Article
Cell Biology
Ke-Bing Chen, Min-Min Chang, Sheng-Li Wang, Yong-Xin Li, Yi-Xi Wang, Zhi-Guang Xu, Hong Wang, Bing-Cheng Zhao, Wei-Ying Ma
Summary: The study demonstrated the important role of HMGB1 in inflammation after spinal cord injury, with neutralizing HMGB1 significantly reducing SCI pathogenesis and hind limb paralysis. Additionally, blocking HMGB1 also led to a decrease in various pro-inflammatory cytokines levels at the SCI lesion site.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Immunology
William A. Banks, Kim M. Hansen, Michelle A. Erickson, Fulton T. Crews
Summary: High-mobility group box 1 (HMGB1) is a protein that regulates transcription in the cell nucleus and activates the innate immune system. It can cross the blood-brain barrier (BBB) and affect neuroimmune signaling in the brain and periphery. In this study, the ability of radioactively labeled HMGB1 to cross the BBB was examined. The results showed that HMGB1 could bidirectionally cross the BBB and its transport rates were enhanced by inflammation. This finding suggests that HMGB1 levels have an impact on neuroimmune signaling in various conditions.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Multidisciplinary Sciences
Huan Yang, Qiong Zeng, Harold A. Silverman, Manojkumar Gunasekaran, Sam J. George, Alex Devarajan, Meghan E. Addorisio, Jianhua Li, Tea Tsaava, Vivek Shah, Timothy R. Billiar, Haichao Wang, Michael Brines, Ulf Andersson, Valentin A. Pavlov, Eric H. Chang, Sangeeta S. Chavan, Kevin J. Tracey
Summary: Inflammation is initiated by molecular signatures of microbes and tissue injury, triggering the body's defensive response. Neuronal synthesis of HMGB1 is an important mediator of inflammation, with the release of HMGB1 by nociceptors playing a role in neurogenic inflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Anesthesiology
Cunjin Wang, Yuchen Pan, Wenwen Zhang, Ying Chen, Chuhan Li, Fang Zhao, Thomas Behnisch
Summary: PRDM1 contributes to peripheral nerve injury-induced nociception by repressing Kv4.3 channel expression in injured dorsal root ganglion neurons. PRDM1 downregulation can reduce the calcium signaling response of spinal dorsal horn neurons to thermal stimulation.
Article
Medicine, Research & Experimental
Luana Heimfarth, Marilia Matos Rezende, Erik Willyame Menezes Pereira, Fabiolla Rocha Santos Passos, Brenda Souza Monteiro, Tiffany Karoline Barroso Santos, Natalia Teles Lima, Isana Carla Leal Souza, Ricardo Luiz Cavalcanti de Albuquerque Junior, Pollyana de Souza Siqueira Lima, Adriano Antunes de Souza Araujo, Lucindo Jose Quintans Junior, Bonglee Kim, Henrique D. M. Coutinho, Jullyana de Souza Siqueira Quintans
Summary: Inflammatory arthritis is a common chronic inflammatory disease, and oral administration of BIS and β CD/BIS can significantly alleviate its symptoms, with the cyclodextrin inclusion complex also improving the pharmacological profile of the drug.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Neurosciences
Liang-Biao Wang, Xiao-Jing Su, Qiao-Feng Wu, Xiang Xu, Xin-Yue Wang, Mo Chen, Jia-Reng Ye, Abasi Maimaitiabula, Xiao-Qing Liu, Wen Sun, Yan Zhang
Summary: In this study, the researchers used transgenic mice to activate Mrgprd(+) and TRPV1(+) sensory neurons and found that different behavioral responses represent different pain perceptions. This finding has significant implications for the development and evaluation of new analgesic drugs.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Nurul Ajilah Mohamed Khir, Ain Sabreena Mohd Noh, Idris Long, Norjihada Izzah Ismail, Rosfaiizah Siran, Che Aishah Nazariah Ismail
