Neural Correlates of Auditory Hypersensitivity in Fragile X Syndrome

Network asynchrony underlying increased broadband gamma power

(2021) Nicolas Guyon et al.   JOURNAL OF NEUROSCIENCE

Increased aperiodic gamma power in young boys with Fragile X Syndrome is associated with better language ability

(2021) Carol L. Wilkinson et al.   Molecular Autism

Perineuronal nets are under the control of type-5 metabotropic glutamate receptors in the developing somatosensory cortex

(2021) Giada Mascio et al.   Translational Psychiatry

Correction to: The PDE10A Inhibitor TAK-063 Reverses Sound-Evoked EEG Abnormalities in a Mouse Model of Fragile X Syndrome

(2021) Carrie R. Jonak et al.   Neurotherapeutics

Mechanisms underlying auditory processing deficits in Fragile X syndrome

(2020) Elizabeth A. McCullagh et al.   FASEB JOURNAL

Reactivation of FMR1 gene expression is a promising strategy for fragile X syndrome therapy

(2020) Ekaterina M. Shitik et al.   GENE THERAPY

Acute pharmacological inhibition of matrix metalloproteinase‐9 activity during development restores perineuronal net formation and normalizes auditory processing in Fmr1 KO mice

(2020) Patricia S. Pirbhoy et al.   JOURNAL OF NEUROCHEMISTRY

Developmental studies in fragile X syndrome

(2020) Khaleel A. Razak et al.   Journal of Neurodevelopmental Disorders

Abnormal development of auditory responses in the inferior colliculus of a mouse model of Fragile X Syndrome

(2020) Anna O. Nguyen et al.   JOURNAL OF NEUROPHYSIOLOGY

Multielectrode array analysis of EEG biomarkers in a mouse model of Fragile X Syndrome

(2020) Carrie R. Jonak et al.   NEUROBIOLOGY OF DISEASE

Minocycline Treatment Reverses Sound Evoked EEG Abnormalities in a Mouse Model of Fragile X Syndrome

(2020) Jonathan W. Lovelace et al.   Frontiers in Neuroscience

Parameterizing neural power spectra into periodic and aperiodic components

(2020) Thomas Donoghue et al.   NATURE NEUROSCIENCE

Local cortical circuit correlates of altered EEG in the mouse model of Fragile X syndrome

(2019) Sonal Goswami et al.   NEUROBIOLOGY OF DISEASE

Increased Excitation-Inhibition Ratio Stabilizes Synapse and Circuit Excitability in Four Autism Mouse Models

(2019) Michelle W. Antoine et al.   NEURON

Homeostatic Intrinsic Plasticity Is Functionally Altered in Fmr1 KO Cortical Neurons

(2019) Pernille Bülow et al.   Cell Reports

Emerging pharmacological therapies in fragile X syndrome and autism

(2019) Hidenori Yamasue et al.   CURRENT OPINION IN NEUROLOGY

Deletion of Fmr1 from Forebrain Excitatory Neurons Triggers Abnormal Cellular, EEG, and Behavioral Phenotypes in the Auditory Cortex of a Mouse Model of Fragile X Syndrome

(2019) Jonathan W Lovelace et al.   CEREBRAL CORTEX

Genetic reduction of MMP-9 in the Fmr1 KO mouse partially rescues prepulse inhibition of acoustic startle response

(2019) Jamiela Kokash et al.   BRAIN RESEARCH

Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models

(2019) Lauren L. Orefice et al.   CELL

Reversal of ultrasonic vocalization deficits in a mouse model of Fragile X Syndrome with minocycline treatment or genetic reduction of MMP-9

(2019) Maximiliano A. Toledo et al.   BEHAVIOURAL BRAIN RESEARCH

Audiogenic Seizures in the Fmr1 Knock-Out Mouse Are Induced by Fmr1 Deletion in Subcortical, VGlut2-Expressing Excitatory Neurons and Require Deletion in the Inferior Colliculus

(2019) Darya Gonzalez et al.   JOURNAL OF NEUROSCIENCE

Auditory EEG Biomarkers in Fragile X Syndrome: Clinical Relevance

(2019) Lauren E. Ethridge et al.   Frontiers in Integrative Neuroscience

Beneficial effects of sound exposure on auditory cortex development in a mouse model of Fragile X Syndrome

(2019) Anna O. Kulinich et al.   NEUROBIOLOGY OF DISEASE

Translation-relevant EEG phenotypes in a mouse model of Fragile X Syndrome

(2018) Jonathan W. Lovelace et al.   NEUROBIOLOGY OF DISEASE

Sensory Processing Phenotypes in Fragile X Syndrome

(2018) Maham Rais et al.   ASN Neuro

Impaired perceptual learning in a mouse model of Fragile X syndrome is mediated by parvalbumin neuron dysfunction and is reversible

