Article
Genetics & Heredity
Lirong Yang, Yang Yang, Mingyao Meng, Wenju Wang, Shan He, Yiyi Zhao, Hui Gao, Weiwei Tang, Shijie Liu, Zhuying Lin, Lin Li, Zongliu Hou
Summary: By analyzing the gene expression profiles and clinical data of 307 cervical cancer patients from the TCGA database, it was found that immune scores were associated with patient survival, T cells and mast cells were significantly related to survival rates, and the CCR5 and CXCL9,-10,-11/CXCR3 axis may serve as potential targets for cervical cancer treatment.
Article
Oncology
Longwen Xu, Mengjie Liu, Jie Lian, Enmeng Li, Chang Dongmin, Xuqi Li, Wenjuan Wang
Summary: We developed a Treg-related classifier and generated a prognostic nomogram that predicts recurrence-free survival in stage I-III colon cancer. This classifier can identify high-risk patients for more personalized and effective therapy. The performance of the classifier was validated using multiple datasets and compared with other signatures.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Immunology
Lu Han, Shiyun Chen, Zhe Luan, Mengjiao Fan, Yanrong Wang, Gang Sun, Guanghai Dai
Summary: Colon cancer is a complex disease involving interactions between cancer cells and the immune microenvironment. Recent studies have shown that microRNAs (miRNAs) play a critical role in gene regulation in colon cancer, particularly in modulating the immune microenvironment. Identifying miRNAs associated with colon cancer and their regulation of immune function-related genes could provide insights into prognosis and guide personalized treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Paolo Gennari, Svetlana Tchaikovski, Jozsef Meszaros, Michael Gerken, Monika Klinkhammer-Schalke, George Toth, Olaf Ortmann, Holm Eggemann, Atanas Ignatov
Summary: Pre-operative conization is associated with improved DFS in early-stage cervical cancer independently of the surgical approach. This study suggests that conization prior to radical hysterectomy can reduce recurrence rates and improve disease-free survival in patients with early-stage cervical cancer.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Yuanyuan Chen, Yiming Zhu, Jinchang Wu
Summary: The study aimed to determine the value of patterns of recurrence for predicting prognosis of early-stage cervical cancer. Results showed that patients with central pattern of recurrence, distant lymph node recurrence, and peritoneal recurrence had better outcomes, while those with other recurrent patterns and early recurrence required more effective therapeutic strategies to improve survival.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Health Care Sciences & Services
Wanling Jing, Runjie Zhang, Xinyi Chen, Xuemei Zhang, Jin Qiu
Summary: This study explored the relationship between glycosylation-related genes, the immune microenvironment, and the prognosis of cervical cancer. Functional analyses revealed enrichment in proteoglycans in cancer, cytokine-cytokine receptor interaction, and the PI3K/AKT and Hippo signaling pathways. A prognostic risk model successfully predicted the survival and prognosis of cervical cancer patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Chunhong Hu, Long Shu, Chen Chen, Songqing Fan, Qingchun Liang, Hongmei Zheng, Yue Pan, Lishu Zhao, Fangwen Zou, Chaoyuan Liu, Wenliang Liu, Feng-Lei Yu, Xianling Liu, Lijuan Liu, Lingling Yang, Yang Shao, Fang Wu
Summary: High TMS and low IS were identified as independent predictors for early recurrence in stage I NSCLC patients. Integration of TMS and IS in a predictive model could help identify patients at high risk of recurrence, providing evidence for perioperative treatment research in the future.
TRANSLATIONAL LUNG CANCER RESEARCH
(2022)
Article
Oncology
Wen-Fang Tang, Xiao-Jun Fan, Hua Bao, Rui Fu, Yi Liang, Min Wu, Chao Zhang, Jian Su, Yi-Long Wu, Wen-Zhao Zhong
Summary: This study investigated the immune profile changes from primary tumors to distant and local metastases in NSCLC patients. Distant metastases showed immune suppression and immune evasion, whereas local metastases exhibited immune competence. High levels of CD4+ T cells in primary tumors were associated with distant metastases.
