Article
Public, Environmental & Occupational Health
W. Imoto, K. Yamada, G. Kuwabara, K. Yamairi, W. Shibata, K. Oshima, K. Nakaie, T. Watanabe, K. Asai, Y. Kaneko, T. Kawaguchi, H. Kakeya
Summary: This study retrospectively evaluated 2002 patients with positive sputum cultures, finding that pneumonia caused by S. maltophilia is rare. The S. maltophilia pneumonia group had a significantly lower median age compared to the non-S. maltophilia pneumonia group, and had higher SOFA scores.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Medicine, General & Internal
George Dimopoulos, Jose Garnacho-Montero, Elisabeth Paramythiotou, Antonio Gutierrez-Pizarraya, Charalambos Gogos, Maria Adriansen-Perez, Chrysa Diakaki, Dimitrios K. Matthaiou, Garyphalia Poulakou, Karolina Akinosoglou
Summary: This study investigated the clinical features and risk factors for mortality in ICU patients with S. maltophilia infections. The results showed that advanced age and hematologic-oncologic disease were independent risk factors for 28-day mortality. Despite initial treatment response, respiratory infections caused by S. maltophilia had a high mortality rate in critically ill patients.
Article
Pharmacology & Pharmacy
Rima Fanaei Pirlar, Jeroen Wagemans, Fabian Kunisch, Rob Lavigne, Andrej Trampuz, Mercedes Gonzalez Moreno
Summary: CUB19 is a novel bacteriophage that specifically targets the bacterial species Stenotrophomonas maltophilia. It exhibits stability over a wide range of temperatures and pH values and has potent antimicrobial and antibiofilm activity. The study also suggests that CUB19 is effective when co-administered with antibiotics, making it a promising targeted therapeutic agent against biofilm-associated Stenotrophomonas infections.
Article
Infectious Diseases
Lei Zha, Dayan Zhang, Lingling Pan, Zhichu Ren, Xiang Li, Yi Zou, Shirong Li, Shuangqi Luo, Gang Yang, Boris Tefsen
Summary: Tigecycline showed lower clinical and microbiological cure rates compared to fluoroquinolones in treating Stenotrophomonas maltophilia ventilator-associated pneumonia (VAP), but did not result in increased 28-day mortality. Therefore, the use of standard dose tigecycline in treating S. maltophilia VAP is not recommended due to unfavorable clinical outcomes unless new clinical evidence emerges.
INFECTIOUS DISEASES AND THERAPY
(2021)
Review
Virology
Jaclyn G. McCutcheon, Jonathan J. Dennis
Summary: The isolation and characterization of bacteriophages for treating infections caused by multidrug resistant Stenotrophomonas maltophilia is crucial. Research has focused on isolating new phages from the environment or induced from bacterial strains. Clinical significance, virulence factors, and antimicrobial resistance mechanisms of S. maltophilia have been summarized, along with strategies for using phages as an alternative treatment option. Limited in vivo phage therapy studies have been conducted, highlighting the need for future research in this area.
Article
Critical Care Medicine
Arnaud Foucrier, Thomas Dessalle, Sophie Tuffet, Laura Federici, Claire Dahyot-Fizelier, Francois Barbier, Julien Pottecher, Antoine Monsel, Tarik Hissem, Jean-Yves Lefrant, Alexandre Demoule, Jean-Michel Constantin, Alexandra Rousseau, Tabassome Simon, Marc Leone, Adrien Bougle
Summary: This study aimed to evaluate whether combination antibiotic therapy is superior to monotherapy in reducing recurrence and death in patients with Pseudomonas aeruginosa ventilator-associated pneumonia (PA-VAP). The results showed that although patients in the combination therapy group had longer durations of mechanical ventilation and antibiotic therapy, there were no significant differences in mortality rate and recurrence rate compared to the monotherapy group.
Article
Immunology
Archana Koirala, Bharath Krishnappa, Caroline Banh, Ulrike Brandenburg, Michael Findlay, Phoebe C. M. Williams
Summary: This is a case report on the use of cefiderocol for the treatment of VAP in a preterm neonate. The neonate showed continuous deterioration after initial treatment with corticosteroids, vancomycin, and ceftazidime. However, after switching to cefiderocol monotherapy, there was significant clinical improvement.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Immunology
Jiun-Ji Lai, L. Kristopher Siu, Feng-Yee Chang, Jung-Chung Lin, Ching-Mei Yu, Rui-Xin Wu, Ching-Hsun Wang
Summary: This study assessed the relationship between antibiotic therapy and outcome in ICU patients with Stenotrophomonas maltophilia bloodstream infection (BSI). Appropriate antibiotic therapy was associated with decreased 14-day mortality, and levofloxacin-containing regimens may be a better choice for treating ICU patients with S. maltophilia BSI.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Respiratory System
Shuping Chen, Dongdong Zou
Summary: In this study, we compared the prognosis and risk factors of Stenotrophomonas maltophilia (SM)-induced hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) with Klebsiella pneumoniae (KP)-induced HAP/VAP in the intensive care unit (ICU). The results showed that SM-HAP/VAP and KP-HAP/VAP patients in the ICU might have a similar prognosis in terms of mortality, duration of artificial airway and ventilator use, length of ICU stay, and hospital stay.