Summary: This review uncovers the roles of apoptotic markers in the occurrence and transmission of pain in rheumatoid arthritis. Modulating apoptotic pathways may be beneficial in alleviating pain.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Emilie Boissady, Yara Abi Zeid Daou, Estelle Faucher, Matthias Kohlhauer, Fanny Lidouren, Cynthia El Hedjaj, Sophie Chateau-Joubert, Hakim Hocini, Sophie Hue, Bijan Ghaleh, Renaud Tissier
Summary: The inhibition of the HMGB1-signaling pathway by glycyrrhizin improves neurological recovery and systemic immune response in rabbits after cardiac arrest. Glycyrrhizin reduces the levels of HMGB1, interleukin-6, and interleukin-10 in the blood. It also improves clinical recovery and histopathological damages associated with reduced cerebral CD4(+) and CD8(+) T-cell infiltration.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Immunology
Yuan Qu, Yang Fu, Yuan Liu, Chuanguo Liu, Bing Xu, Qian Zhang, Ping Jiang
Summary: Transient receptor potential cation channel subfamily V member 1 (TRPV1) has been found to play a role in immune regulation and its dysregulation affects the development of rheumatoid arthritis. Understanding the mechanism of TRPV1 can lead to the design of new drugs and improved treatment of RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jie Zhao, Fang Xu, Wanying Xu, Rong Lv, Juan Wang, Xufeng Yang
Summary: This study found an association between elevated HMGB1 levels and the severity of white matter lesions (WMLs) in stroke patients, particularly in the periventricular region.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Zixuan Wang, Stefano Martellucci, Alicia Van Enoo, Dana Austin, Cohava Gelber, Wendy M. Campana
Summary: SP16, derived from AAT, is a bioactive peptide that can increase neurite length and regenerative gene expression in sensory neurons. It activates the Akt and ERK1/2 cell-signaling pathways in an LRP1-dependent manner. SP16 shows efficacy in attenuating nociceptive, inflammatory, and neuropathic pain in three different pain models, and also inhibits inflammatory cell recruitment and satellite cell activation.
Article
Chemistry, Medicinal
Verena Peek, Lois M. Harden, Jelena Damm, Ferial Aslani, Stephan Leisengang, Joachim Roth, Ruediger Gerstberger, Marita Meurer, Maren von Koeckritz-Blickwede, Sabine Schulz, Bernhard Spengler, Christoph Rummel
Summary: This study revealed the mechanisms of HMGB1 action in the brain during rat sepsis, finding that HMGB1 enhances brain inflammatory responses and is associated with sustained sepsis symptoms.
Article
Medical Laboratory Technology
Dong Zang, Wen Li, Fan Cheng, Xiaobin Zhang, Ting Rao, Weimin Yu, Jie Wei, Yangyiyan Song, Wanli Jiang
Summary: This study investigated the diagnostic value of HMGB1 levels in patients with acute kidney injury (AKI) caused by sepsis and its relationship with disease prognosis. The results showed that HMGB1 in serum and urine could be used as diagnostic markers for sepsis complicated with AKI, and serum HMGB1 could also be used to assess disease prognosis with good clinical promotion.
CLINICA CHIMICA ACTA
(2022)
Review
Critical Care Medicine
Yupei Li, Yu Chen, Tinghang Yang, Kaixi Chang, Ningyue Deng, Weifeng Zhao, Baihai Su
Summary: Both HMGB1 and histones play major roles in mediating inflammation, immune thrombosis, and organ dysfunction in critical illnesses. Targeting them with specific antibodies or inhibitors has shown promise in animal models, but their routine clinical use is not recommended. On the other hand, extracorporeal blood purification may remove these DAMPs and exert an immunomodulatory effect in critically ill patients. This review summarizes the immunopathological roles of HMGB1 and histones, discusses the rationale for using hemofilters to remove these DAMPs, and gathers the latest evidence for the use of extracorporeal blood purification to improve clinical outcomes in critically ill patients.
