Article
Neurosciences
Gerardo R. Corradi, Luciana R. Mazzitelli, Guido D. Petrovich, Felicitas de Tezanos Pinto, Lucia Rochi, Hugo P. Adamo
Summary: PMCA isoforms control Ca2+ signaling by transporting Ca2+ out of eukaryotic cells. PMCA4 has two A splice variants, x and z, with z showing higher ATPase activity and greater sensitivity to acidic lipids compared to x.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Materials Science, Multidisciplinary
Maria Berrocal, Juan J. Cordoba-Granados, Sonia A. C. Carabineiro, Carlos Gutierrez-Merino, Manuel Aureliano, Ana M. Mata
Summary: The study demonstrates that gold compounds can interfere with the activity of the key protein PMCA responsible for calcium homeostasis and exhibit cytotoxic effects on human neuroblastoma cells.
Review
Biochemistry & Molecular Biology
Daniela Baracaldo-Santamaria, Sara Sofia Avendano-Lopez, Daniel Felipe Ariza-Salamanca, Mateo Rodriguez-Giraldo, Carlos A. Calderon-Ospina, Rodrigo E. Gonzalez-Reyes, Mauricio O. Nava-Mesa
Summary: Alzheimer's disease is a chronic neurodegenerative disease that causes progressive dementia in older adults. It is characterized by memory loss and cognitive impairment due to dysfunction in cholinergic pathways and neurotoxicity mediated by N-methyl-D-aspartate (NMDA). The presence of intracellular neurofibrillary tangles, extracellular amyloid-beta (A beta) plaques, and selective neurodegeneration are the pathological hallmarks of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Wenji Hu, Minkai Song, Chunyue Wang, Ziang Guo, Yu Li, Di Wang
Summary: Purified polysaccharides from Hericium erinaceus fermented mycelium, known as PHEB, showed significant improvement in cognitive behavior of AD mice by alleviating oxidative stress through Nrf2 regulation. Furthermore, PHEB regulated calcium homeostasis in the brain by modulating CaMK II/IV, ultimately exhibiting anti-AD properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Microbiology
Congcong Sun, Xingyue Li, Yuanwei Zhang, Ling Lu
Summary: The study identified a crucial role of VmaC gene in Aspergillus fumigatus, involving in maintaining cellular homeostasis and cell wall integration pathway regulation. Compared to model yeasts, VmaC in A. fumigatus is essential for hyphal growth and conidiation.
Article
Neurosciences
Malwina Lisek, Joanna Mackiewicz, Marta Sobolczyk, Bozena Ferenc, Feng Guo, Ludmila Zylinska, Tomasz Boczek
Summary: This study demonstrates that developmentally controlled PMCA expression can dictate the pattern of differentiation in hippocampal progenitor cells. Moreover, the presence of PMCA2b is protective against ketamine-induced apoptosis in differentiating progenitor cells. Additionally, PMCA2b expression influences GABA signaling and metabolism.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Anatomy & Morphology
Xiao Lin, Michael G. K. Brunk, Pingan Yuanxiang, Andrew W. Curran, Enqi Zhang, Franziska Stoeber, Juergen Goldschmidt, Eckart D. Gundelfinger, Maike Vollmer, Max F. K. Happel, Rodrigo Herrera-Molina, Dirk Montag
Summary: The study found that the absence of neuroplastin in mice leads to hearing impairment, accompanied by degeneration of hair cells and spiral ganglion cells, as well as reduced baseline blood flow in the auditory cortex. Neuroplastin is required for the expression of PMCA 2 in outer hair cells, suggesting that altered Ca2+ homeostasis underlies the observed hearing impairments and hair cell degeneration.
