SynergyFinder Plus: Toward Better Interpretation and Annotation of Drug Combination Screening Datasets

The Aurora kinase/β-catenin axis contributes to dexamethasone resistance in leukemia

(2021) Kinjal Shah et al.   npj Precision Oncology

An Evidence‐Based Framework for Evaluating Pharmacogenomics Knowledge for Personalized Medicine

(2021) Michelle Whirl‐Carrillo et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

DrugComb update: a more comprehensive drug sensitivity data repository and analysis portal

(2021) Shuyu Zheng et al.   NUCLEIC ACIDS RESEARCH

Charting the Fragmented Landscape of Drug Synergy

(2020) Christian T. Meyer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Resisting antimicrobial resistance

(2020) Carl Nathan   NATURE REVIEWS MICROBIOLOGY

SynergyFinder 2.0: visual analytics of multi-drug combination synergies

(2020) Aleksandr Ianevski et al.   NUCLEIC ACIDS RESEARCH

Rational Cancer Treatment Combinations: An Urgent Clinical Need

(2020) Julia Boshuizen et al.   MOLECULAR CELL

Guided screen for synergistic three-drug combinations

(2020) Melike Cokol-Cakmak et al.   PLoS One

Multiple low dose therapy as an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours

(2020) João M. Fernandes Neto et al.   Nature Communications

Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers

(2020) Irem Ozkan-Dagliyan et al.   Cell Reports

Machine learning approaches to drug response prediction: challenges and recent progress

(2020) George Adam et al.   npj Precision Oncology

synergy - A Python library for calculating, analyzing, and visualizing drug combination synergy

(2020) David J Wooten et al.   BIOINFORMATICS

Anticancer drug synergy prediction in understudied tissues using transfer learning

(2020) Yejin Kim et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

Representation of features as images with neighborhood dependencies for compatibility with convolutional neural networks

(2020) Omid Bazgir et al.   Nature Communications

Binimetinib, Encorafenib, and Cetuximab Triplet Therapy for Patients With BRAF V600E–Mutant Metastatic Colorectal Cancer: Safety Lead-In Results From the Phase III BEACON Colorectal Cancer Study

(2019) Eric Van Cutsem et al.   JOURNAL OF CLINICAL ONCOLOGY

DrugComb: an integrative cancer drug combination data portal

(2019) Bulat Zagidullin et al.   NUCLEIC ACIDS RESEARCH

Drug combination sensitivity scoring facilitates the discovery of synergistic and efficacious drug combinations in cancer

(2019) Alina Malyutina et al.   PLoS Computational Biology

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

(2019) Michael P. Menden et al.   Nature Communications

Applying synergy metrics to combination screening data: agreements, disagreements and pitfalls

(2019) Anna H.C. Vlot et al.   DRUG DISCOVERY TODAY

Low-dose triple drug combination targeting the PI3K/AKT/mTOR pathway and the MAPK pathway is an effective approach in ovarian clear cell carcinoma

(2019) Joseph J. Caumanns et al.   CANCER LETTERS

A view on drug resistance in cancer

(2019) Neil Vasan et al.   NATURE

ChEMBL: towards direct deposition of bioassay data

(2018) David Mendez et al.   NUCLEIC ACIDS RESEARCH

DrugBank 5.0: a major update to the DrugBank database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Combenefit: an interactive platform for the analysis and visualization of drug combinations

(2016) Giovanni Y. Di Veroli et al.   BIOINFORMATICS

An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies

(2016) Jennifer O'Neil et al.   MOLECULAR CANCER THERAPEUTICS

BRAID: A Unifying Paradigm for the Analysis of Combined Drug Action

(2016) Nathaniel R. Twarog et al.   Scientific Reports

ZINC 15 – Ligand Discovery for Everyone

(2015) Teague Sterling et al.   Journal of Chemical Information and Modeling

ChEBI in 2016: Improved services and an expanding collection of metabolites

(2015) Janna Hastings et al.   NUCLEIC ACIDS RESEARCH

BindingDB in 2015: A public database for medicinal chemistry, computational chemistry and systems pharmacology

(2015) Michael K. Gilson et al.   NUCLEIC ACIDS RESEARCH

What is synergy? The Saariselkä agreement revisited

(2015) Jing Tang et al.   Frontiers in Pharmacology

Searching for Drug Synergy in Complex Dose–Response Landscapes Using an Interaction Potency Model

(2015) Bhagwan Yadav et al.   Computational and Structural Biotechnology Journal

Mechanism-independent method for predicting response to multidrug combinations in bacteria

(2012) Kevin Wood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How to obtain the P value from a confidence interval

(2011) D. G. Altman et al.   BMJ-British Medical Journal

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH