Review
Geriatrics & Gerontology
Ping-an Zhu, Qi-qi Lu, Zhi-liang Li, Rong-liang Hu, Shu Xu, Lisa Brodersen, Yuan-xin Liu, Howe Liu, Xiao Bao
Summary: This meta-analysis examined the effect of Tai Chi on lower limb function in patients with Parkinson's disease. The analysis revealed that Tai Chi improves motor function, balance function, functional walking ability, and gait velocity, but does not have a significant impact on walking endurance, stride length, and cadence.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Honghui Lei, Zhen Ma, Kexin Tian, Ke Liu, Jiaying Wang, Xiangyu Zhu, Baohong Mi, Ying Chen, Qihao Yang, Huili Jiang
Summary: This study compared the effects of different types of Tai Chi on motor function improvement in Parkinson's patients, and analyzed the UPDRSIII and BBS scores. The results showed that the 24-form Tai Chi and Tai Chi exercise programs were more effective than other types of Tai Chi.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Cell Biology
Ana Beatriz Ramalho Leite Silva, Roger Wilson Goncalves de Oliveira, Guilherme Pinheiro Diogenes, Marina Feitosa de Castro Aguiar, Camilla Costa Sallem, Micael Porto Portela Lima, Luciano Barroso de Albuquerque Filho, Sara Di ogenes Peixoto de Medeiros, Lucas Lopes Penido de Mendonca, Paulo Cesar de Santiago Filho, Diogo Pasquali Nones, Pamella Mendes Martiniano da Silva Cardoso, Michelle Zonkowski Ribas, Stefani Lara Galvao, Gabriel Felipe Gomes, Amanda Reboucas Bezerra de Menezes, Nayla Lima dos Santos, Victor Monteiro Mororo, Fairane Sousa Duarte, Julio Cesar Claudino dos Santos
Summary: Parkinson's Disease (PD) is a neurodegenerative disorder that affects dopaminergic neurons in the mesencephalic substantia nigra, causing a progressive clinical course characterized by pre-motor, non-motor and motor symptoms. The study aims to discuss the clinical manifestations of PD and the correlation with the gut-brain axis, focusing on epidemiology and therapeutic perspectives for early identification of symptoms.
AGEING RESEARCH REVIEWS
(2023)
Article
Neurosciences
Xiaoyuan Li, Jintao Geng, Xiaoyu Du, Hongyu Si, Zhenlong Wang
Summary: This study demonstrates that Tai Chi practice has significant effects on the brain connectivity, positive psychological capital, and cognitive response time of college students. The Tai Chi group showed higher scores in positive psychological capital questionnaire, increased node degree in the frontal and temporal lobes, shorter response time under auditory stimulation, and higher clustering coefficient, global efficiency and local efficiency in brain network analysis.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Neurosciences
Emahnuel Troisi Lopez, Roberta Minino, Marianna Liparoti, Arianna Polverino, Antonella Romano, Rosa De Micco, Fabio Lucidi, Alessandro Tessitore, Enrico Amico, Giuseppe Sorrentino, Viktor Jirsa, Pierpaolo Sorrentino
Summary: The clinical connectome fingerprint (CCF) is a method for assessing brain dynamics and can identify individuals based on brain networks. This study examines the performance of CCF in Parkinson's disease (PD) patients and healthy controls. It finds that PD patients have reduced identifiability compared to controls, and this reduction can be used to predict motor impairment. The findings suggest that CCF captures disrupted dynamics in neurodegenerative diseases and is particularly effective in predicting motor clinical impairment in PD.
HUMAN BRAIN MAPPING
(2023)
Article
Genetics & Heredity
Guang Yang, Qun Dong, Huixin Yang, Fan Wang, Linwei Chen, Junze Tang, Guoyuan Huang, Ying Zhao
Summary: This study analyzed gene expression data and found that Tai Chi had an impact on the peripheral immune response of Parkinson's disease patients. The specific molecular mechanisms involved were identified, providing novel targets for future research.
Article
Clinical Neurology
Chunguang Chu, Shang Liu, Naying He, Zhitong Zeng, Jiang Wang, Zhen Zhang, Kristina Zeljic, Odin van der Stelt, Bomin Sun, Fuhua Yan, Chen Liu, Dianyou Li, Chencheng Zhang
Summary: Aberrant dynamic switches between internal brain states are believed to underlie motor dysfunction in Parkinson's disease. Deep brain stimulation of the subthalamic nucleus is a well-established treatment for the motor symptoms of Parkinson's disease, yet it remains poorly understood how subthalamic stimulation modulates the whole-brain intrinsic motor network state dynamics.
