Article
Immunology
Rienk Gerben van der Meer, Anneke Spoorenberg, Elisabeth Brouwer, Berber van der Meer, Annemieke M. H. Boots, Suzanne Arends, Wayel H. Abdulahad
Summary: This study reveals the changes in the number and phenotype of CD8+ mucosal-associated invariant T-cells (MAIT) in peripheral blood of patients with spondyloarthritis. Additionally, the study suggests that the inflammatory function of these cells is also affected, which might be implicated in the pathogenesis of axial diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Thibault Ghesquiere, Marion Ciudad, Andre Ramon, Helene Greigert, Claire Gerard, Claudie Cladiere, Marine Thebault, Coraline Genet, Herve Devilliers, Francois Maurier, Paul Ornetti, Valerie Quipourt, Pierre-Henry Gabrielle, Catherine Creuzot-Garcher, Georges Tarris, Laurent Martin, Agnes Soudry-Faure, Philippe Saas, Sylvain Audia, Bernard Bonnotte, Maxime Samson
Summary: This study found that MAIT cells in patients with giant cell arteritis (GCA) have differences in cytokine production and proliferation, suggesting that MAIT may play a role in the pathogenesis of GCA.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Multidisciplinary Sciences
Sara De Biasi, Lara Gibellini, Domenico Lo Tartaro, Simone Puccio, Claudio Rabacchi, Emilia M. C. Mazza, Jolanda Brummelman, Brandon Williams, Kelly Kaihara, Mattia Forcato, Silvio Bicciato, Marcello Pinti, Roberta Depenni, Roberto Sabbatini, Caterina Longo, Massimo Dominici, Giovanni Pellacani, Enrico Lugli, Andrea Cossarizza
Summary: Through single-cell analyses, the authors found that patients in a 28-patient cohort stratified by mucosal-associated invariant T (MAIT) percentages showed different response rates, with immune checkpoint inhibition (ICI) responders having more MAIT cells expressing CXCR4 and granzyme B.
NATURE COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Hong Zhou, Junting Xu, Ling Hong, Yanping Jia, Lilo Valerie Burk, Fengli Chi, Mei Zhao, Xiaohong Guan, Dan Liu, Xiangjie Yin, Yiqiao Zhang, Xiaoming Teng, Liyan Duan, Kunming Li
Summary: This study aimed to evaluate the correlation between characteristics of PCOS and MAIT cells as well as their impact on cytokine secretion. The results showed that the frequency of MAIT cells was significantly reduced in the blood of PCOS patients and negatively correlated with BMI, HOMA-IR index, and AMH. The cytokine IL-17 was significantly higher in PCOS patients and negatively correlated with the frequency of MAIT cells. The frequency change of MAIT cells may play a significant role in the pathogenesis of PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Immunology
Xue Wen, Xingli Zhang, Siji Nian, Gang Wei, Xiyuan Guo, Hong Yu, Xiang Xie, Yingchun Ye, Qing Yuan
Summary: MAIT cells, a subset of unconventional T cells, play an important role in immune surveillance and lung diseases. Despite their small proportion in lung immune cells, evidence suggests they can mediate immune response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Immunology
Yanmei Li, Jun Du, Wei Wei
Summary: This review discusses the role of mucosal-associated invariant T (MAIT) cells in rheumatic diseases, emphasizing the potential for further research on MAIT cells to inform the development of novel biomarkers and therapeutic approaches in rheumatology.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Zhilei Chen, Suying Liu, Chengmei He, Jinlei Sun, Li Wang, Hua Chen, Fengchun Zhang
Summary: The study showed that in patients with PBC, MAIT cells in the peripheral blood were significantly reduced and negatively correlated with alkaline phosphatase levels. MAIT cells from PBC patients accumulated in the liver, expressed higher levels of CXCR4 and CXCL12, produced more pro-inflammatory cytokines, and were influenced by elevated IL-18 levels. Targeting MAIT cells may be a potential therapeutic approach for PBC.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Xiaoyan Ye, Yachun Li, Bixing Fang, Yizhang Yuan, Danni Feng, Hexin Chen, Jian Li, Qingxiang Meng, Shaobing Xiong, Dongmei Ye, Linyi Jiao, Dehua Chen, Ruchong Chen, Wenbin Lei, Yifang Gao, Chunwei Li
