A Phase Ib Study of Sotrastaurin, a PKC Inhibitor, and Alpelisib, a PI3Kα Inhibitor, in Patients with Metastatic Uveal Melanoma

Genomic Profiling of Metastatic Uveal Melanoma and Clinical Results of a Phase I Study of the Protein Kinase C Inhibitor AEB071

(2020) Sophie Piperno-Neumann et al.   MOLECULAR CANCER THERAPEUTICS

LBA73SELPAC: A 3 arm randomised phase II study of the MEK inhibitor selumetinib alone or in combination with paclitaxel (PT) in metastatic uveal melanoma (UM)

(2019) P Nathan et al.   ANNALS OF ONCOLOGY

Selumetinib in Combination With Dacarbazine in Patients With Metastatic Uveal Melanoma: A Phase III, Multicenter, Randomized Trial (SUMIT)

(2018) Richard D. Carvajal et al.   JOURNAL OF CLINICAL ONCOLOGY

A phase 2 trial of everolimus and pasireotide long-acting release in patients with metastatic uveal melanoma

(2016) Alexander N. Shoushtari et al.   MELANOMA RESEARCH

Targeting inflammasome/IL-1 pathways for cancer immunotherapy

(2016) Beichu Guo et al.   Scientific Reports

The role of IL-21 in immunity and cancer

(2015) Matthew R. Davis et al.   CANCER LETTERS

The Phosphoinositide 3-Kinase   Selective Inhibitor BYL719 Enhances the Effect of the Protein Kinase C Inhibitor AEB071 in GNAQ/GNA11-Mutant Uveal Melanoma Cells

(2014) E. Musi et al.   MOLECULAR CANCER THERAPEUTICS

Protein Kinase C Inhibitor AEB071 Targets Ocular Melanoma Harboring GNAQ Mutations via Effects on the PKC/Erk1/2 and PKC/NF- B Pathways

(2012) X. Wu et al.   MOLECULAR CANCER THERAPEUTICS

The Protein Kinase C Inhibitor Enzastaurin Exhibits Antitumor Activity against Uveal Melanoma

(2012) Xinqi Wu et al.   PLoS One

Involvement of distinct PKC gene products in T cell functions

(2012) Christa Pfeifhofer-Obermair et al.   Frontiers in Immunology

Uveal Melanoma: Trends in Incidence, Treatment, and Survival

(2011) Arun D. Singh et al.   OPHTHALMOLOGY

Mutations inGNA11in Uveal Melanoma

(2010) Catherine D. Van Raamsdonk et al.   NEW ENGLAND JOURNAL OF MEDICINE

Overview of Sotrastaurin Clinical Pharmacokinetics

(2010) John M Kovarik et al.   THERAPEUTIC DRUG MONITORING

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

(2008) Catherine D. Van Raamsdonk et al.   NATURE