Article
Geriatrics & Gerontology
Lin Meng, Deyu Wang, Yu Shi, Zhuo Li, Jinghui Zhang, Hanna Lu, Xiaodong Zhu, Dong Ming
Summary: This study investigated the effects of Tai Chi-based action observation training on clinical and brain functional connectivity in early-stage Parkinson's disease patients. The results showed significant increases in FCs in the TC-AOT group, which were positively correlated with improved motor and cognitive performance in patients.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Francesco Bove, Francesco Cavallieri, Anna Castrioto, Sara Meoni, Emmanuelle Schmitt, Amelie Bichon, Eugenie Lhommee, Pierre Pelissier, Andrea Kistner, Eric Chevrier, Eric Seigneuret, Stephan Chabardes, Franco Valzania, Valerie Fraix, Elena Moro
Summary: Research on patients with Parkinson's disease (PD) shows that the side of motor symptom onset does not significantly affect the outcome of bilateral subthalamic nucleus deep brain stimulation (STN-DBS).
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Review
Integrative & Complementary Medicine
Cristina Garcia-Munoz, Paula Gonzalez-Garcia, Maria Jesus Casuso-Holgado, Javier Martinez-Calderon, Alberto Marcos Heredia-Rizo
Summary: This study aimed to synthesize evidence from systematic reviews on the effects of qigong, tai chi, and yoga in people with neurological diseases. The results showed that qigong, tai chi, and yoga can improve balance performance in people with Parkinson's disease, and tai chi practice enhances motor function and independency in stroke patients. However, the effects on health-related quality of life and quality of sleep in stroke patients are inconclusive.
COMPLEMENTARY THERAPIES IN MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Si-Chun Gu, Qing Ye, Chang-De Wang, Shao-Rong Zhao, Jie Zhou, Chen Gao, Yu Zhang, Zhen-Guo Liu, Can-Xing Yuan
Summary: Pingchan granule (PCG) has a long-lasting and extensive symptomatic efficacy for both motor and non-motor symptoms of Parkinson's disease (PD) with good tolerance.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Song Gao, Keneilwe Kenny Kaudimba, Jiaxin Cai, Yao Tong, Qianqian Tian, Peize Liu, Tiemin Liu, Peijie Chen, Ru Wang
Summary: This study aims to evaluate the effectiveness of Tai Chi training based on a mobile phone app on the balance function of persons with Parkinson's disease. The study will assess individuals with PD on balance and motor function outcomes to determine the impact of Tai Chi training on their balance ability.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Daniele Urso, Lucia Batzu, Giancarlo Logroscino, K. Ray Chaudhuri, Joana B. Pereira
Summary: This study investigated the potential of cerebrospinal fluid (CSF) and serum neurofilament light (NfL) levels as biomarkers for predicting the progression of nonmotor symptoms (NMS) in Parkinson's disease (PD) patients. The findings showed that both CSF and serum NfL levels were associated with the progression of depression and anxiety in PD patients, with serum NfL showing stronger associations with NMS.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Clinical Neurology
Renyan Ma, Yuning Hou, Yiyin Zhang, Muyang He, Song Gao, Keneilwe Kenny Kaudimba, Kaiqing Lin, Lingjing Jin, Tiemin Liu, Ru Wang
Summary: This study aims to evaluate the efficacy of Tai Chi and stretching exercises on the quality of life and disease progression of PD patients based on the smartphone application Care-PD. By integrating subject recruitment, intervention, and evaluation processes, it provides a new perspective on clinical rehabilitation for persons with PD.
FRONTIERS IN NEUROLOGY
(2021)
Review
Integrative & Complementary Medicine
Shu-zhao Zhuang, Pei-jie Chen, Jia Han, Wei-hua Xiao
Summary: This review elucidates the beneficial effects of Tai Chi in lower limb osteoarthritis from the perspective of biology, psychology, and social factors, and discusses the potential mechanisms including biomechanical, biochemical, neurological, psychological, and social aspects.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Xiaoyu Chen, Zhen Wang, Qian Lv, Qiming Lv, Guido van Wingen, Egill Axfjord Fridgeirsson, Damiaan Denys, Valerie Voon, Zheng Wang
Summary: The study identified shared downregulated cortico-subcortical and upregulated cortico-cortical network communication induced by both DBS and capsulotomy. Furthermore, increased cortico-cortical communication at ventrolateral and centrolateral prefrontal cortices induced by DBS and capsulotomy contributed to improvement of mood and anxiety symptoms, respectively. Importantly, pretreatment communication of ventrolateral and centrolateral prefrontal cortices were differentially predictive of mood and anxiety improvements by DBS and capsulotomy.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Pingchen Zhang, Pei Huang, Juanjuan Du, Yixi He, Jin Liu, Guiying He, Shishuang Cui, Weishan Zhang, Gen Li, Shengdi Chen
Summary: This study reveals gut dysbiosis in ET and provides new insight into the pathogenesis of ET and helps distinguishing ET from PD.
