Article
Chemistry, Analytical
Yuning Wang, Kun Zhang, Xuedong Huang, Liang Qiao, Baohong Liu
Summary: This study proposes an ultrasensitive method for quantitatively profiling protein biomarkers on the surface of exosomes, which can be used for cancer subtype diagnosis. The strategy shows potential prospects in biomarker discovery, cellular phenotype characterization, and cancer diagnosis due to its advantages in sensitivity, accuracy, and simplicity.
ANALYTICAL CHEMISTRY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Michaela Plaikner, Lukas Lanser, Christian Kremser, Guenter Weiss, Benjamin Henninger
Summary: The study compares the measurement of splenic and pancreatic iron content using a commercial 3D-Dixon sequence (qDixon) and an established fat-saturated R2* relaxometry method (ME-GRE). The results show good concordance between the two methods, with the qDixon sequence proving to be a reliable tool for non-invasive evaluation of iron content in the spleen and pancreas.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vincenzo Positano, Antonella Meloni, Maria Filomena Santarelli, Laura Pistoia, Anna Spasiano, Liana Cuccia, Tommaso Casini, Maria Rita Gamberini, Massimo Allo, Pier Paolo Bitti, Alessia Pepe, Filippo Cademartiri
Summary: This study developed a deep-learning method for unsupervised classification of liver iron content (LIC) from TEE multiecho MR images. The results showed that the HippoNet-Ensemble network achieved higher accuracy, sensitivity, and specificity in LIC staging compared to other networks.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Biochemistry & Molecular Biology
Darrell H. G. Crawford, Diana G. F. Ross, Lesley-Anne Jaskowski, Leslie J. Burke, Laurence J. Britton, Nick Musgrave, David Briskey, Gautam Rishi, Kim R. Bridle, Nathan Subramaniam
Summary: Results from experiments on Hfe(-/-) mice indicate that reducing iron intake can alleviate the development of steatosis caused by a high-calorie diet, suggesting that modulation of iron balance could be a potential approach for treating NAFLD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Chemistry, Analytical
Wenling Gu, Xiaosi Wang, Mengzhen Xi, Xiaoqian Wei, Lei Jiao, Ying Qin, Jiajia Huang, Xiaowen Cui, Lirong Zheng, Liuyong Hu, Chengzhou Zhu
Summary: In this study, iron single-atom catalysts were used as efficient co-reaction accelerators to achieve strong cathodic electrochemiluminescence at an ultralow potential. The catalysts activate H2O2 to produce reactive oxygen species, which directly react with a luminol to generate intense emission.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Estela Climent, Knut Rurack
Summary: The research developed a simple and generic method that combines ECL and gAID technologies to rapidly detect ultra-trace levels of penicillin in milk using modified nanomaterials, with higher sensitivity, measurement uncertainty, and robustness compared to traditional fluorescence or electrochemical detection methods.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Engineering, Electrical & Electronic
Lijie Wu, Kai Lou, Junchen Ke, Jingcheng Liang, Zhangjie Luo, Jun Yan Dai, Qiang Cheng, Tie Jun Cui
Summary: In this paper, a C-band amplifying reconfigurable intelligent surface (ARIS) integrated with a power amplifier (PA) is presented to enhance reflected electromagnetic signals. An aperture-coupled patch element with two orthogonal hourglass-shaped slots is elaborately constructed to ensure a broad operation bandwidth. A power combining and dividing network is also introduced to reduce the number of PAs and system cost. Simulation results show that the achieved gain of the ARIS is 7.7-12.2 dB from 5.0 to 6.0 GHz. A prototype of the proposed ARIS is designed, fabricated, and experimentally verified, with measured results agreeing well with the simulation. The proposed ARIS shows promise for applications in future wireless communication systems for signal enhancement and coverage extension.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2022)
Article
Chemistry, Analytical
Yi Ma, Xueping Ma, Li Bu, Jingwen Shan, Danni Liu, Likun Zhang, Xiemin Qi, Yanan Chu, Haiping Wu, Bingjie Zou, Guohua Zhou
Summary: A multiplex and versatile lateral flow strip (LFS) based on flap endonuclease 1 (FEN1)-induced steric hindrance change (FISH-LFS) is proposed in this study. The method shows great potential for multiplex detection with efficient capture and accurate identification.
