A BRD4 PROTAC nanodrug for glioma therapy via the intervention of tumor cells proliferation, apoptosis and M2 macrophages polarization

The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors

(2021) Mukaddes Izci et al.   CHEMICAL REVIEWS

Evolution of blood–brain barrier in brain diseases and related systemic nanoscale brain-targeting drug delivery strategies

(2021) Liang Han et al.   Acta Pharmaceutica Sinica B

Brd4 regulates NLRC4 inflammasome activation by facilitating IRF8-mediated transcription of Naips

(2021) Xingchen Dong et al.   JOURNAL OF CELL BIOLOGY

Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion

(2021) Ester Gangoso et al.   CELL

KDM6A-ARHGDIB axis blocks metastasis of bladder cancer by inhibiting Rac1

(2021) Lei Liu et al.   Molecular Cancer

One-step and facile synthesis of peptide-like poly(melphalan) nanodrug for cancer therapy

(2021) Xinyu Zhang et al.   Nano Today

Conformable hierarchically engineered polymeric micromeshes enabling combinatorial therapies in brain tumours

(2021) Daniele Di Mascolo et al.   Nature Nanotechnology

Overcoming Mfsd2a‐Mediated Low Transcytosis to Boost Nanoparticle Delivery to Brain for Chemotherapy of Brain Metastases

(2021) Xiufeng Ju et al.   Advanced Healthcare Materials

Rebirth of Aspirin Synthesis By‐Product: Prickly Poly(salicylic acid) Nanoparticles as Self‐Anticancer Drug Carrier

(2021) Xinru You et al.   ADVANCED FUNCTIONAL MATERIALS

Integrin α2β1-targeting ferritin nanocarrier traverses the blood–brain barrier for effective glioma chemotherapy

(2021) Chiun-Wei Huang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

(2020) George M. Burslem et al.   CELL

BRD4 levels determine the response of human lung cancer cells to BET degraders that potently induce apoptosis through suppression of Mcl-1

(2020) Dan Zong et al.   CANCER RESEARCH

Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells

(2020) Ping-Pui Wong et al.   CELL

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer

(2020) Shaokun Shu et al.   MOLECULAR CELL

BRD4 as a therapeutic target for nonfunctioning and growth hormone pituitary adenoma

(2020) Chengzhang Shi et al.   NEURO-ONCOLOGY

Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction

(2020) Mingzhu Yin et al.   Nature Communications

Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers

(2020) Jun Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

Management of glioblastoma: State of the art and future directions

(2020) Aaron C. Tan et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Comprehensive Genomic Analysis in NRG Oncology/RTOG 9802: A Phase III Trial of Radiation Versus Radiation Plus Procarbazine, Lomustine (CCNU), and Vincristine in High-Risk Low-Grade Glioma

(2020) Erica H. Bell et al.   JOURNAL OF CLINICAL ONCOLOGY

Linc00514 promotes breast cancer metastasis and M2 polarization of tumor-associated macrophages via Jagged1-mediated notch signaling pathway

(2020) Sifeng Tao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Nanoformulation of BRD4-Degrading PROTAC: Improving Druggability To Target the ‘Undruggable’ MYC in Pancreatic Cancer

(2020) Tamara Minko   TRENDS IN PHARMACOLOGICAL SCIENCES

Escape from abluminal LRP1-mediated clearance for boosted nanoparticle brain delivery and brain metastasis treatment

(2020) Naveed Ullah Khan et al.   Acta Pharmaceutica Sinica B

BRD4 regulates self‐renewal ability and tumorigenicity of glioma‐initiating cells by enrichment in the Notch1 promoter region

(2020) Zhennan Tao et al.   Clinical and Translational Medicine

Temperature-triggered micellization of interferon alpha-diblock copolypeptide conjugate with enhanced stability and pharmacology

(2020) Zhuoran Wang et al.   JOURNAL OF CONTROLLED RELEASE

BRD4 directs hematopoietic stem cell development and modulates macrophage inflammatory responses

(2019) Anup Dey et al.   EMBO JOURNAL

Inhibition of BRD4 suppresses the malignancy of breast cancer cells via regulation of Snail

(2019) Linlin Lu et al.   CELL DEATH AND DIFFERENTIATION

BETP degradation simultaneously targets acute myelogenous leukemic stem cells and the microenvironment