Summary: This study found that MAIT cells in neutrophilic CRSwNP exhibit type 17 functional properties and promote neutrophil infiltration in nasal mucosa.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Tejpal Gill, Patrick Stauffer, Mark Asquith, Ted Laderas, Tammy M. Martin, Sean Davin, Matthew Schleisman, Claire Ramirez, Kimberly Ogle, Ingrid Lindquist, Justine Nguyen, Stephen R. Planck, Carley Shaut, Sarah Diamond, James T. Rosenbaum, Lisa Karstens
Summary: This study investigated the altered immunoglobulin A (IgA) response in the gut and oral microbial communities of patients with axial spondyloarthritis (axSpA). The results showed that axSpA patients had distinct populations of immunoreactive microbes in their fecal and salivary microbiomes. Predictive metagenomic analysis revealed perturbation of metabolites and metabolic pathways in axSpA patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Sebastian Deschler, Juliane Kager, Johanna Erber, Lisa Fricke, Plamena Koyumdzhieva, Alexandra Georgieva, Tobias Lahmer, Johannes R. Wiessner, Florian Voit, Jochen Schneider, Julia Horstmann, Roman Iakoubov, Matthias Treiber, Christof Winter, Jurgen Ruland, Dirk H. Busch, Percy A. Knolle, Ulrike Protzer, Christoph D. Spinner, Roland M. Schmid, Michael Quante, Katrin Bottcher
Summary: MAIT cells in patients with COVID-19 show high activation and expression of proinflammatory cytokines, while their antibacterial and antiviral function is impaired. The data points towards the importance of MAIT cells in the pathogenesis of COVID-19.
Review
Virology
Bin Su, Deshenyue Kong, Xiaodong Yang, Tong Zhang, Yi-Qun Kuang
Summary: The decreased number of MAIT cells in HIV-infected individuals affects intestinal barrier integrity and microbial homeostasis, which in turn further compromises immune reconstitution.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Immunology
Lichen Ouyang, Mi Wu, Juan Zhao, Lang Jiang, Zhijun Shen, Xue Cheng, Wei Wang, Xiongwen Wu, Xiaonian Cao, Xiufang Weng
Summary: This study evaluates the clinical relevance of MAIT cells in blood and tumor tissues of NSCLC patients. The results show a significant decline in the frequency of MAIT cells in lung tumor tissues, which is related to TNM stage. Additionally, tumor-infiltrating MAIT cells exhibit increased levels of exhaustion markers.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lara Marie DeAngelis, Nicola Cirillo, Alexis Perez-Gonzalez, Michael McCullough
Summary: This study used multiplex immunohistochemistry (mIHC) to investigate the presence and abundance of mucosal-associated invariant T (MAIT) cells in oral lichen planus (OLP) tissue samples, as well as their relationship with Candida infection and symptoms. The results showed the presence of MAIT cell phenotypes in OLP tissue, with significant differences in the percentage of positive cells between different OLP groups. The relative abundance of triple-stained cells also varied significantly. Reduced percentage of certain cells was observed in symptomatic OLP with and without Candida, suggesting a potential role of these cells in OLP pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Xue Wen, Siji Nian, Gang Wei, Pengyuan Kang, Yaqi Yang, Lin Li, Yingchun Ye, Lulu Zhang, Songping Wang, Qing Yuan
Summary: This study evaluated the phenotype and function of circulating mucosal-associated invariant T (MAIT) cells in patients with neutrophilic asthma (NA). The results showed that NA patients had significantly decreased frequency of MAIT cells, altered phenotype, and biased Th17 immune response. The study suggests that MAIT cells could be a potential therapeutic target for NA asthma.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Immunology
Xingzhou Wang, Mengjie Liang, Peng Song, Wenxian Guan, Xiaofei Shen
Summary: Mucosa-associated invariant T (MAIT) cells are a type of innate-like T lymphocytes with CD8(+) phenotype and a semi-invariant alpha beta T-cell receptor, which specifically recognizes MR1-presented biosynthetic derivatives of riboflavin synthesis produced by various types of microbiomes. MAIT can be activated by various cytokines and mount immediate immune responses to infection and tumor cues. The interaction between MAIT and local microbiomes is crucial for the homeostasis of mucosal immunity. Inflammation and tumorigenesis can affect MAIT development and function through changes in the abundance and structure of the microbial community, emphasizing the importance of understanding MAIT response and their interaction with microbiomes in the digestive tract.
