An Intranasal OMV-Based Vaccine Induces High Mucosal and Systemic Protecting Immunity Against a SARS-CoV-2 Infection

Association of Age With Likelihood of Developing Symptoms and Critical Disease Among Close Contacts Exposed to Patients With Confirmed SARS-CoV-2 Infection in Italy

(2021) Piero Poletti et al.   JAMA Network Open

Vaccination with meningococcal outer membrane vesicles carrying Borrelia OspA protects against experimental Lyme borreliosis

(2021) M.J. Klouwens et al.   VACCINE

Mucosal and transdermal vaccine delivery strategies against COVID-19

(2021) Ashwini Kumar et al.   Drug Delivery and Translational Research

A Structural Landscape of Neutralizing Antibodies Against SARS-CoV-2 Receptor Binding Domain

(2021) Ling Niu et al.   Frontiers in Immunology

Six months of COVID vaccines: what 1.7 billion doses have taught scientists

(2021) Heidi Ledford   NATURE

COVID vaccines protect against Delta, but their effectiveness wanes

(2021) Katharine Sanderson   NATURE

Spike D614G — A Candidate Vaccine Antigen Against Covid-19

(2021) Paul-Albert Koenig et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS-CoV-2 escape from a highly neutralizing COVID-19 convalescent plasma

(2021) Emanuele Andreano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scent of a vaccine

(2021) Frances E. Lund et al.   SCIENCE

A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters

(2021) Yangtao Wu et al.   Science Translational Medicine

Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces viral shedding after SARS-CoV-2 D614G challenge in preclinical models

(2021) Neeltje van Doremalen et al.   Science Translational Medicine

Immunogenicity and protective efficacy of an intranasal live-attenuated vaccine against SARS-CoV-2

(2021) Jun-Gyu Park et al.   iScience

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Human neutralizing antibodies elicited by SARS-CoV-2 infection

(2020) Bin Ju et al.   NATURE

Intranasal immunization with outer membrane vesicle pertussis vaccine confers broad protection through mucosal IgA and Th17 responses

(2020) René H. M. Raeven et al.   Scientific Reports

Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus

(2020) Bette Korber et al.   CELL

SARS‐CoV‐2 S1 is superior to the RBD as a COVID‐19 subunit vaccine antigen

(2020) Yunfei Wang et al.   JOURNAL OF MEDICAL VIROLOGY

Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike

(2020) Lihong Liu et al.   NATURE

Structure-based design of prefusion-stabilized SARS-CoV-2 spikes

(2020) Ching-Lin Hsieh et al.   SCIENCE

Distinct conformational states of SARS-CoV-2 spike protein

(2020) Yongfei Cai et al.   SCIENCE

Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

(2020) Leonid Yurkovetskiy et al.   CELL

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

IgA dominates the early neutralizing antibody response to SARS-CoV-2

(2020) Delphine Sterlin et al.   Science Translational Medicine

Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis

(2020) Natalia G. Herrera et al.   ACS Omega

Spontaneously released Neisseria meningitidis outer membrane vesicles as vaccine platform: production and purification

(2019) Matthias J.H. Gerritzen et al.   VACCINE

Synergistic Protective Activity of Tumor-Specific Epitopes Engineered in Bacterial Outer Membrane Vesicles

(2017) Alberto Grandi et al.   Frontiers in Oncology

The human cathelicidin LL-37 — A pore-forming antibacterial peptide and host-cell modulator

(2016) Daniela Xhindoli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Surface display of a borrelial lipoprotein on meningococcal outer membrane vesicles

(2016) Merijn L.M. Salverda et al.   VACCINE

Current prospects and future challenges for nasal vaccine delivery

(2016) Helmy Yusuf et al.   Human Vaccines & Immunotherapeutics

Improved Production Process for Native Outer Membrane Vesicle Vaccine against Neisseria meningitidis

(2013) Bas van de Waterbeemd et al.   PLoS One

In Vivo Adaptation and Persistence of Neisseria meningitidis within the Nasopharyngeal Mucosa

(2013) Kay O. Johswich et al.   PLoS Pathogens

Nonclinical vaccine safety evaluation: advantages of continuous temperature monitoring using abdominally implanted data loggers

(2012) Patricia Kaaijk et al.   JOURNAL OF APPLIED TOXICOLOGY

Identification and optimization of critical process parameters for the production of NOMV vaccine against Neisseria meningitidis

(2012) Bas van de Waterbeemd et al.   VACCINE

Mucosal IgA responses in influenza virus infections; thoughts for vaccine design

(2012) Elly van Riet et al.   VACCINE

Preclinical safety and immunogenicity evaluation of a nonavalent PorA native outer membrane vesicle vaccine against serogroup B meningococcal disease

(2012) Patricia Kaaijk et al.   VACCINE

A phase 1 study of a meningococcal native outer membrane vesicle vaccine made from a group B strain with deleted lpxL1 and synX, over-expressed factor H binding protein, two PorAs and stabilized OpcA expression

(2011) P.B. Keiser et al.   VACCINE

Improved OMV vaccine against Neisseria meningitidis using genetically engineered strains and a detergent-free purification process

(2010) Bas van de Waterbeemd et al.   VACCINE