Rapid Identification of the Tumor-Specific Reactive TIL Repertoire via Combined Detection of CD137, TNF, and IFNγ, Following Recognition of Autologous Tumor-Antigens

T cells expanded from renal cell carcinoma display tumor-specific CD137 expression but lack significant IFN-γ, TNF-α or IL-2 production

(2021) Saskia D. van Asten et al.   OncoImmunology

In vitro 4-1BB stimulation promotes expansion of CD8+ tumor-infiltrating lymphocytes from various sarcoma subtypes

(2020) Morten Nielsen et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

BIOMEX: an interactive workflow for (single cell) omics data interpretation and visualization

(2020) Federico Taverna et al.   NUCLEIC ACIDS RESEARCH

Overcoming genetically-based resistance mechanisms to PD-1 blockade

(2020) Davis Y. Torrejon et al.   Cancer Discovery

Adoptive cell therapy in combination with checkpoint inhibitors in ovarian cancer

(2020) Anders Handrup Kverneland et al.   Oncotarget

CD39 identifies the CD4+ tumor-specific T cell population in human cancer

(2020) Kim E Kortekaas et al.   Cancer Immunology Research

Neoantigen-Specific Adoptive Cell Therapies for Cancer: Making T-Cell Products More Personal

(2020) Valentina Bianchi et al.   Frontiers in Immunology

Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer

(2020) Sri Krishna et al.   SCIENCE

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

(2019) Moshe Sade-Feldman et al.   CELL

Tumour-reactive T cell subsets in the microenvironment of ovarian cancer

(2019) Marie Christine Wulff Westergaard et al.   BRITISH JOURNAL OF CANCER

T cells isolated from patients with checkpoint inhibitor-resistant melanoma are functional and can mediate tumor regression

(2018) R Andersen et al.   ANNALS OF ONCOLOGY

Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing

(2018) Xinyi Guo et al.   NATURE MEDICINE

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

(2018) Thomas Duhen et al.   Nature Communications

Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates

(2018) Yannick Simoni et al.   NATURE

1132PDClinical efficacy of T-cell therapy after short-term BRAF-inhibitor induction in checkpoint inhibitor resistant metastatic melanoma patients

(2018) T H Borch et al.   ANNALS OF ONCOLOGY

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

(2018) Livnat Jerby-Arnon et al.   CELL

Differential effects of corticosteroids and anti-TNF on tumor-specific immune responses: implications for the management of irAEs

(2018) Arianna Draghi et al.   INTERNATIONAL JOURNAL OF CANCER

Lineage tracking reveals dynamic relationships of T cells in colorectal cancer

(2018) Lei Zhang et al.   NATURE

Bystander T Cells: A Balancing Act of Friends and Foes

(2018) Sarah K. Whiteside et al.   TRENDS IN IMMUNOLOGY

CD137 is a Useful Marker for Identifying CD4+ T Cell Responses to Mycobacterium tuberculosis

(2017) Z.-h. Yan et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma

(2017) Martin Lauss et al.   Nature Communications

Isolation of T-Cell Receptors Specifically Reactive with Mutated Tumor-Associated Antigens from Tumor-Infiltrating Lymphocytes Based on CD137 Expression

(2016) Maria Parkhurst et al.   CLINICAL CANCER RESEARCH

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

(2016) I. Tirosh et al.   SCIENCE

Efficient Gene Disruption in Cultured Primary Human Endothelial Cells by CRISPR/Cas9Novelty and Significance

(2015) Parwiz Abrahimi et al.   CIRCULATION RESEARCH

T cell receptor binding affinity governs the functional profile of cancer-specific CD8+T cells

(2015) M. P. Tan et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

CD8+CD103+Tumor–Infiltrating Lymphocytes Are Tumor-Specific Tissue-Resident Memory T Cells and a Prognostic Factor for Survival in Lung Cancer Patients

(2015) Fayçal Djenidi et al.   JOURNAL OF IMMUNOLOGY

PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors

(2014) Alena Gros et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation-induced CD137 is a fast assay for identification and multi-parameter flow cytometric analysis of alloreactive T cells

(2013) N. H. R. Litjens et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Tumor-Infiltrating Lymphocytes Expressing the Tissue Resident Memory Marker CD103 Are Associated with Increased Survival in High-Grade Serous Ovarian Cancer

(2013) J. R. Webb et al.   CLINICAL CANCER RESEARCH

CD137 Accurately Identifies and Enriches for Naturally Occurring Tumor-Reactive T Cells in Tumor

(2013) Q. Ye et al.   CLINICAL CANCER RESEARCH

Sprouty-2 regulates HIV-specific T cell polyfunctionality

(2013) Yen-Ling Chiu et al.   JOURNAL OF CLINICAL INVESTIGATION

Elevated Granzyme B in Cytotoxic Lymphocytes is a Signature of Immune Activation in Hemophagocytic Lymphohistiocytosis

(2013) Sabine Mellor-Heineke et al.   Frontiers in Immunology

Preformed CD40L Is Stored in Th1, Th2, Th17, and T Follicular Helper Cells as Well as CD4+8− Thymocytes and Invariant NKT Cells but Not in Treg Cells

(2012) Yoshinobu Koguchi et al.   PLoS One

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Characterization and Comparison of ‘Standard’ and ‘Young’ Tumour-Infiltrating Lymphocytes for Adoptive Cell Therapy at a Danish Translational Research Institution

(2011) M. Donia et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired

(2009) M. Ahmadzadeh et al.   BLOOD

Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma

(2009) Wendy Anne Boivin et al.   LABORATORY INVESTIGATION

Standardization and optimization of multiparameter intracellular cytokine staining

(2008) Laurel Nomura et al.   CYTOMETRY PART A

Active and zymogen forms of granzyme B are constitutively released from cytotoxic lymphocytes in the absence of target cell engagement

(2008) Monica D Prakash et al.   IMMUNOLOGY AND CELL BIOLOGY

Rapid identification and sorting of viable virus-reactive CD4+ and CD8+ T cells based on antigen-triggered CD137 expression

(2008) Thomas C. Wehler et al.   JOURNAL OF IMMUNOLOGICAL METHODS