Journal
CANCERS
Volume 13, Issue 20, Pages -Publisher
MDPI
DOI: 10.3390/cancers13205235
Keywords
cancer; DARPin; gold nanorods; mice treatment; near-infrared illumination; photothermal therapy
Categories
Funding
- Russian Foundation for Basic Research [19-54-06001, 18-29-09023]
- Ministry of Science and Technology of Israel [3-16495]
- Russian Science Foundation [21-74-30016]
- Russian Science Foundation [21-74-30016] Funding Source: Russian Science Foundation
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Breast cancer is one of the main causes of cancer-related death in women globally, with high levels of HER2 associated with more aggressive clinical behavior and poor prognosis. Research shows that selective photothermal therapy using HER2-specific designed protein-conjugated nano-biomaterials can effectively target HER2-positive breast cancers.
Simple Summary Breast cancer is one of the main causes of cancer-related death in women all around the world. The disease becomes largely incurable and lethal after metastasis to distant organs. High level of HER2, a tyrosine kinase receptor, is associated with more aggressive clinical behavior and poor prognosis for breast cancer patients. In this paper, we developed a novel nano-biomaterial for selective photothermal therapy of HER2-positive breast cancers. We demonstrate that bovine serum albumin (BSA)-coated mini gold nanorods (GNRs) chemically conjugated with a HER2-specific designed ankyrin repeat protein, DARPin_9-29, selectively accumulate in HER2-positive xenograft tumors in mice and lead to a strong reduction in the tumor size when being illuminated with near-infrared light. Near-infrared phototherapy has great therapeutic potential for cancer treatment. However, for efficient application, in vivo photothermal agents should demonstrate excellent stability in blood and targeted delivery to pathological tissue. Here, we demonstrated that stable bovine serum albumin-coated gold mini nanorods conjugated to a HER2-specific designed ankyrin repeat protein, DARPin_9-29, selectively accumulate in HER2-positive xenograft tumors in mice and lead to a strong reduction in the tumor size when being illuminated with near-infrared light. The results pave the way for the development of novel DARPin-based targeted photothermal therapy of cancer.
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