Smad4 Deficiency Promotes Pancreatic Cancer Immunogenicity by Activating the Cancer‐Autonomous DNA‐Sensing Signaling Axis

A four-chemokine signature is associated with a T cell-inflamed phenotype in primary and metastatic pancreatic cancer

(2020) Joan Miguel Romero et al.   CLINICAL CANCER RESEARCH

TGF-β orchestrates fibrogenic and developmental EMTs via the RAS effector RREB1

(2020) Jie Su et al.   NATURE

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

(2020) Keisuke Yamamoto et al.   NATURE

Tumor microenvironment remodeling enables bypass of oncogenic KRAS dependency in pancreatic cancer

(2020) Pingping Hou et al.   Cancer Discovery

IFN-III is selectively produced by cDC1 and predicts good clinical outcome in breast cancer

(2020) Margaux Hubert et al.   Science Immunology

A phase I study of toripalimab, an anti‐PD‐1 antibody, in patients with refractory malignant solid tumors

(2020) Xiao‐Li Wei et al.   Cancer Communications

TGF-β suppresses type 2 immunity to cancer

(2020) Ming Liu et al.   NATURE

Cancer immunotherapy via targeted TGF-β signalling blockade in TH cells

(2020) Shun Li et al.   NATURE

Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer

(2019) Triparna Sen et al.   Cancer Discovery

Tumor cell–intrinsic EPHA2 suppresses antitumor immunity by regulating PTGS2 (COX-2)

(2019) Nune Markosyan et al.   JOURNAL OF CLINICAL INVESTIGATION

Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade

(2019) Joseph L. Benci et al.   CELL

STING activation reprograms tumor vasculatures and synergizes with VEGFR2 blockade

(2019) Hannah Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

SMAD4 Y353C promotes the progression of PDAC

(2019) Zusen Wang et al.   BMC CANCER

Extrinsic Phagocyte-Dependent STING Signaling Dictates the Immunogenicity of Dying Cells

(2018) Jeonghyun Ahn et al.   CANCER CELL

SMAD4Gene Mutation Renders Pancreatic Cancer Resistance to Radiotherapy through Promotion of Autophagy

(2018) Feng Wang et al.   CLINICAL CANCER RESEARCH

Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy

(2018) Jinyang Li et al.   IMMUNITY

Novel Function of Cyclooxygenase-2: Suppressing Mycobacteria by Promoting Autophagy via the Protein Kinase B/Mammalian Target of Rapamycin Pathway

(2018) Wenjing Xiong et al.   JOURNAL OF INFECTIOUS DISEASES

TGF-β transactivates EGFR and facilitates breast cancer migration and invasion through canonical Smad3 and ERK/Sp1 signaling pathways

(2018) Yuanyuan Zhao et al.   Molecular Oncology

Therapeutic developments in pancreatic cancer: current and future perspectives

(2018) John P. Neoptolemos et al.   Nature Reviews Gastroenterology & Hepatology

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

(2018) Sanjeev Mariathasan et al.   NATURE

A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily

(2018) Anil Korkut et al.   Cell Systems

Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss

(2018) Huayang Liu et al.   NATURE MEDICINE

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

(2017) Giovanni Germano et al.   NATURE

Reversing SKI–SMAD4-mediated suppression is essential for TH17 cell differentiation

(2017) Song Zhang et al.   NATURE

Combination Cancer Therapies with Immune Checkpoint Blockade: Convergence on Interferon Signaling

(2016) Andy J. Minn et al.   CELL

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

(2016) Cristovão M. Sousa et al.   NATURE

Innate Immune Recognition of Cancer

(2015) Seng-Ryong Woo et al.   Annual Review of Immunology

Loss of SMAD4 Promotes Colorectal Cancer Progression by Accumulation of Myeloid-Derived Suppressor Cells through the CCL15-CCR1 Chemokine Axis

(2015) S. Inamoto et al.   CLINICAL CANCER RESEARCH

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Whole genomes redefine the mutational landscape of pancreatic cancer

(2015) Nicola Waddell et al.   NATURE

Robust enumeration of cell subsets from tissue expression profiles

(2015) Aaron M Newman et al.   NATURE METHODS

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

Genome-Derived Cytosolic DNA Mediates Type I Interferon-Dependent Rejection of B Cell Lymphoma Cells

(2015) Yu J. Shen et al.   Cell Reports

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

(2014) Antonella Sistigu et al.   NATURE MEDICINE

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Immune Cell-Poor Melanomas Benefit from PD-1 Blockade after Targeted Type I IFN Activation

(2014) T. Bald et al.   Cancer Discovery

Immunohistochemically Detected Expression of 3 Major Genes (CDKN2A/p16, TP53, and SMAD4/DPC4) Strongly Predicts Survival in Patients With Resectable Pancreatic Cancer

(2013) Minoru Oshima et al.   ANNALS OF SURGERY

Loss of SMAD4 From Colorectal Cancer Cells Promotes CCL15 Expression to Recruit CCR1+ Myeloid Cells and Facilitate Liver Metastasis

(2013) Yoshiro Itatani et al.   GASTROENTEROLOGY

Smad4 Loss in Mouse Keratinocytes Leads to Increased Susceptibility to UV Carcinogenesis with Reduced Ercc1-Mediated DNA Repair

(2013) Doyel Mitra et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Type I Interferons as Stimulators of DC-Mediated Cross-Priming: Impact on Anti-Tumor Response

(2013) Giovanna Schiavoni et al.   Frontiers in Immunology

Re(de)fining the dendritic cell lineage

(2012) Ansuman T Satpathy et al.   NATURE IMMUNOLOGY

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

TGFβ prevents proteasomal degradation of the cyclin-dependent kinase inhibitor p27kip1 for cell cycle arrest

(2011) Jon Lecanda et al.   CELL CYCLE

Host type I IFN signals are required for antitumor CD8+T cell responses through CD8α+dendritic cells

(2011) Mercedes B. Fuertes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type I interferon is selectively required by dendritic cells for immune rejection of tumors

(2011) Mark S. Diamond et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of the cytosolic DNA-sensing system in innate immunity: a current view

(2009) Hideyuki Yanai et al.   CURRENT OPINION IN IMMUNOLOGY