Article
Immunology
Kai Kang, Fucun Xie, Yijun Wu, Zhile Wang, Li Wang, Junyu Long, Xin Lian, Fuquan Zhang
Summary: In diffuse gliomas, a negative correlation was found between TMB and prognosis. The relationship of immune infiltration with TMB and prognosis varied depending on the type of immune cells. The nomogram and risk score models developed can accurately predict prognosis and help identify suitable patients for ICIs and potential therapeutic targets to improve the treatment of diffuse gliomas.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Fang Wen, Shuai Ruan, Wenjie Huang, Xiaoxue Chen, Yulan Wang, Suping Gu, Jiatong Liu, Shenlin Liu, Peng Shu
Summary: The study identified gene mutation characteristics in cervical squamous cell carcinoma and the association between tumor mutation burden (TMB) and prognosis. By establishing a prognostic model with five hub genes, the sensitivity of patients to immunotherapy can be predicted.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Jiawei Dai, Minlin Jiang, Kan He, Hao Wang, Peixin Chen, Haoyue Guo, Wencheng Zhao, Hui Lu, Yayi He, Caicun Zhou
Summary: DDR gene alterations in lung cancer without oncogenic drivers are positively associated with high TMB, and specific DDR gene alterations tend to associate with worse progression-free survival to initial chemotherapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Hao Huang, Ding Zhang, Jinming Fu, Liyuan Zhao, Dapeng Li, Hongru Sun, Xinyan Liu, Jing Xu, Tian Tian, Lei Zhang, Ying Liu, Yuanyuan Zhang, Yashuang Zhao
Summary: The study found that high TSKU expression is associated with poor prognosis in NSCLC patients, especially when B cell infiltration is low. Additionally, the proportion of B cells with TSKU hypermethylation was higher in NSCLC patients.
Article
Cell Biology
Congkuan Song, Zhiquan Wu, Qingwen Wang, Yujin Wang, Zixin Guo, Sheng Li, Weidong Hu
Summary: A study identified two genes that can predict response to immunotherapy in lung adenocarcinoma patients, developed a signature to distinguish high- and low-risk patients, and constructed a nomogram by combining immune prognostic signature with clinical features.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hai-Bin Ou, Yan Wei, Yu Liu, Fu-Xiang Zhou, Yun-Feng Zhou
Summary: This study proposes a new immunophenotyping method for evaluating the prognosis and tumor microenvironment cellular infiltration characteristics in lung adenocarcinoma (LUAD) patients and their response to immunotherapy. The results demonstrate that the tumor immune infiltration score is associated with immune activation and apoptosis signaling pathways and can predict patient response to immune checkpoint inhibitors.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Endocrinology & Metabolism
J-Z. Zhang, S-H. Bai, Y-L. Yan, H-J. Kang, G-Z. Li, Z-D. Feng, W. Ma, X. Wang, J. Ren
Summary: This study elucidated the molecular mechanism of N6-methyladenosine (m6A) regulation in lung adenocarcinoma (LUAD) development. It identified specific m6A regulators associated with prognosis and immune cell infiltration and constructed a risk score system for reliable prognosis prediction and guidance in LUAD therapy.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Cell Biology
Jia Wang, Xiaolu Zhang, Jie Li, Xiaoran Ma, Fubin Feng, Lijuan Liu, Jibiao Wu, Changgang Sun
Summary: Breast cancer (BRCA) has traditionally been considered to have poor immunogenicity and low tumor mutational burden (TMB). However, high TMB in BRCA is more likely to activate a partial immune response. The mutation of ADRB1, identified as a potential biomarker, is associated with lower TMB and shows a satisfactory clinical prognosis, providing new insights for co-therapy of BRCA.
