Journal
FRONTIERS IN PHARMACOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.821358
Keywords
sepsis; resveratrol; organ protection; antioxidation; SIRT-1; animal model
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Funding
- Key research and development project of Science and Technology of Sichuan Province [20ZDYF 1870]
- Chengdu Technology Innovation Research and Development Project [2021-YF05-02246-SN]
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Sepsis is a life-threatening organ dysfunction syndrome. Resveratrol has the potential to treat sepsis by improving survival time and reducing mortality.
Sepsis is a life-threatening organ dysfunction syndrome caused by host response disorders due to infection or infectious factors and is a common complication of patients with clinical trauma, burns, and infection. Resveratrol is a natural polyphenol compound that is a SIRT-1 activator with anti-inflammatory, antiviral, antibacterial, antifungal inhibitory abilities as well as cardiovascular and anti-tumor protective effects. In recent years, some scholars have applied resveratrol in animal models of sepsis and found that it has an organ protective effect and can improve the survival time and reduce the mortality of animals with sepsis. In this study, Medline (Pubmed), embase, and other databases were searched to retrieve literature published in 2021 using the keywords resveratrol and sepsis, and then the potential of resveratrol for the treatment of sepsis was reviewed and prospected to provide some basis for future clinical research.
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