Article
Immunology
Lea Meyer, Isoline Duquenois, Stacy Gellenoncourt, Marie Pellerin, Ailona Marcadet-Hauss, Nicole Pavio, Virginie Doceul
Summary: Hepatitis E virus (HEV) is a common cause of enterically transmitted acute hepatitis worldwide. Swine are the main reservoir of zoonotic HEV and can control the virus pathogenesis. Interferon-stimulated genes (ISGs) can restrict the replication of HEV.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Virology
Hankun Wang, Weijian Peng, Jialin Wang, Chunling Zhang, Wangchun Zhao, Yanhong Ran, Xiaoping Yang, Jun Chen, Hongjian Li
Summary: This study discovered that Interferon-? (IFN-?) plays a crucial role in innate immune responses against human cytomegalovirus (HCMV). It was found that the HCMV tegument protein UL23 could regulate the expression of many IFN-? stimulated genes (ISGs) under IFN-? treatment or HCMV infection. The study also demonstrated that APOL1, CMPK2, and LGALS9, among the ISGs, inhibit HCMV replication and show a synergistic effect. UL23 appears to counteract the antiviral effect of IFN-? by downregulating the expression of APOL1, CMPK2, and LGALS9.
Article
Biochemistry & Molecular Biology
Michael J. T. McFadden, Matthew T. A. Sacco, Kristen A. Murphy, Moonhee S. Park, Nandan S. Y. Gokhale, Kim Y. M. Somfleth, Stacy M. Horner
Summary: This study reveals the role of RNA demethylase FTO in the type I interferon response. FTO negatively regulates the interferon response by suppressing the transcription of a subset of ISGs, independent of its effect on m(6)Am. Depletion of FTO also activates the transcription factor STAT3, leading to increased expression of a subset of ISGs.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Immunology
Priyanka Talukdar, Beth F. Junecko, Daniel S. Lane, Pauline Maiello, Joshua T. Mattila
Summary: IFN-λ is expressed in granulomas and may influence myeloid cell function and immunity in tuberculosis. The expression of IFN-λ varies in different granuloma microenvironments, primarily expressed by macrophages and neutrophils, with differences in subcellular localization.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Rebecca L. Casazza, Drake T. Philip, Helen M. Lazear
Summary: IFN-lambda has antiviral effects during pregnancy, but its effects depend on the gestational stage. Infection with ZIKV earlier in pregnancy enhances transplacental transmission. IFN-lambda signaling in maternal tissues causes fetal resorption and intrauterine growth restriction in dams with robust ZIKV infection. Maternal IFN-lambda signaling also contributes to pregnancy pathology induced by poly(I.C) treatment.
Review
Immunology
Dan Zhang, Aaron T. Irving
Summary: The interferon pathway is the first line of defense against viral infections in mammals, and it induces the expression of interferon-stimulated genes (ISGs). The antiviral function of ISGs has been extensively studied in mice and humans. Bats, as an important viral reservoir, can coexist with pathogenic viruses without showing signs of disease, but limited data are available on the role of ISGs in bats. This review summarizes the current understanding of conserved and bat-specific ISGs and their known antiviral functions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Immunology
Jiahui Ding, Anthony Maxwell, Nicholas Adzibolosu, Anna Hu, Yuan You, Aihua Liao, Gil Mor
Summary: Pregnancy is a unique condition where the maternal immune system adapts in response to fetal development and environmental signals. The placenta plays a crucial role in regulating maternal immune function and protecting the fetus from dangerous signals. Type I interferon and its downstream genes are important for maintaining pregnancy and responding to infections. Disruption of this signaling pathway can lead to complications and compromise fetal development.