NPJ PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Shi-Shuang Cui, Ling-Yu Wu, Gen Li, Juan-Juan Du, Pei Huang, Jin Liu, Yun Ling, Kang Ren, Zhong-Lue Chen, Sheng-Di Chen
Summary: Genetic factors play an important role in the risk of Parkinson's disease. This study investigated genetic associations with disease progression in Chinese PD patients using 30 PD risk loci common in a longitudinal cohort. The findings suggest specific genetic polymorphisms like MAOB rs1799836, RIT2 rs12456492, PARK16 haplotype, and SNCA haplotype may have different impacts on disease progression in Chinese and non-Chinese PD patients.
PARKINSONS DISEASE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Feng-Tao Liu, Jia-Ying Lu, Xin-Yi Li, Xiao-Niu Liang, Fang-Yang Jiao, Jing-Jie Ge, Ping Wu, Gen Li, Bo Shen, Bin Wu, Yi-Min Sun, Yu-Hua Zhu, Jian-Feng Luo, Tzu-Chen Yen, Jian-Jun Wu, Chuan-Tao Zuo, Jian Wang
Summary: This study aimed to investigate the distribution patterns and regional vulnerability of tau pathology in patients with PSP using F-18-Florzolotau PET imaging, and to devise a novel image-based staging system. The findings showed that F-18-Florzolotau PET imaging can effectively capture the distribution patterns and regional vulnerability of tau pathology in PSP patients. The F-18-Florzolotau modified staging system holds promise for early tracking of tau deposition in living brains.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Letter
Clinical Neurology
Xin-Yi Li, Fang-Yang Jiao, Rui-Xin Yao, Zi-Zhao Ju, Ming-Jia Chen, Jing-Jie Ge, Gen Li, Yi-Min Sun, Ping Wu, Jian-Jun Wu, Tzu-Chen Yen, Chuantao Zuo, Jian Wang, Jia-Ying Lu, Feng-Tao Liu
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Xin-Yi Li, Ming-Jia Chen, Xiao-Niu Liang, Rui-Xin Yao, Bo Shen, Bin Wu, Gen Li, Yi-Min Sun, Jian-Jun Wu, Feng-Tao Liu, Yu-Jie Yang, Jian Wang
Summary: This study aimed to test the effectiveness of the short Parkinson's Disease Questionnaire-8 (PDQ-8) in assessing quality of life (QoL) in patients with progressive supranuclear palsy (PSP), compared to the PSP-QoL and PDQ-39. The results showed that PDQ-8 is an easy, reliable, and valid tool to evaluate QoL in PSP patients.
JOURNAL OF PARKINSONS DISEASE
(2023)
Review
Cell Biology
Wangrui Lei, Liyuan Jia, Zheng Wang, Zhenxing Liang, Zhao Aizhen, Yanqing Liu, Ye Tian, Lin Zhao, Yawu Chen, Guangyong Shi, Zhi Yang, Yang Yang, Xuezeng Xu
Summary: Fibrosis is an excessive self-repair response in the aging process of various organs. It is necessary to develop therapeutic strategies to restore tissue architecture without side effects. Chemokines play a crucial role in controlling the pathological processes involved in fibrosis, including inflammation, endothelial cell injury, and macrophage recruitment.
AGEING RESEARCH REVIEWS
(2023)
Article
Clinical Neurology
Feng-Tao Liu, Jia-Ying Lu, Xin-Yi Li, Fang-Yang Jiao, Ming-Jia Chen, Rui-Xin Yao, Xiao-Niu Liang, Zi-Zhao Ju, Jing-Jie Ge, Gen Li, Bo Shen, Ping Wu, Jiong Song, Ji Li, Yi-Min Sun, Jian-Jun Wu, Tzu-Chen Yen, Jian-Feng Luo, Qian-hua Zhao, Chuantao Zuo, Jian Wang
Summary: This study used F-18-florzolotau PET imaging technology to analyze the spatial distribution of tau pathology in the brains of patients with CBS, and found that compared to other neurodegenerative tauopathies, patients with CBS showed higher F-18-florzolotau signals in cortical and subcortical regions, and exhibited an asymmetric pattern of F-18-florzolotau uptake associated with motor severity.
