Identification of novel SARS-CoV-2 RNA dependent RNA polymerase (RdRp) inhibitors: From in silico screening to experimentally validated inhibitory activity

Structure-Based Peptide Design Targeting Intrinsically Disordered Proteins: Novel Histone H4 and H2A Peptidic Inhibitors

(2021) Kanin Wichapong et al.   Computational and Structural Biotechnology Journal

Remdesivir for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials

(2021) Ahmad Al-Abdouh et al.   Contemporary Clinical Trials

The coronavirus is here to stay — here’s what that means

(2021) Nicky Phillips   NATURE

Significant Inhibition of Porcine Epidemic Diarrhea Virus In Vitro by Remdesivir, Its Parent Nucleoside and β-d-N4-hydroxycytidine

(2021) Yuanchao Xie et al.   VIROLOGICA SINICA

Why Remdesivir Failed: Preclinical Assumptions Overestimate the Clinical Efficacy of Remdesivir for COVID-19 and Ebola

(2021) Victoria C. Yan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): a phase 3, randomised, controlled, open-label trial

(2021) Florence Ader et al.   LANCET INFECTIOUS DISEASES

Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant

(2021) Jamie Lopez Bernal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Remdesivir for Early COVID-19 Treatment of High-Risk Individuals Prior to or at Early Disease Onset—Lessons Learned

(2021) Lars Dölken et al.   Viruses-Basel

Concurrent mutations in RNA-dependent RNA polymerase and spike protein emerged as the epidemiologically most successful SARS-CoV-2 variant

(2021) Sten Ilmjärv et al.   Scientific Reports

Prevention and therapy of SARS-CoV-2 and the B.1.351 variant in mice

(2021) David R. Martinez et al.   Cell Reports

Estimating clinical SARS-CoV-2 infectiousness in Vero E6 and primary airway epithelial cells

(2021) Manel Essaidi-Laziosi et al.   Lancet Microbe

Xanthohumol Is a Potent Pan-Inhibitor of Coronaviruses Targeting Main Protease

(2021) Yuxi Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Early Remdesivir to Prevent Progression to Severe Covid-19 in Outpatients

(2021) Robert L. Gottlieb et al.   NEW ENGLAND JOURNAL OF MEDICINE

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Remdesivir for Treatment of COVID-19: Combination of Pulmonary and IV Administration May Offer Aditional Benefit

(2020) Duxin Sun   AAPS Journal

Structure of replicating SARS-CoV-2 polymerase

(2020) Hauke S. Hillen et al.   NATURE

Remdesivir for the Treatment of Covid-19 — Preliminary Report

(2020) John H. Beigel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

(2020) Wanchao Yin et al.   SCIENCE

Remdesivir for Severe COVID-19 versus a Cohort Receiving Standard of Care

(2020) Susan A Olender et al.   CLINICAL INFECTIOUS DISEASES

Decoding SARS-CoV-2 Transmission and Evolution and Ramifications for COVID-19 Diagnosis, Vaccine, and Medicine

(2020) Rui Wang et al.   Journal of Chemical Information and Modeling

SARS-CoV-2 jumping the species barrier: zoonotic lessons from SARS, MERS and recent advances to combat this pandemic virus

(2020) Kuldeep Dhama et al.   Travel Medicine and Infectious Disease

RdRp mutations are associated with SARS-CoV-2 genome evolution

(2020) Doğa Eskier et al.   PeerJ

Laboratory biosafety measures involving SARS-CoV-2 and the classification as a Risk Group 3 biological agent

(2020) Alexa M. Kaufer et al.   PATHOLOGY

Porcine epidemic diarrhea virus (PEDV): An update on etiology, transmission, pathogenesis, and prevention and control

(2020) Kwonil Jung et al.   VIRUS RESEARCH

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

(2019) Robert N. Kirchdoerfer et al.   Nature Communications

Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

(2019) Ariane J. Brown et al.   ANTIVIRAL RESEARCH

Surveillance of Bat Coronaviruses in Kenya Identifies Relatives of Human Coronaviruses NL63 and 229E and Their Recombination History

(2017) Ying Tao et al.   JOURNAL OF VIROLOGY

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

(2017) Timothy P. Sheahan et al.   Science Translational Medicine

Molecular Evolution of Human Coronavirus Genomes

(2017) Diego Forni et al.   TRENDS IN MICROBIOLOGY

Origin and Evolution of RNA-Dependent RNA Polymerase

(2017) Savio T. de Farias et al.   Frontiers in Genetics

Structure-Based Design of Peptidic Inhibitors of the Interaction between CC Chemokine Ligand 5 (CCL5) and Human Neutrophil Peptides 1 (HNP1)

(2016) Kanin Wichapong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Genetic manipulation of porcine epidemic diarrhoea virus recovered from a full-length infectious cDNA clone

(2015) Juggragarn Jengarn et al.   JOURNAL OF GENERAL VIROLOGY

Biochemical characterization of a recombinant SARS coronavirus nsp12 RNA-dependent RNA polymerase capable of copying viral RNA templates

(2012) Dae-Gyun Ahn et al.   ARCHIVES OF VIROLOGY

Unipro UGENE: a unified bioinformatics toolkit

(2012) Konstantin Okonechnikov et al.   BIOINFORMATICS

Discovery of Seven Novel Mammalian and Avian Coronaviruses in the Genus Deltacoronavirus Supports Bat Coronaviruses as the Gene Source of Alphacoronavirus and Betacoronavirus and Avian Coronaviruses as the Gene Source of Gammacoronavirus and Deltacoronavirus

(2012) P. C. Y. Woo et al.   JOURNAL OF VIROLOGY

BLAST+: architecture and applications

(2009) Christiam Camacho et al.   BMC BIOINFORMATICS