Management of drug–drug interactions of targeted therapies for haematological malignancies and triazole antifungal drugs

Duration of cytopenias with concomitant venetoclax and azole antifungals in acute myeloid leukemia

(2021) Caitlin R. Rausch et al.   CANCER

The Randomized AMBORA Trial: Impact of Pharmacological/Pharmaceutical Care on Medication Safety and Patient-Reported Outcomes During Treatment With New Oral Anticancer Agents

(2021) Pauline Dürr et al.   JOURNAL OF CLINICAL ONCOLOGY

Hope on the Horizon: Novel Fungal Treatments in Development

(2020) Adriana M Rauseo et al.   Open Forum Infectious Diseases

Isavuconazole as Primary Anti-Fungal Prophylaxis in Patients with Acute Myeloid Leukemia or Myelodysplastic Syndrome: An Open-Label, Prospective, Phase II Study

(2020) Prithviraj Bose et al.   CLINICAL INFECTIOUS DISEASES

Pharmacokinetic Profile of Gilteritinib: A Novel FLT-3 Tyrosine Kinase Inhibitor

(2020) Angela Joubert James et al.   CLINICAL PHARMACOKINETICS

Review of the Novel Investigational Antifungal Olorofim

(2020) Nathan P. Wiederhold   Journal of Fungi

Fosmanogepix: A Review of the First-in-Class Broad Spectrum Agent for the Treatment of Invasive Fungal Infections

(2020) Karen Joy Shaw et al.   Journal of Fungi

Venetoclax penetrates in cerebrospinal fluid and may be effective in CLL with central nervous system involvement.

(2019) Gianluigi Reda et al.   HAEMATOLOGICA

Isavuconazole Prophylaxis in Patients With Hematologic Malignancies and Hematopoietic Cell Transplant Recipients

(2019) Lauren Fontana et al.   CLINICAL INFECTIOUS DISEASES

Extended Dosing Regimens for Fungal Prophylaxis

(2019) Thomas Lehrnbecher et al.   CLINICAL MICROBIOLOGY REVIEWS

Effect of itraconazole, food, and ethnic origin on the pharmacokinetics of ivosidenib in healthy subjects

(2019) David Dai et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Multiple administrations of fluconazole increase plasma exposure to ruxolitinib in healthy adult subjects

(2019) Vassilios Aslanis et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Saprochaete clavata Infections in Patients Undergoing Treatment for Hematological Malignancies: A Report of a Monocentric Outbreak and Review of the Literature

(2019) Marta Stanzani et al.   MYCOSES

Itraconazole Increases Ibrutinib Exposure 10‐Fold and Reduces Interindividual Variation—A Potentially Beneficial Drug‐Drug Interaction

(2019) Tuija Tapaninen et al.   CTS-Clinical and Translational Science

Effect of rifampin and itraconazole on the pharmacokinetics of zanubrutinib (a Bruton's tyrosine kinase inhibitor) in Asian and non-Asian healthy subjects

(2019) Song Mu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline

(2018) A.J. Ullmann et al.   CLINICAL MICROBIOLOGY AND INFECTION

OUP accepted manuscript

(2018)   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Micafungin versus posaconazole prophylaxis in acute leukemia or myelodysplastic syndrome: A randomized study

(2018) David J. Epstein et al.   JOURNAL OF INFECTION

A drug–drug interaction study of ibrutinib with moderate/strong CYP3A inhibitors in patients with B-cell malignancies

(2018) Jan de Jong et al.   LEUKEMIA & LYMPHOMA

Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML

(2018) Courtney D. DiNardo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Individualised medicine: why we need Bayesian dosing

(2017) Joni Donagher et al.   INTERNAL MEDICINE JOURNAL

Randomized comparison of liposomal amphotericin B versus placebo to prevent invasive mycoses in acute lymphoblastic leukaemia

(2017) Oliver A. Cornely et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Precision dosing of targeted anticancer drugs—challenges in the real world

(2017) Hannah Yejin Kim et al.   Translational Cancer Research

Clinical Predictors of Venetoclax Pharmacokinetics in Chronic Lymphocytic Leukemia and Non-Hodgkin’s Lymphoma Patients: a Pooled Population Pharmacokinetic Analysis

(2016) Aksana K. Jones et al.   AAPS Journal

Inhibitory Potential of Antifungal Drugs on ATP-Binding Cassette Transporters P-Glycoprotein, MRP1 to MRP5, BCRP, and BSEP