IMMUNOLOGICAL REVIEWS
(2022)
Review
Immunology
Jiashu Han, Mengwei Wu, Ziwen Liu
Summary: Interferon-gamma (IFN-γ) is crucial for determining immunotherapy responsiveness. It promotes immune cell activation and tumor cell apoptosis, but tumor cells can develop IFN-γ resistance, acquiring stemness characteristics and expressing immunosuppressive molecules. This review summarizes the potential mechanisms of IFN-γ resistance and highlights the importance of elucidating these mechanisms to improve immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Margherita Boieri, Emanuela Marchese, Quan Minh Pham, Marjan Azin, Lauren E. Steidl, Anna Malishkevich, Shadmehr Demehri
Summary: Research shows that TSLP-activated CD4(+) T cells have antitumor effects in advanced breast cancer by inducing cancer cells into a senescent-like state. Inflammatory CD4(+) T cells release interferon-gamma and tumor necrosis factor-alpha, which directly affects cancer cell receptors, driving them into senescence.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Virology
Carolina Scagnolari, Alessandra Pierangeli, Federica Frasca, Camilla Bitossi, Agnese Viscido, Giuseppe Oliveto, Mirko Scordio, Laura Mazzuti, Daniele Di Carlo, Massimo Gentile, Angelo Solimini, Giancarlo Ceccarelli, Francesco Pugliese, Claudio Maria Mastroianni, Gabriella d'Ettorre, Ombretta Turriziani, Guido Antonelli
Summary: The heterogeneous patterns of IFN-I/III response in the respiratory tract of COVID-19 patients may be associated with disease severity.
Article
Cell Biology
Manjarika De, Anand Bhushan, Sreedhar Chinnaswamy
Summary: Human IFN-lambda 4 is expressed by individuals with the Delta G variant allele at rs368234815 and may influence immune responses through immunomodulation. Studies indicate that IFN-lambda 4 has lower specific activity compared to IFN-lambda 3 in certain environments, potentially playing a role in promoting Th2-biased immune responses.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Microbiology
Chandrika Senthilkumaran, Andrea L. Kroeker, Gregory Smith, Carissa Embury-Hyatt, Brad Collignon, Elizabeth Ramirez-Medina, Paul A. Azzinaro, Bradley S. Pickering, Fayna Diaz-San Segundo, Hana M. Weingartl, Teresa de los Santos
Summary: This study tested the use of a specific viral vector to deliver porcine interferon and limit Ebola virus replication and shedding in pigs. The results showed that treated pigs did not develop clinical symptoms, had reduced viral load and shedding, and displayed an upregulation of immune and inflammatory responses. This treatment approach has the potential to limit the spread of Ebola virus in pigs.
Article
Virology
Connor G. G. Bamford, Elihu Aranday-Cortes, Ricardo Sanchez-Velazquez, Catrina Mullan, Alain Kohl, Arvind H. Patel, Sam J. Wilson, John McLauchlan
Summary: The cellular gene ARHGEF3 has been found to inhibit the replication of HCV and other Flaviviridae viruses, and this activity is conserved between humans and rhesus macaques.
Article
Developmental Biology
Magdalina J. Cummings, Hongyao Yu, Sudikshya Paudel, Guang Hu, Xiaoling Li, Myriam Hemberger, Xiaoqiu Wang
Summary: A distinct age-related alteration in the uterine environment has been identified as a prevalent cause of reproductive decline in older female mice. Sirtuin 1 (SIRT1), a multifunctional enzyme involved in regulating cell viability, senescence, and inflammation during aging, is reduced in aged decidua. Uterine-specific ablation of Sirt1 gene accelerates premature uterine aging and impairs invasion and spacing of blastocysts, as well as decidualization of stromal cells.
MOLECULAR HUMAN REPRODUCTION
(2022)
Review
Immunology
Kumaraswami Chintala, Krishnaveni Mohareer, Sharmistha Banerjee
Summary: Host restriction factors have a significant impact on the viral life cycle, particularly through interferon induction, but HIV-1 can counteract these mechanisms through its encoded components.
FRONTIERS IN IMMUNOLOGY
(2021)