Review
Biochemistry & Molecular Biology
Fabio Ramos Costa, Mariana Ramos Costa Marques, Vinicius Calumby Costa, Gabriel Silva Santos, Rubens Andrade Martins, Marcia da Silva Santos, Maria Helena Andrade Santana, Arulkumar Nallakumarasamy, Madhan Jeyaraman, Joao Vitor Bizinotto Lana, Jose Fabio Santos Duarte Lana
Summary: Musculoskeletal diseases, such as osteoarthritis and tendinopathies, have a significant impact on society and individuals' quality of life. Intra-articular hyaluronic acid (HA) has emerged as a safe and effective treatment option for these conditions, providing multiple benefits such as lubrication, anti-inflammation, and stimulation of cellular activity. This review addresses the scientific, commercial, and clinical aspects of HA, providing physicians with a deeper understanding of disease processes, tissue repair mechanisms, and the advantages of different HA types.
Review
Biochemistry & Molecular Biology
Guzel Rafikova, Svetlana Piatnitskaia, Elena Shapovalova, Svyatoslav Chugunov, Victor Kireev, Daria Ialiukhova, Azat Bilyalov, Valentin Pavlov, Julia Kzhyshkowska
Summary: The immuno-compatibility of ceramic implants, which depends on the interaction with immune cells, is still insufficiently understood and requires intensive experimental research. This review summarizes the state of the art in ceramic implants, including their mechanical properties, chemical modifications, surface structures, and shapes. The gaps in knowledge are identified, and the possibilities for further research using advanced quantitative technologies are outlined.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Qifeng Ou, Rachael Power, Matthew D. Griffin
Summary: Regulatory T cells (Treg) play a critical role in maintaining immune homeostasis and have direct modulatory effects on innate immune responses in various acute and chronic diseases. Therapeutic interventions aimed at enhancing Treg numbers or potency show promising outcomes in autoimmunity and allogeneic transplants. Furthermore, interactions between Treg and innate immune effectors significantly impact disease severity and treatment. Treg-based therapeutic strategies hold potential for globally impactful inflammatory conditions such as type 2 diabetes, ischemia reperfusion injury, and atherosclerosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pathology
Aseel Riyadh Luaibi, Montaha Al-Saffar, Abduladheem Turki Jalil, Mustafa Asaad Rasol, Eremin Vladimir Fedorovich, Marwan Mahmood Saleh, Omar Saad Ahmed
Summary: Before the discovery of sensitive genomics platforms, long non-coding RNAs (lncRNAs) were considered genetic garbage. However, recent experimental research has revealed the association of lncRNAs with immunity and disease progression. Only a limited subset of lncRNAs have been proven to play a role, and different immune cells express lncRNAs differently. It is crucial to investigate lncRNA expression and understand its significance for the immune system.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Arshi Khanam, Joel V. Chua, Shyam Kottilil
Summary: This review discusses the current knowledge of innate and adaptive immune cell transformations associated with immunopathogenesis and disease outcome in chronic hepatitis B patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Donald R. Griffin, Maani M. Archang, Chen-Hsiang Kuan, Westbrook M. Weaver, Jason S. Weinstein, An Chieh Feng, Amber Ruccia, Elias Sideris, Vasileios Ragkousis, Jaekyung Koh, Maksim Plikus, Dino Di Carlo, Tatiana Segura, Philip O. Scumpia
Summary: The study aimed to slow MAP scaffold degradation by changing the chirality of peptides, but unexpectedly, D-peptide crosslinked MAP scaffolds led to accelerated degradation in vivo, promoting tissue regeneration and enhancing wound healing. D-MAP triggered an immune response against D-chiral peptides and intact adaptive immune system was crucial for skin regeneration induced by the hydrogel.
Review
Cell Biology
Rafael Leite Dantas, Jana Freff, Oliver Ambree, Eva C. Beins, Andreas J. Forstner, Udo Dannlowski, Bernhard T. Baune, Stefanie Scheu, Judith Alferink
Summary: Dendritic cells (DCs), a heterogeneous population of myeloid cells, are believed to play a role in peripheral immune responses and neuroinflammation in mood disorders, although their specific mechanisms of involvement remain unclear. The review summarizes current knowledge on the role of DCs in mood disorders and discusses their impact on neuroinflammation and behavior in animal models of AD.