Article
Genetics & Heredity
Xianzhe Li, Minghao Xie, Shi Yin, Zhizhong Xiong, Chaobin Mao, Fengxiang Zhang, Huaxian Chen, Longyang Jin, Ping Lan, Lei Lian
Summary: This study developed and validated a novel immune prognostic signature based on six differentially expressed IRGs for predicting disease-free survival and immune status in patients with stage II CRC. The high-risk group exhibited a higher percentage of infiltrated immune cells. The accuracy of the signature was confirmed through experimental validation.
FRONTIERS IN GENETICS
(2021)
Review
Cell Biology
Yoshitaka Murota, Kouichi Tabu, Tetsuya Taga
Summary: Glioblastoma multiforme is an incurable tumor with a high relapse frequency. Cancer stem cells play a crucial role in therapy resistance and cancer recurrence by manipulating the microenvironment. However, there is limited research on recurrence, particularly regarding the tumor immune microenvironment.
Article
Medicine, Research & Experimental
Yiwei Tong, Jiahui Huang, Weili Ren, Jing Yu, Xu Zhang, Zheng Wang, Jin Hong, Weiqi Gao, Jiayi Wu, Min Ji, Kunwei Shen, Xiaosong Chen
Summary: This study evaluated the association between tumor immune microenvironment (TIME) and 21-gene recurrence score (RS) in early Luminal breast cancer patients. The results showed that breast cancer TIME markers were correlated with 21-gene RS score and associated with survival rate.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Immunology
Shijie Yao, Liyang Zhao, Siming Chen, Hua Wang, Yang Gao, Ning-Yi Shao, Mengyuan Dai, Hongbing Cai
Summary: This study comprehensively assessed the immune microenvironment of cervical cancer and identified key immune-related genes IL1B, CST7, and ITGA5. A scoring system for immune cell infiltration was established, providing a potential indicator for immunotherapy susceptibility in cervical cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Chigozirim N. Ekeke, Chandler Mitchell, Matthew Schuchert, Rajeev Dhupar, James D. Luketich, Olugbenga T. Okusanya
Summary: Operable stage I non-small-cell lung cancer has a positive prognosis, but some patients may develop early distant recurrence with poor survival outcomes. Elderly smokers with adenocarcinoma are at higher risk for early distant recurrence. The 5-year survival rate after recurrence and surgery is 13.2%.
CLINICAL LUNG CANCER
(2021)
Article
Biochemistry & Molecular Biology
Tae Oike, Yoshihito Sekiguchi, Yuya Yoshimoto, Takahiro Oike, Ken Ando, Wenchao Gu, Yasushi Sasaki, Takashi Tokino, Akira Iwase, Tatsuya Ohno
Summary: Simultaneous mutations in KRAS and SMAD4 may be associated with radioresistance in cervical cancer, and carbon ion radiotherapy could be a potential treatment option for these cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Nandie Wu, Fangcen Liu, Ying Huang, Xinyu Su, Yaping Zhang, Lixia Yu, Baorui Liu
Summary: The high-risk group of gastric cancer patients showed higher clinical stage or grade and worse prognosis compared to the low-risk group. The low-risk group had higher levels of immunity and immune cell infiltration. Necroptosis was triggered by the TNF pathway in myeloid cells and the glycolysis pathway was altered. In vitro experiments demonstrated that necroptosis-related genes modulated cell function, including proliferation and migration, and the low-risk subgroup showed higher sensitivity to potential drugs. These findings contribute to a better understanding and improvement of treatment potential and prognosis in gastric cancer patients.
Article
Cell Biology
Leonoor Wismans, Boaz Lopuhaa, Willem de Koning, Hazra Moeniralam, Matthijs van Oosterhout, Carmen Ambarus, Frederik N. Hofman, Thijs Kuiken, Henrik Endeman, Dana A. M. Mustafa, Jan H. von der Thusen
Summary: Lung tissue from COVID-19 patients shows histomorphological features similar to chronic lung allograft disease, suggesting activation of autoimmune-related pathways. Analysis of mRNA expression in post-mortem lung tissue reveals significant up-regulation of mast cell-related genes in COVID-19. Genes associated with fibrosis and thrombosis are also up-regulated, indicating that mast cells may play a crucial role in the pathogenesis of COVID-19.
