Article
Chemistry, Multidisciplinary
Jun Young Hwang, Kyung Ho Kim, Sung Eun Seo, Youngju Nam, Sanghee Jwa, Inwoo Yang, Tai Hyun Park, Oh Seok Kwon, Seung Hwan Lee
Summary: A bioelectronic tongue system is developed to characterize the agonism and antagonism of bitter taste receptors through the combination of human bitter taste receptors with nanodiscs and graphene field-effect transistors. The system can sensitively detect bitter agonists and evaluate antagonism-based bitterness masking. This is of great importance in the food and pharmaceutical industries.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Yanping Deng, Lian Shen, Yan Yang, Jie Shen
Summary: This study developed a nanoparticle-based orodispersible pediatric drug delivery platform to improve the oral bioavailability and taste of poorly water-soluble and unpalatable therapeutics. Through in vitro and in vivo testing, it was found that the platform effectively enhanced the oral bioavailability and taste of LPV and RTV, while maintaining good stability of the raw drugs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Analytical
Regina Belugina, Anna Senchikhina, Sergey Volkov, Alexander Fedorov, Andrey Legin, Dmitry Kirsanov
Summary: This study proposes a new method for evaluating phospholipid concentrations in vegetable oils using potentiometric multisensor systems and chemometric data processing. The method is rapid and simple, and can effectively quantify the phosphatides in sunflower oils.
ANALYTICAL METHODS
(2022)
Article
Food Science & Technology
Lizeng Cheng, Yuanfeng Wang, Jiarong Zhang, Lurong Xu, Hui Zhou, Kang Wei, Lanlan Peng, Jie Zhang, Zhonghua Liu, Xinlin Wei
Summary: This study analyzed the chemical profile and taste quality of five typical dark teas, revealing variations among them and providing guidance for dark tea taste quality control.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Food Science & Technology
Jie Liu, Peng Wan, Wenjie Zhao, Caifeng Xie, Qinzhi Wang, De-Wei Chen
Summary: The effect of lime water and temperature on the taste characteristics of sugarcane juice, syrup and brown sugar was studied. Lime water increased sweetness and umami during the clarification stage, while both lime water and high-temperature heating accelerated the Maillard reaction and caramelization of the syrup. Temperature had the greatest influence on the taste during the concentration stage.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Marta Czapiewska, Patrycja Ciosek-Skibinska, Joanna Lenik, Piotr Bilski, Tomasz Gnatowski, Jerzy Krysinski
Summary: This study investigated the effect of three sweeteners on masking the bitter taste of levocetirizine dihydrochloride in a mucoadhesive gel, and observed the release process of the bitter substance using an electronic tongue. The results showed that sweeteners at appropriate concentrations could mask the bitter taste effectively.
Article
Chemistry, Applied
Bing Fu, Mengping Zheng, Huici Yang, Junming Zhang, Yichao Li, Guangjun Wang, Jingjing Tian, Kai Zhang, Yun Xia, Zhifei Li, Wangbao Gong, Hongyan Li, Jun Xie, Huirong Yang, Ermeng Yu
Summary: This study found that a broad bean diet can significantly improve the texture of grass carp muscle, but reduce the overall taste and flavor. Analysis of volatile compounds and differential metabolites revealed that these changes in taste and flavor are associated with the metabolism of amino acids, lipids, and nucleotides.
Article
Pharmacology & Pharmacy
Rama Jayasundar, Somenath Ghatak, Dushyant Kumar, Aruna Singh, Preeti Bhosle
Summary: This study explored the use of an Electronic tongue for rasa-based classification of medicinal plants, finding chemosensory similarities between taste standards and plant samples. Multivariate analysis successfully discriminated between different taste categories of medicinal plants, indicating the potential of using E-tongue for ayurvedic classification.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Applied
Pham-Thi-Phuong Dung, Thanh-Dat Trinh, Quoc-Hoai Nguyen, Huu-Manh Nguyen, Ngoc-Chien Nguyen, Ngoc-Bao Tran, Cao-Son Tran, Thi-Hong-Ngoc Nguyen, Nguyen-Thach Tung
Summary: This research aims to develop microcapsules containing azithromycin (AZI) with a bitter taste-masking effect using fluid-bed coating technology. The taste-masking polymers Eudragit L100, Eudragit RL100, and ethyl cellulose were used individually and in combination. The combination of ethyl cellulose and Eudragit E100 showed the best results in preventing the release of AZI above the bitter taste threshold.
JOURNAL OF MICROENCAPSULATION
(2023)
Article
Biochemistry & Molecular Biology
Fengxia Wang, Qi Qian, Hanyu Ma, Yu Feng, Jingnan Hu, Baolin Li, Liying Niu, Xinguo Wang
Summary: This study developed a method that combines electronic tongue, electronic nose, and HS-GC-MS to elucidate the flavor and aroma differences between three types of stir-fried Cyperus rotundus (CR) and to identify aroma difference components. As the degree of stir-frying increased, the sweet, bitter, astringent, and umami flavors of the stir-fried CR diminished while the aroma intensified. This method effectively differentiates the three levels of stir-fried CR and provides a foundation for the use of stir-fried CR in food processing and pharmaceutical applications.
