Article
Oncology
Jiehui Zhong, Zezhen Liu, Chao Cai, Xiaolu Duan, Tuo Deng, Guohua Zeng
Summary: This study revealed the correlation between m(6)A modification and the tumor immune landscape in ccRCC patients. The m6Ascore was established to quantify the m(6)A modification pattern and was confirmed to be an independent prognostic factor for ccRCC. The findings provide a new approach for immunotherapeutic strategies in ccRCC patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Weiwei Deng, Zhen Su, Panpan Liang, Yubo Ma, Yufang Liu, Kai Zhang, Yi Zhang, Tianyu Liang, Jin Shao, Xiao Liu, Wenling Han, Ruoyu Li
Summary: The study revealed the expression patterns of immune checkpoints after Candida albicans infection by reanalyzing single-cell RNA-sequencing data, showing different immune pathway activities among cell subpopulations post-infection, indicating the importance of immune checkpoints in fungal infections.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Oncology
Dan Bai, Huhu Feng, Jiajun Yang, Aiping Yin, Airong Qian, Hiroshi Sugiyama
Summary: The study revealed the immune infiltrative landscape of ccRCC patients, showing that a high TII score is associated with better prognosis and increased drug sensitivity, while a low TII score is related to high expression of certain immune cells and immune checkpoint genes.
Article
Oncology
Yongfeng Wang, Ci Yin, Lele Geng, Weiyang Cai
Summary: This research investigated the immune cell invasion characteristics of clear cell renal cell carcinoma (ccRCC) and found that tumor infiltrating immune cells (TIICs) play a crucial role in tumorigenesis. Different TIICs subpopulations are associated with distinct survival patterns and have significant impacts on the prognosis and treatment of ccRCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jiwei Huang, Wen Cai, Biao Cai, Wen Kong, Wei Zhai, Jin Zhang, Yonghui Chen, Shiqing Chen, Yuezong Bai, Yiran Huang, Wei Xue
Summary: The study investigated the molecular features of Chinese ccRCC patients, revealing differences in mutation frequencies of genes like VHL and PBRM1 compared to the TCGA database. Some patients showed positive PD-L1 expression, while a small portion carried pathogenic or likely pathogenic germline mutations.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Shuchi Gulati, Chris Labaki, Georgia Sofia Karachaliou, Toni K. Choueiri, Tian Zhang
Summary: The treatment paradigm for metastatic clear cell renal cell carcinoma has changed dramatically in recent decades. Combinations of immune checkpoint inhibitors have become the first-line treatment for mccRCC. There are currently multiple first-line treatment options, and physicians need to consider various factors to determine the optimal treatment regimen.
Article
Cell Biology
Ning Wen, Jihua Wu, Haibin Li, Jixiang Liao, Liugen Lan, Xiawei Yang, Guangyi Zhu, Zhiying Lei, Jianhui Dong, Xuyong Sun
Summary: This study used single-cell RNA sequencing to investigate the cellular landscape of kidney transplant rejection. Different cell types, including immune cells, renal cells, and stromal cells, were identified, and their functions were explored. The study also found that rejection patients showed inflammatory activation and fibrosis, and oxidative stress was associated with rejection.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Virology
Tianyu Lei, Xiaohui Li, Fuhao Wang, Qingyu Huang, Tianxing Liu, Chao Liu, Qinyong Hu
Summary: Viral infections can lead to immune responses that trigger tumorigenesis and progression of cancer. To understand and target these responses, single-cell sequencing approaches have been used to analyze the tumor immune microenvironment (TIME). This review summarizes recent findings from sequencing studies on the immune infiltrate and antitumor response in virus-associated cancers, as well as the advancements in immunotherapy for these cancers. The strategic use of single-cell sequencing is expected to enhance our understanding of the TIME in viral cancers and lead to the development of more effective treatments.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Oncology
Kevin Zarrabi, Emily Walzer, Matthew Zibelman
Summary: Kidney cancer has various forms, with clear cell renal cell carcinoma being the most common type and all others categorized as non-clear cell renal cell carcinoma. Patients with non-clear cell renal cell carcinomas tend to have poorer outcomes and fewer treatment options. Recent advancements in understanding non-clear cell tumors have led to the development of more effective therapies, including immunotherapy, to improve the lives of these patients.
