Journal
MICROBIOLOGYOPEN
Volume 11, Issue 1, Pages -Publisher
WILEY
DOI: 10.1002/mbo3.1260
Keywords
antibiotic resistance; gut bacteria; microbiome
Categories
Funding
- APC Microbiome Institute Ireland
- Science Foundation Ireland
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Antibiotic-induced changes in the gut microbiota have negative effects on host health, including reduced microbial diversity and the formation of antibiotic-resistant strains. The increased use of antibiotics over time warrants investigation into their effects on microbiota and health.
It is well established that the gut microbiota plays an important role in host health and is perturbed by several factors including antibiotics. Antibiotic-induced changes in microbial composition can have a negative impact on host health including reduced microbial diversity, changes in functional attributes of the microbiota, formation, and selection of antibiotic-resistant strains making hosts more susceptible to infection with pathogens such as Clostridioides difficile. Antibiotic resistance is a global crisis and the increased use of antibiotics over time warrants investigation into its effects on microbiota and health. In this review, we discuss the adverse effects of antibiotics on the gut microbiota and thus host health, and suggest alternative approaches to antibiotic use.
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