Article
Immunology
Margaux Vienne, Marion Etiennot, Bertrand Escaliere, Justine Galluso, Lionel Spinelli, Sophie Guia, Aurore Fenis, Eric Vivier, Yann M. Kerdiles
Summary: NK cells are known to have cytotoxic effects on tumor cell lines, but their specific roles in primary tumor detection and elimination remain unclear. ILC1 play an active role in inhibiting the antitumoral immune response, suggesting the need to evaluate the tumor infiltration of ILC1 and NK cells to optimize immune harnessing in cancer therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sandra Winning, Joachim Fandrey
Summary: Oxygen deprivation is a common feature at inflamed sites, and immune cells adapt to this condition by activating HIF. HIF plays a significant role in regulating the inflammatory phenotype of immune cells, including migration, phagocytosis, and induction of inflammatory cytokines. However, further research is needed to understand the specific roles of HIF-1 and HIF-2 in different cell types.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Cell & Tissue Engineering
G. Crosio, A. H. Huang
Summary: This review summarizes the literature on various immune cell types that have been implicated in tendon healing or disease. In addition to macrophages, other immune cell types may also play a role in regulating the immune environment and directly interacting with tendon cells.
EUROPEAN CELLS & MATERIALS
(2022)
Review
Polymer Science
Emma J. Murphy, Gustavo Waltzer Fehrenbach, Ismin Zainol Abidin, Ciara Buckley, Therese Montgomery, Robert Pogue, Patrick Murray, Ian Major, Emanuele Rezoagli
Summary: The prevention and treatment of diseases require effective functioning immune systems, which can be achieved by eliminating infections and abnormal cells. Immune or biological therapy can stimulate or inhibit the immune system depending on the circumstances. Polysaccharides, abundant biomacromolecules in plants, animals, and microbes, interact with and affect the immune response, playing a crucial role in treating various human illnesses. There is an urgent need to identify natural biomolecules that can prevent infection and treat chronic diseases. This article discusses the therapeutic potential of naturally occurring polysaccharides, extraction methods, and immunological modulatory capabilities.
Review
Immunology
Daniela E. Kirwan, Deborah L. W. Chong, Jon S. Friedland
Summary: In 2019, 10 million people developed symptomatic tuberculosis (TB) disease, resulting in 1.2 million deaths. The tissue destruction in TB is mainly mediated by enzymes, particularly matrix metalloproteinases (MMPs) secreted by leukocytes and stromal cells. Platelets are implicated in TB immunopathology, with high platelet counts in TB patients correlating with disease severity and a hypercoagulable profile. Platelets likely drive TB immunopathology by influencing other immune cells, such as monocytes, leading to increased activation markers, MMP secretion, and enhanced phagocytosis. Targeted anti-platelet agents are being considered for the treatment of TB as part of host-directed therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Apple Cortez Vollmers, Sergio Covarrubias, Daisy Kuang, Aaron Shulkin, Justin Iwuagwu, Sol Katzman, Ran Song, Kasthuribai Viswanathan, Christopher Vollmers, Edward Wakeland, Susan Carpenter
Summary: Recent studies have identified a previously unknown function for the lncRNA GAPLINC, which acts as a negative regulator of inflammation in the context of innate immunity, macrophages, and LPS-induced endotoxic shock. Transcriptome analysis in human and mouse macrophages showed that GAPLINC is highly expressed following macrophage differentiation, but rapidly down-regulated upon inflammatory activation. Depletion of GAPLINC leads to enhanced expression of inflammatory genes, while overexpression suppresses this response, ultimately modulating endotoxic shock and multiorgan failure.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Pharmacology & Pharmacy
Chengyong Ma, Hanrui Liu, Shuo Yang, Hong Li, Xuelian Liao, Yan Kang
Summary: Sepsis is a life-threatening syndrome caused by abnormal host response to infection. Immune dysfunction is central to its occurrence and development. Dysfunction of B cells in sepsis is linked to immune derangement mechanisms.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Marietta M. Ravesloot-Chavez, Erik Van Dis, Sarah A. Stanley
Summary: Infection with Mycobacterium tuberculosis causes a significant number of deaths annually worldwide, where the role of innate immune cells and the inflammatory response in the infection process are crucial yet complex.Understanding the balance of cell-intrinsic control and inflammation regulation is essential for developing effective therapeutics and vaccines.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 39
(2021)
Article
Environmental Sciences
Samia Mokh, Rania Nassar, Atika Berry, Mohammad El Khatib, Samah Doumiati, Mariam Taha, Raed Ezzeddine, Mohamad Al Iskandarani
Summary: The study utilized a solid-phase extraction method combined with liquid and gas chromatography-mass spectrometry to determine 18 organic UV filters in water samples, successfully detecting 8 target compounds. The method showed good recovery rates and acceptable repeatability and reproducibility, providing data support for future evaluation of UV filter residues in Lebanese swimming pools and their impact on the ecosystem.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biology
Francesca Veronesi, Milena Fini, Lucia Martini, Paolo Berardinelli, Valentina Russo, Giuseppe Filardo, Berardo Di Matteo, Maurilio Marcacci, Elizaveta Kon
Summary: Early treatment of osteoarthritis (OA) is crucial for restoring daily and sport activities. This study compared the effects of three orthobiological treatments on OA and found that adipose-derived mesenchymal stromal cells (ADSCs) and amniotic epithelial stem cells (AECs) showed superior results in cartilage regeneration and inflammation reduction.