(2016) Vincent J. C. Lempers et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme

(2016) Andrew G. S. Warrilow et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Clinical Pharmacokinetics and Pharmacodynamics of Bosutinib

(2016) Richat Abbas et al.   CLINICAL PHARMACOKINETICS

Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): a phase 3, randomised-controlled, non-inferiority trial

(2016) Johan A Maertens et al.   LANCET

A cluster ofGeotrichum clavatum(Saprochaete clavata) infection in haematological patients: a first Italian report and review of literature

(2016) Maria Ilaria Del Principe et al.   MYCOSES

Therapeutic Drug Monitoring of Imatinib, Nilotinib, and Dasatinib for Patients with Chronic Myeloid Leukemia

(2015) Masatomo Miura   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Population pharmacokinetic modeling of idelalisib, a novel PI3Kδ inhibitor, in healthy subjects and patients with hematologic malignancies

(2015) Feng Jin et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America

(2015) Peter G. Pappas et al.   CLINICAL INFECTIOUS DISEASES

Epidemiology of invasive fungal diseases among patients with haematological disorders in the Asia-Pacific: a prospective observational study

(2015) L.Y. Hsu et al.   CLINICAL MICROBIOLOGY AND INFECTION

Predicting Drug-Drug Interactions Involving Multiple Mechanisms Using Physiologically Based Pharmacokinetic Modeling: A Case Study With Ruxolitinib

(2015) JG Shi et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Effectiveness of Primary Anti-Aspergillus Prophylaxis during Remission Induction Chemotherapy of Acute Myeloid Leukemia

(2014) M. Z. R. Gomes et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Clinical Candidate VT-1161 Is a Highly Potent Inhibitor of Candida albicans CYP51 but Fails To Bind the Human Enzyme

(2014) A. G. S. Warrilow et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Evaluation of the effect of food and ketoconazole on the pharmacokinetics of the smoothened inhibitor PF-04449913 in healthy volunteers

(2014) M. Naveed Shaik et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Investigation into CYP3A4-mediated drug–drug interactions on midostaurin in healthy volunteers

(2013) Catherine Dutreix et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Effects of Ketoconazole on the Pharmacokinetics of Ponatinib in Healthy Subjects

(2013) Narayana I. Narasimhan et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

(2013) Ulrich M. Zanger et al.   PHARMACOLOGY & THERAPEUTICS

Ascending Single-Dose Study of the Safety Profile, Tolerability, and Pharmacokinetics of Bosutinib Coadministered With Ketoconazole to Healthy Adult Subjects

(2012) Richat Abbas et al.   CLINICAL THERAPEUTICS

Nilotinib population pharmacokinetics and exposure-response analysis in patients with imatinib-resistant or -intolerant chronic myeloid leukemia

(2012) Francis J. Giles et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Plasma exposure of imatinib and its correlation with clinical response in the Tyrosine Kinase Inhibitor Optimization and Selectivity Trial

(2012) F. Guilhot et al.   HAEMATOLOGICA

Variability of Sorafenib Toxicity and Exposure over Time: A Pharmacokinetic/Pharmacodynamic Analysis

(2012) P. Boudou-Rouquette et al.   ONCOLOGIST

On-target and Off-target-based Toxicologic Effects

(2012) Daniel G. Rudmann   TOXICOLOGIC PATHOLOGY

The Effect of CYP3A4 Inhibition or Induction on the Pharmacokinetics and Pharmacodynamics of Orally Administered Ruxolitinib (INCB018424 Phosphate) in Healthy Volunteers

(2011) Jack G. Shi et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Effects of Rifampin and Ketoconazole on the Pharmacokinetics of Nilotinib in Healthy Participants

(2010) Chiaki Tanaka et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Effect of Ketoconazole on the Pharmacokinetics of Oral Bosutinib in Healthy Subjects

(2010) Richat Abbas et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Clinical Relevance of the Pharmacokinetic Interactions of Azole Antifungal Drugs with Other Coadministered Agents

(2009) Roger J. M. Brüggemann et al.   CLINICAL INFECTIOUS DISEASES

Imatinib pharmacokinetics and its correlation with response and safety in chronic-phase chronic myeloid leukemia: a subanalysis of the IRIS study

(2008) R. A. Larson et al.   BLOOD