Article
Materials Science, Multidisciplinary
Jingjing Xu, Xiaojing Yang, Xianjiao Tang, Mei-Xia Zhao
Summary: This study introduces pH-sensitive Cy7-PEG-CA-DOX micelles for controlled drug release, tumor imaging, and synergistic cancer therapy. The micelles effectively released the anticancer drug doxorubicin in tumor cells and exhibited optimal tumor imaging properties. They also facilitated the favorable anti-breast cancer effects of photothermal therapy and chemotherapy in vivo.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Article
Nanoscience & Nanotechnology
Tianxiang Yi, Jieying Qian, Yayi Ye, Hao Zhang, Xin Jin, Meimei Wang, Zhenyu Yang, Wang Zhang, Longping Wen, Yunjiao Zhang
Summary: TP53 missense mutations leading to highly stabilized mutant p53 protein (mutp53) have been observed in a significant proportion of human cancers. Crizotinib, an FDA-approved antitumor drug, has been discovered to effectively degrade mutp53 protein, resulting in reduced cancer cell proliferation, migration, and enhanced sensitivity to doxorubicin. Delivery of crizotinib and doxorubicin using PEG-PLGA nanomicelles has demonstrated promising results, enhancing the therapeutic efficacy of doxorubicin against mutp53 pancreatic cancer in vitro and in vivo. This study suggests a novel combination therapeutic strategy for targeting p53 cancer in clinical application.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Pharmacology & Pharmacy
Muhammad Sohail, Bin Yu, Zheng Sun, Jiali Liu, Yanli Li, Feng Zhao, Daquan Chen, Xin Yang, Hui Xu
Summary: Combinational therapy is a new trend in medical sciences to achieve maximum therapeutic response with minimal adverse effects. In this study, a polymer-based nanomicellar system was developed to co-deliver an anti-cancer agent and antioxidant. The system showed good colloidal stability and controlled drug release properties. Animal experiments demonstrated improved anti-cancer efficacy and reduced toxicity.
Article
Engineering, Biomedical
Xifa Lan, Quanling Guo, Zhiwei Liu, Kai Liu, Jinfeng He, Ruyu Li, Haotian Sun, Wenxiu Yao, Longgang Wang
Summary: The study introduced a method to prepare DOX-loaded polymyxin E micelles to enhance the therapeutic effect of anticancer drug doxorubicin. The PE-DOX micelles exhibited higher cytotoxicity to cancer cells and showed good biocompatibility and antitumor effect in vivo. The PE-DOX micelles have great potential to be used as anticancer agent in the future.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2022)
Article
Chemistry, Multidisciplinary
Xiaoyan Wang, Lixiong Zeng, Shan Tu, Fei Ye, Zhihui Zhang
Summary: The study demonstrated that calycosin-triblock copolymer nanomicelles could mitigate Doxorubicin-induced cardiotoxicity by reducing ROS and RNS generation, as well as modulating the expression levels of related proteins.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Zhuang Hu, Siyu Han, Nan Nie, Jiwei Wang, Jianshe Hu, Aikebaier Reheman
Summary: In this study, a pH-sensitive nanomicelle drug delivery carrier was constructed using a synthesized triblock copolymer mPEG113-Lysinen-Leucine10 based on methoxypolyethylene glycol, lysine, and leucine. The copolymer formed self-assembled spherical nanomicelles in aqueous solution. The drug-loaded nanomicelles showed uniform dispersion and had an average particle size of about 200 nm, meeting the requirements for sustained release. The nanomicelles exhibited pH responsive drug release and dimensional stability at different temperatures.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Reza Karimi-Soflou, Akbar Karkhaneh
Summary: This study successfully prepared a targeted intracellular doxorubicin delivery system based on redox-sensitive hyaluronic acid-palmitoyl (HA-ss-PA) copolymers, showing good drug loading capacity and encapsulation efficiency, and inducing apoptosis in tumor cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Dinesh Motilal Dhumal, Mrunal Unmesh Patil, Raghavendra Vinayakarao Kulkarni, Krishnacharya Govindacharya Akamanchi
Summary: In this study, the potential of synthesized heterolipids in nano-drug delivery systems was evaluated. The heterolipid HLysA-3 demonstrated self-assembling properties and pH sensitive drug release, making it a promising candidate for cancer therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yunchu Zhang, Tingting Li, Yuzhu Hu, Jing Chen, Yihong He, Xiang Gao, Yan Zhang
Summary: Lung cancer is a common and deadly malignancy. This study developed a method to co-deliver curcumin and doxorubicin using biodegradable materials and peptide-modified polymers, which effectively induced apoptosis and inhibited tumor growth in lung cancer cells.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Qingtao Song, Yilin Liu, Xiaoyong Ding, Miao Feng, Jing Li, Wenjuan Liu, Bohan Wang, Zhongwei Gu
Summary: An active drug delivery platform of Mg micromotors is proposed to overcome MDR and enhance drug permeability for treating HCC. The platform, made of biocompatible materials, allows autonomous motion and increases the diffusion of chemotherapy drugs, leading to improved drug distribution within cells. Moreover, the hydrogen produced during the motion helps eliminate reactive oxygen species in cells. Compared to inert groups, the absorption of drugs from the active micromotors is significantly higher. At a concentration of 1 mg/mL, the micromotors also exhibit enhanced anti-tumor activity, reducing cell proliferation by almost 30%.
