Isolation and Identification of Andrographis paniculata (Chuanxinlian) and Its Biologically Active Constituents Inhibited Enterovirus 71-Induced Cell Apoptosis

Ergosterol peroxide exhibits antiviral and immunomodulatory abilities against porcine deltacoronavirus (PDCoV) via suppression of NF-κB and p38/MAPK signaling pathways in vitro

(2021) Cong Duan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Andrographis paniculata (Burm.f.) Nees and its major constituent andrographolide as potential antiviral agents

(2021) Maoyuan Jiang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Anti-SARS-CoV-2 Activity of Andrographis paniculata Extract and Its Major Component Andrographolide in Human Lung Epithelial Cells and Cytotoxicity Evaluation in Major Organ Cell Representatives

(2021) Khanit Sa-ngiamsuntorn et al.   JOURNAL OF NATURAL PRODUCTS

Andrographis paniculata (Burm.f.) Nees: Traditional uses, phytochemistry, pharmacological properties and quality control/quality assurance

(2021) Sunil Kumar et al.   JOURNAL OF ETHNOPHARMACOLOGY

14-Deoxy-11,12-didehydroandrographolide inhibits apoptosis in influenza A(H5N1) virus-infected human lung epithelial cells via the caspase-9-dependent intrinsic apoptotic pathway which contributes to its antiviral activity

(2020) Wentao Cai et al.   ANTIVIRAL RESEARCH

Structure activity relationship of novel antiviral nucleosides against Enterovirus A71

(2020) Dilip K. Tosh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Application of metabolomics in viral pneumonia treatment with traditional Chinese medicine

(2019) Lili Lin et al.   Chinese Medicine

Characteristics of enterovirus 71-induced cell death and genome scanning to identify viral genes involved in virus-induced cell apoptosis

(2019) Jinjin Bai et al.   VIRUS RESEARCH

Ergosterol peroxide suppresses influenza A virus-induced pro-inflammatory response and apoptosis by blocking RIG-I signaling

(2019) Beixian Zhou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of EV71 by curcumin in intestinal epithelial cells

(2018) Hsing-I Huang et al.   PLoS One

Inhibition of enterovirus 71 replication and viral 3C protease by quercetin

(2018) Chenguang Yao et al.   Virology Journal

The Dual Nature of Type I and Type II Interferons

(2018) Amanda J. Lee et al.   Frontiers in Immunology

14-Deoxy-11,12-didehydroandrographolide attenuates excessive inflammatory responses and protects mice lethally challenged with highly pathogenic A(H5N1) influenza viruses

(2016) Wentao Cai et al.   ANTIVIRAL RESEARCH

Cinnamic Acid Derivatives as Inhibitors of Oncogenic Protein Kinases – Structure, Mechanisms and Biomedical Effects#

(2016) Marcin Mielecki et al.   CURRENT MEDICINAL CHEMISTRY

Luteoloside Acts as 3C Protease Inhibitor of Enterovirus 71 In Vitro

(2016) Zeyu Cao et al.   PLoS One

Chinese herbal medicines as a source of molecules with anti-enterovirus 71 activity

(2016) Mengjie Wang et al.   Chinese Medicine

Specificity and Inhibitory Mechanism of Andrographolide and Its Analogues as Antiasthma Agents on NF-κB p50

(2015) Van Sang Nguyen et al.   JOURNAL OF NATURAL PRODUCTS

Synthesis, structure–activity relationships and biological evaluation of dehydroandrographolide and andrographolide derivatives as novel anti-hepatitis B virus agents

(2014) Hao Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Prenylated Benzoylphloroglucinols and Xanthones from the Leaves of Garcinia oblongifolia with Antienteroviral Activity

(2014) Hong Zhang et al.   JOURNAL OF NATURAL PRODUCTS

Glycyrrhizic acid as the antiviral component of Glycyrrhiza uralensis Fisch. against coxsackievirus A16 and enterovirus 71 of hand foot and mouth disease

(2013) Jingjing Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Enterovirus 71 infection increases expression of interferon-gamma-inducible protein 10 which protects mice by reducing viral burden in multiple tissues

(2013) F.-H. Shen et al.   JOURNAL OF GENERAL VIROLOGY

Anti-HIV activity of semisynthetic derivatives of andrographolide and computational study of HIV-1 gp120 protein binding

(2012) Mayur M. Uttekar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antiviral activity of punicalagin toward human enterovirus 71 in vitro and in vivo

(2012) Yajun Yang et al.   PHYTOMEDICINE

Enterovirus type 71 neutralizing antibodies in the serum of macaque monkeys immunized with EV71 virus-like particles

(2012) Yu-Li Lin et al.   VACCINE

Bilirubin: An Endogenous Molecule with Antiviral Activity in vitro

(2012) Rosaria Santangelo et al.   Frontiers in Pharmacology

Inhibition of enterovirus 71 replication by chrysosplenetin and penduletin

(2011) Qin-Chang Zhu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

T Cell-, Interleukin-12-, and Gamma Interferon-Driven Viral Clearance in Measles Virus-Infected Brain Tissue

(2011) S. R. Stubblefield Park et al.   JOURNAL OF VIROLOGY

In vitro modulation of LPS/calcimycin induced inflammatory and allergic mediators by pure compounds of Andrographis paniculata (King of bitters) extract

(2010) C.V. Chandrasekaran et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Anti-inflammatory Activity of New Compounds from Andrographis paniculata by NF-κB Transactivation Inhibition

(2010) Wen-Wan Chao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmCold™) in patients with uncomplicated upper respiratory tract infection

(2010) R.C. Saxena et al.   PHYTOMEDICINE

Enterovirus 71 virus-like particle vaccine: Improved production conditions for enhanced yield

(2010) Cheng-Yu Chung et al.   VACCINE

Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian)

(2010) Wen-Wan Chao et al.   Chinese Medicine

Activity of Andrographolide and Its Derivatives against Influenza Virus in Vivo and in Vitro

(2009) Jian-Xin Chen et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Enterovirus 71 induces COX-2 expression via MAPKs, NF-κB, and AP-1 in SK–N–SH cells: Role of PGE2 in viral replication

(2009) Wei-Hsuan Tung et al.   CELLULAR SIGNALLING

Antiviral Effect of Epigallocatechin Gallate on Enterovirus 71

(2009) Hung-Yao Ho et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The ethyl acetate extract of alfalfa sprout ameliorates disease severity of autoimmune-prone MRL-lpr/lpr mice

(2009) YH Hong et al.   LUPUS

Inhibition of the Epstein–Barr Virus Lytic Cycle by Andrographolide

(2008) Tsuey-Pin Lin et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Synthesis and evaluation of antibacterial activities of andrographolide analogues

(2008) Xiaojian Jiang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The production of nitric oxide and prostaglandin E2 in peritoneal macrophages is inhibited by Andrographis paniculata, Angelica sinensis and Morus alba ethyl acetate fractions

(2008) Wen-Wan Chao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Ribavirin Reduces Mortality in Enterovirus 71–Infected Mice by Decreasing Viral Replication

(2008) Zhao‐Hong Li et al.   JOURNAL OF INFECTIOUS DISEASES