CLINICAL RESPIRATORY JOURNAL
(2022)
Article
Microbiology
Vidmantas Petraitis, Ruta Petraitiene, Povilas Kavaliauskas, Ethan Naing, Andrew Garcia, Naoki Ishibashi, Benjamin Georgiades, Roger Echols, Robert A. Bonomo, Yoshinori Yamano, Michael J. Satlin, Thomas J. Walsha
Summary: Cefiderocol demonstrates high efficacy in the treatment of S. maltophilia pneumonia, leading to improved survival rate, reduced bacterial burden, and lung injury in a rabbit model.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Medicine, General & Internal
Muhammad Humayoun Rashid, Syeda Neelam Yamin Bukhari, Aliaa Mousa, Ahmed Ali Aziz, Knkush Hakobyan
Summary: Multidrug-resistant gram-negative bacteria pose a significant challenge to the healthcare system due to limited treatment options. Stenotrophomonas maltophilia, a non-fermenting gram-negative bacterium, is resistant to multiple antibiotics. Cefiderocol, a novel antibiotic still in preclinical stages of FDA approval, showed potential as a treatment option for MDR Stenotrophomonas maltophilia in a case study of a 76-year-old male with ventilator-associated pneumonia.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Critical Care Medicine
Adrien Bougle, Sophie Tuffet, Laura Federici, Marc Leone, Antoine Monsel, Thomas Dessalle, Julien Amour, Claire Dahyot-Fizelier, Francois Barbier, Charles-Edouard Luyt, Olivier Langeron, Bernard Cholley, Julien Pottecher, Tarik Hissem, Jean-Yves Lefrant, Benoit Veber, Matthieu Legrand, Alexandre Demoule, Pierre Kalfon, Jean-Michel Constantin, Alexandra Rousseau, Tabassome Simon, Arnaud Foucrier
Summary: In the treatment of ventilator-associated pneumonia (VAP) caused by Pseudomonas aeruginosa (PA-VAP), there is no difference in the composite or separate outcomes between short- and long-duration antibiotic treatments.
INTENSIVE CARE MEDICINE
(2022)
Article
Ophthalmology
B. -C Park, Hwa-Rang Lim, Seon-Joo Park, Jae-Woong Koh
Summary: Stenotrophomonas maltophilia keratitis is an uncommon infectious disease of the cornea. Risk factors for S. maltophilia keratitis include trauma and the use of contact lenses. Most isolates showed susceptibility to fluoro-quinolones, aminoglycosides, and beta-lactams. Mixed use of these antibiotics may be considered as a preferred treatment option for S. maltophilia infection.
OPHTHALMOLOGY AND THERAPY
(2021)
Article
Infectious Diseases
Margaret Ming-Chih Ho, Ming-Hui Sun, Wei-Chi Wu, Chi-Chun Lai, Lung-Kun Yeh, Yih-Shiou Hwang, Ching-Hsi Hsiao, Kuan-Jen Chen
Summary: This study evaluated the antibiotic susceptibility and minimum inhibitory concentrations of Stenotrophomonas maltophilia isolates from ocular infections. The results showed higher susceptibility and lower MICs for fluoroquinolones, which can be recommended for treating S. maltophilia ocular infections. Tigecycline and TMP-SMX could be alternative antibiotics.
Article
Biotechnology & Applied Microbiology
Sarunas Paskevicius, Yuri Gleba, Ausra Razanskiene
Summary: This study reports the discovery of modular bacteriocins called stenocins in the genomes of S. maltophilia. The plant-expressed stenocins were found to be functional and capable of inhibiting the growth of Stenotrophomonas strains in vitro.