Article
Chemistry, Multidisciplinary
Qingtao Song, Yilin Liu, Xiaoyong Ding, Miao Feng, Jing Li, Wenjuan Liu, Bohan Wang, Zhongwei Gu
Summary: An active drug delivery platform of Mg micromotors is proposed to overcome MDR and enhance drug permeability for treating HCC.
Article
Chemistry, Physical
Vahid Mohammadzadeh, Amin Norouzi, Marjan Ghorbani
Summary: Developing pH-sensitive multifunctional nanocomposites for drug targeted delivery and controlled release is a promising approach for cancer treatment. In this study, a nanocomposite of doxorubicin/Lactose@layered double hydroxide-hydroxyapatite was designed and thoroughly analyzed. The nanocomposite showed high encapsulation efficiency, controlled drug release behavior, and strong cytotoxicity against liver cancer cells. These results suggest that the designed nanocomposite could be used for targeted and controlled delivery of anti-cancer drugs and other biomedical applications.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Nanoscience & Nanotechnology
Liu Zi, Wencheng Zhou, Jiake Xu, Junshu Li, Ning Li, Jianguo Xu, Chao You, Chengwei Wang, Meng Tian
Summary: This study developed rosuvastatin-loaded nanomicelles to target neuroinflammation in a mouse model of ICH, which significantly reduced neuron degeneration, inhibited inflammatory cell infiltration, reduced brain edema, and improved neurological deficits. The nanomicelles also promoted the polarization of microglia/macrophages to M2 phenotype and down-regulated proinflammatory cytokines while up-regulating anti-inflammatory cytokines, suggesting potential clinical application for promoting nerve functional recovery in ICH.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Oncology
Zhiyong Li, Jiali Liu, Zheng Sun, Yanli Li, Bin Yu, Feng Zhao, Hongbo Wang, Hui Xu
Summary: A multi-drug delivery system based on polymer micelles was developed to overcome cardiotoxicity associated with doxorubicin (DOX) in breast cancer chemotherapy. The system showed favorable biopharmaceutical properties, maintained the anticancer efficacy and action mechanism of DOX, and provided cardioprotective effect against DOX-induced oxidative stress injuries in tumor-bearing mice.
CANCER NANOTECHNOLOGY
(2022)
Article
Cell Biology
Bao-Biao Zhuo, Lun-Qing Zhu, Chen Yao, Xi-Hua Wang, Shi-Xian Li, Rong Wang, Yuan Li, Zhuo-Yan Ling
Summary: We have shown that ADCK1, a mitochondrial protein, is upregulated in human osteosarcoma tissues and cells. ADCK1 plays a crucial role in cell viability, proliferation, migration, apoptosis, and mitochondrial functions. Inhibition of ADCK1 enhances doxorubicin-induced apoptosis and decreases cell growth. The mTOR pathway is important for ADCK1 expression. ADCK1 is a novel therapeutic target for osteosarcoma.
CELL DEATH & DISEASE
(2022)