MOVEMENT DISORDERS
(2023)
Article
Multidisciplinary Sciences
Tingting Bo, Jie Li, Ganlu Hu, Ge Zhang, Wei Wang, Qian Lv, Shaoling Zhao, Junjie Ma, Meng Qin, Xiaohui Yao, Meiyun Wang, Guang-Zhong Wang, Zheng Wang
Summary: Integrative analyses of transcriptomic and neuroimaging data in cynomolgus macaques reveal the link between brain-wide gene expression and regional variation in morphometry, providing a unique resource to study nonhuman primate models of human diseases and explore cross-species evolutionary mechanisms.
NATURE COMMUNICATIONS
(2023)
Review
Neurosciences
Qian Lv, Kristina Zeljic, Shaoling Zhao, Jiangtao Zhang, Jianmin Zhang, Zheng Wang
Summary: Machine learning approaches are applied to neuroimaging data for diagnosis and prognosis in psychiatric disorders. This review discusses recent practices in evaluating these applications for obsessive-compulsive and related disorders, and proposes a novel strategy of building machine learning models based on core brain regions for better performance, interpretability, and generalizability. The identification of core regions from the entire brain is demonstrated using hypothesis-driven and data-driven approaches. This strategy offers a roadmap for accelerating the discovery of neuroimaging-based markers in psychiatric disorders.
NEUROSCIENCE BULLETIN
(2023)
Article
Cell Biology
Wenhua Liu, Hao Xie, Xian Liu, Shoujing Xu, Shanshan Cheng, Zheng Wang, Ting Xie, Zi Chao Zhang, Junhai Han
Summary: The balance between cell proliferation and differentiation is crucial for brain development. This study reveals that the alternative splicing regulator PQBP1 plays a role in regulating striatal progenitor proliferation and differentiation. Deletion of PQBP1 leads to defective striatal development and impaired neurogenesis. These findings provide new insights into the post-transcriptional regulation of cell proliferation and differentiation.
Article
Cell Biology
Wei Wang, Tingting Bo, Ge Zhang, Jie Li, Junjie Ma, Liangxiao Ma, Ganlu Hu, Huige Tong, Qian Lv, Daniel J. Araujo, Dong Luo, Yuejun Chen, Meiyun Wang, Zheng Wang, Guang-Zhong Wang
Summary: By integrating transcriptomes from 757 cortical regions in macaques with resting-state brain activity, it is revealed that noncoding genes can explain variations in resting-state activity at a comparable level with protein-coding genes. These noncoding genes are found to be connected to the function of nonneuronal cells and have links with autism and schizophrenia risk genes. Additionally, genes associated with resting-state noncoding genes show enrichment in human resting-state functional genes and memory-effect genes, and their links with resting-state functional magnetic resonance imaging (fMRI) signals are altered in the brains of autistic patients.
Article
Clinical Neurology
Gen Li, Pei Huang, Shishuang Cui, Yachao He, Yuyan Tan, Shengdi Chen
Summary: Long-term Tai Chi training in patients with Parkinson's disease showed maintenance of improvement in motor and non-motor symptoms, reducing the need for increasing antiparkinsonian therapies. The annual increase in levodopa equivalent daily dosage was significantly lower in the Tai Chi group, indicating the benefits of Tai Chi training on PD symptoms and complications.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Pingchen Zhang, Pei Huang, Yuanyuan Li, Juanjuan Du, Ningdi Luo, Yixi He, Jin Liu, Guiying He, Shishuang Cui, Weishan Zhang, Gen Li, Xin Shen, Liu Jun, Shengdi Chen
Summary: Rapid eye movement sleep behavior disorder (RBD) has a close relationship with Parkinson's disease (PD) and might have similar gut microbial changes. This study aims to investigate consistent changes between RBD and PD in gut microbiota, and find potential biomarkers indicating phenoconversion of RBD to PD.
Article
Neurosciences
Qian Lv, Miao Zhang, Haifeng Jiang, Yilin Liu, Shaoling Zhao, Xiaomin Xu, Wenlei Zhang, Tianzhen Chen, Hang Su, Jiangtao Zhang, Heqiu Wang, Jianmin Zhang, Yuanjing Feng, Yongqiang Li, Biao Li, Min Zhao, Zheng Wang
Summary: Elevated impulsivity is commonly observed in individuals receiving methadone maintenance therapy (MMT) for opioid addiction. This study aimed to understand the underlying neural mechanisms and cognitive subprocesses associated with this impulsivity. The results showed that individuals receiving MMT exhibited higher self-reported impulsivity and had a tendency for impulsive decision-making without available evidence. The impulsive decision bias was associated with the dose and duration of methadone use, rather than the duration of heroin use. Furthermore, the hypoactivation in the left rostral middle frontal gyrus during a decision-making task was correlated with the impulsive decision bias. The findings suggest that elevated impulsivity in individuals receiving MMT is driven by deficits in top-down cognitive control, rather than reward sensitivity.