Journal
PHARMACEUTICS
Volume 13, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/pharmaceutics13122145
Keywords
multi-walled carbon nanotube; photothermal therapy; indocyanine green; synergistic strategy; cancer treatment; targeted drug delivery
Categories
Funding
- National Nature Science Foundation of China [31872756, 32071387]
- National Major Scientific and Technological Special Project for 'Significant New Drugs Development' [2016ZX09101031]
- Six Talent Peaks Project in Jiangsu Province [JY-079]
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The synergistic strategy involving MWNT and ICG derivative has led to the development of MWNT-HA-ICG/DOX nanocomplexes, showing promising therapeutic efficacy in cancer treatment through improved photothermal performance and strengthened cytotoxicity.
The combinational application of photothermal therapy (PTT), chemotherapy, and nanotechnology is a booming therapeutic strategy for cancer treatment. Multi-walled carbon nanotube (MWNT) is often utilized as drug carrier in biomedical fields with excellent photothermal properties, and indocyanine green (ICG) is a near-infrared (NIR) dye approved by FDA. In addition, ICG is also a photothermal agent that can strongly absorb light energy for tumor ablation. Herein, we explored a synergistic strategy by connecting MWNT and a kind of ICG derivate ICG-NH2 through hyaluronic acid (HA) that possesses CD44 receptor targeting ability, which largely enhanced the PTT effect of both MWNT and ICG-NH2. To realize the synergistic therapeutic effect of chemotherapy and phototherapy, doxorubicin (DOX) was attached on the wall of MWNT via pi-pi interaction to obtain the final MWNT-HA-ICG/DOX nanocomplexes. Both in vitro and in vivo experiments verified the great therapeutic efficacy of MWNT-HA-ICG/DOX nanocomplexes, which was characterized by improved photothermal performance, strengthened cytotoxicity, and elevated tumor growth inhibition based on MCF-7 tumor models. Therefore, this synergistic strategy we report here might offer a new idea with promising application prospect for cancer treatment.
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