Article
Immunology
Wei Xu, Feiwei Cao, Ming Zhao, Xinyu Fu, Siyuan Yin, Yijia Sun, Teresa G. Valencak, Daxi Ren
Summary: This study found that EPS-3A, a lactic acid bacteria-derived exopolysaccharide, can activate macrophages through the MAPK and NF-kappa B signaling pathways, thereby promoting immune responses. The results also suggest that the recognition of EPS-3A is partially mediated by TLR2 and TLR4 receptors.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Parasitology
Hongyu Li, Yihan Chen, Yunhuan Zhu, Yilu Feng, Yuncheng Qian, Xiaoyu Ye, Jiatong Xu, Hanyu Yang, Jiawei Yu, Jingyu Chen, Keda Chen
Summary: Schistosomiasis, a major parasitic disease, primarily affects economically underdeveloped tropical regions. Controlling the life cycle of intermediate host snails is crucial for preventing and controlling the disease. Exploring the immune interactions between the snails and schistosomes can provide valuable insights for further research and the development of comprehensive strategies.
PARASITES & VECTORS
(2023)
Article
Biochemistry & Molecular Biology
Feng Wang, Frank Stappenbeck, Liu-Ya Tang, Ying E. Zhang, Simon T. Hui, Aldons J. Lusis, Farhad Parhami
Summary: Inflammatory responses are crucial for protecting against infections and maintaining health. Many diseases involve chronic inflammation, but current anti-inflammatory drugs often have adverse effects for long-term use. Therefore, the development of effective and non-toxic anti-inflammatory drugs is important. A semi-synthetic oxysterol called Oxy210 and its analogs have been found to exhibit anti-inflammatory effects in both animal models and cell experiments, making them potential candidates for future therapeutic development against inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jian Zhao, Baoshan Cai, Zhugui Shao, Lei Zhang, Yi Zheng, Chunhong Ma, Fan Yi, Bingyu Liu, Chengjiang Gao
Summary: The study reveals that TRIM26 positively regulates TAK1 activation by ubiquitinating its binding partner TAB1. Trim26 deficiency reduces the induction of inflammatory cytokines, protecting mice from septic shock and attenuating the severity of colitis.
CELL DEATH AND DIFFERENTIATION
(2021)
Review
Cell Biology
Valerie Lannoy, Anthony Cote-Biron, Claude Asselin, Nathalie Rivard
Summary: Phosphatases are important regulators of TLRs signaling and may represent novel therapeutic targets to control pathogenic TLRs signaling.
CELL COMMUNICATION AND SIGNALING
(2021)
Review
Nutrition & Dietetics
Eric C. Bredahl, Joan M. Eckerson, Steven M. Tracy, Thomas L. McDonald, Kristen M. Drescher
Summary: The use of dietary supplements has become increasingly common over the past 20 years, extending beyond elite athletes to include recommendations from healthcare professionals to patients. Creatine is a widely used supplement that has been well-studied for its positive effects on performance and health, especially in recovery from exercise. However, limited research exists on the effects of creatine on children and the elderly.
Review
Pharmacology & Pharmacy
Imene Arab, Jeongkwang Park, Jae-Joon Shin, Hyeung-Seob Shin, Kyoungho Suk, Won-Ha Lee
Summary: This review provides an overview of the interactions among macrophages, cancer cells, and endothelial cells in the tumor microenvironment, as well as the role of tumor-associated lncRNAs in macrophage functionality and cancer progression. The study highlights the therapeutic potential of manipulating macrophage lncRNA activity in the treatment of cancer.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Soudeh Ghafouri-Fard, Atefe Abak, Shamim Tavakkoli Avval, Hamed Shoorei, Mohammad Taheri, Mohammad Samadian
Summary: Macrophage polarization is a process where macrophages respond to external stimuli to acquire unique functional features, regulated by various miRNAs and lncRNAs. This process holds significance in many human disorders, particularly in immune disorders and cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Gastroenterology & Hepatology
Honglin Jiang, Tristan Courau, Joseph Borison, Alexa J. Ritchie, Aaron T. Mayer, Matthew F. Krummel, Eric A. Collisson
Summary: MEK and autophagy co-inhibition coupled with CD40 agonism activates the STING/type I interferon pathway and enhances immunogenicity of tumor-associated macrophages in pancreatic ductal adenocarcinoma (PDA) cells. This treatment strategy achieves cytotoxic T-cell activation and enhances antitumor immunity in an immunologically cold mouse PDA model.
