Oxidative stress transforms 3CLpro into an insoluble and more active form to promote SARS-CoV-2 replication

Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents

(2021) Vicky Mody et al.   Communications Biology

The serum metabolome of COVID-19 patients is distinctive and predictive

(2021) Ding Shi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A Convenient and Biosafe Replicon with Accessory Genes of SARS-CoV-2 and Its Potential Application in Antiviral Drug Discovery

(2021) Yun-Yun Jin et al.   VIROLOGICA SINICA

SARS-CoV2 infection impairs the metabolism and redox function of cellular glutathione

(2021) Desirée Bartolini et al.   Redox Biology

Emerging coronaviruses: Genome structure, replication, and pathogenesis

(2020) Yu Chen et al.   JOURNAL OF MEDICAL VIROLOGY

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

(2020) Zhenming Jin et al.   NATURE

Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur

(2020) Zhenming Jin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of SARS-CoV-2 3CLpro and anti-COVID-19 drug discovery from medicinal plants

(2020) Muhammad Tahir ul Qamar et al.   Journal of Pharmaceutical Analysis

The Development of Coronavirus 3C-Like Protease (3CLpro) Inhibitors from 2010 to 2020

(2020) Yuzhi Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

3CLpro inhibitors as a potential therapeutic option for COVID-19: Available evidence and ongoing clinical trials

(2020) Mekonnen Sisay   PHARMACOLOGICAL RESEARCH

Quinolines-Based SARS-CoV-2 3CLpro and RdRp Inhibitors and Spike-RBD-ACE2 Inhibitor for Drug-Repurposing Against COVID-19: An in silico Analysis

(2020) Rajaiah Alexpandi et al.   Frontiers in Microbiology

Extracellular acidification induces ROS- and mPTP-mediated death in HEK293 cells

(2018) José Teixeira et al.   Redox Biology

The Cellular Environment Affects Monomeric α-Synuclein Structure

(2018) Amberley D. Stephens et al.   TRENDS IN BIOCHEMICAL SCIENCES

p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis

(2017) Hyunjoo Cha-Molstad et al.   Nature Communications

TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis

(2016) Ji-An Pan et al.   MOLECULAR CELL

SARS and MERS: recent insights into emerging coronaviruses

(2016) Emmie de Wit et al.   NATURE REVIEWS MICROBIOLOGY

Intermolecular disulfide bond formation promotes immunoglobulin aggregation: Investigation by fluorescence correlation spectroscopy

(2014) Moupriya Nag et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

No evident dose-response relationship between cellular ROS level and its cytotoxicity – a paradoxical issue in ROS-based cancer therapy

(2014) Chunpeng Zhu et al.   Scientific Reports

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

(2012) Zhigao Wang et al.   CELL

Hyperactivation of the Mammalian Degenerin MDEG Promotes Caspase-8 Activation and Apoptosis

(2012) Ji-An Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

(2011) Fajian Hou et al.   CELL

Inhibition of Protein Degradation Induces Apoptosis through a Microtubule-Associated Protein 1 Light Chain 3-Mediated Activation of Caspase-8 at Intracellular Membranes

(2011) J.-A. Pan et al.   MOLECULAR AND CELLULAR BIOLOGY

Acidic Environment Leads to ROS-Induced MAPK Signaling in Cancer Cells

(2011) Anne Riemann et al.   PLoS One

Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

(2010) Edith Lubos et al.   ANTIOXIDANTS & REDOX SIGNALING

Genome-Wide Analysis of Protein-Protein Interactions and Involvement of Viral Proteins in SARS-CoV Replication

(2008) Ji'An Pan et al.   PLoS One