Article
Immunology
Shukur Wasman Smail, Shang Ziyad Abdulqadir, Zhikal Omar Khudhur, Sonia Elia Ishaq, Abdullah Faqiyazdin Ahmed, Mohammed B. Ghayour, Arash Abdolmaleki
Summary: This study investigated the neuroprotective effects of IL-33 in relieving sciatic nerve injury. The results showed that IL-33 at doses of 50 and 25 μg/kg can promote nerve regeneration and improve sensorimotor recovery, while exerting its effects through regulating the inflammatory microenvironment and inducing macrophage polarization towards the M2 phenotype.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Yiting Tang, Xiangyu Wang, Zhaozheng Li, Zhihui He, Xinyu Yang, Xiaoye Cheng, Yue Peng, Qianqian Xue, Yang Bai, Rui Zhang, Kai Zhao, Fang Liang, Xianzhong Xiao, Ulf Andersson, Haichao Wang, Timothy R. Billiar, Ben Lu
Summary: Heparin prevents immune responses and reduces mortality in sepsis independently of its anticoagulant properties. This previously unrecognized function of heparin reveals a link between innate immune responses and coagulation.
Article
Rheumatology
AnnaCarin Horne, Tatiana von Bahr Greenwood, Samuel C. C. Chiang, Marie Meeths, Caroline Bjorklund, Maria Ekelund, Peter Erensjo, Stefan Berg, Stefan Hagelberg, Yenan T. Bryceson, Ulf Andersson, Jan-Inge Henter
Summary: Moderately dosed etoposide demonstrated effectiveness in treating severe MAS-HLH, with all children responding well and surviving at latest follow-up. Some children showed improvement in neurological symptoms after treatment.
JOURNAL OF RHEUMATOLOGY
(2021)
Review
Pediatrics
Ulf Andersson
Summary: Macrophage activation syndrome (MAS) is a subtype of hemophagocytic lymphohistiocytosis (HLH) diseases, with impaired granule-mediated cytotoxicity of natural killer (NK) cells and T lymphocytes contributing to its pathogenesis, particularly through the promotion of proinflammatory lytic cell death.
Article
Hematology
Brian M. Dulmovits, Yuefeng Tang, Julien Papoin, Mingzhu He, Jianhua Li, Huan Yang, Meghan E. Addorisio, Lauren Kennedy, Mushran Khan, Elena Brindley, Ryan J. Ashley, Cheryl Ackert-Bicknell, John Hale, Ryo Kurita, Yukio Nakamura, Betty Diamond, Betsy J. Barnes, Olivier Hermine, Patrick G. Gallagher, Laurie A. Steiner, Jeffrey M. Lipton, Naomi Taylor, Narla Mohandas, Ulf Andersson, Yousef Al-Abed, Kevin J. Tracey, Lionel Blanc
Summary: High mobility group box-1 protein (HMGB1) interferes with EPO signaling pathways, leading to reduced expansion and increased death of EPO-sensitive erythroid precursors in patients with anemia of inflammation. This study provides important insights into the chronic phase of anemia of inflammation.
Article
Biochemistry & Molecular Biology
Zamzam Awida, Almog Bachar, Hussam Saed, Anton Gorodov, Nathalie Ben-Califa, Maria Ibrahim, Albert Kolomansky, Jennifer Ana Iden, Liad Graniewitz Visacovsky, Tamar Liron, Sahar Hiram-Bab, Michael Brines, Yankel Gabet, Drorit Neumann
Summary: The study shows that Cibinetide (CIB) can increase bone density and inhibit osteoclastogenesis in mice, suggesting it as a potential candidate for the treatment of bone loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Pharmacology & Pharmacy
Michael Brines, Stephana Carelli, Michele Samaja, Edith Schneider M. Gasser
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Huan Yang, Sam J. George, Dane A. Thompson, Harold A. Silverman, Tea Tsaava, Aisling Tynan, Valentin A. Pavlov, Eric H. Chang, Ulf Andersson, Michael Brines, Sangeeta S. Chavan, Kevin J. Tracey
Summary: Recent studies have shown that famotidine has anti-inflammatory effects and can attenuate the clinical course of COVID-19 by preventing cytokine storm. The mechanism of action involves activation of the inflammatory reflex, which inhibits inflammation and is mediated by alpha 7 nicotinic acetylcholine receptors (alpha 7nAChR).
