Article
Multidisciplinary Sciences
Xiaokang He, Fei Yao, Jie Chen, Yan Wang, Xiangming Fang, Xuan Lin, Hui Long, Qiang Wang, Qingming Wu
Summary: The study found that D-dimer levels are closely related to the clinical classification and prognosis of COVID-19 patients, with a D-dimer value of 2.025 mg/L regarded as the optimal probability cutoff for predicting death. Advanced age, male gender, dyspnea symptoms, and some underlying diseases are influencing factors for D-dimer levels.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Bin Yang, Junpeng Fan, Jia Huang, Ensong Guo, Yu Fu, Si Liu, Rourou Xiao, Chen Liu, Funian Lu, Tianyu Qin, Chao He, Zizhuo Wang, Xu Qin, Dianxing Hu, Lixin You, Xi Li, Tian Wang, Peng Wu, Gang Chen, Jianfeng Zhou, Kezhen Li, Chaoyang Sun
Summary: Persistent SARS-CoV-2 infection in COVID-19 patients is associated with immune suppression and reduced expression of ribosomal protein genes, as revealed by single-cell RNA sequencing and other data analysis.
NATURE COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Edouard Charles Le Carpentier, Emmanuel Canet, Damien Masson, Maelle Martin, Guillaume Deslandes, Aurelie Gaultier, Eric Dailly, Ronan Bellouard, Matthieu Gregoire
Summary: In this study, the impact of inflammation on the pharmacokinetics of midazolam in COVID-19 patients was investigated. The results suggest that inflammation could reduce the metabolism of midazolam by CYP3A. Therefore, caution should be exercised when administering drugs metabolized by CYP3A in cases of severe inflammation.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Multidisciplinary Sciences
David Garcia-Azorin, Alvaro Sierra, Javier Trigo, Ana Alberdi, Maria Blanco, Ismael Calcerrada, Ana Cornejo, Miguel Cubero, Ana Gil, Cristina Garcia-Iglesias, Ana Guiomar Lozano, Cristina Martinez Badillo, Carol Montilla, Marta Mora, Gabriela Nunez, Marina Paniagua, Carolina Perez, Maria Rojas, Marta Ruiz, Leticia Sierra, Maria Luisa Hurtado, Angel Luis Guerrero Peral
Summary: Headache occurred in 23.4% of patients with confirmed COVID-19, being more intense in females. Headache was the most frequent first symptom of COVID-19, with characteristics of being bilateral with pressing quality and typically lasting for 7 days.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Shaul Lev, Tamar Gottesman, Gal Sahaf Levin, Doron Lederfein, Evgeny Berkov, Dror Diker, Aliza Zaidman, Amir Nutman, Tahel Ilan Ber, Alon Angel, Lior Kellerman, Eran Barash, Roy Navon, Olga Boico, Yael Israeli, Michal Rosenberg, Amir Gelman, Roy Kalfon, Einav Simon, Noa Avni, Mary Hainrichson, Oren Zarchin, Tanya M. Gottlieb, Kfir Oved, Eran Eden, Boaz Tadmor
Summary: This single-center cohort study found that IP-10 levels correlated with COVID-19 severity and admission to the intensive care unit, and corticosteroid therapy significantly decreased IP-10 levels. Serial IP-10 measurements may serve as an actionable aid in managing inflammation and guiding therapeutic decisions in COVID-19 patients.
