Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation

Once-Weekly Semaglutide in Adults with Overweight or Obesity

(2021) John P.H. Wilding et al.   NEW ENGLAND JOURNAL OF MEDICINE

Whole-brain activation signatures of weight-lowering drugs

(2021) Henrik H. Hansen et al.   Molecular Metabolism

Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism

(2021) Diba Borgmann et al.   Cell Metabolism

GIP Receptor Agonism Attenuates GLP-1 Receptor Agonist Induced Nausea and Emesis in Preclinical Models

(2021) Tito Borner et al.   DIABETES

Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding

(2020) Wenwen Cheng et al.   Cell Metabolism

GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats

(2020) Samantha M. Fortin et al.   Science Translational Medicine

Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

(2020) Julia Ast et al.   Nature Communications

Area Postrema Cell Types that Mediate Nausea-Associated Behaviors

(2020) Chuchu Zhang et al.   NEURON

Glucagon-like peptide 1 (GLP-1)

(2019) T.D. Müller et al.   Molecular Metabolism

Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1

(2018) Daniel J. Drucker   Cell Metabolism

Liraglutide Modulates Appetite and Body Weight Through Glucagon-Like Peptide 1 Receptor–Expressing Glutamatergic Neurons

(2018) Jessica M. Adams et al.   DIABETES

Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial

(2018) Juan Pablo Frias et al.   LANCET

LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept

(2018) Tamer Coskun et al.   Molecular Metabolism

Oxytocin-receptor-expressing neurons in the parabrachial nucleus regulate fluid intake

(2017) Philip J. Ryan et al.   NATURE NEUROSCIENCE

A tale of two circuits: CCK NTS neuron stimulation controls appetite and induces opposing motivational states by projections to distinct brain regions

(2017) Carolyn W. Roman et al.   NEUROSCIENCE

Parabrachial CGRP Neurons Control Meal Termination

(2016) Carlos A. Campos et al.   Cell Metabolism

GLP-1 receptors exist in the parietal cortex, hypothalamus and medulla of human brains and the GLP-1 analogue liraglutide alters brain activity related to highly desirable food cues in individuals with diabetes: a crossover, randomised, placebo-controlled trial

(2016) Olivia M. Farr et al.   DIABETOLOGIA

Genetically and functionally defined NTS to PBN brain circuits mediating anorexia

(2016) Carolyn W. Roman et al.   Nature Communications

Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit

(2016) Giuseppe D'Agostino et al.   eLife

Expression and Distribution of Glucagon-Like Peptide-1 Receptor mRNA, Protein and Binding in the Male Nonhuman Primate (Macaca mulatta) Brain

(2015) Kristy M. Heppner et al.   ENDOCRINOLOGY

Parabrachial Nucleus Contributions to Glucagon-Like Peptide-1 Receptor Agonist-Induced Hypophagia

(2015) Jennifer C Swick et al.   NEUROPSYCHOPHARMACOLOGY

A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management

(2015) Xavier Pi-Sunyer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain

(2015) Simon C. Cork et al.   Molecular Metabolism

Hindbrain nucleus tractus solitarius glucagon-like peptide-1 receptor signaling reduces appetitive and motivational aspects of feeding

(2014) Amber L. Alhadeff et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Neuronal GLP1R mediates liraglutide’s anorectic but not glucose-lowering effect

(2014) Stephanie Sisley et al.   JOURNAL OF CLINICAL INVESTIGATION

A Novel Humanized GLP-1 Receptor Model Enables Both Affinity Purification and Cre-LoxP Deletion of the Receptor

(2014) Lucy S. Jun et al.   PLoS One

Exenatide-Induced Reduction in Energy Intake Is Associated With Increase in Hypothalamic Connectivity

(2013) H. Schlogl et al.   DIABETES CARE

Intracellular Signals Mediating the Food Intake-Suppressive Effects of Hindbrain Glucagon-like Peptide-1 Receptor Activation

(2011) Matthew R. Hayes et al.   Cell Metabolism

The Gut Hormones PYY3-36 and GLP-17-36 amide Reduce Food Intake and Modulate Brain Activity in Appetite Centers in Humans

(2011) Akila De Silva et al.   Cell Metabolism

Peripheral and Central GLP-1 Receptor Populations Mediate the Anorectic Effects of Peripherally Administered GLP-1 Receptor Agonists, Liraglutide and Exendin-4

(2011) Scott E. Kanoski et al.   ENDOCRINOLOGY

Caudal Brainstem Processing Is Sufficient for Behavioral, Sympathetic, and Parasympathetic Responses Driven by Peripheral and Hindbrain Glucagon-Like-Peptide-1 Receptor Stimulation

(2008) Matthew R. Hayes et al.   ENDOCRINOLOGY