(2019) Sujan Piya et al.   JOURNAL OF CLINICAL INVESTIGATION

Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma

(2019) Peiwen Chen et al.   CANCER CELL

Targetable genetic alterations of TCF4 (E2-2) drive immunoglobulin expression in diffuse large B cell lymphoma

(2019) Neeraj Jain et al.   Science Translational Medicine

Activity of BET-proteolysis targeting chimeric (PROTAC) compounds in triple negative breast cancer

(2019) María del Mar Noblejas-López et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Degradation of proteins by PROTACs and other strategies

(2019) Yang Wang et al.   Acta Pharmaceutica Sinica B

A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity

(2019) Sajid Khan et al.   NATURE MEDICINE

Co‐targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor‐resistant melanoma

(2018) Ileabett M Echevarría‐Vargas et al.   EMBO Molecular Medicine

Protein targeting chimeric molecules specific for bromodomain and extra-terminal motif family proteins are active against pre-clinical models of multiple myeloma

(2018) Xiaohui Zhang et al.   LEUKEMIA

Substance P-modified human serum albumin nanoparticles loaded with paclitaxel for targeted therapy of glioma

(2018) Chunhui Ruan et al.   Acta Pharmaceutica Sinica B

Safety and efficacy of targeted alpha therapy with 213Bi-DOTA-substance P in recurrent glioblastoma

(2018) Leszek Królicki et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Targeting nuclear β-catenin as therapy for post-myeloproliferative neoplasm secondary AML

(2018) Dyana T. Saenz et al.   LEUKEMIA

BRD4 and Cancer: going beyond transcriptional regulation

(2018) Benedetta Donati et al.   Molecular Cancer

Novel BET protein proteolysis-targeting chimera exerts superior lethal activity than bromodomain inhibitor (BETi) against post-myeloproliferative neoplasm secondary (s) AML cells

(2017) D T Saenz et al.   LEUKEMIA

BET protein proteolysis targeting chimera (PROTAC) exerts potent lethal activity against mantle cell lymphoma cells

(2017) B Sun et al.   LEUKEMIA

Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation

(2017) Ka Lung Cheung et al.   MOLECULAR CELL

Glioma Dual-Targeting Nanohybrid Protein Toxin Constructed by Intein-Mediated Site-Specific Ligation for Multistage Booster Delivery

(2017) Yingzhi Chen et al.   Theranostics

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

(2016) Jung Soo Suk et al.   ADVANCED DRUG DELIVERY REVIEWS

The transcriptional regulator network of human inflammatory macrophages is defined by open chromatin

(2016) Susanne V Schmidt et al.   CELL RESEARCH

Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation

(2016) Stanley Ching-Cheng Huang et al.   IMMUNITY

The role of microglia and macrophages in glioma maintenance and progression

(2016) Dolores Hambardzumyan et al.   NATURE NEUROSCIENCE

PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer

(2016) Kanak Raina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression

(2016) Hengrui Zhu et al.   Cell Reports

Bromodomain inhibitor OTX015 in patients with lymphoma or multiple myeloma: a dose-escalation, open-label, pharmacokinetic, phase 1 study

(2016) Sandy Amorim et al.   Lancet Haematology

Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells

(2015) David L. Schonberg et al.   CANCER CELL

Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4

(2015) Jing Lu et al.   CHEMISTRY & BIOLOGY

Overcoming the blood–brain tumor barrier for effective glioblastoma treatment

(2015) O. van Tellingen et al.   DRUG RESISTANCE UPDATES

Glioblastoma multiforme: Pathogenesis and treatment

(2015) Constantinos Alifieris et al.   PHARMACOLOGY & THERAPEUTICS

A neurocentric perspective on glioma invasion

(2014) Vishnu Anand Cuddapah et al.   NATURE REVIEWS NEUROSCIENCE

Remodeling of the Enhancer Landscape during Macrophage Activation Is Coupled to Enhancer Transcription

(2013) Minna U. Kaikkonen et al.   MOLECULAR CELL

Differentiation and gene expression profile of tumor-associated macrophages

(2012) Astrid Schmieder et al.   SEMINARS IN CANCER BIOLOGY