Article
Multidisciplinary Sciences
Lior Prozan, Eden Shusterman, Jacob Ablin, Alexis Mitelpunkt, Ahuva Weiss-Meilik, Amos Adler, Guy Choshen, Orli Kehat
Summary: NLR at admission is lower and has more prognostic value in COVID-19 patients when compared to Influenza and RSV. In COVID-19 group, high NLR above 6.82 was identified as a prognostic factor for poor clinical outcome.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Jianbo Tian, Ming Zhang, Meng Jin, Fengqin Zhang, Qian Chu, Xiaoyang Wang, Can Chen, Huihui Yue, Li Zhang, Ronghui Du, Dong Zhao, Zhaofu Zeng, Yang Zhao, Kui Liu, Mengmei Wang, Ke Hu, Xiaoping Miao, Huilan Zhang
Summary: This study found that tocilizumab treatment in COVID-19 patients can lower the risk of in-hospital death and acute respiratory distress syndrome. Patients had heightened inflammation and dysregulated immune cells before treatment, but these indicators improved after tocilizumab administration.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anna Lebedeva, Ivan Molodtsov, Alexandra Anisimova, Anastasia Berestovskaya, Oleg Dukhin, Antonina Elizarova, Wendy Fitzgerald, Darya Fomina, Kseniya Glebova, Oxana Ivanova, Anna Kalinskaya, Anastasia Lebedeva, Maryana Lysenko, Elena Maryukhnich, Elena Misyurina, Denis Protsenko, Alexander Rosin, Olga Sapozhnikova, Denis Sokorev, Alexander Shpektor, Daria Vorobyeva, Elena Vasilieva, Leonid Margolis
Summary: COVID-19 patients with cytokine storm syndrome (CSS) and those without formed distinct clusters based on their cytokine concentrations. However, the administration of tocilizumab therapy did not fully correspond to these CSS clusters. IL-1RA was found to be prognostically significant in both groups and may be useful in defining the onset of a cytokine storm and indicating anti-cytokine therapy in COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Shun Wang, Mengqian Hao, Zishu Pan, Jinzhi Lei, Xiufen Zou
Summary: The study developed a multi-scale computational model to quantitatively understand the heterogeneous progression of COVID-19 patients infected with SARS-CoV-2, revealing the roles of host antiviral state, IFN production rate, and T cell exhaustion in regulating the disease progression. Different therapeutic strategies were evaluated, with single antiviral therapy found sufficient for moderate patients and combination therapies needed for severe patients. The study provides insights into the potential guidance for personalized therapy in COVID-19 patients.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Satoshi Ikeda, Toshihiro Misumi, Shinyu Izumi, Keita Sakamoto, Naoki Nishimura, Shosei Ro, Koichi Fukunaga, Satoshi Okamori, Natsuo Tachikawa, Nobuyuki Miyata, Masaharu Shinkai, Masahiro Shinoda, Yasunari Miyazaki, Yuki Iijima, Takehiro Izumo, Minoru Inomata, Masaki Okamoto, Tomoyoshi Yamaguchi, Keisuke Iwabuchi, Makoto Masuda, Hiroyuki Takoi, Yoshitaka Oyamada, Shigeki Fujitani, Masamichi Mineshita, Haruyuki Ishii, Atsushi Nakagawa, Nobuhiro Yamaguchi, Makoto Hibino, Kenji Tsushima, Tatsuya Nagai, Satoru Ishikawa, Nobuhisa Ishikawa, Yasuhiro Kondoh, Yoshitaka Yamazaki, Kyoko Gocho, Tomotaka Nishizawa, Akifumi Tsuzuku, Kazuma Yagi, Yuichiro Shindo, Yuriko Takeda, Takeharu Yamanaka, Takashi Ogura
Summary: The study indicated that the use of corticosteroids in COVID-19 patients did not improve clinical status on Day 15, but reduced the time to improvement in radiological findings for all patients regardless of disease severity and also reduced the duration of invasive mechanical ventilation in patients who required intubation.
SCIENTIFIC REPORTS
(2021)
Article
Virology
Fares Qeadan, Benjamin Tingey, Lily Y. Gu, Ashley Hafen Packard, Esther Erdei, Ali I. Saeed
Summary: This study aimed to determine the optimal serum cutoff values for ferritin and D-dimer in COVID-19 patients, with findings showing that females generally have lower optimal cutoff values compared to males. The research provides insight for healthcare professionals to predict clinical outcomes and allocate resources appropriately during the COVID-19 pandemic.