(2018) Anubhuti Goel et al.   NATURE NEUROSCIENCE

The fragile X mutation impairs homeostatic plasticity in human neurons by blocking synaptic retinoic acid signaling

(2018) Zhenjie Zhang et al.   Science Translational Medicine

Ube3a reinstatement mitigates epileptogenesis in Angelman syndrome model mice

(2018) Bin Gu et al.   JOURNAL OF CLINICAL INVESTIGATION

Developmental Changes in EEG Phenotypes in a Mouse Model of Fragile X Syndrome

(2018) Teresa H. Wen et al.   NEUROSCIENCE

Autism Symptoms in Fragile X Syndrome

(2017) Manman Niu et al.   JOURNAL OF CHILD NEUROLOGY

A resting EEG study of neocortical hyperexcitability and altered functional connectivity in fragile X syndrome

(2017) Jun Wang et al.   Journal of Neurodevelopmental Disorders

Prefrontal Cortex Dysfunction in Fragile X Mice Depends on the Continued Absence of Fragile X Mental Retardation Protein in the Adult Brain

(2017) Jennifer J. Siegel et al.   JOURNAL OF NEUROSCIENCE

Delayed Maturation of Fast-Spiking Interneurons Is Rectified by Activation of the TrkB Receptor in the Mouse Model of Fragile X Syndrome

(2017) Toshihiro Nomura et al.   JOURNAL OF NEUROSCIENCE

Enhanced Excitatory Connectivity and Disturbed Sound Processing in the Auditory Brainstem of Fragile X Mice

(2017) Elisabet Garcia-Pino et al.   JOURNAL OF NEUROSCIENCE

Genetic Otx2 mis-localization delays critical period plasticity across brain regions

(2017) H H C Lee et al.   MOLECULAR PSYCHIATRY

Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome

(2017) Elizabeth M. Berry-Kravis et al.   NATURE REVIEWS DRUG DISCOVERY

Dynamic, Cell-Type-Specific Roles for GABAergic Interneurons in a Mouse Model of Optogenetically Inducible Seizures

(2017) Sattar Khoshkhoo et al.   NEURON

Distinct Inhibitory Circuits Orchestrate Cortical beta and gamma Band Oscillations

(2017) Guang Chen et al.   NEURON

Neural synchronization deficits linked to cortical hyper-excitability and auditory hypersensitivity in fragile X syndrome

(2017) Lauren E. Ethridge et al.   Molecular Autism

Fragile X syndrome

(2017) Randi J. Hagerman et al.   Nature Reviews Disease Primers

Sensory subtypes and anxiety in older children and adolescents with autism spectrum disorder

(2016) Mirko Uljarević et al.   Autism Research

Peripheral Mechanosensory Neuron Dysfunction Underlies Tactile and Behavioral Deficits in Mouse Models of ASDs

(2016) Lauren L. Orefice et al.   CELL

Disrupted Cortical State Regulation in a Rat Model of Fragile X Syndrome

(2016) Julia Berzhanskaya et al.   CEREBRAL CORTEX

Cellular distribution of the fragile X mental retardation protein in the mouse brain

(2016) Diego A.R. Zorio et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Removal of Perineuronal Nets Unlocks Juvenile Plasticity Through Network Mechanisms of Decreased Inhibition and Increased Gamma Activity

(2016) Kristian Kinden Lensjø et al.   JOURNAL OF NEUROSCIENCE

Matrix metalloproteinase-9 deletion rescues auditory evoked potential habituation deficit in a mouse model of Fragile X Syndrome

(2016) Jonathan W. Lovelace et al.   NEUROBIOLOGY OF DISEASE

Reduced habituation of auditory evoked potentials indicate cortical hyper-excitability in Fragile X Syndrome

(2016) L E Ethridge et al.   Translational Psychiatry

Ube3a reinstatement identifies distinct developmental windows in a murine Angelman syndrome model

(2015) Sara Silva-Santos et al.   JOURNAL OF CLINICAL INVESTIGATION

A delicate balance: role of MMP-9 in brain development and pathophysiology of neurodevelopmental disorders

(2015) Sarah M. Reinhard et al.   Frontiers in Cellular Neuroscience

Postsynaptic FMRP Promotes the Pruning of Cell-to-Cell Connections among Pyramidal Neurons in the L5A Neocortical Network

(2014) A. B. Patel et al.   JOURNAL OF NEUROSCIENCE

Development of Intrinsic Connectivity in the Central Nucleus of the Mouse Inferior Colliculus

(2014) J. Sturm et al.   JOURNAL OF NEUROSCIENCE

Genetic Removal of Matrix Metalloproteinase 9 Rescues the Symptoms of Fragile X Syndrome in a Mouse Model

(2014) H. Sidhu et al.   JOURNAL OF NEUROSCIENCE

A synaptic and circuit basis for corollary discharge in the auditory cortex

(2014) David M. Schneider et al.   NATURE

Failed Stabilization for Long-Term Potentiation in the Auditory Cortex of Fmr1 Knockout Mice

