SUZ12 Loss Amplifies the Ras/ERK Pathway by Activating Adenylate Cyclase 1 in NF1-Associated Neurofibromas

The Role of Polycomb Repressive Complex in Malignant Peripheral Nerve Sheath Tumor

(2020) Xiyuan Zhang et al.   Genes

The 2020 WHO Classification

(2020) Michael E. Kallen et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

EZH1/2 function mostly within canonical PRC2 and exhibit proliferation-dependent redundancy that shapes mutational signatures in cancer

(2019) Michel Wassef et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low mutation burden and frequent loss of CDKN2A/B and SMARCA2, but not PRC2, define pre-malignant neurofibromatosis type 1-associated atypical neurofibromas

(2019) Alexander Pemov et al.   NEURO-ONCOLOGY

Polycomb Repressive 2 Complex—Molecular Mechanisms of Function

(2019) Valentina L Kouznetsova et al.   PROTEIN SCIENCE

WHO 2016 classification: changes and advancements in the diagnosis of miscellaneous primary CNS tumours

(2018) F. Sahm et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Emerging genotype–phenotype relationships in patients with large NF1 deletions

(2017) Hildegard Kehrer-Sawatzki et al.   HUMAN GENETICS

Mechanisms Regulating PRC2 Recruitment and Enzymatic Activity

(2017) Daniel Holoch et al.   TRENDS IN BIOCHEMICAL SCIENCES

The genomic landscape of malignant peripheral nerve sheath tumors: diverse drivers of Ras pathway activation

(2017) Andrew S. Brohl et al.   Scientific Reports

Protein Kinase A-independent Ras Protein Activation Cooperates with Rap1 Protein to Mediate Activation of the Extracellular Signal-regulated Kinases (ERK) by cAMP

(2016) Yanping Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of H3K27 tri-methylation is a diagnostic marker for malignant peripheral nerve sheath tumors and an indicator for an inferior survival

(2016) Arjen H G Cleven et al.   MODERN PATHOLOGY

Role of the Polycomb Repressive Complex 2 (PRC2) in Transcriptional Regulation and Cancer

(2016) Anne Laugesen et al.   Cold Spring Harbor Perspectives in Medicine

PRC2 mediated H3K27 methylations in cellular identity and cancer

(2015) Eric Conway et al.   CURRENT OPINION IN CELL BIOLOGY

Neurofibromatosis type 1: a multidisciplinary approach to care

(2014) Angela C Hirbe et al.   LANCET NEUROLOGY

PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies

(2014) Thomas De Raedt et al.   NATURE

PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors

(2014) William Lee et al.   NATURE GENETICS

Transcriptional regulation by Polycomb group proteins

(2013) Luciano Di Croce et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cardiac characterization of 16 patients with largeNF1gene deletions

(2012) R Nguyen et al.   CLINICAL GENETICS

Relations between the mitogen-activated protein kinase and the cAMP-dependent protein kinase pathways: Comradeship and hostility

(2008) Nancy Gerits et al.   CELLULAR SIGNALLING