DdCBE-mediated mitochondrial base editing in human 3PN embryos

Precision modeling of mitochondrial disease in rats via DdCBE-mediated mtDNA editing

(2021) Xiaolong Qi et al.   Cell Discovery

A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing

(2020) Beverly Y. Mok et al.   NATURE

Movement disorders in mitochondrial disease

(2018) Roula Ghaoui et al.   JOURNAL OF NEUROLOGY

MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation

(2018) Sandra R. Bacman et al.   NATURE MEDICINE

Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease

(2015) Gráinne S. Gorman et al.   ANNALS OF NEUROLOGY

Mitochondrial DNA transmission, replication and inheritance: a journey from the gamete through the embryo and into offspring and embryonic stem cells

(2010) J. C. St. John et al.   HUMAN REPRODUCTION UPDATE