ANALYTICAL CHEMISTRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Michaela Plaikner, Christian Kremser, Heinz Zoller, Stephan Kannengiesser, Benjamin Henninger
Summary: The study compared liver stiffness (LS) between gradient-recalled echo magnetic resonance elastography (GRE-MRE) and different spin-echo echo-planar imaging (SE-EPI-MRE) sequences, finding good agreement between GRE-MRE and SE-EPI-MRE LS values. However, GRE-MRE had a significantly lower number of successful exams, mainly due to high iron content.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Chemistry, Analytical
Frowin Ellermann, Philip Saul, Jan-Bernd Hoevener, Andrey N. Pravdivtsev
Summary: Benchtop NMR (btNMR) spectrometers have revolutionized NMR usage and significantly reduced costs. However, magnetic field cycling (MFC) experiments with precise timing and control over the magnetic field have not been available on btNMRs. This study presents a setup that enables MFC on btNMRs for chemical analysis and hyperpolarization, utilizing modern manufacturing techniques.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Xinghui Zhou, Chengpeng Li, Wanxue Wang, Feng Zhang, Yi Zhou, Danping Chen, Zhenchao Wang
Summary: In this study, a cost-effective and easy-to-operate fluorescence strategy for m6A analysis was developed. The strategy can be easily performed on the ordinary heating apparatus of accessible laboratory, avoiding complex chemical labeling and expensive proteins. It showed satisfactory results in the analysis of m6A in hepatocellular carcinoma-related mRNA.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Zizhong Yang, Birong Liu, Ting Huang, Bao-Ping Xie, Wen-Jun Duan, Min-Min Li, Jin-Xiang Chen, Jun Chen, Zong Dai
Summary: This study presents a Hairpins@MnO2 nanosystem for intracellular enzyme-free exponential amplification for miRNA imaging. The method combines hybridization chain reaction (HCR) and DNAzymes for efficient miRNA detection. The introduced nanosystem allows for a highly sensitive and specific detection of miRNA expression in living cells, with a detection limit 2.4 x 10(4) times lower than traditional HCR system.
ANALYTICAL CHEMISTRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ana Jimenez-Pastor, Angel Alberich-Bayarri, Rafael Lopez-Gonzalez, David Marti-Aguado, Manuela Franca, Rodrigo San Martin Bachmann, Juan Mazzucco, Luis Marti-Bonmati
Summary: The study successfully demonstrated the accurate segmentation of liver parenchyma using CNN, with excellent performance and high correlation in both internal and external validation datasets, showcasing reproducible results with relative errors below 4% for PDFF and 1% for R2*.
EUROPEAN RADIOLOGY
(2021)
Article
Chemistry, Analytical
Zizhong Yang, Birong Liu, Ting Huang, Bao-Ping Xie, Wen-Jun Duan, Min-Min Li, Jin-Xiang Chen, Jun Chen, Zong Dai
Summary: The Hairpins@MnO2 nanosystem enables enzyme-free exponential amplification for miRNA imaging in living cells, offering high sensitivity and specificity. The method combines HCR and DNAzymes for efficient amplification, with a detection limit much lower than traditional HCR systems. It allows accurate differentiation of miRNA expression in cancer cells and normal cells, showing great potential in nucleic acid biological research.
ANALYTICAL CHEMISTRY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Antonella Meloni, Vincenzo Positano, Laura Pistoia, Filippo Cademartiri
Summary: This article serves as a practical guide for radiologists interested in quantifying pancreatic iron overload using MRI. It provides a brief background on iron-deposition diseases and discusses the basic principles, advantages, disadvantages, and key technical aspects of the commonly used MRI-based techniques for pancreatic iron assessment.
ABDOMINAL RADIOLOGY
(2022)
Article
Environmental Sciences
Xiaohong Chen, Wenyang Deng, Luwei Miao, Ming Gao, Tianqi Ao, Wenqing Chen, Tetsuro Ueyama, Qizhou Dai
Summary: In this study, carbon electrode materials were modified to improve sulfate selectivity in capacitive deionization (CDI), resulting in increased adsorption capacity. The surface of the modified carbon material also displayed improved electrochemical properties and better capacitance. These findings suggest the potential for selective sulfate adsorption in practical applications.