Article
Health Care Sciences & Services
Al Shaimaa Ibrahim Rabie, Hager Salah, Amira S. A. Said, Ahmed Hassan Shaaban, Lamya Mohamed Abdou, Doaa Mahmoud Khalil, Zelal Kharaba, Hala Afifi, Mahmoud R. Sofy, Eman M. I. Youssef, Eman S. M. Bayoumy, Raghda R. S. Hussein
Summary: There are currently no therapeutic medications for severe COVID-19 infection. Tocilizumab, an immunomodulatory treatment, was hypothesized to reduce inflammation in the respiratory system and prevent the need for ventilators. However, a randomized controlled trial found that tocilizumab was ineffective in preventing intubation or death in hospitalized patients with severe illness and COVID-19.
Article
Medicine, General & Internal
Felicia Marc, Corina Maria Moldovan, Anica Hoza, Sorina Magheru, Gabriela Ciavoi, Dorina Maria Farcas, Liliana Sachelarie, Gabriela Calin, Laura Romila, Daniela Damir, Alexandru Gratian Naum
Summary: This study investigated the treatment of cytokine storms in patients with moderate and severe COVID-19 pneumonia, comparing the effects of Tocilizumab and Anakinra. The results showed favorable clinical and biochemical effects of both immunomodulators.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Amir Vahedian-Azimi, Mitra Abbasifard, Farshid Rahimi-Bashar, Paul C. Guest, Muhammed Majeed, Asadollah Mohammadi, Maciej Banach, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: This systematic review investigates the efficacy of curcumin supplementation in COVID-19 patients. The findings suggest that curcumin supplementation can significantly decrease symptoms, duration of hospitalization, and deaths. It also shows that curcumin helps balance pro-inflammatory and anti-inflammatory factors, improving the cytokine storm effect. Overall, curcumin supplementation may offer a safe and effective option for improving COVID-19 disease outcomes.
Review
Medicine, Research & Experimental
Jae Seok Kim, Jun Young Lee, Jae Won Yang, Keum Hwa Lee, Maria Effenberger, Wladimir Szpirt, Andreas Kronbichler, Jae Il Shin
Summary: Severe COVID-19 is characterized by systemic hyper-inflammation and cytokine storm, often leading to acute respiratory distress syndrome and multiple organ failure. Treatment of COVID-19 cytokine storm is crucial, with anti-inflammatory therapies playing a significant role. Various approaches are being used, including new cytokine-targeted therapies, to address the cytokine storm associated with COVID-19.
Article
Medicine, Research & Experimental
L. V. Pozdniak, A. N. Chernov, N. M. Chekan, N. M. Beliauski, V. V. Akulich, G. G. Poljanskaya, A. I. Gordienko, V. A. Kulchitsky
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2009)
Article
Materials Science, Multidisciplinary
N. M. Chekan, N. M. Beliauski, V. V. Akulich, L. V. Pozdniak, E. K. Sergeeva, A. N. Chernov, V. V. Kazbanov, V. A. Kulchitsky
DIAMOND AND RELATED MATERIALS
(2009)
Article
Genetics & Heredity
Anton E. Shikov, Yury A. Barbitoff, Andrey S. Glotov, Maria M. Danilova, Ziravard N. Tonyan, Yulia A. Nasykhova, Anastasia A. Mikhailova, Olesya N. Bespalova, Roman S. Kalinin, Azizahon M. Mirzorustamova, Igor Yu Kogan, Vladislav S. Baranov, Alexander N. Chernov, Dragana M. Pavlovich, Sergey Azarenko, Mikhail A. Fedyakov, Victoria V. Tsay, Yuri A. Eismont, Olga Romanova, Dmitry N. Hobotnikov, Dmitry A. Vologzhanin, Sergei Mosenko, Tatiana A. Ponomareva, Yana A. Talts, Anna U. Anisenkova, Dmitrii G. Lisovets, Andrey M. Sarana, Stanislav P. Urazov, Sergey G. Scherbak, Oleg S. Glotov
FRONTIERS IN GENETICS
(2020)
Review
Genetics & Heredity
O. S. Glotov, A. N. Chernov, S. G. Scherbak, V. S. Baranov
Summary: The COVID-19 pandemic has caused significant damage worldwide, highlighting the importance of identifying individual genetic susceptibility and gene variants for disease diagnosis, prognosis, and treatment. Research shows that genetic variants in both the virus and the human body can affect the transmissibility and severity of COVID-19 infection, as well as individual response to drugs and vaccines.
