Journal
PHARMACEUTICS
Volume 13, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/pharmaceutics13122008
Keywords
asthma; chronic obstructive pulmonary disease; pulmonary fibrosis; lung cancer; circadian rhythm; chronotherapy
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Funding
- Prevent Cancer Foundation (PCF)
- International Association for the Study of Lung Cancer(IASLC) foundation, USA
- Sydney Partnership for Health, Education, Research and Enterprise (SPHERE)
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Respiratory diseases are significantly influenced by the circadian rhythm, with disruptions leading to altered lung function. Chronotherapy, based on an individual's circadian rhythm, can help optimize drug action and reduce unwanted effects. This review discusses recent advances in chrono-targeted therapeutics for chronic respiratory diseases.
Respiratory diseases contribute to a significant percentage of mortality and morbidity worldwide. The circadian rhythm is a natural biological process where our bodily functions align with the 24 h oscillation (sleep-wake cycle) process and are controlled by the circadian clock protein/gene. Disruption of the circadian rhythm could alter normal lung function. Chronotherapy is a type of therapy provided at specific time intervals based on an individual's circadian rhythm. This would allow the drug to show optimum action, and thereby modulate its pharmacokinetics to lessen unwanted or unintended effects. In this review, we deliberated on the recent advances employed in chrono-targeted therapeutics for chronic respiratory diseases.
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