Article
Multidisciplinary Sciences
Tullu Bukhari, Vishukumar Aimanianda, Emmanuel Bischoff, Emma Brito-Fravallo, Karin Eiglmeier, Michelle M. Riehle, Kenneth D. Vernick, Christian Mitri
Summary: This study explores the genetic resistance to fungal biopesticides in mosquito populations and its potential implications for malaria control. It identifies genetic components that influence mosquito survival after exposure to the entomopathogenic fungus and reveals a similarity in the protective responses of mosquitoes against fungus and the malaria parasite. The findings suggest that selecting for fungus resistance in vector populations may also enhance resistance to malaria.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Sebastien Triboulet, Maimouna D. N'Gadjaga, Beatrice Niragire, Stephan Koestlbacher, Matthias Horn, Vishukumar Aimanianda, Agathe Subtil
Summary: The obligate intracellular bacteria Chlamydia trachomatis store glycogen in the vacuoles and convert Glc1P to Glc6P through bacterial PGM. Glycogen accumulation in the vacuoles of certain Chlamydia species is correlated with the presence of T3S signals in CT295 orthologs.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Meeting Abstract
Infectious Diseases
Vishukumar Aimanianda, Sarah Sze Wah Wong, Sarah Delliere, Natalia Schiefermeier-Mach, Lukas Lechner, Susanne Perkhofer, Perrine Bomme, Thierry Fontaine, Anders Schlosser, Grith Sorensen, Taruna Madan, Uday Kishore
Meeting Abstract
Infectious Diseases
Sarah Delliere, Sarah Wong, Camille Chauvin, Jagadeesh Bayry, Agostinho Carvalho, Antonio Inforzato, Vishukumar Aimanianda
Article
Immunology
Rajashri Shende, Sarah Sze Wah Wong, Heikrujam Thoihen Meitei, Girdhari Lal, Taruna Madan, Vishukumar Aimanianda, Jayanta Kumar Pal, Arvind Sahu
Summary: Invasive aspergillosis is a life-threatening fungal infection for immunocompromised hosts. The study found that complement deficiency increases susceptibility to systemic infection by Aspergillus fumigatus.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Gaelle Lamona, Alons Lends, Isabel Valsecchi, Sarah Sze Wah Wong, Vincent Dupres, Frank Lafont, James Tolchard, Christine Schmitt, Adeline Mallet, Axelle Grelard, Estelle Morvan, Erick J. Dufourc, Birgit Habenstein, J. Inaki Guijarro, Vishukumar Aimanianda, Antoine Loquet
Summary: Through the use of magic-angle spinning NMR, researchers found that the cell wall polysaccharides of Aspergillus fumigatus undergo dynamic remodeling during conidial germination. They also discovered a significant change in the molar ratio of major polysaccharides after dormancy break, while the chitin content remained constant.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Microbiology
Zhonghua Liu, Isabel Valsecchi, Remy A. Le Meur, Catherine Simenel, J. Inaki Guijarro, Catherine Comte, Laetitia Muszkieta, Isabelle Mouyna, Bernard Henrissat, Vishukumar Aimanianda, Jean-Paul Latge, Thierry Fontaine
Summary: Earlier studies have found that the outer layers of Aspergillus fumigatus conidial and mycelial cell walls are different. This study analyzed the polysaccharidome of the resting conidial cell wall and observed significant differences within the mycelium cell wall. The conidia cell wall had less alpha-(1,3)-glucan and chitin, a larger amount of beta-(1,3)-glucan, and a specific mannan with unique side chains. Furthermore, certain fungal genes were found to play crucial roles in the organization of conidia cell wall beta-(1,3)-glucan and the polymerization of conidium-associated cell wall mannan.
