Article
Agriculture, Dairy & Animal Science
Taotao Li, Huihui Wang, Keyan Ma, Yi Wu, Xingcai Qi, Zilong Liu, Qiao Li, Yong Zhang, Youji Ma
Summary: This study investigated the characteristics and function of piRNAs in the testes of Tibetan sheep. The results showed that piRNAs in Tibetan sheep testes have specific sequence structures and expression profiles. They play a crucial role in testicular development and spermatogenesis by regulating gene expression, transcription, protein modification, and cell development.
JOURNAL OF ANIMAL SCIENCE
(2023)
Review
Endocrinology & Metabolism
Meghali Joshi, Shruti Sethi, Poonam Mehta, Anamika Kumari, Singh Rajender
Summary: Small non-coding RNAs (sncRNAs) play crucial roles in male reproduction, especially in spermatogenesis. miRNAs, piRNAs, and tsRNAs are the most commonly studied sncRNAs. Dysregulation of miRNAs is highly correlated with infertility. Sperm-borne small RNAs have the potential to act as biomarkers of sperm quality and fertility.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Review
Medicine, Research & Experimental
Benchi Ma, Shihao Wang, Wenzheng Wu, Pufan Shan, Yufan Chen, Jiaqi Meng, Liping Xing, Jingyi Yun, Longhui Hao, Xiaoyu Wang, Shuyan Li, Yinghui Guo
Summary: In recent years, significant progress has been made in bioinformatics with the discovery of functional non-coding RNAs (ncRNAs). These ncRNAs play a crucial role in regulating intracellular gene expression, assisting in diagnosis, guiding drug use, and determining prognosis in various diseases. MicroRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) are the three major types of ncRNAs that interact with each other. Studies have shown that lncRNAs and circRNAs can sponge miRNAs, influencing normal physiological processes and regulating mRNA expression, and ultimately affecting cellular physiology. This paper provides a summary of the mechanisms and research progress of these three ncRNAs and their potential implications in disease diagnosis, treatment, and drug development.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemical Research Methods
Garima Singh, Arpit Chandan Swain, Bibekanand Mallick
Summary: The study analyzed the sequences and structures of piRNAs in normal ovary and epithelial ovarian cancer samples, identifying unique features that differentiate piRNAs from miRNAs and other sequences, providing insights into the biogenesis and function of piRNAs.
CURRENT BIOINFORMATICS
(2021)
Article
Cell Biology
Dong Li, Ying Ge, Ze Zhao, Rui Zhu, Xiang Wang, Xiaolin Bi
Summary: The study analyzed the expression profiles of miRNAs and piRNAs in Drosophila during development and DNA damage response, revealing dynamic expression patterns and the key roles of E2f1 and p53 in regulating small ncRNAs. E2f1 may play a major role in modulating miRNAs during development and after X-ray irradiation, showcasing new insights into small ncRNA biology.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
S. Shome, R. L. Jernigan, D. C. Beitz, S. Clark, E. D. Testroet
Summary: The study reveals that bovine milk contains a significant number of ncRNAs with putative regulatory targets associated with immune and developmental functions important for neonatal bovine health. Processing significantly affects ncRNA expression values, but overall abundance values of miRNA samples are not greatly impacted.
Article
Biotechnology & Applied Microbiology
Christoph Keysberg, Oliver Hertel, Louise Schelletter, Tobias Busche, Chiara Sochart, Jorn Kalinowski, Raimund Hoffrogge, Kerstin Otte, Thomas Noll
Summary: CHO cells derived from Chinese hamster ovaries are widely used in biopharmaceutical production, but research on exosomes in these cells is scarce. Exosomes are considered a universal mediator of intercellular communication and a proposed new drug delivery format in biopharmaceuticals. This study analyzed the proteome and RNA of exosomes from CHO-K1 cells, providing reference data for future research.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Cell Biology
Soudabeh Sabetian, Isabella Castiglioni, Bahia Namavar Jahromi, Pegah Mousavi, Claudia Cava
Summary: COVID-19 may cause male reproductive disorders through the ACE2 and TMPRSS2 pathways, with miRNAs and lncRNAs potentially playing a regulatory role in this process.
