Journal
SCIENCE ADVANCES
Volume 8, Issue 3, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abm2469
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Funding
- NSF [DMR 1921835, DMR 1921858, DMR 2004048, CHE-0130903, CHE-1039870, CHE-1726525]
- Russian Science Foundation RSCF grant [20-13-00270]
- Russian Science Foundation [20-13-00270] Funding Source: Russian Science Foundation
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Researchers have developed an injectable hydrogel material with softness and firmness that matches tissue, making it suitable for biomedical applications.
Injectable hydrogels are desired in many biomedical applications due to their minimally invasive deployment to the body and their ability to introduce drugs. However, current injectables suffer from mechanical mismatch with tissue, fragility, water expulsion, and high viscosity. To address these issues, we design brush-like macromolecules that concurrently provide softness, firmness, strength, fluidity, and swellability. The synthesized linear-bottlebrush-linear (LBL) copolymers facilitate improved injectability as the compact conformation of bottlebrush blocks results in low solution viscosity, while the thermoresponsive linear blocks permit prompt gelation at 37 degrees C. The resulting hydrogels mimic the deformation response of supersoft tissues such as adipose and brain while withstanding deformations of 700% and precluding water expulsion upon gelation. Given their low cytotoxicity and mild inflammation in vivo, the developed materials will have vital implications for reconstructive surgery, tissue engineering, and drug delivery applications.
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