Article
Biotechnology & Applied Microbiology
Lakshmi Prabha Venugopalan, Vishukumar Aimanianda, Venkatesh Prajna Namperumalsamy, Lalitha Prajna, Dharmalingam Kuppamuthu, Jeya Maheshwari Jayapal
Summary: In this study, the importance of Aspergillus flavus and Aspergillus fumigatus as human pathogens was highlighted. The surface-associated proteins and early exoproteome of these two pathogens were analyzed and compared, revealing potential species-specific signature proteins. Transcript analysis showed that the correlation between transcript and protein levels varied among different proteins.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Review
Mycology
Sarah Delliere, Vishukumar Aimanianda
Summary: Aspergillus fumigatus is a common airborne fungal pathogen, and understanding its interaction with the host immune system is crucial for explaining the pathobiology of aspergillosis. While cellular immunity has been well studied, humoral immunity has been overlooked despite its important role in connecting the fungus and immune cells. This review summarizes available data on the major players of humoral immunity against A. fumigatus and discusses their potential applications in identifying at-risk individuals, diagnostics, and alternative therapeutic strategies. Challenges and future research directions are highlighted to better understand the complexity of the interaction between humoral immunity and A. fumigatus.
Review
Immunology
Clea Melenotte, Vishukumar Aimanianda, Monica Slavin, Jose Maria Aguado, Darius Armstrong-James, Yee-Chun Chen, Shahid Husain, Christian Van Delden, Faouzi Saliba, Agnes Lefort, Francoise Botterel, Olivier Lortholary
Summary: Invasive aspergillosis is a rare but serious infection in liver transplant recipients, with a high mortality rate. Risk factors before, during, and after transplantation have been identified, and accurate diagnosis requires collaboration between radiology and clinical biology. It is recommended to reduce the dose of tacrolimus and closely monitor blood levels when using certain drugs, and surgery should be considered on a case-by-case basis. Antifungal prophylaxis and environmental measures should be implemented to prevent outbreaks.
TRANSPLANT INFECTIOUS DISEASE
(2023)
Article
Microbiology
Philip E. Alabi, Cecile Gautier, Thomas P. Murphy, Xilin Gu, Mathieu Lepas, Vishukumar Aimanianda, Jason K. Sello, Iuliana V. Ene
Summary: Fungi cause billions of infections each year and have a devastating impact on human health. The limited antifungal arsenal and emerging drug-resistant species necessitate the development of new therapies. A screening effort led to the discovery of small molecules that restore the susceptibility of Candida species to antifungals.
Review
Microbiology
Francois Danion, Anne Coste, Coralie Le Hyaric, Clea Melenotte, Frederic Lamoth, Thierry Calandra, Dea Garcia-Hermoso, Vishukumar Aimanianda, Fanny Lanternier, Olivier Lortholary
Summary: Mucormycosis is a rare and life-threatening fungal infection caused by molds of the order Mucorales. It mainly affects the lungs, following the rhino-orbito-cerebral (ROC) areas and the skin. Risk factors for pulmonary mucormycosis (PM) include hematological malignancies and solid organ transplantation, while ROC infections are commonly associated with diabetes mellitus. The diagnosis of PM relies on CT scans, cultures, PCR tests, and histology, and treatment involves liposomal amphotericin B as the first-line therapy.
Meeting Abstract
Biophysics
Borja Rodriguez de Francisco, Isabel Valsecchi, Ariane Pille, Chi L. Pham, Vincent Dupres, Frank Lafont, Jagadesh Bayry, Vishukumar Aimanianda, Margaret Sunde, Inaki Guijarro
BIOPHYSICAL JOURNAL
(2022)