Article
Dentistry, Oral Surgery & Medicine
Marcelo Vitale, Monica Grazieli Correa, Edilson Ervolino, Fabiano Ribeiro Cirano, Fernanda Vieira Ribeiro, Mabelle Freitas Monteiro, Marcio Zaffalon Casati, Suzana Peres Pimentel
Summary: This study evaluated the effect of resveratrol (RES) on the prevention of medication-related osteonecrosis of the jaws (MRONJ) in ovariectomized (OVX) rats treated with zoledronate (ZOL). The results showed that RES reduced tissue impairment caused by ZOL, but it could not prevent the occurrence of MRONJ.
Article
Multidisciplinary Sciences
Farnoosh Razmara, Mohammad Bayat, Sadegh Shirian, Ghazal Shabankare, Abdolreza Mohamadnia, Mostafa Mortazavi, Mohammad-Reza Alijani, Naghmeh Bahrami
Summary: The study found that using PRP + collagen scaffold showed better therapeutic effects compared to using scaffold alone, increasing bone mineralized density, number of osteoblasts, and new bone formation. In preventing BRONJ, PRP + collagen scaffold demonstrated better efficacy.
Article
Multidisciplinary Sciences
Milad Etemadi Sh, Farnaz Shooshtarian, Golnaz Tajmiri, MohammadSoroush Sehat
Summary: The present experiment aimed to assess the preventive effects of L-PRF on osteonecrosis of the jaw in rats. The application of L-PRF resulted in a significant reduction in osteonecrosis centers and the number of osteoclast cells. Therefore, it can be inferred that possible preventive effects on the clinical occurrence of osteonecrosis could be expected from the application of L-PRF.
Review
Immunology
Weidong Zhang, Ling Gao, Wenhao Ren, Shaoming Li, Jingjing Zheng, Shasha Li, Chunmiao Jiang, Shuying Yang, Keqian Zhi
Summary: Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious adverse drug effect, with hypotheses involving reduced bone remodeling, infection, inflammation, and bisphosphonates-induced immune dysfunction. Treatment with bisphosphonates disrupts mucosal and osteo immune homeostasis, impairing the body's ability to resist infection and repair from injury, contributing to the development of MRONJ.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
George Adrian Ciobanu, Adrian Camen, Mihaela Ionescu, Daniel Vlad, Cristina Maria Munteanu, Mircea Ionut Gheorghita, Cristian Virgil Lungulescu, Ionela Elisabeta Staicu, Elena Claudia Sin, Luminita Chivu, Razvan Mercut, Sanda Mihaela Popescu
Summary: This study aimed to establish the importance of risk factors in the development of MRONJ in cancer patients receiving zoledronic acid therapy. The analysis of 174 cancer patients revealed that treatment duration, chemotherapy, and hypertension were risk factors, while endocrine therapy and obesity were protective factors for MRONJ.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Xin Chen, Weiwen Zhu, Rongyao Xu, Xin Shen, Yu Fu, Jie Cheng, Laikui Liu, Hongbing Jiang
Summary: This study revealed that long-term use of bisphosphonates such as Zoledronic Acid (ZA) may lead to Bisphosphonate-related Osteonecrosis of the Jaw (BRONJ) by inhibiting macrophage efferocytosis and promoting osteocytic apoptosis. Additionally, supplementing with geranylgeraniol (GGOH) can restore Rac1 homeostasis and rescue macrophage efferocytosis, potentially providing a new treatment approach for BRONJ.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Krzysztof Wrobel, Maciej Sikora, Maciej Checinski, Maria Jas, Dariusz Chlubek
Summary: MRONJ is a condition that is becoming more common in dental and maxillofacial practice, requiring comprehensive, accessible, and up-to-date data. Besides bisphosphonates, angiogenesis inhibitors and anti-RANKL monoclonal antibodies can also increase the risk of the disease. Thorough physical examination, periodic correction of dental prostheses, and adequate preparation for oral procedures can prevent or minimize the risk of MRONJ.