Article
Medicine, General & Internal
Hongxiang Feng, Chaoyang Liang, Yuhui Shi, Deruo Liu, Jin Zhang, Zhenrong Zhang
Summary: In this study, a six-gene signature was established to predict the prognosis of lung adenocarcinoma (LUAD) patients and was found to be significantly associated with immune cell infiltration. This finding may provide a theoretical basis for targeted immunotherapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Guangran Guo, Longjun Yang, Yingsheng Wen, Gongming Wang, Rusi Zhang, Dechang Zhao, Zirui Huang, Xuewen Zhang, Yongbin Lin, Lanjun Zhang
Summary: In this study, an immune prognostic signature consisting of 12 immune-related genes was developed for lung cancer patients, showing that the high-risk group had shorter survival time and high-risk immune genes were associated with more malignant clinical manifestations. Additionally, extensive infiltration of B cells, dendritic cells, and mast cells indicated a favorable prognosis.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ti-wei Miao, De-qing Yang, Li-juan Gao, Jie Yin, Qi Zhu, Jie Liu, Yan-qiu He, Xin Chen
Summary: A prognostic redox-related gene signature was successfully established in non-small-cell lung cancer (NSCLC), with potential applications in the clinical setting.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Mathematical & Computational Biology
Yong Luo, Qingbiao Chen, Jingbo Lin
Summary: This study investigated the impact of tumor mutation burden (TMB) on the prognosis and immune microenvironment infiltration in adrenocortical carcinoma (ACC). The results showed that lower TMB levels were associated with improved survival outcomes and younger age and earlier clinical stage. Functional analysis revealed the relationship between TMB and cell cycle, DNA replication, and cancer progression. Furthermore, significant differences in infiltration levels of activated CD4+ T cells, naive B cells, and activated NK cells were observed in different TMB groups. A prognostic signature (TMBPS) was established and its predictive accuracy for ACC was evaluated.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2022)
Article
Cell Biology
Dan Deng, Xin Luo, Sifang Zhang, Zhijie Xu
Summary: The study analyzed the characteristics of tumor immune cell infiltration and constructed an ICI score, which showed a significant correlation with the prognosis of colon cancer patients. A high ICI score was associated with better prognosis, while low ICI score patients had decreased overall survival. Additionally, immune checkpoint molecules were significantly overexpressed in the low ICI score subgroup.
Article
Respiratory System
Guus R. M. van den Heuvel, Leonie I. Kroeze, Marjolijn J. L. Ligtenberg, Katrien Grunberg, Erik A. M. Jansen, Daniel von Rhein, Richarda M. de Voer, Michel M. van den Heuvel
Summary: This study investigated mutational signatures in NSCLC patients using tumor DNA samples, revealing a prominent presence of SBS4 signature in tumors associated with smoking, and SBS2 and/or SBS13 signatures linked to AID/APOBEC enzyme activity. SBS4 signature was significantly more present in early stages of NSCLC, indicating potential clinical significance. Further studies are needed to determine the clinical utility of mutational signature analyses.
RESPIRATORY RESEARCH
(2021)
Article
Oncology
Shailaja K. S. Raj, Eric D. Routh, Jeff W. Chou, Konstantinos Votanopoulos, Pierre L. Triozzi, Lance D. Miller
Summary: In this study, the authors analyzed RNA sequencing and clinical data of soft tissue sarcomas and found that infiltrates of T cells and plasma B cells were associated with a survival benefit. The prognostic power of T-cell signatures was dependent on tumor mutational burden (TMB), whereas plasma B-cell signatures were associated with survival independent of T-cell signature status.
Article
Oncology
Bicheng Zhang, Yuxiao Song, Yang Fu, Bo Zhu, Baocheng Wang, Jun Wang
Article
Biochemical Research Methods
Jian Yi, Longyun Chen, Yajie Xiao, Zhikun Zhao, Xiaofan Su
Summary: HLA typing is crucial for cancer immunotherapy, and this study found that OptiType demonstrated the highest accuracy in HLA-Ia typing from WES data, potentially providing a superior performance for its clinical application.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Immunology
Yuxiao Song, Yang Fu, Qi Xie, Bo Zhu, Jun Wang, Bicheng Zhang
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Virology
Fang Tang, Xiaoshuai Zhang, Bicheng Zhang, Bo Zhu, Jun Wang
Summary: This study developed two nomogram models for distinguishing disease severity and predicting prognosis in COVID-19 patients. The results indicate that immune response phenotyping based on blood indicators can effectively identify high-risk clinical cases.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Medicine, Research & Experimental
Qi Xie, Tong-yao Shang, Shuo Feng, Ru-cai Zhan, Jing Liang, Meng-ge Fan, Liang Zhang, Ju Liu
Summary: The study found that hypoxia inhibits the proliferation of HDLECs, and CEACAM1 plays a crucial role in this process. Silencing of CEACAM1 inhibited HDLEC proliferation through activation of the JNK pathway, providing insights into the specific response mechanisms of LECs to hypoxia and potential novel therapies for pathological lymphangiogenesis.
