Article
Biochemistry & Molecular Biology
Ri-Na Yoo, Ji-Yeon Mun, Hyeon-Min Cho, Bong-Hyeon Kye, Hyung-Jin Kim
Summary: This study investigates the impact of intraoperative colonoscopy on anastomotic problems and finds that it does not immediately reduce the rate of anastomotic complications. However, it may play a role in detecting early technical failure and preventing postoperative anastomotic complications.
Review
Gastroenterology & Hepatology
Elodie Zocola, Jeremy Meyer, Niki Christou, Emilie Liot, Christian Toso, Nicolas Christian Buchs, Frederic Ris
Summary: Near-infrared fluorescence (NIRF) is a valuable technique in colorectal surgery, aiding surgeons in visualizing and assessing bowel vascularization, identifying lymph nodes, and ureters.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Letter
Gastroenterology & Hepatology
Sung Uk Bae
Summary: Near infrared fluorescence using indocyanine green is useful for reducing the risk of iatrogenic ureteral lesions in colorectal surgery. It allows visual assessment of blood vessels, blood flow, and tissue perfusion, as well as sentinel lymph node biopsy and lymph node road mapping.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Surgery
Marius Kryzauskas, Augustinas Bausys, Audrius Dulskas, Ugne Imbrasaite, Donatas Danys, Valdemaras Jotautas, Eugenijus Stratilatovas, Kestutis Strupas, Eligijus Poskus, Tomas Poskus
Summary: This study investigated a novel comprehensive intraoperative colorectal anastomosis testing technique to detect the failure of the anastomosis construction and reduce the risk of postoperative leakage. Trimodal testing can identify anastomoses with initial technical failure and reduce the leakage rate through reinforcement or diversion. However, the incidence of anastomotic leakage remains high even in technically well-performed anastomoses.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
J. Valdes-Hernandez, J. Cintas-Catena, F. J. Del Rio-Lafuente, A. Cano-Matias, C. Torres-Arcos, A. Perez-Sanchez, L. Capitan-Morales, F. Oliva-Mompean, J. C. Gomez-Rosado
Summary: Anastomotic leak is a feared complication of colorectal anastomosis, and there are various techniques for intraoperative testing and management options. This study presents the experience with transanal minimally invasive surgery (TAMIS) approach for anastomotic assessment and repair, showing that it is a safe and feasible technique that may avoid the need for a defunctioning stoma.
TECHNIQUES IN COLOPROCTOLOGY
(2022)
Article
Oncology
Boris Jansen-Winkeln, Michelle Dvorak, Hannes Koehler, Marianne Maktabi, Matthias Mehdorn, Claire Chalopin, Michele Diana, Ines Gockel, Manuel Barberio
Summary: Good bowel oxygenation is crucial for anastomotic healing after colorectal resections. Hyperspectral imaging has the potential to be used as a clinical tool for assessing tissue oxygenation during surgery, as shown in this study involving 105 patients.
Review
Health Care Sciences & Services
Mark Gray, Jamie R. K. Marland, Alan F. Murray, David J. Argyle, Mark A. Potter
Summary: Development of an anastomotic leak (AL) following colorectal cancer surgery is a life-threatening complication that can lead to severe consequences such as abdominal contamination and peritonitis. Current research is focusing on identifying diagnostic or predictive biomarkers for AL to enhance post-operative care and improve outcomes for patients. Although no AL biomarker has been validated in large-scale clinical trials yet, personalized medicine through biomarker analysis could hold promise for colorectal cancer patients undergoing intestinal resection and anastomosis in the future.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Paul Cavallaro, Grace C. Lee, Arielle Kanters, Michael Valente, Stefan D. Holubar, Bradley Champagne, David Rosen, Emre Gorgun, Scott Steele
Summary: This study investigated the association between the position of the stapler spike relative to the rectal transection line and anastomotic integrity in colorectal anastomoses. The results showed that the presence or absence of crossing staple lines had a significant impact on anastomotic integrity.
COLORECTAL DISEASE
(2023)
Review
Surgery
Shaheel Mohammad Sahebally, Erick Chan, Alisha Azmir, Cu Tai Lu, Mark Doudle, Arun Naik, Gregory Nolan, Michael Von Papen
Summary: Omentoplasty may reduce the rate of overall and clinical anastomotic leaks in colorectal surgery, but heterogeneity in the data limits definitive conclusions. Further well-designed trials are needed to investigate this technique.
ANZ JOURNAL OF SURGERY
(2022)
Review
Immunology
Yang Liu, Bowen Li, Yunwei Wei
Summary: This review focuses on the role of gut microbiota in the occurrence of anastomotic leak (AL) following colorectal surgery. It discusses the changes in gut microbiota profiles in patients with AL, the colonization and tissue breakdown effects of AL-specific pathogenic or collagenase bacteria at the anastomosis site, and the potential mechanisms of pathogen-induced impaired anastomotic healing.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Diego Zamorano, Dinka Ivulic, Tomeu Viver, Felipe Morales, Francisco Lopez-Kostner, Roberto M. Vidal
Summary: Anastomotic leakage (AL) is a common complication after colorectal surgery and the underlying mechanism is still not well understood. This study aimed to investigate the association between gut microbiota and colorectal AL development. Through analyzing tissue-associated microbiota using 16S rRNA sequencing, lower microbial diversity was observed in the AL group compared to non-leak anastomosis (NLA) group. The facultative anaerobic bacterium Gemella palaticanis showed high abundance and may be a potential marker for AL.
Review
Surgery
Evan Williams, Swetha Prabhakaran, Joseph C. Kong, Stephen Bell, Satish K. Warrier, Paul Simpson, Peter W. G. Carne, Chip Farmer
Summary: A systematic review comparing IOFS with conventional air leak test shows that IOFS increases the likelihood of positive leak test results, decreases the rate of anastomotic leak, and reduces the need for post-operative intervention for anastomotic bleeding.
ANZ JOURNAL OF SURGERY
(2021)
Article
Gastroenterology & Hepatology
Guy Worley, David Burling, Alison Corr, Susan Clark, Rachel Baldwin-Cleland, Omar Faiz, John Jenkins
Summary: This study compared the effectiveness of MRI-enema with fluoroscopic WSCE in detecting anastomotic leaks, finding that MRI-enema provided greater accuracy and more anatomical detail. Patient experiences were similar, and there is potential for MRI-enema to play a significant role in the UK National Health Service.
COLORECTAL DISEASE
(2021)
Review
Surgery
Alberto Aiolfi, Andrea Sozzi, Gianluca Bonitta, Francesca Lombardo, Marta Cavalli, Giampiero Campanelli, Luigi Bonavina, Davide Bona
Summary: This study compared different techniques for esophagojejunostomy during laparoscopic total gastrectomy and found similar postoperative complications and mortality rates for overlap anastomosis, functional end-to-end anastomosis, single staple technique, hemi-double staple technique, and OrVil technique.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Gastroenterology & Hepatology
Nicola Reeves, Irene Vogel, Arash Ghoroghi, James Ansell, Julie Cornish, Jared Torkington
Summary: This study assessed the applicability of peritoneal cytokine levels as an early predictive test of Anastomotic Leakage (AL) in postoperative colorectal cancer patients. The meta-analysis found that IL-10 was significantly raised in AL patients on postoperative day 1, suggesting its potential as an early predictor for AL in this patient population. More research is needed due to the limited range of cytokines studied and the heterogeneous nature of the existing studies.
TECHNIQUES IN COLOPROCTOLOGY
(2022)