Article
Immunology
Li Tang, Bo Tang, Yuanyuan Lei, Min Yang, Sumin Wang, Shiping Hu, Zhuo Xie, Yaojiang Liu, Israel Vlodavsky, Shiming Yang
Summary: Chronic gastritis caused by H. pylori infection is associated with up-regulation of heparanase, which facilitates the colonization of H. pylori in the gastric mucosa and exacerbates gastritis. Heparanase sustains a vicious cycle of inflammation and tumor progression by activating macrophages and promoting cytokine release, potentially increasing the risk of gastric cancer. Inhibition of heparanase may be a potential therapeutic strategy for reducing the risk of gastritis and gastric cancer.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Fisheries
Sylwia D. Tyrkalska, Annamaria Pedoto, Alicia Martinez-Lopez, Jose A. Ros-Lucas, Pablo Mesa-del-Castillo, Sergio Candel, Victoriano Mulero
Summary: This study reports that injection of silica crystals into zebrafish embryos leads to local and systemic immune responses, as well as induction of fibrotic markers. The Nlrp3 inflammasome is found to regulate inflammation and cell death caused by silica crystals, while emergency myelopoiesis is not affected. Additionally, recruitment of myeloid cells is required for promotion of systemic inflammation.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Peng Peng, Hao Yu, Cong Xing, Bo Tao, Chao Li, Jingyuan Huang, Guangzhi Ning, Bin Zhang, Shiqing Feng
Summary: The study demonstrates that macrophages-derived exosomes can regulate macrophage polarization in the immune microenvironment of SCI, potentially through the miRNA-mRNA network. This suggests that M2 macrophages-derived exosomes may be a promising therapeutic agent for SCI repair by modulating polarization.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Maryam Moradi-Chaleshtori, Samaneh Shojaei, Samira Mohammadi-Yeganeh, Seyed Mahmoud Hashemi
Summary: The study demonstrated that repolarization of M2 macrophages to M1 phenotype using tumor-derived exosomes loaded with miR-130 led to a reduction in migration and invasion abilities of breast cancer cells. The findings suggest a therapeutic potential in targeting tumor invasion and metastasis in breast cancer through this approach.
Article
Oncology
Mahesh Malleswarapu, Narasaiah Kovuru, Nooruddin Khan, Amit Mishra, Ravi Kumar Gutti
Summary: This study aims to understand the role of Toll-like receptors in megakaryocyte biology during dengue infection. The results suggest that TLR2 may play an important role by dimerizing with TLR1, TLR4, and TLR6, and activation of certain signaling pathways may lead to an increase in lipid droplets.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Immunology
Johanna Samulin Erdem, Tana Zavodna, Torunn K. Ervik, Oivind Skare, Tomas Hron, Kristine H. Anmarkrud, Anna Kusnierczyk, Julia Catalan, Dag G. Ellingsen, Jan Topinka, Shan Zienolddiny-Narui
Summary: This study investigated the immunomodulating properties of two industrially relevant high aspect ratio nanomaterials (nanocellulose and multiwalled carbon nanotubes) on alveolar macrophages. Results showed that these nanomaterials can induce phenotypic changes in alveolar macrophages, with nanocellulose exposure leading to enhanced M1 phenotype and multiwalled carbon nanotubes promoting M2 phenotype. Additionally, multiwalled carbon nanotube exposure resulted in changes in epigenetic patterns and miRNA levels, suggesting the importance of histone methylation and acetylation events in the Th2 response to multiwalled carbon nanotubes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Computer Science, Information Systems
Muhammad Umair Hassan, Dongmei Niu, Mingxuan Zhang, Xiuyang Zhao
Summary: This research proposes a novel asymmetric learning-based generative adversarial network (AGAN) for image retrieval, integrating feature learning with hashing and introducing three loss functions that significantly improve retrieval performance.