APPLIED SCIENCES-BASEL
(2021)
Article
Medicine, General & Internal
Gabor Kammerhofer, Daniel Vegh, Dorottya Banyai, Adam Vegh, Arpad Joob-Fancsaly, Peter Hermann, Zoltan Geczi, Tamas Hegedus, Kata Sara Somogyi, Bulcsu Bencze, Zita Biczo, Donat Huba Juhasz, Peter Zaborszky, Marta Ujpal, Mihaly Tamas Vaszilko, Zsolt Nemeth
Summary: This study aimed to evaluate the association between hyperglycemia and medication-related osteonecrosis of the jaw (MRONJ). The results showed a significant association between hyperglycemia and MRONJ, suggesting that hyperglycemia may lead to vascular anomaly and immune dysfunction, resulting in necrosis after tooth extraction.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Pei-An Fu, Chin-Yao Shen, Shuen-Ru Yang, Chun-Hui Lee, Hui-Wen Chen, Edward Chia-Cheng Lai, Wei-Pang Chung
Summary: Denosumab reduces skeletal-related events (SREs) in breast cancer patients with bone metastases, but its long-term efficacy and safety are limited by lack of real-world data. This retrospective study on 132 denosumab-treated patients found that 11.1% experienced SREs in the first year, with the rate increasing over time. Additionally, 7.6% developed osteonecrosis of the jaw (ONJ), but most of those who resumed denosumab did not experience recurrence of ONJ.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Hironobu Hata, Kenji Imamachi, Michihiro Ueda, Masashi Matsuzaka, Hiroaki Hiraga, Toshihisa Osanai, Toru Harabayashi, Katsuya Fujimoto, Satoshi Oizumi, Masato Takahashi, Kazuhito Yoshikawa, Jun Sato, Yutaka Yamazaki, Yoshimasa Kitagawa
Summary: The study aimed to clarify the incidence of MRONJ and the corresponding survival rate of patients treated with zoledronic acid for different types of cancer. The results showed that patients with shorter survival times did not develop MRONJ, and dentists need to be aware of prognosis-related factors to predict MRONJ risk for effective dental management planning.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Medicine, General & Internal
Natalie H. Beth-Tasdogan, Benjamin Mayer, Heba Hussein, Oliver Zolk, Jens-Uwe Peter
Summary: Interventions for the prophylaxis or treatment of MRONJ have shown mixed results with varying levels of certainty due to the diversity of included studies. Preventive measures such as regular dental examinations and specific treatment protocols for dentoalveolar surgery may lower the risk of developing MRONJ. For established MRONJ, different treatments including hyperbaric oxygen therapy and growth factors have been tested, but more research is needed to confirm their effectiveness.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Endocrinology & Metabolism
Vanessa Costa de Sousa, Fatima Regina Nunes Sousa, Raquel Felipe Vasconcelos, Conceicao S. Martins, Amanda Pimentel Lopes, Nicholas Militao, Delane Viana, Karuza Alves, Renata Leitao, Gerly A. C. Brito, Virginia Girao, Paula Goes
Summary: Atorvastatin has a positive effect on bisphosphonate-induced osteonecrosis of the jaw in rats. It improves mucosal healing, increases viable osteocytes, reduces cell apoptosis, and decreases bone sequestration. It also modulates inflammation and improves bone vitality, metabolism, and structure.
Article
Cell Biology
Wen Pan, Jianyu Gu, Shihan Xu, Chunmei Zhang, Jinsong Wang, Songlin Wang, Junji Xu
Summary: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious complication in patients with osteoporosis or metastatic bone cancer. The study found that dietary nitrate, abundant in green vegetables, can protect against BRONJ-like lesions in mice. Nitrate intake increased plasma nitric oxide levels, reducing monocyte necrosis and inflammatory cytokine production. The findings suggest that dietary nitrate can inhibit monocyte necroptosis in BRONJ and promote bone remodeling after injury.
CELL PROLIFERATION
(2023)
Article
Dentistry, Oral Surgery & Medicine
Vanessa Costa de Sousa Ferreira, Amanda Pimentel Lopes, Nicholas Militao Alves, Fatima Regina Nunes Sousa, Karuza Maria Alves Pereira, Delane Viana Gondim, Virginia Claudia Carneiro Girao, Renata Ferreira Carvalho Leitao, Paula Goes
Summary: The study found that the medication-related osteonecrosis of the jaw (MRONJ) model caused bone necrosis mainly due to intense inflammation, and Wnt signaling appears to play an important role in this process.
CLINICAL ORAL INVESTIGATIONS
(2021)
Review
Toxicology
Bhumrapee Srivichit, Chanisa Thonusin, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Bisphosphonates are commonly used in the treatment of bone and joint diseases, but long-term use can lead to osteonecrosis. Osteonecrosis is characterized by cell death and impaired cell functions, with medication-related osteonecrosis of the jaw being the most concerning condition. In addition to surgical treatment, non-surgical interventions have been explored to mitigate bisphosphonate-induced osteonecrosis.
ARCHIVES OF TOXICOLOGY
(2022)