Article
Oncology
Malika Kengsakul, Gatske M. Nieuwenhuyzen-de Boer, Suwasin Udomkarnjananun, Stephen J. Kerr, Helena C. van Doorn, Heleen J. van Beekhuizen
Summary: This study validated the Comprehensive Complication Index (CCI) in patients with advanced-stage epithelial ovarian cancer undergoing cytoreductive surgery. The CCI showed a stronger association with prolonged length of hospital stay compared to the Clavien-Dindo classification.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Immunology
Hosein M. M. Aziz, Lawlaw Saida, Willem de Koning, Andrew P. P. Stubbs, Yunlei Li, Kostandinos Sideras, Elena Palacios, Jaime Feliu, Marta Mendiola, Casper H. J. van Eijck, Dana A. M. Mustafa
Summary: By studying gene expression and protein infiltration, this study found that long-term survivors of pancreatic ductal adenocarcinoma have a higher number and specific location of B cells. This emphasizes the importance of B cells and B cell-based therapy in future personalized immunotherapy for PDAC patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Gatske M. Nieuwenhuyzen-de Boer, Malika Kengsakul, Ingrid A. Boere, Helena C. van Doorn, Heleen J. van Beekhuizen
Summary: This study aimed to address the knowledge gap regarding postoperative treatment and survival of patients with unresectable ovarian cancer. The study found that treatment varied, including cessation of treatment, chemotherapy, and maintenance treatment with bevacizumab and/or PARP inhibitors. The median overall survival was 16 months, with 15% of patients alive at 24 months of follow-up.
Article
Oncology
W. de Koning, F. F. Feenstra, F. G. J. Calkoen, J. van der Lugt, L. A. Kester, D. A. M. Mustafa
Summary: This study compared the use of RNA sequencing and NanoString technology for characterizing the tumor immune microenvironment (TIME) of ependymoma samples. Both techniques consistently identified T cells and showed heterogeneous immune landscapes in the samples.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Oncology
Casper W. F. van Eijck, Willem de Koning, Fleur van der Sijde, Miranda Moskie, Bas Groot Koerkamp, Marjolein Y. V. Homs, Sjoerd H. van der Burg, Casper H. J. van Eijck, Dana A. M. Mustafa
Summary: This study investigated the impact of a single cycle of FOLFIRINOX in combination with a granulocyte colony-stimulating factor on the blood immune transcriptome of patients with pancreatic ductal adenocarcinoma. A novel eight-gene FFX-Delta GEP score was developed to predict the lack of FOLFIRINOX response after one cycle. The findings highlight the potential of using the peripheral immune transcriptome as an early circulating biomarker for predicting treatment outcomes.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Ciska Slaager, Ward Hofhuis, Klaas J. Hoogduin, Patricia C. Ewing-Graham, Heleen J. van Beekhuizen
Summary: This study evaluated the surgical management of patients with serous endometrial intra-epithelial carcinoma and its impact on oncologic outcomes and complications. The results showed that median progression-free survival reached nearly 3 years and no recurrences have been reported in patients with pure serous endometrial intra-epithelial carcinoma. This suggests that full surgical staging might lead to overtreatment.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Review
Obstetrics & Gynecology
A. J. M. van de Sande, M. Kengsakul, M. M. Koeneman, M. Jozwiak, C. G. Gerestein, A. J. Kruse, E. M. G. van Esch, P. J. de Vos van Steenwijk, C. L. P. Muntinga, W. M. Bramer, H. C. van Doorn, F. J. van Kemenade, H. J. van Beekhuizen
Summary: The aim of this study was to determine the efficacy of topical imiquimod in the treatment of high-grade CIN. The results showed a higher histological regression rate in the imiquimod treatment group compared to the placebo group, but lower than the surgical treatment group. Additionally, there was a difference in hr-HPV clearance rate between the imiquimod and surgical treatment groups.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Biochemistry & Molecular Biology
Buesra Koese, Ralf van de Laar, Heleen van Beekhuizen, Folkert van Kemenade, Ahmet Tarik Baykal, Theo Luider, Coskun Guzel
Summary: By using a targeted proteomics approach, it was found that the concentration levels of MCM3 and EVPL proteins can discriminate between non-dysplastic and dysplastic samples, improving the accuracy of cervical cancer screening. This suggests that MCM3 and EVPL may be promising candidate protein biomarkers for population-based cervical cancer screening.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pathology
Jasmijn Vaneman, Heleen J. J. van Beekhuizen, Joost L. L. Boormans, Patricia C. C. Ewing-Graham, Geert J. L. H. van Leenders, Ramon G. V. Smolders, H. (Lena) C. van Doorn
Summary: Diagnosing lymph node metastases in pelvic lymph node dissection (PLND) is crucial for staging and treatment. It is standard practice to submit visible or palpable lymph nodes for histological examination. This study assessed the potential benefits of embedding all residual fatty tissue.