Article
Genetics & Heredity
Feiyang Wang, Wentong Jia, Mengjie Fan, Xuan Shao, Zhilang Li, Yongjie Liu, Yeling Ma, Yu-Xia Li, Rong Li, Qiang Tu, Yan-Ling Wang
Summary: This study compared the cellular and molecular characteristics of decidual and peripheral leukocytes in normal and unexplained recurrent miscarriage (RM) pregnancies using single-cell RNA sequencing (scRNA-seq). The results revealed significant differences in immune cell subsets and molecular properties in RM cases, providing insights into the immune pathogenesis of early pregnancy loss.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2021)
Article
Immunology
Shan Hua, Zhiwen Xie, Yongqing Zhang, Lei Wu, Fei Shi, Xingjie Wang, Shujie Xia, Shengli Dong, Juntao Jiang
Summary: By utilizing a gene signature, we can predict the immunotherapeutic response and overall survival in ccRCC patients, providing guidance for treatment selection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yan Zhang, Xianwu Chen, Qinghe Fu, Feifan Wang, Xuejian Zhou, Jiayong Xiang, Ning He, Zhenghui Hu, Xiaodong Jin
Summary: The study identified two differential levels of pyroptosis subtypes in ccRCC affecting patient prognosis and associated with histological tumor stage and grade. Immune cell infiltration patterns differed between the subtypes, with Cluster 2 showing enrichment in multiple immune-related pathways and overexpression of immune checkpoints related to ccRCC development. Additionally, key pyroptosis regulators were found to be upregulated in ccRCC and pan-cancer analysis indicated their potential role in regulating the tumor immune microenvironment in multiple cancers.
CANCER CELL INTERNATIONAL
(2021)
Article
Immunology
Yi Bai, Dapeng Chen, Chuanliang Cheng, Zhongmin Li, Hao Chi, Yuliang Zhang, Xiaoyu Zhang, Shaohai Tang, Qiang Zhao, Bing Ang, Yamin Zhang
Summary: The study examined the tumor immune microenvironment in hepatocellular carcinoma (HCC) and discovered the specific distribution of regulatory T (Treg) cells in HCC. Immune checkpoints and metabolic pathways were found to be uniquely overexpressed in Treg cells. Additionally, two subsets of NK cells with different cytotoxic capacities and a unique state of memory B cells were identified in HCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Yi Wang, Xin-De Zheng, Gui-Qi Zhu, Na Li, Chang-Wu Zhou, Chun Yang, Meng-Su Zeng
Summary: This study identified four immunometabolism subtypes of clear cell renal cell carcinoma, revealing the interplay between immune and metabolic activities and providing new insights into personalized therapy selection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Tao Guo, Hongxiang Duan, Jinbo Chen, Jinhui Liu, Belaydi Othmane, Jiao Hu, Huihuang Li, Xiongbing Zu
Summary: ZC3H13 is differentially expressed in most tumors, but shows consistent expression profiles and prognostic significance in KIRC only. It may shape a noninflamed phenotype and predict a lower response to ICB, as well as sensitivity to targeted therapy in KIRC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Yinwen Cheng, Nicholas Borcherding, Ayomide Ogunsakin, Caitlin D. Lemke-Miltner, Katherine N. Gibson-Corley, Anand Rajan, Allen B. Choi, Wattawan Wongpattaraworakul, Carlos H. F. Chan, Aliasger K. Salem, George J. Weiner, Andrean L. Simons
Summary: The study found that TLR8 expression in head and neck squamous cell carcinoma patients is associated with CD8+ T cell infiltration and better survival outcomes. The combination of VTX-2337 and cetuximab showed anti-tumor effects on tumor growth, survival and immune cell recruitment.
SCIENTIFIC REPORTS
(2021)
Article
Cell & Tissue Engineering
Vivian W. Gu, Edward Cho, Dakota T. Thompson, Victoria C. Cassady, Nicholas Borcherding, Kelsey E. Koch, Vincent T. Wu, Allison W. Lorenzen, Dana M. van der Heide, Jeffrey R. White, Mikhail V. Kulak, Trevor Williams, Weizhou Zhang, Ronald J. Weigel
Summary: The AP-2 gamma transcription factor plays a crucial role in the maintenance and differentiation of mammary stem cells, with loss of AP-2 gamma leading to altered mammary gland structures and inhibited regenerative capacity.