BRAIN STRUCTURE & FUNCTION
(2021)
Review
Cell Biology
Dong-Xu Huang, Xin Yu, Wen-Jun Yu, Xin-Min Zhang, Chang Liu, Hong-Ping Liu, Yue Sun, Zi-Ping Jiang
Summary: The precise regulation of calcium ion by neurons is essential for cellular signaling and survival, with calcium homeostasis maintained by both endoplasmic reticulum and mitochondria. Dysregulation of calcium signaling is associated with Alzheimer's disease, highlighting the importance of understanding the cellular and molecular mechanisms underlying calcium regulation in neurodegenerative diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell & Tissue Engineering
Ricarda Stock, Pauline Jeckel, Udo Kraushaar, Richard Wuest, Andreas Fallgatter, Hansjuergen Volkmer
Summary: Patient-derived iPSCs are a valuable tool for studying unique disease mechanisms and potential preclinical drug development. Transcriptomic analyses and functional read-outs are the most promising approaches for uncovering specific disease mechanisms in vitro.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Joy Yoon, Yingwei Mao
Summary: Pathogenic copy number variations (CNVs) play a crucial role in neurodevelopmental/neuropsychiatric disorders (NDs), with the 1q21.1 CNVs showing specific associations with different phenotypes. The genetic structure associated with 1q21.1 is strongly linked to neurodevelopmental dysfunctions like cognitive impairment and reduced synaptic plasticity, posing challenges for the discovery of molecular pathways and phenotypic networks. Variations in phenotypic severity, genomic penetrance, and inheritance are also reported.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Zehui Li, Yu Cao, Hui Pei, Lina Ma, Yang Yang, Hao Li
Summary: Alzheimer's disease is the most common neurodegenerative disease without effective treatments. Mitochondria-associated endoplasmic reticulum membranes (MAMs) are associated with AD pathogenesis, but there is a lack of literature summarizing recent advances. This article reviews the roles of MAM structure and tethering proteins in the pathogenesis of AD and potential treatment strategies targeting MAMs.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Cell Biology
Chiara Galber, Simone Fabbian, Cristina Gatto, Martina Grandi, Stefania Carissimi, Manuel Jesus Acosta, Gianluca Sgarbi, Natascia Tiso, Francesco Argenton, Giancarlo Solaini, Alessandra Baracca, Massimo Bellanda, Valentina Giorgio
Summary: Mitochondrial protein IF1 binds to ATP synthase and inhibits ATP hydrolysis in ischemic tissues. It is overexpressed in tumors and acts as a pro-oncogenic protein. Study found that disruption of ATP5IF1 gene decreases colony formation and tumor mass development in HeLa cells, indicating the role of IF1 in cancer. Lack of IF1 does not affect cell proliferation or mitochondrial respiration, but sensitizes cells to opening of the permeability transition pore (PTP). IF1 binds to ATP synthase OSCP subunit in HeLa cells under oxidative phosphorylation conditions, and this interaction protects cancer cells from PTP-dependent apoptosis under normoxic conditions.
CELL DEATH & DISEASE
(2023)
Review
Cardiac & Cardiovascular Systems
Changwon Kho
Summary: Impaired myocardial Ca2+ cycling is a crucial factor in the development of heart failure, leading to changes in contractile function and structural remodeling of the heart. The regulation of sarcoplasmic reticulum Ca2+ storage and release in cardiomyocytes relies heavily on Ca2+ handling proteins like SERCA2a pump. However, reduced expression and activity of SERCA2a are key features of heart failure, resulting in a growing interest in therapeutic approaches targeting SERCA2a. This review provides an overview of the regulatory mechanisms of the SERCA2a pump and explores potential strategies for SERCA2a-targeted therapy in both preclinical and clinical studies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Jefferson A. Leite, Bruno Ghirotto, Vitor P. Targhetta, Jean de Lima, Niels O. S. Camara
Summary: Histone deacetylases (HDACs) play a crucial role in neurodegenerative and neuropsychiatric disorders, with both Zn2+-dependent and NAD(+)-dependent enzymes being potential therapeutic targets. While most studies have focused on Zn2+-dependent HDACs, growing evidence suggests that NAD(+)-dependent HDACs, known as sirtuins, also play an important role in pathogenesis.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biology
Alessandra Preziuso, Silvia Piccirillo, Giorgia Cerqueni, Tiziano Serfilippi, Valentina Terenzi, Antonio Vinciguerra, Monia Orciani, Salvatore Amoroso, Simona Magi, Vincenzo Lariccia
Summary: Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects elderly people and is characterized by brain cell deterioration. The study found that silencing the NCX3 protein can improve cell viability, increase energy production, reduce oxidative stress damage, and decrease abnormal protein levels associated with AD. This discovery provides a potential strategy for preventing the development of AD.