JOURNAL OF BIOTECHNOLOGY
(2022)
Article
Anesthesiology
David Vandroux, Hugo Kerambrun, Cyril Ferdynus, Nicolas Allou, Jerome Allyn, Bernard-Alex Gauzere, Olivier Martinet, Julien Jabot
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2020)
Article
Multidisciplinary Sciences
Thibault Charpentier, Cyril Ferdynus, Thomas Lair, Charlotte Cordier, Caroline Brulliard, Dorothee Valance, Malo Emery, Margot Caron, Nicolas Allou, Jerome Allyn
Article
Pediatrics
L. Harper, D. Alshammari, C. Ferdynus, N. Kalfa
JOURNAL OF PEDIATRIC UROLOGY
(2020)
Review
Health Care Sciences & Services
Maissa Safieddine, Celine Chapelle, Edouard Ollier, Cyril Ferdynus, Laurent Bertoletti, Patrick Mismetti, Michel Cucherat, Silvy Laporte
Summary: The study compared RCTs and observational studies in patients with venous thromboembolism receiving direct oral anticoagulants or conventional treatment. Observational studies may exaggerate treatment effects estimates, especially prospective cohort studies.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2021)
Article
Multidisciplinary Sciences
Antoine Binachon, Adeline Grateau, Nicolas Allou, Cyril Ferdynus, Jerome Allyn, Laurence Dangers, Olivier Martinet, Veronique Boisson, Alexandre Gauthier, Julien Jabot, Romain Persichini
Article
Medicine, General & Internal
Jerome Allyn, Nicolas Allou, Charles Vidal, Amelie Renou, Cyril Ferdynus
Article
Medicine, General & Internal
Eric Lespessailles, Emmanuel Mahe, Ziad Reguiai, Edouard Begon, Francois Maccari, Nathalie Beneton, Guillaume Chaby, Carole Rosenberg, Emmanuelle Dernis, Fabienne Roux, Isabelle Henry-Desailly, Benedicte Charles, Cyril Ferdynus, Marc Marty, Eric Esteve
Summary: The study validated the QualipsoSex Questionnaire (QSQ) in assessing the impact of psoriasis (Pso) and psoriatic arthritis (PsA) on patients' sexuality, demonstrating good psychometric properties and sensitivity to change according to the COSMIN checklist recommendations.
Article
Emergency Medicine
Thomas Nicol, Cedric Gil-Jardine, Patricia Jabre, Frederic Adnet, Patrick Ecollan, Bertrand Guihard, Cyril Ferdynus, Xavier Combes
Summary: This study evaluated the first attempt intubation failure rate and associated factors in out-of-hospital emergency setting. It found that a history of ear, nose, and throat neoplasia was independently associated with first attempt intubation failure, and failure in the first attempt was linked to more intubation-related complications.
PREHOSPITAL EMERGENCY CARE
(2022)
Article
Urology & Nephrology
Luke Harper, T. Blanc, M. Peycelon, J. L. Michel, M. D. Leclair, S. Garnier, V Flaum, A. P. Arnaud, T. Merrot, E. Dobremez, A. Faure, L. Fourcade, M. L. Poli-Merol, Y. Chaussy, O. Dunand, F. Collin, L. Huiart, C. Ferdynus, F. Sauvat
Summary: In a multicentric trial, the study compared the number of febrile urinary tract infections (UTIs) in boys with posterior urethral valves who had either antibiotic prophylaxis alone or antibiotic prophylaxis and circumcision. It was found that those who had a circumcision had a significantly lower risk of febrile UTIs.
Correction
Medicine, General & Internal
Cedric Gil-Jardine, Patricia Jabre, Frederic Adnet, Thomas Nicol, Patrick Ecollan, Bertrand Guihard, Cyril Ferdynus, Valery Bocquet, Xavier Combes
INTERNAL AND EMERGENCY MEDICINE
(2022)
Article
Multidisciplinary Sciences
Axel de Mangou, Agathe Combe, Nathalie Coolen-Allou, Guillaume Miltgen, Nicolas Traversier, Olivier Belmonte, David Vandroux, Michel Bohrer, Julien Cousty, Margot Caron, Charles Vidal, Jerome Allyn, Nicolas Allou
Summary: This study evaluated patients with severe CAP in Reunion Island from 2016 to 2018. The most frequently isolated microorganism in patients with severe CAP in Reunion Island is influenza followed by S. pneumoniae. Physicians should be aware that influenza is the main cause of severe CAP in patients living in or returning from Reunion Island.
Editorial Material
Computer Science, Interdisciplinary Applications
Matthieu Oliver, Jerome Allyn, Remi Carencotte, Nicolas Allou, Cyril Ferdynus
Summary: This study introduces the BlendedICU dataset, a massive dataset of international intensive care data, and aims to facilitate generalizability studies of machine learning models and statistical studies of clinical practices in the intensive care units. By preprocessing and standardizing four publicly available patient-level intensive care databases, the researchers obtained a database with multiple variables and drug exposure data. The study found differences in data collection and clinical practices between different source databases.
JOURNAL OF BIOMEDICAL INFORMATICS
(2023)