Article
Neurosciences
Shiva Najjary, Johan M. M. Kros, Willem de Koning, Disha Vadgama, Karishma Lila, Janina Wolf, Dana A. M. Mustafa
Summary: This study aimed to compare the brain immune response to brain metastasis between lung adenocarcinoma and breast cancer. The results showed a more active immune response in lung adenocarcinoma brain metastasis, with higher expression levels of VISTA and IDO1. Therefore, targeted immune therapy should be considered for patients with lung adenocarcinoma brain metastasis.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Review
Oncology
Nick J. van de Berg, Gatske M. M. Nieuwenhuyzen-de Boer, Xu Shan Gao, L. Lucia Rijstenberg, Heleen J. van Beekhuizen
Summary: This review discusses the historical and future applications of plasma in gynaecology and evaluates the depths of (non-)thermal effects in female pelvic tissues. The study found that the depth of thermal effects for plasma-assisted electrosurgical devices relied on current dispersion in tissue and was less than 2.4 mm, while the depth for electrically neutral argon plasma remained superficial (<1.0 mm). The depth and uniformity of cold atmospheric plasma effects require further investigation.
Article
Oncology
Nick J. van de Berg, Franciscus P. van Beurden, G. C. Wanda Wendel-Vos, Marjolein Duijvestijn, Heleen J. van Beekhuizen, Marianne Maliepaard, Helena C. van Doorn
Summary: For vulvar cancer patients, walking and bicycling can cause discomfort and pain, leading to a decrease in mobility, physical activity, social contacts, self-reliance, and quality of life. We evaluated these problems using questionnaires and found that patients reported lower health, mobility, and physical activity compared to baseline values. Many experienced pain during bicycling and were unable to do it. This highlights the need for interventions to reduce discomfort and help patients regain their mobility and self-reliance.
Article
Oncology
Gatske M. M. Nieuwenhuyzen-de Boer, Hanane Aamran, Caroline B. B. van den Berg, Sten Willemsen, Jurgen M. J. Piek, Nathalie Reesink-Peters, Marianne Maliepaard, Helena C. van Doorn, Suzanne Polinder, Heleen J. van Beekhuizen
Summary: This study aimed to determine whether the use of the PlasmaJet Surgical device during surgery has an effect on the quality-of-life of patients with advanced ovarian cancer. The results showed that using the PlasmaJet device during surgery leads to a higher quality-of-life compared to surgery with electrocoagulation alone. The differences in quality-of-life mainly relate to physical and role functioning, fatigue, and pain.
Article
Obstetrics & Gynecology
Rozi Aditya Aryananda, Johannes J. Duvekot, Heleen J. Van Beekhuizen, Nareswari Imanadha Cininta, Grace Ariani, Erry Gumilar Dachlan
Summary: This retrospective cohort study analyzed the relationship between ultrasound features and the management of placenta accreta spectrum (PAS). The results showed significant correlations between certain ultrasound features and the choice of surgical approach. Placental bulge and higher grades of intracervical hypervascularity were associated with cesarean hysterectomy, while Grade 1 intracervical hypervascularity was associated with one-step conservative surgery (OSCS).
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