Article
Biology
Nicholas Borcherding, Ajaykumar Vishwakarma, Andrew P. Voigt, Andrew Bellizzi, Jacob Kaplan, Kenneth Nepple, Aliasger K. Salem, Russell W. Jenkins, Yousef Zakharia, Weizhou Zhang
Summary: The study utilized single-cell RNA sequencing to analyze the tumor immune microenvironment of ccRCC patients and found an increase in CD8(+) T cells and macrophages in tumor-infiltrated immune cells, as well as identified a proliferation subpopulation associated with the progression of ccRCC. Utilizing gene expression analysis, the study also demonstrated the ability to predict clinical outcomes and pathological diseases based on subcluster assignment.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Ryan Kolb, Umasankar De, Sajid Khan, Yuewan Luo, Myung-Chul Kim, Haijun Yu, Chaoyan Wu, Jiao Mo, Xin Zhang, Peiyi Zhang, Xuan Zhang, Nicholas Borcherding, Daniel Koppel, Yang-Xin Fu, Song Guo Zheng, Dorina Avram, Guangrong Zheng, Daohong Zhou, Weizhou Zhang
Summary: The pharmacological degradation of BCL-X-L preferentially induces apoptosis of tumor-infiltrating Tregs, promoting CD8 T cell activation and effective suppression of tumor growth without causing damage to normal tissues or thrombocytopenia. This finding suggests that targeting BCL-X-L could be a potential therapeutic strategy for cancer immunotherapy.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Nicole Merritt, Keith Garcia, Dushyandi Rajendran, Zhen-Yuan Lin, Xiaomeng Zhang, Katrina A. Mitchell, Nicholas Borcherding, Colleen Fullenkamp, Michael S. Chimenti, Anne-Claude Gingras, Kieran F. Harvey, Munir R. Tanas
Summary: Epithelioid hemangioendothelioma (EHE) is a vascular sarcoma with early metastasis and poor treatment options. Fusion proteins TAZ-CAMTA1 and YAP-TFE3, key drivers of EHE, were found to interact with the ATAC complex, modulating the transcriptome and chromatin environment. Targeting the ATAC complex may provide a potential therapeutic strategy for this sarcoma.
Editorial Material
Medical Laboratory Technology
Nicholas Borcherding, Ann M. Gronowski
CLINICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Yuki Fujiwara, Robert J. Torphy, Yi Sun, Emily N. Miller, Felix Ho, Nicholas Borcherding, Tuoqi Wu, Raul M. Torres, Weizhou Zhang, Richard D. Schulick, Yuwen Zhu
Summary: The GPR171/BigLEN axis acts as a T cell checkpoint pathway that can be utilized for cancer immunotherapy, with GPR171 serving as an inhibitor of signaling in T cells and being relevant to tumor immunity.
NATURE COMMUNICATIONS
(2021)
Review
Oncology
Chandra K. Maharjan, Jiao Mo, Lei Wang, Myung-Chul Kim, Sameul Wang, Nicholas Borcherding, Praveen Vikas, Weizhou Zhang
Summary: The oncogenic role of estrogen receptor (ER) signaling in breast cancer is well-established. Aberrant estrogen signaling enhances mammary epithelial cell proliferation, survival, and angiogenesis, contributing to breast cancer initiation and progression. Estrogen has been found to have both pro- and anti-inflammatory roles, and xenoestrogens can modulate chronic inflammation and breast cancer development. Understanding the complex relationship between estrogens, inflammation, and breast cancer will inform clinical research on prevention and therapy.
Review
Oncology
Lei Wang, Zeng Jin, Rohan P. Master, Chandra K. Maharjan, Madison E. Carelock, Tiffany B. A. Reccoppa, Myung-Chul Kim, Ryan Kolb, Weizhou Zhang
Summary: This article summarizes the important features of breast cancer stem cells, major signaling pathways, and cellular interactions within the tumor microenvironment, highlighting the significance of BCSCs in breast cancer and potential therapeutic strategies.
Article
Veterinary Sciences
Minkun Kim, Woo-Jin Song, Jongjin Park, Saeyoung Lee, Sangkyung Choen, Myung-Chul Kim, Youngmin Yun
Summary: This article reports a case of cerebral salt-wasting syndrome in a cat, describing the clinical presentation and treatment options for this syndrome.
VETERINARY SCIENCES
(2023)