JOURNAL OF FOOD BIOCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Y. Gvozdeva, M. Kassarova, B. Pilicheva
Summary: Polymer microspheres were formulated using the emulsion solvent evaporation technique to mask the bitter taste of enalapril maleate. Results showed that the prepared microspheres had well-defined particle structure and drug release properties.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Adrienn Kazsoki, Barnabas Palcso, Safaa Mohammed Omer, Zoltan Kovacs, Romana Zelko
Summary: This study focused on formulating a levocetirizine-loaded core-shell type hydrophilic polymer-based fibrous system to enable fast drug release and mask the unpleasant taste. The results showed the potential of the developed orally dissolving fibrous web formulation as an alternative to commercially available orally disintegrating tablets.
Article
Food Science & Technology
Jingyu Yao, Wenjie Zhao, Xueying Bai, Peng Wan, Jie Liu, De-Wei Chen
Summary: Free amino acids, nucleotides, organic acids, soluble sugars and alkaloids in the meat of river snail were analyzed to identify the non-volatile taste-active components. Key taste-active compounds and umami attribute were evaluated, and 11 compounds were identified as the key taste-active compounds.
INTERNATIONAL JOURNAL OF GASTRONOMY AND FOOD SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Sally Shahoud, Wassim Abdlwahed, Tamim Hammad
Summary: This study investigated the taste masking of acetaminophen in oral dosage forms using the solid dispersion technique. The results showed that this technique effectively masked the taste of the drug and achieved a high production yield.
JOURNAL OF RESEARCH IN PHARMACY
(2023)
Article
Medicine, Research & Experimental
Hei Ming Kenneth Ho, Duncan Q. M. Craig, Richard M. Day
Summary: This study developed a model to explore the control factors of nanogel physical properties and evaluated its applicability to different drugs. The results showed that the model could be used to predict the size and polydispersity index of nanogels. For structurally unrelated drugs, separate analysis is required, but for structurally similar drugs, there are relationships between drug structure and nanogel properties that can be modeled and predicted using the model.
MOLECULAR PHARMACEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Jiayao Li, Yinan Li, Hend E. Abdelhakim
Summary: Cancer is a serious global health problem and nanotechnology has improved drug delivery systems. Coaxial electrospun nanofibres are an ideal drug delivery carrier.
Article
Pharmacology & Pharmacy
Neel Desai, Marc Masen, Philippa Cann, Ben Hanson, Catherine Tuleu, Mine Orlu
Summary: Orodispersible films (ODFs) have been widely used in paediatric, geriatric and dysphagic patients due to their ease of administration and precise and flexible dose adjustments. However, there is currently a lack of testing methods to accurately assess ODFs for important acceptability sensory perceptions. This study used 3D printing to produce four ODFs and evaluated them using various in vitro methods, finding that increasing polymer molecular weight affected disintegration time, taste and stickiness.
Article
Pharmacology & Pharmacy
Antonio Lopalco, Annachiara Manni, Alexander Keeley, Shozeb Haider, Wenliang Li, Angela Lopedota, Cosimo Damiano Altomare, Nunzio Denora, Catherine Tuleu
Summary: This study investigated the effects of (2-hydroxypropyl)-beta-cyclodextrin on enhancing the solubility of spironolactone in water and masking its unpleasant taste. While in vivo tests did not show significant effects on taste aversion, the findings lay the foundation for investigating other cyclodextrin-based formulations for poorly water-soluble steroidal drugs.
Article
Education & Educational Research
Hend E. Abdelhakim, Louise Brown, Lizzie Mills, Anika Ahmad, James Hammell, Douglas G. J. McKechnie, Tin Wai Terry Ng, Rebecca Lever, Cate Whittlesea, Joe Rosenthal, Mine Orlu
Summary: This study evaluated the perception of pharmacy and medical students' of remote interprofessional education (IPE). The results demonstrated that remote IPE can improve students' understanding of different professional roles and enhance their prescribing skills and ancillary skills. Remote teaching was preferred by a portion of students as a delivery mode.