MULTIMEDIA TOOLS AND APPLICATIONS
(2023)
Article
Pharmacology & Pharmacy
Uttam Sharma, Manjit Kaur Rana, Karuna Singh, Aklank Jain
Summary: Long non-coding RNA LINC00324 promotes proliferation and metastasis in esophageal squamous cell carcinoma (ESCC) through regulating the miR-493-5p/MAPK1 axis. Targeting this axis may provide a new therapeutic approach for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Engineering, Civil
Kashif Naseer Qureshi, Gwanggil Jeon, Mohammad Mehedi Hassan, Md. Rafiul Hassan, Kuljeet Kaur
Summary: Intelligent Transportation Systems (ITS) have gained popularity due to their smart services, but the increasing number of users has raised concerns over data processing, storage, security, and privacy. To address these concerns, this paper proposes a Blockchain-based Privacy-Preserving Authentication (BPPAU) model that uses smart contracts, access control policies, and on-demand functions to manage data while maintaining user privacy. The model's performance is evaluated through simulation tests analyzing transaction cost, transaction per second, and computational time with various data sizes and block times.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2023)
Article
Engineering, Civil
Jia Hu, Kuljeet Kaur, Hui Lin, Xiaoding Wang, Mohammad Mehedi Hassan, Imran Razzak, Mohammad Hammoudeh
Summary: This paper proposes a Transfer Learning based Trajectory Anomaly Detection strategy, named TLTAD, for IoT-empowered Maritime Transportation Systems (IoT-MTS). Experimental results show that TLTAD can accurately detect anomalies in ships' trajectories and reduce model training time.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2023)
Article
Engineering, Civil
Peng Xu, Ke Wang, Mohammad Mehedi Hassan, Chien-Ming Chen, Weiguo Lin, Md Rafiul Hassan, Giancarlo Fortino
Summary: This paper employs a One-Shot Neural Architecture Search (NAS) to generate derivative models with different scales and studies the relationship between network sizes and model robustness. The experimental results show that reducing model parameters can increase model robustness under maximum adversarial attacks, while increasing model parameters can enhance model robustness under minimum adversarial attacks. This analysis helps to understand the adversarial robustness of models with different scales for edge AI transportation systems.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2023)
Article
Oncology
Pawan Kumar, Ram Kumar Kumawat, Vivek Uttam, Alisha Behera, Medha Rani, Neha Singh, Tushar Singh Barwal, Uttam Sharma, Aklank Jain
Summary: This article discusses the current research progress and potential biomarkers for salivary adenoid cystic carcinoma (SACC). The study found that certain miRNAs can promote the development of SACC, while others have inhibitory effects. Additionally, miRNAs target various genes and pathways that play crucial roles in the regulation of SACC.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Oncology
Hardeep Singh Tuli, Vivek Kumar Garg, Sakshi Bhushan, Vivek Uttam, Uttam Sharma, Aklank Jain, Katrin Sak, Vikas Yadav, Jose M. Lorenzo, Kuldeep Dhama, Tapan Behl, Gautam Sethi
Summary: Cancer prevalence and incidence rates have been increasing over the past few decades. To combat this disease, it is necessary to explore safer and more effective molecules. Flavonoids, a class of polyphenols, have shown potential against cancer without significant toxicity to normal cells. They modulate microRNAs to enhance drug sensitivity and suppress cancer cell proliferation, metastasis, and angiogenesis. This review comprehensively discusses the structure, chemistry, and effects of flavonoids like quercetin, luteolin, silibinin, genistein, epigallocatechin gallate, and cyanidin on various cancer types. Targeting miRNAs by flavonoids in cancer cells could be a promising approach for future clinical investigations and affirmation.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tufail Ali, Farah Anjum, Arunabh Choudhury, Alaa Shafie, Amal Adnan Ashour, Abdulraheem Almalki, Taj Mohammad, Md. Imtaiyaz Hassan
Summary: Spleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase that plays a crucial role in signal transduction in different cell types. In this study, two natural compounds, Isolysergic acid and Michelanugine, were identified as potential SYK inhibitors with strong affinity and specificity for the SYK binding pocket. These compounds have the potential to be developed into promising SYK inhibitors for the treatment of autoimmune disorders, cancer, and inflammatory diseases.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Physical
Ishfaq Ahmad Ahanger, Zahoor Ahmad Parray, Neha Raina, Sania Bashir, Faizan Ahmad, Md. Imtaiyaz Hassan, Mohammad Shahid, Anurag Sharma, Asimul Islam
