2013) Hsin-Chieh Yeh et al.   ANNALS OF INTERNAL MEDICINE

Glucagon-Like Peptide-1: Glucose Homeostasis and Beyond

(2013) Young Min Cho et al.   Annual Review of Physiology

Glucose-responsive insulin and glucagon delivery (dual-hormone artificial pancreas) in adults with type 1 diabetes: a randomized crossover controlled trial

(2013) A. Haidar et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Feasibility of Outpatient Fully Integrated Closed-Loop Control: First studies of wearable artificial pancreas

(2013) B. P. Kovatchev et al.   DIABETES CARE

Feasibility of Closed-Loop Insulin Delivery in Type 2 Diabetes: A Randomized Controlled Study

(2013) Kavita Kumareswaran et al.   DIABETES CARE

Multivariable Adaptive Closed-Loop Control of an Artificial Pancreas Without Meal and Activity Announcement

(2013) Kamuran Turksoy et al.   Diabetes Technology & Therapeutics

Feasibility of a Portable Bihormonal Closed-Loop System to Control Glucose Excursions at Home Under Free-Living Conditions for 48 Hours

(2013) Arianne C. van Bon et al.   Diabetes Technology & Therapeutics

Effect of Sensor-Augmented Insulin Pump Therapy and Automated Insulin Suspension vs Standard Insulin Pump Therapy on Hypoglycemia in Patients With Type 1 Diabetes

(2013) Trang T. Ly et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Nocturnal Glucose Control with an Artificial Pancreas at a Diabetes Camp

(2013) Moshe Phillip et al.   NEW ENGLAND JOURNAL OF MEDICINE

Threshold-Based Insulin-Pump Interruption for Reduction of Hypoglycemia

(2013) Richard M. Bergenstal et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Use of an Automated, Portable Glucose Control System for Overnight Glucose Control in Adolescents and Young Adults With Type 1 Diabetes

(2012) M. J. O'Grady et al.   DIABETES CARE

Closed-Loop Basal Insulin Delivery Over 36 Hours in Adolescents With Type 1 Diabetes: Randomized clinical trial

(2012) D. Elleri et al.   DIABETES CARE

Effect of Pramlintide on Prandial Glycemic Excursions During Closed-Loop Control in Adolescents and Young Adults With Type 1 Diabetes

(2012) S. A. Weinzimer et al.   DIABETES CARE

Clinical Evaluation of a Personalized Artificial Pancreas

(2012) E. Dassau et al.   DIABETES CARE

Improved Biomedical and Psychological Outcomes 1 Year After Structured Education in Flexible Insulin Therapy for People With Type 1 Diabetes: The U.K. DAFNE experience

(2012) D. Hopkins et al.   DIABETES CARE

Feasibility Study of Automated Overnight Closed-Loop Glucose Control Under MD-Logic Artificial Pancreas in Patients with Type 1 Diabetes: The DREAM Project

(2012) Revital Nimri et al.   Diabetes Technology & Therapeutics

Minireview: The Role of the Autonomic Nervous System in Mediating the Glucagon Response to Hypoglycemia

(2012) Gerald J. Taborsky et al.   ENDOCRINOLOGY

Insulin-Pump Therapy for Type 1 Diabetes Mellitus

(2012) John C. Pickup   NEW ENGLAND JOURNAL OF MEDICINE

Closed-Loop Insulin Delivery During Pregnancy Complicated by Type 1 Diabetes

(2011) H. R. Murphy et al.   DIABETES CARE

Safety and Efficacy of 24-h Closed-Loop Insulin Delivery in Well-Controlled Pregnant Women With Type 1 Diabetes: A randomized crossover case series

(2011) H. R. Murphy et al.   DIABETES CARE

Effectiveness of sensor-augmented pump therapy in children and adolescents with type 1 diabetes in the STAR 3 study

(2011) Robert H. Slover et al.   PEDIATRIC DIABETES

MD-Logic Artificial Pancreas System: A pilot study in adults with type 1 diabetes

(2010) E. Atlas et al.   DIABETES CARE

Novel Use of Glucagon in a Closed-Loop System for Prevention of Hypoglycemia in Type 1 Diabetes

(2010) J. R. Castle et al.   DIABETES CARE

Manual closed-loop insulin delivery in children and adolescents with type 1 diabetes: a phase 2 randomised crossover trial

(2010) Roman Hovorka et al.   LANCET

Effectiveness of Sensor-Augmented Insulin-Pump Therapy in Type 1 Diabetes

(2010) Richard M. Bergenstal et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Bihormonal Closed-Loop Artificial Pancreas for Type 1 Diabetes

(2010) F. H. El-Khatib et al.   Science Translational Medicine

Gestational diabetes mellitus: Taking it to heart

(2010) Jessica A. Marcinkevage et al.   Primary Care Diabetes

Improved Glycemic Control With Intraperitoneal Versus Subcutaneous Insulin in Type 1 Diabetes: A randomized controlled trial

(2009) S. J. Logtenberg et al.   DIABETES CARE

Closed-Loop Insulin Delivery Using a Subcutaneous Glucose Sensor and Intraperitoneal Insulin Delivery: Feasibility study testing a new model for the artificial pancreas

(2009) E. Renard et al.   DIABETES CARE

A reduction in severe hypoglycaemia in type 1 diabetes in a randomized crossover study of continuous intraperitoneal compared with subcutaneous insulin infusion

(2009) A. Liebl et al.   DIABETES OBESITY & METABOLISM

Fully Automated Closed-Loop Insulin Delivery Versus Semiautomated Hybrid Control in Pediatric Patients With Type 1 Diabetes Using an Artificial Pancreas

(2008) S. A. Weinzimer et al.   DIABETES CARE