(2014) Sungchil Yang et al.   PLoS One

Auditory Processing in Fragile X Syndrome

(2014) Sarah E. Rotschafer et al.   Frontiers in Cellular Neuroscience

Pharmacogenetic Inhibition of eIF4E-Dependent Mmp9 mRNA Translation Reverses Fragile X Syndrome-like Phenotypes

(2014) Christos G. Gkogkas et al.   Cell Reports

High MMP-9 activity levels in fragile X syndrome are lowered by minocycline

(2013) Magdalena Dziembowska et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Altered auditory processing in a mouse model of fragile X syndrome

(2013) Sarah Rotschafer et al.   BRAIN RESEARCH

Intense and specialized dendritic localization of the fragile X mental retardation protein in binaural brainstem neurons: A comparative study in the alligator, chicken, gerbil, and human

(2013) Yuan Wang et al.   JOURNAL OF COMPARATIVE NEUROLOGY

A Randomized Double-Blind, Placebo-Controlled Trial of Minocycline in Children and Adolescents with Fragile X Syndrome

(2013) Mary Jacena S. Leigh et al.   JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS

A Target Cell-Specific Role for Presynaptic Fmr1 in Regulating Glutamate Release onto Neocortical Fast-Spiking Inhibitory Neurons

(2013) A. B. Patel et al.   JOURNAL OF NEUROSCIENCE

The Fragile X Mental Retardation Protein Regulates Matrix Metalloproteinase 9 mRNA at Synapses

(2013) A. Janusz et al.   JOURNAL OF NEUROSCIENCE

Impaired Critical Period Plasticity in Primary Auditory Cortex of Fragile X Model Mice

(2013) H. Kim et al.   JOURNAL OF NEUROSCIENCE

Electrocortical changes associated with minocycline treatment in fragile X syndrome

(2013) Andrea Schneider et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Long-lasting effects of minocycline on behavior in young but not adult Fragile X mice

(2013) L.E. Dansie et al.   NEUROSCIENCE

Minocycline treatment reverses ultrasonic vocalization production deficit in a mouse model of Fragile X Syndrome

(2012) Sarah E. Rotschafer et al.   BRAIN RESEARCH

Event-related potential alterations in fragile X syndrome

(2012) Inga S. Knoth et al.   Frontiers in Human Neuroscience

Trajectories of Early Brain Volume Development in Fragile X Syndrome and Autism

(2012) Heather Cody Hazlett et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Impaired Dendritic Expression and Plasticity of h-Channels in the fmr1−/y Mouse Model of Fragile X Syndrome

(2012) Darrin H. Brager et al.   Cell Reports

Auditory change detection in fragile X syndrome males: A brain potential study

(2011) M.J.W. Van der Molen et al.   CLINICAL NEUROPHYSIOLOGY

Neural circuit architecture defects in a Drosophila model of Fragile X syndrome are alleviated by minocycline treatment and genetic removal of matrix metalloproteinase

(2011) S. S. Siller et al.   Disease Models & Mechanisms

Autism: Alterations in Auditory Perception

(2011) P.L. Nieto Del Rincon   REVIEWS IN THE NEUROSCIENCES

Open-label add-on treatment trial of minocycline in fragile X syndrome

(2010) Carlo Paribello et al.   BMC Neurology

Development of Inhibitory Timescales in Auditory Cortex

(2010) Anne-Marie M. Oswald et al.   CEREBRAL CORTEX

The neural basis of auditory temporal discrimination in girls with fragile X syndrome

(2009) Scott S. Hall et al.   Journal of Neurodevelopmental Disorders

Parvalbumin neurons and gamma rhythms enhance cortical circuit performance

(2009) Vikaas S. Sohal et al.   NATURE

Driving fast-spiking cells induces gamma rhythm and controls sensory responses

(2009) Jessica A. Cardin et al.   NATURE

Phonological Accuracy and Intelligibility in Connected Speech of Boys With Fragile X Syndrome or Down Syndrome

(2009) Elizabeth Barnes et al.   JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH

Deficient brainstem encoding of pitch in children with Autism Spectrum Disorders

(2008) N.M. Russo et al.   CLINICAL NEUROPHYSIOLOGY

Imbalance of Neocortical Excitation and Inhibition and Altered UP States Reflect Network Hyperexcitability in the Mouse Model of Fragile X Syndrome

(2008) Jay R. Gibson et al.   JOURNAL OF NEUROPHYSIOLOGY

Maturation of Intrinsic and Synaptic Properties of Layer 2/3 Pyramidal Neurons in Mouse Auditory Cortex

(2008) Anne-Marie M. Oswald et al.   JOURNAL OF NEUROPHYSIOLOGY

Advances in the Treatment of Fragile X Syndrome

(2008) R. J. Hagerman et al.   PEDIATRICS