Article
Chemistry, Multidisciplinary
Saltanat Kamenova, Aksholpan Sharapkhanova, Aigul Akimniyazova, Karlygash Kuzhybayeva, Aida Kondybayeva, Aizhan Rakhmetullina, Anna Pyrkova, Anatoliy Ivashchenko
Summary: This study used bioinformatic methods to identify endogenous miRNAs and piRNAs involved in the regulation of MS candidate gene expression. It was found that miRNA and piRNA interacted with mRNA binding sites to regulate the expression of MS candidate genes. These findings provide new associations for MS diagnosis.
Review
Biochemistry & Molecular Biology
Caoling Xu, Yuzhu Cao, Jianqiang Bao
Summary: The segregation and maintenance of a dedicated germline is crucial for species propagation in sexually reproducing multicellular organisms. Germ cells have distinct membraneless granules formed through liquid-liquid phase separation. Vasa/Ddx4, a conserved germline marker, plays a vital role in germ granule formation and RNA metabolism.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sweta Khanal, Beatriz Schueng Zancanela, Jacob Oche Peter, Alex Sutton Flynt
Summary: This study provides a comprehensive analysis of small RNAs in annelids, revealing a large number of microRNAs and piRNAs. The study also identifies the expression patterns and pathway composition of miRNAs and piRNAs related to animal development and metamorphosis. Additionally, the study finds that the configuration of RNAi factors in annelids is similar to that of other annelids and mollusks, suggesting the presence of similar biology in a wider clade.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Cell Biology
Masaki Kawase, Kenji Ichiyanagi
Summary: In mammals, germ cells produce small regulatory RNAs called piRNAs, which have different characteristics and expression dynamics during development. The length of piRNAs is correlated with PIWI-like proteins, and retrotransposon-derived piRNAs are abundantly produced but decline in abundance as development proceeds.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemical Research Methods
Wengang Wang, Hailin Chen
Summary: Increasing studies have shown that miRNAs play a critical role in the development of complex human diseases. In this study, a deep learning-based method named MAGCN is proposed to predict potential miRNA-disease associations without using any similarity measurements. The method shows improved prediction accuracy compared to state-of-the-art methods.
BRIEFINGS IN BIOINFORMATICS
(2022)
Review
Cell Biology
Hui Kong, Ming-Li Sun, Xin-An Zhang, Xue-Qiang Wang
Summary: By investigating the roles and interactions of miRNA, lncRNA, and circRNA in osteoarthritis, their significance in the prevention, diagnosis, and treatment of OA can be identified as potential future therapeutic targets.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Chuang Yin, Chuandong Wang, Chen Wang
Summary: This study examines the differential expression of small noncoding RNAs in keloid skin tissue (KST) and reveals potential targets for the development of new treatment for keloids.
FRONTIERS IN GENETICS
(2022)
Article
Chemistry, Multidisciplinary
Jiao Liu, Xiao Zhang, Pengfei Zou, Jiahui Yao, Lingling Liu, Yun Cai, Tongyi Sun, Yuanyuan Gao, Li-Li Li
Summary: Antibiotic resistance is a serious threat to public health. Researchers have developed nano-antibiotic transformers that enhance the effectiveness of antibiotics and effectively clear bacterial infections.
Review
Genetics & Heredity
Kaixian Wang, Yuanyuan Gao, Chen Wang, Meng Liang, Yaping Liao, Ke Hu
Summary: According to WHO statistics, millions of couples and individuals suffer from infertility, with varicocele identified as a leading cause of male infertility. This review examines the role of oxidative stress and reactive oxygen species (ROS) in the pathophysiology of varicocele and its impact on fertility. High levels of ROS can lead to infertility by damaging DNA, affecting lipid peroxidation, and inactivating enzymes and proteins involved in spermatogenesis.