Article
Neurosciences
Nicole Koch, Dennis Koch, Sarah Krueger, Jessica Troeger, Victor Sabanov, Tariq Ahmed, Laura E. McMillan, David Wolf, Dirk Montag, Michael M. Kessels, Detlef Balschun, Britta Qualmann
Article
Neurosciences
Katrina E. Deane, Michael G. K. Brunk, Andrew W. Curran, Marina M. Zempeltzi, Jing Ma, Xiao Lin, Francesca Abela, Suemeyra Aksit, Matthias Deliano, Frank W. Ohl, Max F. K. Happel
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Cell Biology
Alejandro Luarte, Roberto Henzi, Anllely Fernandez, Diego Gaete, Pablo Cisternas, Matias Pizarro, Luis Federico Batiz, Isabel Villalobos, Matias Masalleras, Rodrigo Vergara, Manuel Varas-Godoy, Lorena Abarzua-Catalan, Rodrigo Herrera-Molina, Carlos Lafourcade, Ursula Wyneken
Article
Chemistry, Medicinal
Francisca Garcia, Pedro Lobos, Alejandra Ponce, Karla Cataldo, Daniela Meza, Patricio Farias, Carolina Estay, Felipe Oyarzun-Ampuero, Rodrigo Herrera-Molina, Andrea Paula-Lima, Alvaro O. Ardiles, Cecilia Hidalgo, Tatiana Adasme, Pablo Munoz
Article
Anatomy & Morphology
Xiao Lin, Michael G. K. Brunk, Pingan Yuanxiang, Andrew W. Curran, Enqi Zhang, Franziska Stoeber, Juergen Goldschmidt, Eckart D. Gundelfinger, Maike Vollmer, Max F. K. Happel, Rodrigo Herrera-Molina, Dirk Montag
Summary: The study found that the absence of neuroplastin in mice leads to hearing impairment, accompanied by degeneration of hair cells and spiral ganglion cells, as well as reduced baseline blood flow in the auditory cortex. Neuroplastin is required for the expression of PMCA 2 in outer hair cells, suggesting that altered Ca2+ homeostasis underlies the observed hearing impairments and hair cell degeneration.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Biochemistry & Molecular Biology
Katarina Ilic, Xiao Lin, Ayse Malci, Mario Stojanovic, Borna Puljko, Marko Rozman, Zeljka Vukelic, Marija Heffer, Dirk Montag, Ronald L. Schnaar, Svjetlana Kalanj-Bognar, Rodrigo Herrera-Molina, Kristina Mlinac-Jerkovic
Summary: The study found that PMCA-Neuroplastin complexes exist in specific ganglioside-containing rafts, affecting calcium homeostasis in neurons. GM1 was identified as the main ganglioside co-localizing with Neuroplastin, and blocking GM1 resulted in delayed calcium restoration in hippocampal neurons. The findings suggest that altered composition of ganglioside-containing rafts could lead to changes in calcium signal regulation in neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Dirk Montag
Summary: Retrograde amnesia refers to the inability to recall events or information, often triggered by traumatic events. It can be caused by either the loss of memory itself or the inability to access existing memories, and can result from various external or internal factors leading to variable degrees of memory loss.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Cell Biology
Ayse Malci, Xiao Lin, Rodrigo Sandoval, Eckart D. Gundelfinger, Michael Naumann, Constanze Seidenbecher, Rodrigo Herrera-Molina
Summary: The study demonstrates that Np65 coordinates the functions of PMCA and iGluRs to modulate the duration and amplitude of cytosolic Ca2+ transients in dendrites and spines of hippocampal neurons.
Article
Multidisciplinary Sciences
Dirk Montag, Laura Pelz, Fritz Rathjen
Summary: The study found that mice lacking BT-IgSF displayed altered behaviors, including reduced anxiety or increased fear of darkness, decreased behavioral flexibility, and increased aggression. These results demonstrate the importance of BT-IgSF in regulating specific behaviors and its contribution to network functions.