ENVIRONMENTAL TECHNOLOGY
(2023)
Article
Engineering, Civil
Xiaohong Chen, Tianhao Li, Quan Yuan
Summary: This paper examines the travel behaviors and preferences of Generation Z using the latest data. The results indicate that Generation Z tends to choose environmentally friendly mode of transportation in response to changes in the built environment, showing their potential to support sustainable transportation.
Article
Chemistry, Physical
Jidong Chu, Zhijin Ge, Jiahui Peng, Hui Hu, Shujuan Guo, Xiaohui Chen
Summary: The study proposes a novel method, refluxing and implanting titanium, for synthesizing high catalytic performance MWW zeolite. By conducting titanium implantation under mild conditions, the preparation time is reduced. This method also explains the formation mechanism of the zeolite structure through density functional theory and achieves larger pore structure and improved catalytic performance through modified treatment.
Article
Cell Biology
Daji Guo, Xiaoman Yang, Ming Gao, Xiaoqing Chen, Yanping Tang, Lingling Shen, Keshen Li, Lei Shi
Summary: This study found that ASD-like behaviors persist into late-middle age in Dock4 KO mice, with specific alterations in spatial memory and hippocampal anatomy by age.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Xuexian Fang, Hossein Ardehali, Junxia Min, Fudi Wang
Summary: Iron homeostasis is crucial for proper cardiac function, and iron imbalance is a common factor in various cardiovascular diseases. Ferroptosis, an iron-dependent regulated cell death, has been increasingly recognized as an important process underlying the pathogenesis and progression of cardiovascular diseases. Understanding the mechanisms of iron metabolism and ferroptosis regulation in cardiomyocytes may lead to improvements in disease management.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Food Science & Technology
Xiaohong Yu, Bingye Gong, Mengyue Li, Wei Li, Xiaodong Chen
Summary: Wheat bran extracts (WBE), consisting primarily of feruloyl oligosaccharides (FOs), have been approved by the FDA for use in microcapsules made with octenyl succinate anhydride-modified starch (OSA-starch) as a protective wall material for beta-carotene (BC) against oxidation. The retention and antioxidant properties of the microcapsules were studied in vivo and in vitro, and it was found that these characteristics were dependent on the amount of WBE in the wall material. In mouse serum and liver, the in vivo antioxidant properties were regulated positively at a dosage similar to that found in wheat grain, but became imbalanced at higher dosages. These findings demonstrate that WBE is a beneficial component for improving the antioxidant environment during storage and consumption, providing a theoretical basis for its industrial application in microcapsules.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Surgery
Yao Liu, Nan Xia, Yuhe Duan, Xiongwei Wu, Chunyang Zhao, Chen Jin, Xue Chen, Qiang Gao, Yingming Wang, Feifei Wang, Fengjiao Wang, Yongjian Chen, Qian Dong, Xiwei Hao
Summary: This study investigated the clinical application of Computer-assisted Surgery system (CAS) in pediatric mediastinal tumor resection. The results showed that the CAS-assisted group had shorter operative duration, less intraoperative blood loss, shorter postoperative drain indwelling time, and shorter duration of hospitalization compared to the control group. However, there was no significant difference in the rate of blood transfusion and the incidence of postoperative complications between the two groups.
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
(2023)
Article
Plant Sciences
Yongliang Hu, Yuqin Chen, Xiaoxia Su, Jiawei Huang, Hongxing Yin, Jie Zhang, Zhongkai Zhang, Yong Ding, Kuanyu Zheng
Summary: The present study characterized two potyviruses, wild tomato mosaic virus Dehong isolate (WTMV-Dh) and chilli veinal mottle virus Dehong isolate (ChiVMV-Dh), and assessed their mix-infection on chilli pepper. The complete genome sequences of both viruses were obtained using transcriptome next-generation sequencing technology and RT-PCR. Phylogenetic analysis revealed the relationship between these Dehong isolates and previously reported isolates of the same viruses. Mix-inoculation of these two viruses resulted in more severe symptoms compared to single-infection.
JOURNAL OF PHYTOPATHOLOGY
(2023)
Article
Cell Biology
Qian Wu, Euclides Sacomboio, Lara Valente de Souza, Rui Martins, Jamil Kitoko, Silvia Cardoso, Temitope W. Ademolue, Tiago Paixao, Jaakko Lehtimaki, Ana Figueiredo, Caren Norden, Pierre-Louis Tharaux, Guenter Weiss, Fudi Wang, Susana Ramos, Miguel P. Soares
Summary: Iron recycling is important in preventing anemia, and its role in preventing anemia during infection is unclear. In severe Plasmodium falciparum malaria, acute kidney injury (AKI) is associated with life-threatening anemia. A study using a rodent model shows that renal proximal tubule epithelial cells (RPTECs) have the ability to store and recycle iron during P. chabaudi chabaudi (Pcc) infection, preventing the onset of life-threatening malarial anemia.