RUSSIAN JOURNAL OF GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Alexandr N. Chernov, Anna Tsapieva, Diana A. Alaverdian, Tatiana A. Filatenkova, Elvira S. Galimova, Mariia Suvorova, Olga V. Shamova, Alexander N. Suvorov
Summary: Glioblastoma, as a major type of brain cancer, is difficult to treat. In this study, the researchers investigated new approaches for the treatment of glioblastoma. They found that live S. pyogenes and certain peptides showed high antitumor efficiency against glioma cells, surpassing the effect of chemotherapeutics. Additionally, combinations of certain peptides with chemotherapeutics displayed synergistic effects.
Article
Genetics & Heredity
Sergey G. Shcherbak, Anton Changalidi, Yury A. Barbitoff, Anna Yu Anisenkova, Sergei Mosenko, Zakhar P. Asaulenko, Victoria V. Tsay, Dmitrii E. Polev, Roman S. Kalinin, Yuri A. Eismont, Andrey S. Glotov, Evgeny Y. Garbuzov, Alexander N. Chernov, Olga A. Klitsenko, Mikhail O. Ushakov, Anton E. Shikov, Stanislav P. Urazov, Vladislav S. Baranov, Oleg S. Glotov
Summary: The COVID-19 pandemic has sparked interest in the interaction between pathogen and host genomes, with studies identifying candidate genes and genetic variants associated with quantitative traits in COVID-19 patients. These findings may contribute to the identification of genetic risk factors for severe COVID-19.
Article
Biochemistry & Molecular Biology
Alexandr N. Chernov, Tatiana A. Filatenkova, Ruslan Glushakov, Alexandra S. Buntovskaya, Diana A. Alaverdian, Anna N. Tsapieva, Alexandr Kim, Evgeniy Fedorov, Sofia S. Skliar, Marina Matsko, Elvira S. Galimova, Olga Shamova
Summary: This study investigated the effects of nerve growth factor (NGF), human cathelicidin (LL-37), protegrin-1 (PG-1), and temozolomide on bioenergetic function, clonogenicity, and migration of human U251 glioma cells. The results showed that LL-37 and NGF have anti-proliferative and anti-migratory effects on U251 glioma cells, indicating their potential therapeutic use for gliomas.
Article
Pharmacology & Pharmacy
Alexandr Chernov, Daria Kilina, Tatiana Smirnova, Elvira Galimova
Summary: The ABCB1 genetic variants, particularly the C1236T, G2677T/A, and C3435T SNPs, are significantly associated with a negative response to cyclosporine therapy in Russian psoriasis patients. Further studies are needed to validate these findings in different ethnic populations prior to clinical application.
Article
Biochemistry & Molecular Biology
Stanislav Urazov, Alexandr Chernov, Oleg Popov, Natalya Klenkova, Natalya Sushentseva, Irina Polkovnikova, Svetlana Apalko, Kseniya Kislyuk, Dragana Pavlovich, Andrey Ivanov, Sergey Shcherbak
Summary: This study aimed to analyze the levels of IL-6 and sPLA2 in the blood of COVID-19 patients and compare them with the severity and outcome of the disease. The results showed that high levels of IL-6 and sPLA2 significantly increase the severity and risk of death from COVID-19 infection. Therefore, IL-6 and sPLA2 can be considered as early predictors of aggravation of COVID-19 infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Vladimir A. Kulchitsky, Vladimir I. Potkin, Yuri S. Zubenko, Alexander N. Chernov, Michael V. Talabaev, Yuri E. Demidchik, Sergei K. Petkevich, Vladimir V. Kazbanov, Tatiana A. Gurinovich, Margarita O. Roeva, Dmitry G. Grigoriev, Alexei V. Kletskov, Vladimir N. Kalunov
MEDICINAL CHEMISTRY
(2012)