CURRENT MEDICAL SCIENCE
(2021)
Article
Immunology
Lei Wang, Hongbing Zhang, Chaohu Pan, Jian Yi, Xiaoli Cui, Na Li, Jiaqian Wang, Zhibo Gao, Dongfang Wu, Jun Chen, Jizong Jiang, Qian Chu
Summary: A comprehensive predictive model is urgently needed to predict the response to immune checkpoint inhibitors (ICIs) in cancer patients. By studying 162 non-small-cell lung cancer (NSCLC) patients, three genomic biomarkers were identified and used to construct a durable clinical benefit (DCB) prediction model, which showed good predictive value.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Xing Chen, Lin Ma, Xiaolin Liu, Jun Wang, Yan Li, Qi Xie, Jing Liang
Summary: Clostridium butyricum may alleviate inflammation in DSS-induced IBD-model mice by promoting intestinal lymphatic vessel regeneration.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Review
Oncology
Lu Yu, Min Cheng, Jie Liu, Xin Ye, Zhigang Wei, Jiamei Xu, Qi Xie, Jing Liang
Summary: Microwave ablation is a thermal ablation method used for treating various tumors, which can locally control tumors that cannot be surgically removed. Ferroptosis is an iron-dependent cell death caused by cumulative reactive oxygen species and lipid peroxidation products. Recent evidence suggests that ferroptosis may play a crucial role in the tumor suppression induced by microwave ablation.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Baocheng Wang, Chen Zhong, Zijun Liao, Haitao Wang, Xiuyu Cai, Yanbing Zhang, Jun Wang, Tianxiao Wang, Hongtao Yao
Summary: This study aimed to analyze the effectiveness and safety of H101 in Chinese patients with malignant pleural effusion and ascites. The results showed that H101 has a high overall remission rate and good safety profile in the treatment of this disease, and it can be used in combination with chemotherapy.
Review
Oncology
Jun Wang, Bicheng Zhang, Ling Peng, Xiufeng Liu, Jianguo Sun, Chunxia Su, Huijuan Wang, Zheng Zhao, Lu Si, Jianchun Duan, Hongmei Zhang, Mengxia Li, Bo Zhu, Li Zhang, Jin Li, Jun Guo, Rongcheng Luo, Wensheng Qiu, Dingwei Ye, Qian Chu, Jiuwei Cui, Xiaorong Dong, Yun Fan, Quanli Gao, Ye Guo, Zhiyong He, Wenfeng Li, Gen Lin, Lian Liu, Yutao Liu, Haifeng Qin, Shengxiang Ren, Xiubao Ren, Yongsheng Wang, Junli Xue, Yunpeng Yang, Zhenzhou Yang, Lu Yue, Xianbao Zhan, Junping Zhang, Jun Ma, Shukui Qin, Baocheng Wang
Summary: The National Medical Products Administration of China has approved 17 immune checkpoint inhibitors as the standard treatment for certain advanced or metastatic solid tumors. However, the use of immune checkpoint inhibitors in special patient populations remains challenging due to their exclusion or underrepresentation in clinical trials, leading to insufficient guidance for clinical management. A consensus developed by leading experts aims to provide important reference for clinicians to properly apply immune checkpoint inhibitors in special patient populations.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Article
Oncology
Yaping Guan, Dongfeng Feng, Beibei Yin, Kun Li, Jun Wang
Summary: Immune checkpoint blockade with immune checkpoint inhibitors has revolutionized systematic treatment for advanced solid tumors. However, the response rate to these inhibitors is unsatisfactory, and atypical radiological responses, including delayed responses, pseudoprogression, hyperprogression, and dissociated responses, are observed in some patients. The conventional response evaluation criteria in solid tumors underestimate the benefit of immunotherapy for patients with atypical responses. This review aims to comprehensively analyze the frequency, definition, radiological evaluation, probable molecular mechanisms, prognosis, and clinical management of immune-related dissociated responses.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)
Article
Oncology
Ting Li, Qi Xie, Junwei Li, Zhen Li, Junjuan Xiao, Mingguo Liu, Jun Wang, Yan Li, Fang Tang, Jing Liang
Summary: This study utilized data from the SEER database to investigate the prognosis of SpCC patients and the impact of different treatment strategies. The results showed that different treatments for SpCC in different organs or systems were associated with patient prognosis, with surgery alone showing survival benefit. Adjuvant therapy did not demonstrate survival benefit for SpCC patients and even increased mortality risk.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2021)