Article
Multidisciplinary Sciences
Na Li, Bowen Wu, Jifeng Wang, Yumeng Yan, Peng An, Yuezhen Li, Yuning Liu, Yanfei Hou, Xiaoqing Qing, Lili Niu, Xiang Ding, Zhensheng Xie, Mengmeng Zhang, Xiaojing Guo, Xiulan Chen, Tanxi Cai, Jianming Luo, Fudi Wang, Fuquan Yang
Summary: New diagnostic strategies are needed to determine the subtypes of beta-thalassemia and facilitate personalized therapeutic regimens. This study explored the characteristics and potential biomarkers of beta-thalassemia subtypes using quantitative proteomics of plasma-derived extracellular vesicles. The findings showed that the proteomic patterns of extracellular vesicles were consistent with, but more distinct than, those of plasma, and they had superior discriminatory ability for beta-thalassemia subtypes.
Article
Computer Science, Artificial Intelligence
Liuqing Yang, Shoudong Wang, Xiaohong Chen, Wei Chen, Omar M. Saad, Xu Zhou, Nam Pham, Zhicheng Geng, Sergey Fomel, Yangkang Chen
Summary: This article proposes a deep learning model combining convolutional and recurrent networks for predicting reservoir permeability and porosity. By training a combination of nonlinear and linear modules, the mapping between logging data and reservoir parameters is established. Optimization algorithms and a self-attention mechanism are used to improve prediction accuracy. Testing on blind wells from different regions demonstrates the accuracy and robustness of the proposed method.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)
Review
Biochemistry & Molecular Biology
Jie Fu, Xin Zong, Mingliang Jin, Junxia Min, Fudi Wang, Yizhen Wang
Summary: As cationic host defense peptides, defensins are synthesized by various cells and serve as crucial components of host defense. Recent research has focused on their biological functions, structure-activity relationships, mechanisms of action, and therapeutic potential. This review provides an overview of the roles of defensins in immune homeostasis, mucosal barrier function, gut microbiota regulation, and various diseases, as well as their regulation by nutrients. It offers important insights into the biology and potential clinical applications of defensins.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Review
Urology & Nephrology
Xihao Cheng, Chao Yu, Xinquan Yang, Fudi Wang, Junxia Min
Summary: A review of the latest progress in the field of ferroptosis in cardiovascular disease (CVD) reveals that ferroptosis plays a pathogenic role in various forms of CVD, and targeting ferroptosis through modulation of iron metabolism, lipid metabolism, and oxidative metabolism represents a promising approach for the prevention and treatment of CVD.
Review
Cell & Tissue Engineering
Qin Ru, Yusheng Li, Wenqing Xie, Yilan Ding, Lin Chen, Guodong Xu, Yuxiang Wu, Fudi Wang
Summary: Ferroptosis, a unique form of cell death driven by iron accumulation and lipid peroxidation, is closely associated with iron metabolism, polyunsaturated fatty acid metabolism, and antioxidant pathways. Recent research has revealed a potential link between ferroptosis and age-related orthopedic diseases, such as osteoporosis and osteoarthritis. Understanding the regulatory mechanisms of ferroptosis in these diseases could lead to improved treatment and prevention strategies.
Article
Gastroenterology & Hepatology
Qiuyuan Yang, Yue Wu, Wei Liu, Xiaojuan Ou, Wei Zhang, Jianning Wang, Yanzhong Chang, Fudi Wang, Ming Gao, Sijin Liu
Summary: Our study explores the role of iron in liver lipid metabolism and finds that iron overload can disrupt the normal distribution of lipids within the liver, particularly in the periportal zone. Through gene expression analysis in both the pericentral and periportal zones, we identify pyruvate carboxylase (PC) as a key regulator in iron overload-induced lipid accumulation. We also reveal that the activation of cyclic adenosine monophosphate response element binding protein (CREB) is essential for Pc gene expression in response to iron overload.
LIVER INTERNATIONAL
(2023)
