Article
Pediatrics
Babajide Shenkoya, Shakir Atoyebi, Ibrahim Eniayewu, Abdulafeez Akinloye, Adeniyi Olagunju
Summary: Pregnancy-induced changes in pharmacokinetics of antiretrovirals can impact drug exposure in pregnant women and the fetal compartment. Limited knowledge about ARV exposure in lymphoid tissues and fetal plasma poses challenges in ensuring virological suppression during pregnancy. The study demonstrates how certain ARVs penetrate lymphoid tissues and the fetal compartment, highlighting the importance of adequate drug exposure for preventing mother-to-child transmission risk.
FRONTIERS IN PEDIATRICS
(2021)
Article
Pharmacology & Pharmacy
David Lartey, Danielle Jateng, Miao Li, Christine Nguyen, Victor Crentsil, Julie Beitz, Blessy George
Summary: A physiologically based pharmacokinetic (PBPK) model was developed to assess fetal exposure to sertraline during pregnancy. The model accurately predicted the concentrations of sertraline in maternal plasma and cord blood, providing a useful tool for dose adjustment.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Rachel E. E. Hudson, Torri D. D. Metz, Robert M. M. Ward, Autumn M. M. McKnite, Elena Y. Y. Enioutina, Catherine M. M. Sherwin, Kevin M. M. Watt, Kathleen M. M. Job
Summary: Prescription drug use during pregnancy is common, but there is limited knowledge about its safety and efficacy due to the exclusion of pregnant individuals from clinical trials. This lack of representation has led to a lack of data on fetal drug exposure. Various methods, such as sampling different biospecimens, can be used to study fetal drug pharmacology. Alternative approaches, such as physiologically based PK modeling, can also help address challenges in studying maternal-fetal pharmacology.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Liang Zheng, Hongyi Yang, Andre Dallmann, Xuehua Jiang, Ling Wang, Wei Hu
Summary: A physiologically based pharmacokinetic (PBPK) model of olanzapine in pregnant women was developed and validated in this study. The model predicted that dose adjustment of olanzapine may not be necessary for pregnant women if effective treatment was achieved before pregnancy and fetal toxicity can be ruled out.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Caroline Charlier, Julia Dina, Francois Freymuth, Astrid Vabret, Olivier Lortholary, Denise Antona, Marc Lecuit
Summary: Research shows that measles virus can be detected in the saliva and blood of pregnant women, leading to transmission to the fetus during pregnancy, resulting in asymptomatic infection at birth. Despite severe peripartum congenital measles, asymptomatic vertical transmission of the measles virus can occur in early pregnancy.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Pediatrics
Xiaomei Liu, Dionna J. Green, John N. van den Anker, Natella Y. Rakhmanina, Homa K. Ahmadzia, Jeremiah D. Momper, Kyunghun Park, Gilbert J. Burckart, Andre Dallmann
Summary: The study found that different maternal and fetal unbound drug fractions in the PBPK model can affect fetal pharmacokinetics, especially for highly protein-bound drugs. Various model parameter alterations have significant effects on predicted fetal pharmacokinetics.
FRONTIERS IN PEDIATRICS
(2021)
Review
Chemistry, Multidisciplinary
Davell Carter, Marina Better, Saed Abbasi, Fareeha Zulfiqar, Rachel Shapiro, Laura M. Ensign
Summary: Conception, pregnancy, and childbirth are complex processes that have significant impact on both the mother and fetus. However, there is a lack of safe and effective treatment options in women's health and pregnancy. The physiological changes during menstrual cycle and pregnancy make drug administration and delivery more complicated, and overcoming physiological barriers is also challenging. Nanomedicine offers a unique opportunity to improve safety and minimize side effects by targeting drug delivery to the reproductive tract and other relevant organs in the mother and fetus, and has the potential to improve the management and treatment of infertility, obstetric complications, and fetal conditions.
Article
Pediatrics
Udoamaka Ezuruike, Alexander Blenkinsop, Amita Pansari, Khaled Abduljalil
Summary: Accurate prediction of fetal exposure to drugs excreted by the kidney requires considering the time-varying renal function parameters. This study collected and integrated data on fetal urinary production rate (FUPR) and creatinine measured at different gestational ages, and compared the predicted fetal glomerular filtration rate (GFR) with neonatal values. The results showed that 3D ultrasound methods yielded higher estimates of FUPR compared to 2D methods, and a power law function accurately captured the change in FUPR with fetal age. The predicted FUPR based on 3D data showed a strong linear relationship with amniotic creatinine concentration, and the predicted fetal GFR values were in good agreement with neonatal values at birth.
