Article
Oncology
Rami Imam, Qing Chang, Margaret Black, Caroline Yu, Wenqing Cao
Summary: This study revealed that low CD47 expression and high levels of CD163+ TAMs may indicate poor prognosis in pancreatic neuroendocrine tumors.
Article
Oncology
Tao Xue, Kejing Yan, Yiqi Cai, Jiancheng Sun, Zhejing Chen, Xiaolei Chen, Wenyi Wu
Summary: Infiltration of CD163+ TAMs in CRC tissue is an independent adverse factor for the prognosis of CRC patients, with high-level infiltration associated with shorter overall survival and disease-free survival.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Takuto Nosaka, Yosuke Murata, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani, Katsushi Hiramatsu, Yoshiaki Imamura, Takanori Goi, Yasunari Nakamoto
Summary: This study identified the role of 5-LOX in hepatocellular carcinoma (HCC) progression and demonstrated that inhibition of 5-LOX activity can regulate HCC progression, suggesting it as a potential therapeutic target.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Yicheng Liang, Yangyang Lei, Mei Liang, Minjun Du, Zixu Liu, Xingkai Li, Xiangzhi Meng, Boxuan Zhou, Yushun Gao
Summary: The expression of GBE1 is associated with the prognosis and infiltration of tumor-associated macrophages in LUAD, suggesting it as a potential prognostic and immunological biomarker in LUAD.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hajime Shinohara, Maki Kobayashi, Kumiko Hayashi, Daichi Nogawa, Ayaka Asakawa, Yae Ohata, Kazuishi Kubota, Hisashi Takahashi, Miyuki Yamada, Masanori Tokunaga, Yusuke Kinugasa, Goshi Oda, Tsuyoshi Nakagawa, Iichiroh Onishi, Yuko Kinowaki, Morito Kurata, Kenichi Ohashi, Masanobu Kitagawa, Kouhei Yamamoto
Summary: This study used high-throughput multiple immunohistochemistry to analyze the role of TAMs in breast cancer. The specific subpopulation and localization of TAMs were found to be closely related to clinical outcomes in breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Hao Wang, Jinwen Yin, Yuntian Hong, Anli Ren, Haizhou Wang, Mengting Li, Qiu Zhao, Congqing Jiang, Lan Liu
Summary: In this study, the researchers found that SCG2 expression was significantly decreased in CRC tumor tissues and differentially distributed between tumor and adjacent normal tissues. High expression of SCG2 correlated with poor survival and advanced clinical stage in CRC patients. SCG2 might regulate tumor immunity by influencing immune cell infiltration and macrophage polarization in CRC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yunze Liu, Haocheng Zheng, Anna Meilin Gu, Yuan Li, Tieshan Wang, Chengze Li, Yixiao Gu, Jie Lin, Xia Ding
Summary: Through the TCGA and GEO databases, we identified 173 metabolism-related genes (MRGs) associated with M2 macrophage infiltration in gastric cancer. Twelve MRGs were adopted as a prognostic signature and used to develop a risk model. Patients in the high-risk group had poorer survival outcomes and were less sensitive to certain drugs. Risk scores were correlated with immune cell infiltration, including CD8+ T cells and M2 macrophages. Single-cell sequencing analysis revealed differences in the expression and distribution of the 12 signature genes in the tumor microenvironment. In vitro experiments confirmed that Sorcin-knockdown gastric cancer cells suppressed M2 polarization of macrophages, inhibiting the proliferation and migration of gastric cancer cells. These findings provide a valuable prognostic signature for evaluating clinical outcomes, treatment options, and potential targets for gastric cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Hui Wang, Tian Tian, Jinhua Zhang
Summary: Colorectal cancer (CRC) is a highly prevalent and lethal malignant tumor in the digestive system. Tumor-associated macrophages (TAMs) play a crucial role in various mechanisms of CRC progression, such as promoting tumor proliferation, invasion, angiogenesis, and immunosuppression, although their exact role is still debated in clinical evidence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Jian Yang, Yongzheng Li, Zhaowei Sun, Hanxiang Zhan
Summary: This review summarizes recent advances in understanding the origin, distribution, and polarization of macrophages in pancreatic cancer, as well as their role in carcinogenesis and development, and potential therapeutic value. Macrophages play a crucial role in creating an immunosuppressive tumor microenvironment, ultimately facilitating tumor initiation and progression in pancreatic cancer.
Review
Cell Biology
Tianyi Zhang, Yanxian Ren, Pengfei Yang, Jufang Wang, Heng Zhou
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with a high deposition of extracellular matrix (ECM) and poor prognosis. ECM proteins derived from tumor cells reduce the effectiveness of conventional cancer treatment and contribute to tumor progression and metastasis. Cancer-associated fibroblasts (CAFs) in the ECM are promising targets for novel anti-tumor interventions.
CELL DEATH & DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Pedram Moeini, Paulina Niedzwiedzka-Rystwej
Summary: Macrophages, crucial cells of the innate immune system, play a significant role in cancer progression and therapy failure by transforming into tumor-associated macrophages (TAMs) within the tumor microenvironment. This review aims to explore the advantages and disadvantages of TAMs in the immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Ling Xue, Wei Chu, Fangsheng Wan, Pingfan Wu, Xiaowen Zhao, Linna Ma, Yali She, Changtian Li, Yaling Li
Summary: In this study, the relationship between YKL-39 and tumor-associated macrophages and microangiogenesis in gastric cancer was investigated. The results showed that the expression of YKL-39 was associated with depth of tumor infiltration, lymph node metastasis, and TNM stage. YKL-39 expression was also positively correlated with CD68 and CD34, and high expression of YKL-39 was associated with poor prognosis.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Immunology
Xin Li, Yan Du, Wenkai Jiang, Shi Dong, Wancheng Li, Huan Tang, Jianfeng Yi, Wence Zhou, Hui Zhang
Summary: This study explored the metabolic heterogeneity involved in TAM2 by constructing TAM2-associated metabolic subtypes in PAAD. The results showed that TAM2 infiltration levels were upregulated in PAAD and were associated with poor patient prognosis. Multiple metabolic processes were aberrantly regulated in PAAD, and this dysregulation was linked to the level of TAM2 infiltration. Based on transcriptomic data, PAAD samples were classified into four TAM2-associated metabolic subtypes, which provided new insights into prognosis prediction and therapy for PAAD patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Ryota Sumitomo, Cheng-Long Huang, Hidenori Ando, Tatsuhiro Ishida, Hiroyuki Cho, Hiroshi Date
Summary: Tumor-associated macrophages (TAMs), especially M2 macrophages, play a promoting role in tumor progression, while Wnt2b and Wnt5a genes are involved in tumorigenesis in non-small cell lung cancer (NSCLC). This study found that the expression of Wnt2b and Wnt5a in tumor cells and stromal cells is closely associated with the density of M2 TAMs, tumor cell proliferation, and overall survival rate in NSCLC patients.
Article
Immunology
Guozeng Xu, Lei Jiang, Cheng Ye, Guizhen Qin, Zhanxiong Luo, Yuzhen Mo, Jian Chen
Summary: The ratio of stromal CD86+TAM/CD163+TAM (CD86/CD163) was investigated as a prognostic biomarker for colorectal cancer, with results showing its effectiveness in predicting recurrence-free survival and overall survival. The ratio was found to be an independent predictor in different cohorts and showed better predictive values than tumor stage. The stromal CD86/CD163 ratio could be useful for individual risk assessment and personalized treatment in stage II-III colorectal cancer.
FRONTIERS IN IMMUNOLOGY
(2021)