MOLECULAR MEDICINE
(2022)
Article
Geriatrics & Gerontology
Sandra Palus, Yulia Elkina, Tanja Braun, Stephan von Haehling, Wolfram Doehner, Stefan D. Anker, Anthony Cerami, Michael Brines, Jochen Springer
Summary: ARA 284 can reverse the loss in cancer cachexia, improve spontaneous activity, induce anabolic pathways, increase muscle mass, and enhance survival in animals.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Cardiac & Cardiovascular Systems
Nolan M. M. Winicki, Alay P. P. Nanavati, Christopher H. H. Morrell, Jack M. M. Moen, Jessie E. E. Axsom, Melissa Krawczyk, Natalia N. N. Petrashevskaya, Max G. G. Beyman, Christopher Ramirez, Irene Alfaras, Sarah J. J. Mitchell, Magdalena Juhaszova, Daniel R. R. Riordon, Mingyi Wang, Jing Zhang, Anthony Cerami, Michael Brines, Steven J. J. Sollott, Rafael De Cabo, Edward G. G. Lakatta
Summary: ARA290 (cibinetide) alleviates age-related cardiac inflammation and cellular damage, improves structural and functional changes in the cardiovascular system, and promotes overall health and longevity.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Clinical Neurology
Stavros Zanos, Despoina Ntiloudi, John Pellerito, Richard Ramdeo, John Graf, Kirk Wallace, Victoria Cotero, Jeff Ashe, Jessica Moon, Meghan Addorisio, David Shoudy, Thomas R. Coleman, Michael Brines, Chris Puleo, Kevin J. Tracey, Sangeeta S. Chavan
Summary: Focused ultrasound stimulation (FUS) has been found to be effective in noninvasive modulation of inflammatory response in humans. The study demonstrates that both continuously swept and focused pulsed ultrasound can suppress inflammation without adverse effects, regardless of the ultrasound energy level and target site, providing potential implications for noninvasive treatment of inflammatory disorders.
Article
Immunology
Dane A. Thompson, Tea Tsaava, Arvind Rishi, Sandeep Nadella, Lopa Mishra, David A. Tuveson, Valentin A. Pavlov, Michael Brines, Kevin J. Tracey, Sangeeta S. Chavan
Summary: Inflammation is a self-amplifying process that can result in tissue damage. The nervous system has evolved to detect inflammatory signals and respond with anti-inflammatory processes, including the cholinergic anti-inflammatory pathway mediated by the vagus nerve. This study used optogenetics to selectively activate vagus nerve fibers originating in the brainstem and found that stimulation of cholinergic neurons in the dorsal motor nucleus of the vagus significantly reduced the severity of pancreatitis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Laura Kate Gadanec, Ulf Andersson, Vasso Apostolopoulos, Anthony Zulli
Summary: High levels of HMGB-1 have been found in patients with Hyperhomocysteinemia (HHcy), which worsens cardiovascular outcomes. Targeting HMGB-1 may be a potential therapy for improving HHcy-induced cardiovascular pathologies.
Article
Medicine, General & Internal
Ulf Andersson, Kevin J. Tracey
Summary: Autonomic dysfunction is a common feature of SARS-CoV-2 infection, but the mechanisms behind it remain unknown. Recent evidence suggests that viral infection and inflammation in the vagus nerve may contribute to dysregulated respiration and impairment of the vagus nerve inflammatory reflex. This reflex is an important mechanism for suppressing cytokine storm, and its dysfunction may contribute to hyperinflammatory pathogenesis in COVID-19 patients.
JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Immunology
Aisling Tynan, Michael Brines, Sangeeta S. Chavan
Summary: This article reviews the novel target of the nervous system in regulating inflammation and discusses the non-invasive neuromodulation methods, such as transcutaneous electrical, magnetic, and ultrasound neuromodulation. It also explores the underlying mechanisms and pathways of neural regulation of inflammation.
INTERNATIONAL IMMUNOLOGY
(2022)