FRONTIERS IN GENETICS
(2022)
Article
Neurosciences
Yuanyuan Gao, Hanqing Chao, Lora Cavuoto, Pingkun Yan, Uwe Kruger, Jack E. Norfleet, Basiel A. Makled, Steven Schwaitzberg, Suvranu De, Xavier Intes
Summary: This study presents a motion artifact removal method for fNIRS data using a deep learning approach. The developed deep learning model, with a specific loss function and generated training data, outperforms conventional methods in removing motion artifacts.
Article
Biochemistry & Molecular Biology
Yirong Wang, Li Guo, Jiao Liu, Xiaofei Huang, Xinxin Wang, Xiaolong Guo, Xinguo You, Wenhui Li, Lili Li, Tongyi Sun, Yuanyuan Gao
Summary: Wound treatment is a common healthcare issue, and Tylotoin, a peptide derived from salamander, has shown skin wound healing properties. However, its degradation and administration limitations hinder its use. In this study, Chitosan-PLGA-Tylotoin nanoparticles were developed to deliver Tylotoin for wound healing. The nanoparticles demonstrated good antibacterial properties, biocompatibility, and sustained release of Tylotoin, leading to improved wound healing in vitro and in vivo.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Wen Tian, Shao-Yuan Liu, Meng Zhang, Jing-Ru Meng, Na Tang, Ying-Da Feng, Yang Sun, Yuan-Yuan Gao, Lei Zhou, Wei Cao, Xiao-Qiang Li
Summary: TRPC1 plays a crucial role in endotoxemia-induced cardiac dysfunction by mediating myocardial apoptosis and autophagy.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Clinical Neurology
Cunsheng Wei, Tingwen Shen, Xuelian Tang, Yuanyuan Gao, Xiaorong Yu, Xuemei Chen
Summary: This study examined the impact of cerebral small vessel disease (SVD) and its interaction with cerebral collaterals on the prognosis of patients with large artery atherosclerotic (LAA) stroke. The study found that the combination of cerebral collaterals and total SVD burden was better at predicting the prognosis of acute LAA stroke patients compared to cerebral collaterals or SVD alone.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Antonio Ortega-Martinez, De'Ja Rogers, Jessica Anderson, Parya Farzam, Yuanyuan Gao, Bernhard Zimmermann, Meryem A. Yucel, David A. Boas
Summary: This research proposes a TD GLM method based on temporal moment analysis, which improves the recovery of HRF by incorporating TD moment data and auxiliary physiological measurements. The results show that properly covariance-scaled TD moment techniques outperform their CW equivalents in both RMSE and correlation, and the proposed TD GLM outperforms regular TD moment analysis while allowing the incorporation of auxiliary measurements.
Article
Chemistry, Multidisciplinary
Pengfei Zou, Jiao Liu, Xinyu Li, Muhammad Yaseen, Jiahui Yao, Lingling Liu, Lujun Luo, Hui Wang, Xinghua Shi, Zhiping Li, Tongyi Sun, Yuanyuan Gao, Chunsheng Gao, Li-Li Li
Summary: A lipopeptide nanomicelle (LP 20) with the ability to modulate membrane curvature was developed, resulting in accelerated and enhanced antibacterial activity against multidrug-resistant (MDR) Gram-negative pathogens. LP-20 effectively targeted multiple components on the bacterial membrane, causing efficient damage to both inner and outer membrane. In addition, LP-20 showed prolonged lifetime in mice infected with MDR pathogens.