BMC MEDICAL EDUCATION
(2022)
Review
Pharmacology & Pharmacy
Charles C. Adenot, Hend E. Abdelhakim
Summary: The administration of oral dosage forms to companion animals is challenging and affects treatment outcomes. There is a need for highly palatable treatments, but the lack of standardized palatability assessment methods hinders comparison between studies. Solid oral dosage forms are well tolerated by dogs, but poorly by cats. Cats accept pastes more readily, while liquid formulations seem to be well tolerated by cats but poorly by dogs. Meat-based flavors yield high palatability. The shape and color of dosage forms also influence palatability. The methodology used can introduce bias and should be adapted accordingly. There is a lack of evidence on formulation parameters for achieving high palatability in companion animals. Additional studies and revised guidelines are needed.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Tian Zhang, Qiang Zheng, Congkun Xie, Gonglin Fan, Yifan Wang, Yongjun Wu, Yike Fu, Jie Huang, Duncan Q. M. Craig, Xiujun Cai, Xiang Li
Summary: Due to their radiation-free nature and deep-penetration ability, ultrasound-mediated tumor theranostics have great potential in clinical cancer treatment. In this study, a novel theranostic system called SMISO was developed, consisting of r-SiO2 loaded with Mn-doped In2S3/InOOH. This system enables improved ultrasound imaging-guided therapy by generating reactive oxygen species for sonodynamic therapy and enhancing acoustic reflection for ultrasound imaging. The SMISO composite nanoparticles effectively inhibited tumor growth without adverse side effects under ultrasound irradiation treatment, offering a new approach for cancer theranostics.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Pharmacology & Pharmacy
Jiayu Hu, Rawan Fitaihi, Shorooq Abukhamees, Hend E. Abdelhakim
Summary: This study developed a child-appropriate dosage form, orodispersible mini-tablet (ODMT), using carbamazepine (CBZ) as the model drug. ODMTs were prepared and 3D-printed through a semi-solid extrusion technique. Design of Experiment methods were employed to optimize the formulation, and the selected formulation with 40% (w/w) SSG and 5% (w/w) PVP K30 exhibited desirable properties. The ODMTs showed high drug loading ratio, acceptable disintegrating time, and appropriate compatibility with the drug.
Review
Pharmacology & Pharmacy
Shazia Bashir, Rawan Fitaihi, Hend E. Abdelhakim
Summary: Therapeutic proteins and peptides (TPPs) are becoming more popular and there is a need to develop pharmaceutical strategies to incorporate them into orally disintegrating dosage forms (ODDF) for easy administration to a wider patient population.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Stefania Marano, Manish Ghimire, Shahrzad Missaghi, Ali Rajabi-Siahboomi, Duncan Q. M. Craig, Susan A. Barker
Summary: This study investigated the incorporation of drug-loaded sucrose microfibres into tablets and found that the dissolution advantage of the microfibres was maintained and enhanced after humidity treatment. The tablets showed controlled disintegration rate and drug content, allowing optimization of the formulation for improved dissolution performance.
Article
Pharmacology & Pharmacy
Sejal R. Ranmal, Zeineb Nhouchi, Alexander Keeley, Lisa Adler, Marc Lavarde, Anne-Marie Pense-Lheritier, Catherine Tuleu
Summary: Medicines for children often taste bitter, making treatment compliance challenging. This study investigated perceived bitterness aversion in school-aged children towards taste strips impregnated with different concentrations of quinine hydrochloride. The results showed that younger children had difficulty discriminating higher bitter concentrations, while pre-adolescents and naive adults showed better discrimination. These findings highlight the importance of adult panels in pediatric formulation development and suggest that taste strips can be a useful tool for sensory pharmaceutical evaluations.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
David Clapham, Emilie Belissa, Sabine Inghelbrecht, Anne-Marie Pense-Lheritier, Fabrice Ruiz, Liz Sheehan, Margaret Shine, Thibault Vallet, Jennifer Walsh, Catherine Tuleu
Summary: Treatment regime compliance is linked to the acceptability of a pharmaceutical formulation, and poor sensory characteristics, especially taste, often contribute to poor patient acceptability. Sensory analysis provides objective data for the development of pharmaceutical products. This paper proposes the application of sensory analysis principles to pharmaceutical product development, provides guidance on reducing the number of samples assessed by human volunteers, and emphasizes the importance of sensory assessments throughout the development process.
Article
Pharmacology & Pharmacy
Sejal R. Ranmal, Marc Lavarde, Elodie Wallon, Samar Issa, Walter R. Taylor, Julie L. A. Nguyen Ngoc Pouplin, Catherine Tuleu, Anne-Marie Pense-Lheritier
Summary: This study developed palatable primaquine tablets for children by using a responsive sensory pharmaceutics approach. Different taste-masking agents and excipient blends were screened and validated with trained sensory assessors and naive assessors. Two different flavoring systems have been developed for the tablets.
Review
Pharmacology & Pharmacy
Elisa Alessandrini, Milena Gonakova, Hannah Batchelor, Sveinbjorn Gizurarson, Sonia Iurian, Sandra Klein, Daniel Schaufelberger, Roy Turner, Jennifer Walsh, Catherine Tuleu
Summary: The color of a product, particularly in the pharmaceutical context, can significantly affect patient expectations and behaviors. Although studies have been conducted on adults, there is limited understanding of how children perceive the colors of medicines and the extent to which color impacts their acceptability. A systematic search was conducted to identify relevant research conducted on children's preferences and opinions regarding the color of oral medications, revealing a scarcity of information. The review indicates that red and pink were the most preferred colors and suggests a potential relationship between medicine color and expected taste/flavor.
Article
Chemistry, Multidisciplinary
Zoe Whiteley, Giulia Massaro, Georgios Gkogkos, Asterios Gavriilidis, Simon N. Waddington, Ahad A. Rahim, Duncan Q. M. Craig
Summary: Nanogels produced by microfluidics are a new alternative for the production of AAV vectors with comparable yields to traditional transfection reagents. The optimized nanogels showed no significant difference in titer compared to traditional reagents, but at lower costs.