FRONTIERS IN PEDIATRICS
(2022)
Review
Biochemistry & Molecular Biology
Caitlyn E. Bowman, Zoltan Arany, Michael J. Wolfgang
Summary: Pregnancy is a nutritionally sensitive stage, and communication between mother and fetus through metabolites is crucial. Studies on humans and animals provide insights into the metabolic adaptations of the fetus, placenta, and mother during pregnancy. Understanding the dynamic nature of maternal-fetal metabolic communication may lead to the discovery of new biomarkers and therapeutic targets for metabolic disorders in pregnancy.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Multidisciplinary Sciences
Alfred T. Harding, Marisa A. Goff, Heather M. Froggatt, Jean K. Lim, Nicholas S. Heaton
Summary: The activation of GPER1 during pregnancy is crucial in suppressing IFN signaling in reproductive and fetal tissues, with inactivation of GPER1 leading to fetal developmental arrest and demise in mice, particularly in the presence of maternal inflammation. GPER1 serves as a central regulator of IFN signaling during pregnancy, allowing for dynamic antiviral responses in maternal tissues while protecting fetal health.
Review
Immunology
Ellen Menkhorst, Nandor Gabor Than, Udo Jeschke, Gabriela Barrientos, Laszlo Szereday, Gabriela Dveksler, Sandra M. Blois
Summary: Lectin-glycan interactions, particularly those mediated by the galectin family, play crucial roles in regulating processes necessary for a successful pregnancy. Galectins specifically bind to intracellular and membrane bound carbohydrate ligands, influencing angiogenesis, immune-cell adaptations, and embryogenesis. They contribute to fetal development and placental health, with implications for pathological conditions like preeclampsia.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Michael M. Dagher, Emily M. Eichenberger, Kateena L. Addae-Konadu, Sarah K. Dotters-Katz, Celia L. Kohler, Vance G. Fowler, Jerome J. Federspiel
Summary: Maternity-associated IE does not appear to confer additional risk for adverse outcomes over nonmaternity-associated infection. Patients who deliver with IE have worse maternal and fetal outcomes than those whose deliveries are not complicated by IE.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Biology
Suhas Sureshchandra, Brianna M. Doratt, Norma Mendza, Oleg Varlamov, Monica Rincon, Nicole E. Marshall, Ilhem Messaoudi
Summary: Maternal pre-pregnancy obesity is linked to unfavorable outcomes in both mother and offspring, including increased susceptibility and severity of neonatal infections. This study reveals that pregravid obesity disrupts umbilical cord blood monocyte responses to bacterial and viral pathogens. It demonstrates that interferon-stimulated gene expression and inflammatory responses to respiratory syncytial virus and E. coli are significantly dampened. Additionally, it suggests that maternal obesity alters metabolic, signaling, and epigenetic profiles of fetal monocytes, leading to immune paralysis during late gestation and at birth.
Article
Nutrition & Dietetics
Maria de la Calle, Jose L. Bartha, Clara Marin, Juan Carlos Rus, Guillermo Corcoles, Santiago Ruvira, David Ramiro-Cortijo
Summary: There is an increasing number of obese mothers having twin pregnancies, and proper gestational weight control is crucial for mothers with high pre-gestational BMI.
Article
Endocrinology & Metabolism
Xiaxia Cai, Ning Liang, Xueping Cai, Qi Zhou, Qinyu Dang, Zhuo Hu, Huanling Yu
Summary: This study found that maternal APOE gene rs429358 C allele, fetal APOE gene rs440446 G allele, and fetal LPL gene rs263 T allele increased the risk of MSPH, while maternal LDLR gene rs7258950 A allele decreased the risk of MSPH. The maternal-fetal variant concordance is associated with the risk of MSPH.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Medical Laboratory Technology
Prerna Dodeja, Spiros Giannoutsos, Steve Caritis, Raman Venkataramanan
Summary: Microsampling is a technique that uses a small volume of biological matrix for quantitative analysis. Dried blood spots, a commonly used microsampling method, has limitations such as sample inhomogeneity and environmental degradation. A novel microsampling device called Volumetric Absorptive Microsampling (VAMS) has shown promise in resolving these issues and improving sample collection precision.
THERAPEUTIC DRUG MONITORING
(2023)