Article
Pharmacology & Pharmacy
Danli Zhao, Yuanyuan Gao, Ying Su, Yuanyuan Zhou, Ting Yang, Yang Li, Yingqian Wang, Ying Sun, Li Chen, Feng Zhang, Zili Zhang, Feixia Wang, Jiangjuan Shao, Shizhong Zheng
Summary: Relevant studies have shown that Oroxylin A promotes senescence in hepatic stellate cells (HSC) by activating the cGAS-STING pathway. The activation of this pathway is dependent on the downregulation of DNMT3A, which suppresses cGAS gene DNA methylation. Oroxylin A prevents the production of methionine metabolites, leading to a decrease in SAM levels and consequently a reduction in DNMT activity. In vivo experiments also confirmed the induction of HSC senescence by Oroxylin A, with partially offset by DNMT3A overexpression.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Engineering, Biomedical
Xinxin Wang, Yiting Wang, Mengteng Tang, Xiaoyi Wang, Wei Xue, Xiao Zhang, Yuxia Wang, Wen-Hui Lee, Yingshuai Wang, Tong-Yi Sun, Yuanyuan Gao, Li-Li Li
Summary: This paper proposes a drug delivery strategy for the treatment of aerobic vaginitis by utilizing the changing dynamics of the bacterial flora. The strategy involves the use of a core-shell nanogel to encapsulate prebiotic inulin and antimicrobial peptide Cath 30, allowing for sequential drug release and selective killing of pathogenic bacteria, followed by the promotion of beneficial bacteria proliferation in the vagina.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Endocrinology & Metabolism
Ping Chen, Min Mao, Chendan Wang, Xu Zhang, Xiaoyu Zhao, Yuanyuan Gao, Yankun Luo, Yun Zhou
Summary: This study investigated the efficacy of rituximab in the treatment of idiopathic membranous nephropathy (IMN). The results showed that rituximab treatment significantly improved the clinical and biochemical indexes of patients with IMN, regardless of whether it was used as an initial therapy or for refractory/relapsed nephropathy.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Anil Kamat, Condell Eastmond, Yuanyuan Gao, Arun Nemani, Erim Yanik, Lora Cavuoto, Matthew Hackett, Jack Norfleet, Steven Schwaitzberg, Suvranu De, Xavier Intes
Summary: This study presents a fNIRS dataset acquired on mobile subjects performing FLS tasks in a laboratory environment. Relevant information and FLS scores are provided to facilitate the use of this open-access dataset.
Meeting Abstract
Oncology
Yuanyuan Gao, Xiaohua Yin, Can Wang, Yinqiao Kou, Lupeng Wang, Yuxuan Qin, Wenhui Bian, Jing Wang
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Cell Biology
Zejie Mei, Tao Yang, Ying Liu, Yuanyuan Gao, Zemin Hou, Qian Zhuang, Dongyin He, Xuebin Zhang, Qilong Tan, Xuyou Zhu, Yingyi Qin, Xi Chen, Chengdang Xu, Cuidong Bian, Xinan Wang, Chenyang Wang, Denglong Wu, Shengsong Huang, Zhenfei Li
Summary: Novel strategies are required to overcome drug resistance in prostate cancer. The study demonstrates that increasing 3 beta HSD1 is essential for drug resistance after abiraterone and enzalutamide treatment, and the inhibitor biochanin A (BCA) can overcome drug resistance. Furthermore, BCA also suppresses prostate cancer development.
CELL REPORTS MEDICINE
(2022)
Article
Cell Biology
Zemin Hou, Shengsong Huang, Zejie Mei, Longlong Chen, Jiacheng Guo, Yuanyuan Gao, Qian Zhuang, Xuebin Zhang, Qilong Tan, Tao Yang, Ying Liu, Yongnan Chi, Lifengrong Qi, Ting Jiang, Xuefeng Shao, Yan Wu, Xiaojun Xu, Jun Qin, Ruobing Ren, Huiru Tang, Denglong Wu, Zhenfei Li
Summary: In this study, it was found that progesterone has oncogenic effects in prostate cancer patients, activating androgen receptor target genes and promoting cell proliferation. Inhibiting the generation of progesterone may eliminate its oncogenic effects, and increased levels of progesterone could serve as a predictive biomarker for poor clinical outcomes.
CELL REPORTS MEDICINE
(2022)
