Clinically aggressive pediatric spinal ependymoma with novel MYC amplification demonstrates molecular and histopathologic similarity to newly described MYCN-amplified spinal ependymomas

Targeting MYCN in Molecularly Defined Malignant Brain Tumors

(2021) Anna Borgenvik et al.   Frontiers in Oncology

The 2021 WHO Classification of Tumors of the Central Nervous System: a summary

(2021) David N Louis et al.   NEURO-ONCOLOGY

cIMPACT‐NOW update 7: advancing the molecular classification of ependymal tumors

(2020) David W. Ellison et al.   BRAIN PATHOLOGY

High level MYCN amplification and distinct methylation signature define an aggressive subtype of spinal cord ependymoma

(2020) Mark Raffeld et al.   Acta Neuropathologica Communications

Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma

(2020) Jonas Ecker et al.   NEURO-ONCOLOGY

HDACs and MYC in medulloblastoma: how do HDAC inhibitors control MYC-amplified tumors?

(2020) Tomoko Shofuda et al.   NEURO-ONCOLOGY

EPEN-54. ACNS0831, PHASE III RANDOMIZED TRIAL OF POST-RADIATION CHEMOTHERAPY IN PATIENTS WITH NEWLY DIAGNOSED EPENDYMOMA AGES 1 TO 21 YEARS

(2020) Amy Smith et al.   NEURO-ONCOLOGY

Spinal Cord Ependymomas With MYCN Amplification Show Aggressive Clinical Behavior

(2019) Amy A Swanson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

MYCN amplification drives an aggressive form of spinal ependymoma

(2019) David R. Ghasemi et al.   ACTA NEUROPATHOLOGICA

Molecular subgrouping of atypical teratoid/rhabdoid tumors—a reinvestigation and current consensus

(2019) Ben Ho et al.   NEURO-ONCOLOGY

Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia

(2019) Cornelis M. van Tilburg et al.   Clinical Epigenetics

DNA methylation-based classification of central nervous system tumours

(2018) David Capper et al.   NATURE

Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma

(2018) Sara Bolin et al.   ONCOGENE

Pediatric Spinal Ependymomas

(2018) Özden Erhan Sofuoğlu et al.   MEDICAL SCIENCE MONITOR

MYC Deregulation in Primary Human Cancers

(2017) Manpreet Kalkat et al.   Genes

Modeling and Targeting MYC Genes in Childhood Brain Tumors

(2017) Sonja Hutter et al.   Genes

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC- Driven Medulloblastoma

(2016) Yanxin Pei et al.   CANCER CELL

Small Molecule Inhibitors of Aurora-A Induce Proteasomal Degradation of N-Myc in Childhood Neuroblastoma

(2016) Markus Brockmann et al.   CANCER CELL

A Myc Activity Signature Predicts Poor Clinical Outcomes in Myc-Associated Cancers

(2016) MoonSun Jung et al.   CANCER RESEARCH

Primary spinal myxopapillary ependymoma in the pediatric population: a study from the Surveillance, Epidemiology, and End Results (SEER) database

(2016) Kelly M. Lucchesi et al.   JOURNAL OF NEURO-ONCOLOGY

Checkpoint kinase 1 expression is an adverse prognostic marker and therapeutic target in MYC-driven medulloblastoma

(2016) Eric W. Prince et al.   Oncotarget

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

(2015) Kristian W. Pajtler et al.   CANCER CELL

Combined MYC Activation and Pten Loss Are Sufficient to Create Genomic Instability and Lethal Metastatic Prostate Cancer

(2015) Gretchen K. Hubbard et al.   CANCER RESEARCH

MB-32 * FEASIBILITY OF VORINOSTAT COMBINED WITH ISOTRETINOIN AND CHEMOTHERAPY FOR YOUNG CHILDREN WITH NEWLY DIAGNOSED EMBRYONAL BRAIN TUMORS: A PEDIATRIC BRAIN TUMOR CONSORTIUM STUDY

(2015) S. Leary et al.   NEURO-ONCOLOGY

Predictors of survival in patients with spinal ependymoma

(2015) Yimo Lin et al.   NEUROLOGICAL RESEARCH

MYC, Metabolism, and Cancer

(2015) Z. E. Stine et al.   Cancer Discovery

Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma

(2015) Jonas Ecker et al.   Acta Neuropathologica Communications

BET bromodomain protein inhibition is a therapeutic option for medulloblastoma

(2015) Anton George Henssen et al.   Oncotarget

The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma

(2014) Gang Wu et al.   NATURE GENETICS

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

BET Bromodomain Inhibition of MYC-Amplified Medulloblastoma

(2013) P. Bandopadhayay et al.   CLINICAL CANCER RESEARCH

Tumor control after surgery for spinal myxopapillary ependymomas: distinct outcomes in adults versus children

(2013) William B. Feldman et al.   JOURNAL OF NEUROSURGERY-SPINE

A pediatric phase 1 trial of vorinostat and temozolomide in relapsed or refractory primary brain or spinal cord tumors: A children's oncology group phase 1 consortium study

(2013) Trent R. Hummel et al.   PEDIATRIC BLOOD & CANCER

Role of MYC in Medulloblastoma

(2013) M. F. Roussel et al.   Cold Spring Harbor Perspectives in Medicine

Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

(2012) Marcel Kool et al.   ACTA NEUROPATHOLOGICA

Spinal cord ependymomas in children and adolescents

(2012) Martin Benesch et al.   CHILDS NERVOUS SYSTEM

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

(2012) Paul A. Northcott et al.   NATURE

The Aurora Kinase Inhibitor CCT137690 Downregulates MYCN and Sensitizes MYCN-Amplified Neuroblastoma In Vivo

(2011) A. Faisal et al.   MOLECULAR CANCER THERAPEUTICS

Pediatric Phase I Trial and Pharmacokinetic Study of Vorinostat: A Children's Oncology Group Phase I Consortium Report

(2010) Maryam Fouladi et al.   JOURNAL OF CLINICAL ONCOLOGY

Ependymoma of the spinal cord in children and adolescents: a retrospective series from the HIT database

(2010) Martin Benesch et al.   Journal of Neurosurgery-Pediatrics

Surgery for Spinal Cord Ependymomas

(2010) Azize Boström et al.   NEUROSURGERY

Interactions between Cells with Distinct Mutations in c-MYC and Pten in Prostate Cancer

(2009) Jongchan Kim et al.   PLoS Genetics

Modelling Myc inhibition as a cancer therapy

(2008) Laura Soucek et al.   NATURE