Article
Chemistry, Medicinal
Liqiang Hu, Huixin Yang, Tao Yu, Fangfang Chen, Runqiu Liu, Shuyuan Xue, Shuangzhan Zhang, Wuyu Mao, Changge Ji, Hao Wang, Hexin Xie
Summary: This study demonstrates the effectiveness of stereochemically altered cephalosporins as potent inhibitors against NDM-1, a major cause of antibiotic resistance. The findings provide a new approach to combat antibiotic resistance.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Immunology
Katariina Koskinen, Reetta Penttinen, Anni-Maria Ormala-Odegrip, Christian G. Giske, Tarmo Ketola, Matti Jalasvuori
Summary: The extensively drug resistant Klebsiella pneumoniae poses a significant burden to healthcare systems worldwide, with certain sequence types being more prevalent in hospital settings. There are clear differences between isolates, and drought tolerance was found to notably associate with non-epidemic strains of K. pneumoniae.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Xiaoyu Ma, Fan Zhang, Bing Bai, Zhiwei Lin, Guangjian Xu, Zhong Chen, Xiang Sun, Jinxin Zheng, Qiwen Deng, Zhijian Yu
Summary: This study investigated the resistance mechanisms, molecular characteristics, and risk factors of E. faecalis clinical isolates from UTI patients in China. The findings revealed a high frequency of linezolid and tedizolid resistance in E. faecalis isolates, with erm(A) being the predominant resistance gene. Indwelling catheters and tracheal cannulas were identified as independent predictors of linezolid resistance. Further research is needed to understand the transmission mechanisms of linezolid-resistant E. faecalis in this hospital setting.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Microbiology
Fatemeh Zangane Matin, Seyedeh Elham Rezatofighi, Mohammad Roayaei Ardakani, Mohammad Reza Akhoond, Fahimeh Mahmoodi
Summary: This study found carbapenem-resistant UPEC isolates, with most being MBL-producing strains, in the Ahvaz region of Iran. These isolates exhibited multidrug resistance and potential pandrug resistance, along with the ability to transfer resistance genes to other bacteria via plasmids. Furthermore, the main virulence trait among these bacteria was siderophore production.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2021)
Article
Critical Care Medicine
Erwann Cariou, Romain Griffier, Arthur Orieux, Stein Silva, Stanislas Faguer, Thierry Seguin, Saad Nseir, Emmanuel Canet, Arnaud Desclaux, Bertrand Souweine, Kada Klouche, Olivier Guisset, Jerome Pillot, Walter Picard, Tahar Saghi, Pierre Delobel, Didier Gruson, Renaud Prevel, Alexandre Boyer
Summary: This study compared the effectiveness of non carbapenem regimen with carbapenem regimen for ESBL-E urinary septic shock. The results showed that non carbapenem regimen was not associated with higher mortality compared to carbapenem regimen.
ANNALS OF INTENSIVE CARE
(2023)
Article
Infectious Diseases
Qian Xu, Ying Fu, Jingshu Ji, Xiaoxing Du, Yunsong Yu
Summary: The study revealed the combined effect of aztreonam and amoxicillin/clavulanic acid against carbapenem-resistant Gram-negative pathogens, showing bactericidal effects against infections caused by MBL-producing CR-GNOs.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Infectious Diseases
Leah J. Toombs-Ruane, Jonathan C. Marshall, Jackie Benschop, Dragana Drinkovi, Anne C. Midwinter, Patrick J. Biggs, Zoe Grange, Michael G. Baker, Jeroen Douwes, Mick G. Roberts, Nigel P. French, Sara A. Burgess
Summary: This study aimed to assess whether having a pet in the home is a risk factor for community-acquired urinary tract infections associated with extended-spectrum β-lactamase (ESBL)-or AmpC β-lactamase (ACBL)-producing Enterobacterales. Through telephone questionnaire and logistic regression analysis, it was found that pet ownership was not associated with ESBL-or ACBL-producing Enterobacterales-related urinary tract infections, while the main risk factors included recent antimicrobial treatment, travel to Asia in the previous year, and a doctor's visit in the last 6 months.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Laurent Gavara, Alice Legru, Federica Verdirosa, Laurent Sevaille, Lionel Nauton, Giuseppina Corsica, Paola Sandra Mercuri, Filomena Sannio, Georges Feller, Remi Coulon, Filomena De Luca, Giulia Cerboni, Silvia Tanfoni, Giulia Chelini, Moreno Galleni, Jean-Denis Docquier, Jean-Francois Hernandez
Summary: Researchers are developing compounds based on the 1,2,4-triazole-3-thione scaffold to target resistance mechanisms in Gram-negative bacteria, with promising potential for broad-spectrum inhibitors. These compounds, particularly those containing a carboxylic group at the 4-position, have shown potent inhibition against VIM-type enzymes. Further exploration is needed to improve outer membrane penetration and efficacy against other carbapenemases.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Marco J. J. Rotter, Sabrina Zentgraf, Lilia Weizel, Denia Frank, Luisa D. Burgers, Steffen Brunst, Robert Fuerst, Anna Proschak, Thomas A. Wichelhaus, Ewgenij Proschak
Summary: Metallo beta lactamases (MBLs) have become a major problem in treating multidrug-resistant Gram-negative pathogens due to their ability to resist a broad range of drugs and lack of effective inhibitors. In this study, we designed catechol-containing MBL inhibitors that mimic bacterial siderophores, which are actively taken up by bacteria through their iron acquisition system. The most potent catechol-containing MBL inhibitor demonstrated binding to Fe3+ ions and restored the effectiveness of imipenem in NDM-1-expressing K. pneumoniae without affecting healthy cells. These siderophore-containing MBL inhibitors could be a promising strategy to combat MBL-mediated resistance to beta lactam antibiotics.