Article
Biochemistry & Molecular Biology
Alessia Peserico, Chiara Di Berardino, Giulia Capacchietti, ChiaraCamerano Spelta Rapini, Liliana Liverani, Aldo Roberto Boccaccini, Valentina Russo, Annunziata Mauro, Barbara Barboni
Summary: Comparing with the validated cumulus-oocyte complex (COC) protocol, a three-dimensional (3D) scaffold-mediated follicle-enclosed oocytes (FEO) system was found to optimize in vitro maturation (IVM) for ovine early antral (EA)-derived oocytes. By combining hCG stimulation with ovarian surface epithelium (OSE) cells coculture exclusively on the FEO system, the maturation rate and parthenogenetic activation of EA-derived oocytes were significantly improved. The paracrine factors released specifically from OSE enhanced the hCG-triggering of oocyte maturation mechanisms by acting through the mural compartment, stimulating the EGFR signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alessia Peserico, Barbara Barboni, Valentina Russo, Delia Nardinocchi, Maura Turriani, Costanza Cimini, Nicola Bernabo, Ornella Parolini, Antonietta Rosa Silini, Ivana Antonucci, Liborio Stuppia, Paolo Berardinelli, Ilaria Falanga, Davide Perruzza, Luca Valbonetti, Annunziata Mauro
Summary: Amniotic membrane and amniotic fluid derived cells show potential as stem cell sources for regenerative medicine in male infertility diseases. This study examined the effects of two cell sources, hAFMSCs and hAECs, on male fertility outcomes in a rat VAR model. The results demonstrated that hAECs were more effective in restoring fertility rate by enhancing both structural and immune response mechanisms, while hAFMSCs contributed to different mechanisms leading to testis homeostasis. These findings propose innovative stem-based regenerative medicine protocols for male infertility conditions such as VAR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Veterinary Sciences
Alessia Peserico, Barbara Barboni, Valentina Russo, Nicola Bernabo, Mohammad El Khatib, Giuseppe Prencipe, Adrian Cervero-Varona, Arlette Alina Haidar-Montes, Melisa Faydaver, Maria Rita Citeroni, Paolo Berardinelli, Annunziata Mauro
Summary: The study aimed to create a comparative map of molecules that control tendon development and model their signaling cascades and physiological paths using systems biology. Through computational analysis, a tendon network was constructed, revealing the central role of neuro and endocrine axes in tenogenesis. This study emphasizes the value of systems biology in integrating molecular data and guiding the direction and priority of signaling flows.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Valeria Di Lollo, Angelo Canciello, Alessia Peserico, Massimiliano Orsini, Valentina Russo, Adrian Cervero-Varona, Beatrice Dufrusine, Mohammad El Khatib, Valentina Curini, Annunziata Mauro, Paolo Berardinelli, Cathy Tournier, Massimo Ancora, Cesare Camma, Enrico Dainese, Luana Fiorella Mincarelli, Barbara Barboni
Summary: This study reveals the impact of epithelial-mesenchymal transition (EMT) on the immune properties of amniotic epithelial cells (AECs). The response to lipopolysaccharide differs between pre-EMT (eAECs) and post-EMT (mAECs), with eAECs upregulating genes involved in antigen-presenting response and mAECs over-expressing soluble inflammatory mediator transcripts. Network analysis identifies CIITA and Nrf2 as the main drivers of eAECs and mAECs immune response, respectively.
Article
Engineering, Biomedical
Adrian Cervero-Varona, Angelo Canciello, Alessia Peserico, Arlette Alina Haidar Montes, Maria Rita Citeroni, Annunziata Mauro, Valentina Russo, Samanta Moffa, Serena Pilato, Stefano Di Giacomo, Beatrice Dufrusine, Enrico Dainese, Antonella Fontana, Barbara Barboni
Summary: The use of biomaterials in immune regenerative strategies for unresolved pathologies is gaining attention in tissue engineering. Graphene oxide (GO) has been proposed as an immune-mimetic material for stem cell-based regenerative therapies, influencing stem cell behavior and immune response. Amniotic epithelial stem cells (AECs) are also of interest due to their plasticity and immunomodulatory paracrine activities, and the effects of GO on AECs are explored in this study. GO-coating induced and accelerated the Epithelial-Mesenchymal Transition (EMT) in AECs, leading to changes in cytokine secretion and enhanced activation of macrophages. Adhesion of AECs on GO-functionalized surfaces could create a tailored microenvironment for the regenerative process.
MATERIALS TODAY BIO
(2023)