Summary: This study investigates the effect of heparin on CTAB-induced aggregation of bovine serum albumin (BSA) using biophysical techniques. The results show that heparin completely inhibits CTAB-induced protein aggregation and reduces the apparent rate constant. CTAB acts as a protein-aggregating agent, but heparin prevents the perturbation of secondary and tertiary structure induced by CTAB and the formation of amyloid-like structures. ITC measurements reveal that CTAB and heparin form a complex that does not bind with protein. The CTAB-heparin complex may play a role in inhibiting protein aggregation and could serve as a basis for developing therapeutic strategies for various neurodegenerative complications.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Review
Biochemistry & Molecular Biology
Neha Basheer, Tomas Smolek, Imtaiyaz Hassan, Fei Liu, Khalid Iqbal, Norbert Zilka, Petr Novak
Summary: Protein kinases (PKs) are extensively studied drug targets, particularly in the field of oncology and neurodegeneration. Tau protein hyperphosphorylation, a post-translational modification observed in Alzheimer's disease (AD), highlights the involvement of PKs in neurodegeneration. The efficacy of protein kinase inhibitors (PKIs) and protein phosphatase 2 A (PP2A) activators in AD has been investigated in preclinical and clinical studies, but the outcomes have been variable. This review examines the results of these studies and evaluates the potential of targeting tau hyperphosphorylation as a disease modifying therapy.
MOLECULAR PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Pallabi Banerjee, Anshuman Chandra, Taj Mohammad, Nagendra Singh, Md. Imtaiyaz Hassan, Imteyaz Qamar
Summary: This study identified six potential inhibitors that can selectively interrupt the binding of PDXK with its substrate PLP, stabilizing the structure of PDXK. The findings provide valuable information for designing specific and effective PDXK inhibitors.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Biochemistry & Molecular Biology
Manzar Alam, Sarfraz Ahmed, Mohammad Abid, Gulam Mustafa Hasan, Asimul Islam, Md. Imtaiyaz Hassan
Summary: Microtubule affinity-regulating kinase 4 (MARK4) is a crucial protein kinase involved in the development of cancer and neurodegenerative diseases. It modulates various signaling pathways and has potential as a drug target for cancer, diabetes, and Alzheimer's. However, there is limited knowledge on its structure, function, and clinical significance. This review provides detailed information on MARK4's structure, role in signaling pathways, and therapeutic potential as well as updates on its research, which will aid in the development of effective therapeutic molecules.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Engineering, Environmental
Amina Ashraf, Ruba Munir, Gadah Albasher, Madiha Ghamkhar, Amna Muneer, Muhammad Yaseen, Tamsal Murtza, Saima Noreen
Summary: In this study, ZnFe2O4 nanocomposites were successfully synthesized and used for dye removal from aqueous solutions. The results showed that pH, adsorbent dosage, contact time, and initial concentration of dyes had an effect on the adsorption performance. The nanocomposites were found to be reusable to some extent.
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING
(2023)
Article
Biotechnology & Applied Microbiology
Prithvi Singh, Aanchal Rathi, Rashmi Minocha, Anuradha Sinha, Mohammad Mahfuzul Haque, Md Imtaiyaz Hassan, Ravins Dohare
Summary: Breast cancer, the second-most common type of cancer and leading cause of cancer-related deaths worldwide, exhibits marked person-to-person variability in susceptibility, phenotypic expression, and prognosis. In this study, we identified PI15 and KRT5 as prognostic hub genes and potential biomarkers in breast cancer, highlighting the need for personalized medicine.
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anam Ashraf, Mohammad Ahmad, Richard Mariadasse, Monis Ali Khan, Saba Noor, Asimul Islam, Md. Imtaiyaz Hassan
Summary: Staphylococcus aureus is a significant human pathogen that is becoming increasingly resistant to antibiotics. This study focuses on thymidine kinase (TK), an enzyme essential for DNA synthesis and repair, and investigates how different pH levels affect its structure and function. The findings indicate that pH variation disrupts the secondary and tertiary structures of TK, leading to aggregate formation at pH 5.0. The enzyme displays maximum activity within the physiological pH range, suggesting a connection between structural changes and enzymatic activity.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