Article
Microbiology
Kayoko Hayakawa, Yasufumi Matsumura, Kohei Uemura, Shinya Tsuzuki, Aki Sakurai, Ryutaro Tanizaki, Koh Shinohara, Takehiro Hashimoto, Ryota Hase, Takashi Matono, Hideaki Kato, Momoko Mawatari, Hiroshi Hara, Yukihiro Hamada, Sho Saito, Norio Ohmagari, Yohei Doi
Summary: Cefmetazole showed clinical and bacteriological effectiveness comparable to meropenem against invasive urinary tract infection due to ESBLECs.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Health Care Sciences & Services
Narcisa Muresu, Giovanna Deiana, Marco Dettori, Alessandra Palmieri, Maria Dolores Masia, Andrea Cossu, Cristina D'Avino, Illari Sechi, Arcadia Del Rio, Andrea Piana, Paolo Castiglia
Summary: The spread of multi-drug resistant organisms (MDROs) is increasing globally. This report presents two independent cases of patients from Ukraine infected with Carbapenemase-producing Klebsiella pneumoniae, and the infection prevention control (IPC) strategies implemented to prevent further contamination. These cases highlight the importance of early recognition of multidrug-resistant bacteria, effective inter-hospital communication, antimicrobial stewardship protocols, and adequate IPC policies. Improvement in screening procedures is necessary to prevent potential nosocomial outbreaks and endemization.
Article
Chemistry, Multidisciplinary
Matthijs J. van Haren, Kamaleddin H. M. E. Tehrani, Ioli Kotsogianni, Nicola Wade, Nora C. Bruchle, Vida Mashayekhi, Nathaniel I. Martin
Summary: The increasing prevalence of metallo-beta-lactamase (MBL)-expressing bacteria is a worrying trend in antibiotic resistance. Studies have shown that zinc ions, which are essential for the hydrolytic activity of MBLs, can be targeted for inhibition. Researchers have developed a series of cephalosporin prodrugs that exhibit potent activity against MBLs and can act synergistically with specific antibiotics.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Infectious Diseases
Pisut Pongchaikul, Paninee Mongkolsuk
Summary: Antibiotic resistance, especially beta-lactam resistance, is a significant problem worldwide. IMP-type metallo-beta-lactamase (MBL) has become a prominent enzyme in Asia, with 88 variants currently identified. IMP-1 is the most common variant. IMP-type MBLs have been detected in multiple species, with Pseudomonas aeruginosa being the most frequent carrier. The distribution of IMP-type MBLs in Asia has been observed in various countries. This study provides comprehensive insight into the global and regional prevalence of IMP-type MBLs, highlighting their resistance to carbapenems and third-generation cephalosporins.
Article
Microbiology
Satomi Takei, Yu Jie Lu, Mari Tohya, Shin Watanabe, Shigeki Misawa, Yoko Tabe, Takashi Miida, San Mya, Htay Htay Tin, Tatsuya Tada, Teruo Kirikae
Summary: This study demonstrates the spread of carbapenem-resistant K. pneumoniae strains in medical settings in Myanmar. Specifically, plasmid genes encoding NDMs and 16S rRNA methylases have been spreading in high-risk clones of K. pneumoniae.
MICROBIOLOGY SPECTRUM
(2022)
Review
Emergency Medicine
Ralphe Bou Chebl, Mohamad Assaf, Nadim Kattouf, Samer Abou Arbid, Saadeddine Haidar, Mirabelle Geha, Maha Makki, Hani Tamim, Gilbert Abou Dagher
Summary: The prevalence of ESBL organisms in urinary tract infections was found to be 24.9%. Predictors of an ESBL UTI infection included antibiotic use in the last 90 days and a history of ESBL producing isolate at any site in the previous year. Based on these findings, modifying initial empiric antibiotic treatment for UTI patients with these risk factors could be considered.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)